{"id":281154,"date":"2024-12-03T18:44:00","date_gmt":"2024-12-03T10:44:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=281154"},"modified":"2024-12-03T18:44:00","modified_gmt":"2024-12-03T10:44:00","slug":"%e7%b6%a0%e8%91%89%e8%a3%bd%e8%97%a5%e5%ae%a3%e4%bd%88%e6%b2%bb%e7%99%82%e5%b0%8f%e7%b4%b0%e8%83%9e%e8%82%ba%e7%99%8c%e5%89%b5%e6%96%b0%e8%97%a5%e8%b4%8a%e5%bf%85%e4%bd%b3%ef%bc%88%e6%b3%a8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=281154","title":{"rendered":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e7412\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\uff0cZepzelca<sup>\u00ae<\/sup>\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p>\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002<\/p>\n<p>\u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b<sup>[1]<\/sup>\u3002SCLC\u5360\u80ba\u764c\u768413%-17%<sup>[2]<\/sup>\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%<sup>[3]<\/sup>\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708<sup>[2]<\/sup>\u3002<\/p>\n<p>\u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d<\/p>\n<p>\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m<sup>2<\/sup>\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bc<i>The Lancet Oncology<\/i>\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708<sup>[4]<\/sup>\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m<sup>2<\/sup>\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002<\/p>\n<p>\u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002<\/p>\n<p>\u7576\u524d\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b<sup>[2]<\/sup>\u3002<\/p>\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002<\/p>\n<p>\u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73<sup>\u00ae<\/sup>\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d<\/p>\n<p><b><u>\u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718<\/u><\/b><\/p>\n<p>\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002<\/p>\n<p>\u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4] Trigo J, et al. Lancet Oncol. 2020; 21:645-54<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-281154","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002           \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035         \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024         Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105.         Trigo J, et al. Lancet Oncol. 2020; 21:645-54         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=281154\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002           \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035         \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024         Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105.         Trigo J, et al. Lancet Oncol. 2020; 21:645-54         \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=281154\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-03T10:44:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\",\"datePublished\":\"2024-12-03T10:44:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154\"},\"wordCount\":83,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154\",\"name\":\"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"datePublished\":\"2024-12-03T10:44:00+00:00\",\"description\":\"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\\\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\\\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\\\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\\\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\\\/cma.j.cn112152-20240119-00035 \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024 Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\\\/fonc.2022.932105. Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":\"3000\",\"height\":\"1990\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=281154#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002           \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035         \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024         Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105.         Trigo J, et al. Lancet Oncol. 2020; 21:645-54         \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=281154","og_locale":"zh_TW","og_type":"article","og_title":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002           \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035         \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024         Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105.         