{"id":282915,"date":"2024-12-10T21:06:00","date_gmt":"2024-12-10T13:06:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=282915"},"modified":"2024-12-10T21:06:00","modified_gmt":"2024-12-10T13:06:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8aash-2024%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91apg-2575%e8%81%af%e5%90%88%e7%99%82%e6%b3%95%e5%9c%a8%e7%b6%ad%e5%a5%88%e5%85%8b","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=282915","title":{"rendered":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n

\n<\/p><\/div>\n

ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002<\/p>\n

\u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002<\/p>\n

Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n

\u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n

Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax<\/b><\/p>\n

Lisaftoclax<\/b>\uff08<\/b>APG-2575<\/b>\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5<\/b>\/<\/b>\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08<\/b>CLL\/SLL<\/b>\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005<\/b>\u00a0<\/p>\n

\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a
\u6458\u8981\u7de8\u865f\uff1a<\/b>4614
\u5206\u6703\u5834\uff1a<\/b>642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII<\/p>\n

\u6838\u5fc3\u8981\u9ede\uff1a<\/b><\/p>\n

\u7814\u7a76\u80cc\u666f<\/u>\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002<\/p>\n

\u7814\u7a76\u4ecb\u7d39<\/u>\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n

\u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5<\/u>\uff1a<\/p>\n

    \n
  • \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53<\/i>\u7a81\u8b8a\u3002<\/li>\n
  • APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53<\/i>\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV<\/i>\u672a\u7a81\u8b8a\u3002<\/li>\n
  • \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/li>\n<\/ul>\n

    \u7642\u6548\u6578\u64da<\/u>\uff1a<\/p>\n

    \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002<\/p>\n

      \n
    • \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002<\/li>\n
    • \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002<\/li>\n<\/ul>\n

      \u5b89\u5168\u6027\u6578\u64da<\/u>\uff1a<\/p>\n

        \n
      • \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002<\/li>\n
      • \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b[61%]\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b[38%]\uff09\u3001\u8ca7\u8840\uff0851\u4f8b[29%]\uff09\u3001\u8179\u7009\uff0851\u4f8b[29%]\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b[22%]\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002<\/li>\n
      • APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n

        \u7d50\u8ad6<\/u>\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002<\/p>\n

        \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/u><\/b><\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002<\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002<\/p>\n

        \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n

        \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002<\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

