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href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03903705\" target=\"_blank\" rel=\"nofollow noopener\">NCT03903705<\/a>\u67e5\u770b\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u8207\u592b\u594e\u66ff\u5c3c\u806f\u5408\u7642\u6cd5\u7528\u65bc\u6cbb\u7642\u6b64\u985e\u60a3\u8005\u7684\u4e00\u9805III\u671f\u78ba\u8b49\u6027\u7814\u7a76\u5df2\u8a08\u5283\u958b\u5c55\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06584032\" target=\"_blank\" rel=\"nofollow noopener\">NCT06584032<\/a>\uff09\u3002<\/p>\n<p><b>\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c<\/b><b>\u816b<\/b><b>\u7624\u91ab\u9662<\/b><b>\u5a66<\/b><b>\u7624\u79d1\u4e3b\u4efb\u3001<\/b><b>FRUSICA-1 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417,000\u4f8b\u5b50\u5bae\u5167\u819c\u764c\u65b0\u75c7\uff0c\u4e26\u9020\u6210\u7d04 97,000 \u4eba\u6b7b\u4ea1\u3002<sup>[ii]<\/sup>\u00a0\u5728\u4e2d\u570b\uff0c2020\u5e74\u4f30\u8a08\u65b0\u589e\u00a082,000\u4f8b\u5b50\u5bae\u5167\u819c\u764c\u65b0\u75c7\uff0c\u4e26\u9020\u6210\u7d04\u00a017,000 \u4eba\u6b7b\u4ea1\u3002<sup>[iii]<\/sup>\u00a0\u5118\u7ba1\u65e9\u671f\u5b50\u5bae\u5167\u819c\u764c\u53ef\u4ee5\u901a\u904e\u624b\u8853\u5207\u9664\uff0c\u4f46\u5fa9\u767c\u6027\u548c\/\u6216\u8f49\u79fb\u6027\u5b50\u5bae\u5167\u819c\u764c\u9818\u57df\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u672a\u6eff\u8db3\u7684\u9700\u6c42\uff0c\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u4e0d\u4f73\u4e14\u6cbb\u7642\u9078\u64c7\u6709\u9650\u3002<sup>[iv],[v],[vi]<\/sup><\/p>\n<p><b>\u95dc\u65bc\u4fe1\u8fea\u5229\u55ae\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\uff0c\u4e2d\u570b\u5546\u54c1\u540d\u70ba\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff08\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u548c\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u5408\u4f5c\u7814\u767c\u7684\u5177\u6709\u570b\u969b\u54c1\u8cea\u7684\u5275\u65b0PD-1\u6291\u5236\u5291\u85e5\u7269\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u662f\u4e00\u7a2e\u4eba\u985e\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u80fd\u7279\u7570\u6027\u7d50\u5408T\u7d30\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u5f9e\u800c\u963b\u65b7\u5c0e\u81f4\u816b\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u9ad4\u914d\u9ad41\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u555f\u52d5\u6dcb\u5df4\u7d30\u80de\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5f9e\u800c\u9054\u5230\u6cbb\u7642\u816b\u7624\u7684\u76ee\u7684 \u3002<sup>[vii]<\/sup><\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e26\u7d0d\u5165\u65b0\u7248\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u4e03\u9805\u9069\u61c9\u75c7\uff0c\u5354\u8b70\u671f\u5167\u91ab\u4fdd\u76ee\u9304\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u7bc4\u570d\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u81f3\u5c11\u7d93\u904e\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u7d93\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7642\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9670\u6027\u3001 \u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08EGFR-TKI\uff09 \u6cbb\u7642\u5931\u6557\u7684 EGFR \u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u809d\u7d30\u80de\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u00a0<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u7684\u7b2c\u516b\u9805\u9069\u61c9\u75c7\uff0c\u5373\u8207\u592b\u594e\u66ff\u5c3c\u7684\u806f\u5408\u7642\u6cd5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7cfb\u7d71\u6027\u6297\u816b\u7624\u6cbb\u7642\u5f8c\u5931\u6557\u4e14\u4e0d\u9069\u5408\u9032\u884c\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\u6216\u6839\u6cbb\u6027\u653e\u7642\u7684\u665a\u671f\u932f\u914d\u4fee\u5fa9\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684NDA\u5df2\u65bc2024\u5e7412\u6708\u53d6\u5f97NMPA\u6279\u51c6\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u53e6\u6709\u5169\u9805\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u7814\u7a76\u7d42\u9ede\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u55ae\u85e5\u7528\u65bc\u665a\u671f\/\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u4e8c\u7dda\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b<\/li>\n<li>\u55ae\u85e5\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u7684\u665a\u671f\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e8c\u7dda\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u95dc\u65bc\u592b\u594e\u66ff\u5c3c<\/b><\/p>\n<p>\u592b\u594e\u66ff\u5c3c\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u53e3\u670d\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-1\u3001-2\u53ca-3\u6291\u5236\u5291\u3002VEGFR\u6291\u5236\u5291\u5728\u6291\u5236\u816b\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\u3002\u592b\u594e\u66ff\u5c3c\u88ab\u8a2d\u8a08\u70ba\u64c1\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9078\u64c7\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u812b\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u5f9e\u800c\u5be6\u73fe\u66f4\u9ad8\u7684\u85e5\u7269\u66b4\u9732\u3001\u5c0d\u9776\u9ede\u7684\u6301\u7e8c\u8986\u84cb\u4ee5\u53ca\u7576\u6f5b\u5728\u4f5c\u70ba\u806f\u5408\u7642\u6cd5\u6642\u64c1\u6709\u66f4\u9ad8\u7684\u9748\u6d3b\u5ea6\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u592b\u594e\u66ff\u5c3c\u5c55\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u5176\u8207\u5176\u4ed6\u6297\u816b\u7624\u7642\u6cd5\u806f\u5408\u4f7f\u7528\u7684\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