Trigo J, et al. Lancet Oncol. 2020; 21:645-54         \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=281154","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-12-03T10:44:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6","datePublished":"2024-12-03T10:44:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154"},"wordCount":83,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=281154","url":"https:\/\/pingtungtimes.com.tw\/?p=281154","name":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","datePublished":"2024-12-03T10:44:00+00:00","description":"\u4e0a\u6d772024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u5ba3\u4f48\uff0c\u5275\u65b0\u85e5\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff08\u8d0a\u5fc5\u4f73\u00ae\uff0cZepzelca\u00ae\uff09\u4f5c\u70ba\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u7684\u54c1\u7a2e\uff0c\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u542b\u9251\u5316\u7642\u4e2d\u6216\u5316\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u4eba\u60a3\u8005\u3002 \u8d0a\u5fc5\u4f73\u00ae\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728\u6291\u5236\u816b\u7624\u57fa\u56e0\u8f49\u9304\u3001\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u7684\u540c\u6642\uff0c\u9084\u53ef\u8abf\u7bc0\u816b\u7624\u5fae\u74b0\u5883\uff0c\u9032\u4e00\u6b65\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002\u8a72\u7522\u54c1\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u662f\u81ea1997\u5e74\u4ee5\u4f86\u7684\u8fd127\u5e74\u5167\u3001\u552f\u4e00\u7372\u5f97FDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 \u80ba\u764c\u5728\u6211\u570b\u7684\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u9ad8\u5c45\u5404\u5927\u60e1\u6027\u816b\u7624\u4e4b\u9996\uff0c\u65bc2022\u5e74\u7684\u65b0\u767c\u75c5\u4f8b\u8d85\u904e106\u842c\u4f8b\u3002SCLC\u5360\u80ba\u764c\u768413%-17%\uff0c\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e9e\u578b\u4e4b\u4e00\uff0c\u4e94\u5e74\u7e3d\u751f\u5b58\u7387\u4f4e\u65bc10%\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u50c5\u70ba4-5\u500b\u6708\u3002 \u300c\u8010\u85e5\u53ca\u5fa9\u767c\u662fSCLC\u6cbb\u7642\u4e2d\u7121\u6cd5\u907f\u514d\u7684\u68d8\u624b\u96e3\u984c\uff0c\u5fa9\u767c\u5f8c\u5e7e\u4e4e\u6c92\u6709\u53ef\u7528\u7684\u6cbb\u7642\u9078\u64c7\u4f7fSCLC\u60a3\u8005\u9677\u5165\u751f\u5b58\u56f0\u5883\u3002\u8d0a\u5fc5\u4f73\u00ae\u6253\u7834\u4e8620\u591a\u5e74\u4f86SCLC\u4e8c\u7dda\u6cbb\u7642\u7684\u74f6\u9838\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u5409\u6797\u7701\u816b\u7624\u91ab\u9662\u60e1\u6027\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u4e00\u9ad4\u5316\u8a3a\u7642\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u7a4e\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8a72\u85e5\u7269\u7684\u6d77\u5916\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u8457\u512a\u65bc\u7576\u524dSCLC\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e26\u5728\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u7684\u6a4b\u63a5\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u751f\u5b58\u7372\u76ca\u3002\u6211\u5011\u671f\u5f85\u9019\u4e00\u5275\u65b0\u85e5\u7269\u76e1\u5feb\u6295\u5165\u81e8\u5e8a\u4f7f\u7528\uff0c\u9020\u798f\u60a3\u8005\u3002\u300d \u8d0a\u5fc5\u4f73\u00ae\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u4e3b\u8981\u57fa\u65bc\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3002\u5176\u4e00\uff0c\u5728\u6d77\u5916\u958b\u5c55\u7684\u95dc\u9375\u8a66\u9a57\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u70ba\u4e00\u9805\u8d0a\u5fc5\u4f73\u00ae\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u6cbb\u7642\u7684\u7e3d\u9ad4\u4eba\u7fa4\u7684\u6709\u6548\u7387\uff08ORR\uff09\u70ba35.2%\u3001\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba5.3\u500b\u6708\u3001\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba3.5\u500b\u6708\u3001mOS\u70ba9.3\u500b\u6708\u3002\u5176\u4e8c\uff0c\u8d0a\u5fc5\u4f73\u00ae\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u6a4b\u63a5\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767cSCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\u63a5\u53d7\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642\uff083.2 