{"id":282947,"date":"2024-12-10T21:49:00","date_gmt":"2024-12-10T13:49:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=282947"},"modified":"2024-12-10T21:49:00","modified_gmt":"2024-12-10T13:49:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8aash-2024%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5%e8%80%90%e7%ab%8b%e5%85%8b%e6%b5%b7%e5%a4%96%e7%a0%94%e7%a9%b61-5%e5%b9%b4%e9%9a%a8%e8%a8%aa%e6%95%b8%e6%93%9a%e5%85%ac","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=282947","title":{"rendered":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a761.5\u5e74\u96a8\u8a2a\u6578\u64da\u516c\u4f48\uff0c\u518d\u8b49\u53ef\u514b\u670d\u60a3\u8005\u5c0dponatinib\u6216asciminib\u7684\u8010\u85e5\/\u4e0d\u8010\u53d7"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p id=\"temp_ReleaseStart\"><span class=\"legendSpanClass\">\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u6cbb\u7642\u53cd\u8986\u7d93\u6cbb\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u60a3\u8005\u7684\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08The <span class=\"xn-org\">University of Texas<\/span> MD Anderson Cancer Center\uff09\u767d\u8840\u75c5\u79d1\u7684Hagop Kantarjian\u6559\u6388\u548cElias Jabbour \u6559\u6388\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p class=\"prntaj\">ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u4e5f\u662f\u8010\u7acb\u514b\u7684\u7814\u767c\u6578\u64da\u9023\u7e8c\u7b2c\u4e03\u5e74\u5165\u9078ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u3002<\/p>\n<p class=\"prntaj\">\u7e7c2022\u5e74\u5728ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u7d50\u679c\u30012023\u5e74\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u8a72\u54c1\u7a2e\u5728\u66f4\u5927\u6a23\u672c\u91cf\u7684\u60a3\u8005\u4e2d\u7684\u9032\u5c55\u5f8c\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u5c55\u793a\u4e86\u8010\u7acb\u514b\u6cbb\u7642\u53cd\u8986\u7d93\u6cbb\u7684CML-CP\u60a3\u8005\u76841.5\u5e74\u96a8\u8a2a\u6700\u65b0\u6578\u64da\u3002\u6b64\u6b21\u7814\u7a76\u7d50\u679c\u518d\u6b21\u8868\u660e\uff0c\u8010\u7acb\u514b\u5728\u524d\u671f\u7d93\u904e\u6df1\u5ea6\u6cbb\u7642\u7684CML-CP\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u3001\u6301\u4e45\u800c\u7a69\u5b9a\u7684\u6297\u767d\u8840\u75c5\u6d3b\u6027\uff0c\u4e26\u53ef\u514b\u670d\u60a3\u8005\u5c0d\u7b2c\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09Ponatinib\u6216\u8b8a\u69cb\u6291\u5236\u5291Asciminib\u7684\u8010\u85e5\/\u4e0d\u8010\u53d7\uff0c\u540c\u6642\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/p>\n<p class=\"prntaj\">\u8010\u7acb\u514b\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372\u6279\u7528\u65bc\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\uff0c\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684CML-CP\u6216CML-\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u4eca\u5e741\u6708\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u540c\u610f\u8010\u7acb\u514b\u958b\u5c55\u4e00\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002<\/p>\n<p class=\"prntaj\">Elias Jabbour\u6559\u6388\u8868\u793a\uff1a \u300c\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u6b3e\u6975\u5177\u6f5b\u529b\u7684\u65b0\u4e00\u4ee3TKI\u85e5\u7269\u3002\u73fe\u6709\u6578\u64da\u986f\u793a\uff0c\u8a72\u85e5\u7269\u5728\u5c0d\u5169\u7a2e\u6216\u66f4\u591aTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CP-CML\u60a3\u8005\u4e2d\u5177\u6709\u7642\u6548\u3002\u6b64\u5916\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u5728Ponatinib\u6216Asciminib\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\u986f\u793a\u7684\u9ad8\u7de9\u89e3\u7387\u4ee4\u4eba\u632f\u596e\u3002\u6211\u5011\u6b63\u5728\u70ba\u4e00\u9805\u8a55\u4f30\u8a72\u65b0\u578b\u85e5\u7269\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u62db\u52df\u60a3\u8005\u3002\u300d<\/p>\n<p