        \u524d\u77bb\u6027\u8072\u660e<\/u><\/b><\/p>\n

        \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

        \u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607…<\/p>\n","protected":false},"author":16,"featured_media":282916,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-282915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=282915\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=282915\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-10T13:06:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"77\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d\",\"datePublished\":\"2024-12-10T13:06:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915\"},\"wordCount\":207,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_Pharma_Logo-12.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915\",\"name\":\"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_Pharma_Logo-12.jpg\",\"datePublished\":\"2024-12-10T13:06:00+00:00\",\"description\":\"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\uff08R\\\/R\uff09\u00a0CLL\\\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\\\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\\\/Small Lymphocytic Lymphoma (CLL\\\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\uff08R\\\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\\\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\\\/R\u536087.5%\uff08154\\\/176\uff09, TN\u536012.5%\uff0822\\\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\\\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\\\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\\\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\\\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\\\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\\\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\\\/R CLL\\\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\\\/\u9032\u884c\u4e2d\\\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_Pharma_Logo-12.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_Pharma_Logo-12.jpg\",\"width\":400,\"height\":77},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=282915#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=282915","og_locale":"zh_TW","og_type":"article","og_title":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=282915","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-12-10T13:06:00+00:00","og_image":[{"width":400,"height":77,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d","datePublished":"2024-12-10T13:06:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915"},"wordCount":207,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=282915","url":"https:\/\/pingtungtimes.com.tw\/?p=282915","name":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg","datePublished":"2024-12-10T13:06:00+00:00","description":"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u65bc\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u8981\u54c1\u7a2eAPG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u70ba\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u516c\u4f48\u7684\u7814\u7a76\u6578\u64da\u518d\u6b21\u986f\u793a\u4e86\u4e9e\u76db\u91ab\u85e5\u7684\u81ea\u7814Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f37\u52c1\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u5c24\u5176\u986f\u793a\u4e86APG-2575\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u4e2d\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c0\u5bdf\u5230\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002 Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-2575\u518d\u4e00\u6b21\u5728\u591a\u500b\u4e9e\u7d44\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f37\u7684\u7642\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7d93\u904e\u7dad\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u7dad\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8a72\u54c1\u7a2e\u9084\u5177\u6709\u6975\u4f73\u7684\u8010\u53d7\u6027\uff0c\u4e26\u53ef\u4fbf\u6377\u5730\u901a\u904e\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u9054\u5230\u76ee\u6a19\u5291\u91cf\u3002\u57fa\u65bc\u9019\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0cAPG-2575\u6709\u4e00\u9805\u5168\u7403\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORA\u5df2\u7d93\u555f\u52d5\uff0c\u76ee\u524d\u6b63\u7a4d\u6975\u62db\u52df\u60a3\u8005\u4e2d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u516c\u4f48\u7684\u6578\u64da\u518d\u4e00\u6b21\u5c55\u73fe\u4e86APG-2575\u5728CLL\/SLL\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u76ee\u524d\u5728\u4e2d\u570b\uff0cAPG-2575\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u4e26\u88ab\u63a8\u85a6\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u70ba\u5168\u7403\u7b2c\u4e8c\u500b\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5291\uff1b\u800c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0cAPG-2575\u6709\u4e00\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032APG-2575\u5728\u5167\u7684\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u00a0 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a4614\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aIII \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u7dad\u5948\u514b\u62c9\uff08ven\uff09\u5c0dBcl-2\u7684\u6291\u5236\u662fCLL\u6cbb\u7642\u7684\u91cd\u5927\u9032\u5c55\uff0c\u4f46\u70ba\u6e1b\u8f15\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\u548c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98a8\u96aa\u800c\u9032\u884c\u76845\u5468\u5291\u91cf\u905e\u589e\u7d66\u85e5\u7684\u6cbb\u7642\u65b9\u5f0f\u4e9f\u5f85\u512a\u5316\u3002APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670dBcl-2\u6291\u5236\u5291\uff0c\u5176\u534a\u8870\u671f\u77ed\uff0c\u53ef\u4ee5\u505a\u5230\u6bcf\u65e5\u5291\u91cf\u905e\u589e\u7d66\u85e5\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u672c\u6b21\u516c\u4f48\u4e86APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6216\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\u521d\u6cbb\u00a0(TN\uff09\u3001\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08ven-treated\uff09\u6cbb\u7642\u7684CLL\/SLL\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u5f9e2020\u5e743\u670820\u65e5\u81f32024\u5e746\u670827\u65e5\uff0c\u5171\u5165\u7d44176\u4f8b\u60a3\u8005\uff1a\u55ae\u85e5\u7d4446\u4f8b\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d4439\u4f8b\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d4491\u4f8b\u3002\u5176\u4e2dR\/R\u536087.5%\uff08154\/176\uff09, TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f6163\uff0834-80\uff09\u6b72\uff1b67%\u70ba\u7537\u6027\uff1b25.6% \u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u8b8a\u3002 