/p>\n<p>\u592b\u594e\u66ff\u5c3c\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u6c1f\u5c3f\u5627\u5576\u985e\u3001\u5967\u6c99\u5229\u9251\u548c\u4f0a\u7acb\u66ff\u5eb7\u70ba\u57fa\u790e\u7684\u5316\u7642\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u904e\u6216\u4e0d\u9069\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\uff08VEGF\uff09\u6cbb\u7642\u3001\u6297\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u6cbb\u7642\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\uff0c\u4e26\u7531\u548c\u9ec3\u91ab\u85e5\u53ca\u79ae\u4f86\u5408\u4f5c\u7814\u767c\u53ca\u4ee5\u5546\u54c1\u540d\u611b\u512a\u7279<sup>\u00ae<\/sup>\uff08ELUNATE<sup>\u00ae<\/sup>\uff09\u4e0a\u5e02\u92b7\u552e\u3002\u5176\u65bc2020\u5e741\u6708\u7372\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u3002\u81ea\u592b\u594e\u66ff\u5c3c\u5728\u4e2d\u570b\u4e0a\u5e02\u4ee5\u4f86\u5df2\u60e0\u53ca\u8d85\u904e10\u842c\u540d\u7d50\u76f4\u8178\u764c\u60a3\u8005\u3002<\/p>\n<p>2024\u5e7412\u6708\uff0c\u592b\u594e\u66ff\u5c3c\u806f\u5408\u4fe1\u8fea\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7cfb\u7d71\u6027\u6297\u816b\u7624\u6cbb\u7642\u5f8c\u5931\u6557\u4e14\u4e0d\u9069\u5408\u9032\u884c\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\u6216\u6839\u6cbb\u6027\u653e\u7642\u7684\u665a\u671f\u932f\u914d\u4fee\u5fa9\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684\u4e00\u9805\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u53d6\u5f97NMPA\u6279\u51c6\u3002<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670911\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<sup>\u00ae<\/sup>\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<sup>\u00ae<\/sup>\uff09, \u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279<sup>\u00ae<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67095\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c3\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a> \u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p><i>\u8072\u660e\uff1a<\/i><i>1.\u4fe1\u9054\u751f\u7269\u4e0d\u63a8\u85a6\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u7684\u4f7f\u7528\u3002<\/i><\/p>\n<p><i>2.\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09\u548c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09\u7531\u79ae\u4f86\u516c\u53f8\u7814\u767c<\/i><\/p>\n<p><b>\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/p>\n<p>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[i]<\/sup>\u00a0\u00a0 Wu X, et al. Fruquintinib plus sintilimab in treated advanced endometrial cancer (EMC) patients (pts) with PMMR status: Results from a multicenter, single-arm phase 2 study.\u00a0<i>J Clin Oncol<\/i>\u00a042, 2024 (suppl 16; abstr 5619). DOI: 10.1200\/JCO.2024.42.16_suppl.5619.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[ii]\u00a0<\/sup>\u00a0 <a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>, <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">World Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[iii]<\/sup>\u00a0 <a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>, <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">China Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[iv]<\/sup>\u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0 <i>J Clin Oncol.<\/i> 2023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[v]<\/sup>\u00a0\u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer. <i>ESMO Open<\/i>. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[vi]<\/sup>\u00a0 Siegel RL, et al. Cancer statistics, 2023. <i>CA Cancer J Clin<\/i>. 2023;73(1):17-48. DOI:10.3322\/caac.21763.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[vii]<\/sup> Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. <i>mAbs<\/i> 2019;11(8): 1443-1451. DOI: 10.1080\/19420862.2019.1654303.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-281284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          \u00a0\u00a0 Wu X, et al. Fruquintinib plus sintilimab in treated advanced endometrial cancer (EMC) patients (pts) with PMMR status: Results from a multicenter, single-arm phase 2 study.\u00a0J Clin Oncol\u00a042, 2024 (suppl 16; abstr 5619). DOI: 10.1200\/JCO.2024.42.16_suppl.5619.         \u00a0\u00a0 The Global Cancer Observatory, World Fact Sheet. Accessed June 12, 2023.         \u00a0 The Global Cancer Observatory, China Fact Sheet. Accessed June 12, 2023.         \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0 J Clin Oncol. 2023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.         \u00a0\u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer. ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.         \u00a0 Siegel RL, et al. Cancer statistics, 2023. 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DOI: 10.1080\/19420862.2019.1654303.         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=281284\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u8207\u548c\u9ec3\u91ab\u85e5\u5ba3\u4f48\u9054\u4f2f\u8212\uff08\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\u806f\u5408\u611b\u512a\u7279\uff08\u592b\u594e\u66ff\u5c3c\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u9644\u689d\u4ef6\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5b50\u5bae\u5167\u819c\u764c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u67084\u65e5 \/\u7f8e\u901a\u793e\/ -- 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DOI: 10.1080\\\/19420862.2019.1654303. 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          \u00a0\u00a0 Wu X, et al. 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