class=\"prntaj\"><b>\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u6b64\u6b21\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6578\u64da\u9032\u4e00\u6b65\u8868\u660e\u8a72\u54c1\u7a2e\u5728\u8010\u85e5CML\u3001\u5305\u62ec\u7d93ponatinib\u548casciminib\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u5de8\u5927\u6cbb\u7642\u6f5b\u529b\uff0c\u4e5f\u518d\u6b21\u8868\u660e\u8a72\u54c1\u7a2e\u6709\u671b\u586b\u88dc\u5168\u7403CML\u6cbb\u7642\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u6709\u4e00\u9805\u7d93FDA\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u76f8\u4fe1\u5728\u4e0d\u9060\u7684\u672a\u4f86\uff0c\u6211\u5011\u80fd\u5920\u5c07\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u5e36\u7d66\u5168\u7403\u4e9f\u9700\u65b0\u578b\u7642\u6cd5\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u8010\u7acb\u514b\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n<p>\u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n<p class=\"prntaj\"><b>Olverembatinib (HQP1351) Overcomes Resistance\/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses<\/b><\/p>\n<p class=\"prntaj\"><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u53ef\u514b\u670d\u7d93\u6df1\u5ea6\u6cbb\u7642\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08<\/b><b>CP CML<\/b><b>\uff09\u60a3\u8005\u5c0d<\/b><b>Asciminib<\/b><b>\u548c<\/b><b>Ponatinib<\/b><b>\u7684\u8010\u85e5<\/b><b>\/<\/b><b>\u4e0d\u8010\u53d7\uff1a\u4f86\u81ea<\/b><b>1.5<\/b><b>\u5e74\u96a8\u8a2a\u7684\u6700\u65b0\u6578\u64da\u53ca\u7d9c\u5408\u66b4\u9732<\/b><b>&#8211;<\/b><b>\u53cd\u61c9\uff08<\/b><b>E-R<\/b><b>\uff09\u5206\u6790<\/b><\/p>\n<p class=\"prntaj\"><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a<\/p>\n<p class=\"prntaj\"><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>3151<\/p>\n<p class=\"prntaj\"><b>\u5206\u6703\u5834\uff1a<\/b>632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII<\/p>\n<p class=\"prntaj\"><b>\u6838\u5fc3\u8981\u9ede\uff1a<\/b><\/p>\n<p class=\"prntaj\"><u>\u7814\u7a76\u4ecb\u7d39<\/u>\uff1a\u5c0d\u7b2c\u4e09\u4ee3\uff083G\uff09TKI Ponatinib\u548c\/\u6216Asciminib\uff08\u4e00\u7a2e\u7279\u7570\u6027\u9776\u5411ABL \u8089\u8c46\u853b\u9170 \uff08STAMP\uff09\u7684\u6291\u5236\u5291\uff09\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CP-CML\u60a3\u8005\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u7a2e\u8010\u53d7\u6027\u826f\u597d\u7684TKI\uff0c\u5177\u6709\u514b\u670d\u5176\u4ed6TKI\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u672c\u6b21\u66f4\u65b0\u4ecb\u7d39\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u53cd\u8986\u7d93\u6cbb\u7684CP-CML\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u3002<\/p>\n<p><u>\u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5<\/u>\uff1a<\/p>\n<ul 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\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u6cbb\u7642\u53cd\u8986\u7d93\u6cbb\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u60a3\u8005\u7684\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08The University of Texas MD Anderson Cancer Center\uff09\u767d\u8840\u75c5\u79d1\u7684Hagop Kantarjian\u6559\u6388\u548cElias Jabbour \u6559\u6388\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002     ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u4e5f\u662f\u8010\u7acb\u514b\u7684\u7814\u767c\u6578\u64da\u9023\u7e8c\u7b2c\u4e03\u5e74\u5165\u9078ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u3002 \u7e7c2022\u5e74\u5728ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u7d50\u679c\u30012023\u5e74\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u8a72\u54c1\u7a2e\u5728\u66f4\u5927\u6a23\u672c\u91cf\u7684\u60a3\u8005\u4e2d\u7684\u9032\u5c55\u5f8c\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u5c55\u793a\u4e86\u8010\u7acb\u514b\u6cbb\u7642\u53cd\u8986\u7d93\u6cbb\u7684CML-CP\u60a3\u8005\u76841.5\u5e74\u96a8\u8a2a\u6700\u65b0\u6578\u64da\u3002\u6b64\u6b21\u7814\u7a76\u7d50\u679c\u518d\u6b21\u8868\u660e\uff0c\u8010\u7acb\u514b\u5728\u524d\u671f\u7d93\u904e\u6df1\u5ea6\u6cbb\u7642\u7684CML-CP\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u3001\u6301\u4e45\u800c\u7a69\u5b9a\u7684\u6297\u767d\u8840\u75c5\u6d3b\u6027\uff0c\u4e26\u53ef\u514b\u670d\u60a3\u8005\u5c0d\u7b2c\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09Ponatinib\u6216\u8b8a\u69cb\u6291\u5236\u5291Asciminib\u7684\u8010\u85e5\/\u4e0d\u8010\u53d7\uff0c\u540c\u6642\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 \u8010\u7acb\u514b\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372\u6279\u7528\u65bc\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\uff0c\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684CML-CP\u6216CML-\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u4eca\u5e741\u6708\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u540c\u610f\u8010\u7acb\u514b\u958b\u5c55\u4e00\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002 Elias Jabbour\u6559\u6388\u8868\u793a\uff1a \u300c\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u6b3e\u6975\u5177\u6f5b\u529b\u7684\u65b0\u4e00\u4ee3TKI\u85e5\u7269\u3002\u73fe\u6709\u6578\u64da\u986f\u793a\uff0c\u8a72\u85e5\u7269\u5728\u5c0d\u5169\u7a2e\u6216\u66f4\u591aTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CP-CML\u60a3\u8005\u4e2d\u5177\u6709\u7642\u6548\u3002\u6b64\u5916\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u5728Ponatinib\u6216Asciminib\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\u986f\u793a\u7684\u9ad8\u7de9\u89e3\u7387\u4ee4\u4eba\u632f\u596e\u3002\u6211\u5011\u6b63\u5728\u70ba\u4e00\u9805\u8a55\u4f30\u8a72\u65b0\u578b\u85e5\u7269\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u62db\u52df\u60a3\u8005\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6578\u64da\u9032\u4e00\u6b65\u8868\u660e\u8a72\u54c1\u7a2e\u5728\u8010\u85e5CML\u3001\u5305\u62ec\u7d93ponatinib\u548casciminib\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u5de8\u5927\u6cbb\u7642\u6f5b\u529b\uff0c\u4e5f\u518d\u6b21\u8868\u660e\u8a72\u54c1\u7a2e\u6709\u671b\u586b\u88dc\u5168\u7403CML\u6cbb\u7642\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u6709\u4e00\u9805\u7d93FDA\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u76f8\u4fe1\u5728\u4e0d\u9060\u7684\u672a\u4f86\uff0c\u6211\u5011\u80fd\u5920\u5c07\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u5e36\u7d66\u5168\u7403\u4e9f\u9700\u65b0\u578b\u7642\u6cd5\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u8010\u7acb\u514b\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) Overcomes Resistance\/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses \u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u53ef\u514b\u670d\u7d93\u6df1\u5ea6\u6cbb\u7642\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP CML\uff09\u60a3\u8005\u5c0dAsciminib\u548cPonatinib\u7684\u8010\u85e5\/\u4e0d\u8010\u53d7\uff1a\u4f86\u81ea1.5\u5e74\u96a8\u8a2a\u7684\u6700\u65b0\u6578\u64da\u53ca\u7d9c\u5408\u66b4\u9732-\u53cd\u61c9\uff08E-R\uff09\u5206\u6790 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u6458\u8981\u7de8\u865f\uff1a3151 \u5206\u6703\u5834\uff1a632. 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