APG-2575\uff08Lisaftoclax\uff09\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6301\u7e8c\u6cbb\u7642\u9031\u671f\u5206\u5225\u70ba16.5\uff081-54\uff1b\u55ae\u85e5\u7d44\uff09\u500b\u9031\u671f\uff0c24\uff083-39\uff1b\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\uff09\u500b\u9031\u671f\u548c27\uff081-43\uff1b\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\uff09\u500b\u9031\u671f\u300214\u4f8b\u60a3\u8005\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\uff0c\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u5e74\u9f61\u70ba65\u6b72\uff0851-78\u6b72\uff09\uff0c79%\u70ba\u7537\u6027\uff0c50%\u7684\u60a3\u8005\u6709del\uff0817p\uff09\uff0c36%\u7684\u60a3\u8005\u6709TP53\u7a81\u8b8a\uff0c64%\u7684\u60a3\u8005\u6709del\uff0811q\uff09\uff0c38%\u7684\u60a3\u8005\u6709\u8907\u96dc\u7684\u6838\u578b\uff08\u22653\u7a2e\u7570\u5e38\uff09\uff0c92%\u7684\u60a3\u8005\u4f34IGHV\u672a\u7a81\u8b8a\u3002 \u60a3\u8005\u6bcf\u5929\u55ae\u7368\u53e3\u670dAPG-2575\uff08Lisaftoclax\uff09\u6216\u8207\u963f\u53ef\u66ff\u5c3c\uff08\u6301\u7e8c\u6cbb\u7642\uff09\/\u5229\u59a5\u6614\u55ae\u6297\uff086\u500b\u7642\u7a0b\uff09\u806f\u5408\u6cbb\u7642\uff0c\u6bcf28\u5929\u70ba\u4e00\u7642\u7a0b\u3002APG-2575\uff08Lisaftoclax\uff09\u63a1\u75284-6\u5929\u6bcf\u5929\u68af\u5ea6\u905e\u589e\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u5f9e20mg\u958b\u59cb\uff0c4-6\u5929\u5f8c\u53ef\u9054\u5230\u6700\u7d42\u7684\u76ee\u6a19\u5291\u91cf\uff08400\u3001600\u6216800 mg\uff09\u3002\u806f\u5408\u6cbb\u7642\u7d44\u4e2d\u7684\u60a3\u8005\u5f9e\u7b2c1\u9031\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u958b\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u6cbb\u7642\uff0c\u76f4\u81f3\u9032\u5c55\u6216\u7b2c24\u500b\u9031\u671f\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u6216\u8005\u89c0\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cORR\u70ba98%\uff0c\u5728\u7de9\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u9054\u5230\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u670914\u4f8b\u7d93\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba86%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(11.3-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba84%\uff0c18\u500b\u6708PFS\u7387\u70ba73%\u3002 \u806f\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7642\u7d44\u4e2d\uff0c\u67099\u4f8b\u7dad\u5948\u514b\u62c9\u96e3\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6cbb\u7642\u9031\u671f\u70ba16\uff083-25\uff09\u500b\uff0cORR\u70ba89%\u3002\u4e2d\u4f4dPFS\u672a\u9054\u5230(NE-NE)\uff0c12\u500b\u6708PFS\u7387\u70ba89%\uff0c18\u500b\u6708PFS\u7387\u70ba89%\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a \u5404\u968a\u5217TEAEs\u7684\u767c\u751f\u7387\u548c\u56b4\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002 \u6240\u6709\u968a\u5217\u4e2d\u5e38\u898b\u7684\uff08\u226520%\uff09\u4efb\u610f\u7d1a\u5225TEAEs \u70ba\u611f\u67d3\uff08107\u4f8b\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0867\u4f8b\uff09\u3001\u8ca7\u8840\uff0851\u4f8b\uff09\u3001\u8179\u7009\uff0851\u4f8b\uff09\u3001\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\uff0838\u4f8b\uff09\u3002 \u22653\u7d1aTEAEs\uff08\u226510%\uff09\u5728\u55ae\u85e5\u7d44\u3001\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u7d44\u548c\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u7d44\u4e2d\u5206\u5225\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8ca7\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002 APG-2575\uff08Lisaftoclax\uff09\u55ae\u7368\u6216\u806f\u5408\u4f7f\u7528\uff0c\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u81e8\u5e8a\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81(TLS)\u767c\u751f\u7387\u70ba1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u8207\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u55ae\u6297\u806f\u5408\u4f7f\u7528\u6642\uff0c\u5747\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u7d50\u8ad6\uff1a\u6b64\u6b21\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0dTN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959322.3\u500b\u6708\u6642\uff0cORR\u70ba98%\uff0cDOR\u672a\u9054\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c0d\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u9019\u9805\u96a8\u8a2a\u6642\u9593\u8f03\u9577\u7684\u66f4\u65b0\u5206\u6790\u986f\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u55ae\u85e5\u6cbb\u7642\/\u806f\u5408\u6cbb\u7642\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c0\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u6211\u5011\u6703\u7e7c\u7e8c\u7a4d\u7d2f\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u60a3\u8005\u6578\u64da\u4f86\u9032\u4e00\u6b65\u8b49\u5be6\u9019\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7d50\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7d44\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=282915"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_Pharma_Logo-12.jpg","width":400,"height":77},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=282915#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u3010\u76f4\u64caASH 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u7642\u6cd5\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7642\u6548\u826f\u597d"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/282915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=282915"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/282915\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/282916"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=282915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=282915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=282915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}