mg\/m2\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u60a3\u8005\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mPFS\u70ba5.6\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e0a\u8ff0\u5169\u9805\u8a66\u9a57\u5747\u63d0\u793a\u8d0a\u5fc5\u4f73\u00ae\u4e8c\u7dda\u6cbb\u7642SCLC\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6548\u679c\uff0c\u4e14\u5b89\u5168\u53ef\u8010\u53d7\uff1b\u5176\u4e2d\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u8a66\u9a57\u986f\u793a\u7684\u60a3\u8005\u7372\u76ca\u66f4\u986f\u8457\u3002 \u6b64\u5916\uff0c\u8d0a\u5fc5\u4f73\u00ae\u7684\u591a\u9805\u570b\u969b\u81e8\u5e8a\u7814\u7a76\u4ea6\u5728\u6301\u7e8c\u958b\u5c55\u4e2d\u3002\u5728\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5ee3\u6cdb\u671fSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u7684ORR\u70ba66.67%\u3001mPFS\u70ba4.7\u500b\u6708\u3001mOS\u70ba14.5\u500b\u6708\uff1b\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e8c\u7dda\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u2160\/\u2161\u671f\u7814\u7a76\u4e2d\uff0cORR\u70ba46.4%\u3001mPFS\u70ba5.3\u500b\u6708\u3001mOS\u70ba11.1\u500b\u6708\u3002\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u7528\u65bcSCLC\u4e00\u7dda\u7dad\u6301\u6cbb\u7642\u3001\u806f\u5408\u5316\u7642\u85e5\u7269\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u3001\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u5e73\u6ed1\u808c\u8089\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u4ea6\u5728\u9806\u5229\u9032\u884c\u4e2d\uff0c\u9032\u4e00\u6b65\u63a2\u7d22\u548c\u62d3\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u548c\u6cbb\u7642\u6f5b\u529b\u3002 \u7576\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u3001\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\u548c\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u7684\u63a8\u85a6\uff0c\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u8d0a\u5fc5\u4f73\u00ae\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u85e5\u7269\u4ea6\u9996\u6b21\u88ab\u5beb\u5165\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\uff082024\u7248\uff09\u300b\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5171\u5728\u5168\u740317\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u5730\u5340\u3001\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316\u8a72\u7522\u54c1\uff0c\u4e26\u5df2\u6210\u529f\u63a8\u52d5\u5176\u5728\u4e0a\u8ff0\u4e09\u5730\u7372\u6279\u4e0a\u5e02\u3002 \u300c\u7d50\u5408\u6211\u570b\u9f90\u5927\u7684\u60a3\u8005\u7fa4\u9ad4\uff0c\u76f8\u4fe1\u8d0a\u5fc5\u4f73\u00ae\u4e0a\u5e02\u5f8c\u80fd\u5920\u66f4\u597d\u5730\u670d\u52d9\u65bc\u570b\u5167\u60a3\u8005\u8feb\u5207\u7684\u6cbb\u7642\u9700\u6c42\u3002\u4eca\u5e743\u6708\uff0c\u8d0a\u5fc5\u4f73\u00ae\u5df2\u7387\u5148\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02\u4e26\u7372\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u53cd\u994b\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u4e5f\u5c07\u5354\u540c\u516c\u53f8\u816b\u7624\u9818\u57df\u7684\u5718\u968a\u548c\u512a\u52e2\u8cc7\u6e90\uff0c\u8fc5\u901f\u63a8\u9032\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u5546\u696d\u5316\u5de5\u4f5c\uff0c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u300d\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u7ba1\u7406\u5c64\u8868\u793a\uff1a\u300c\u540c\u6642\uff0c\u6211\u5011\u4e5f\u770b\u5230\u8d0a\u5fc5\u4f73\u00ae\u6b63\u5728\u6d77\u5916\u6301\u7e8c\u958b\u5c55\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63a2\u7d22\u8a72\u85e5\u7269\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u671f\u5f85\u5176\u767c\u63ee\u51fa\u66f4\u5927\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u798f\u97f3\u3002\u300d \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 \u912d\u69ae\u58fd. et al. 2022\u5e74\u4e2d\u570b\u60e1\u6027\u816b\u7624\u6d41\u884c\u60c5\u6cc1\u5206\u6790. \u4e2d\u83ef\u816b\u7624\u96dc\u8a8c, 2024,46(3): 221-231. DOI: 10.3760\/cma.j.cn112152-20240119-00035 \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572024. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2024 Anna Manzo, et al. Lurbinectedin in small cell lung cancer. Front Oncol. 2022 Aug 30; 12:932105. doi: 10.3389\/fonc.2022.932105. Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=281154"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":"3000","height":"1990"},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=281154#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u7da0\u8449\u88fd\u85e5\u5ba3\u4f48\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u5275\u65b0\u85e5\u8d0a\u5fc5\u4f73\u00ae\uff08\u6ce8\u5c04\u7528\u8606\u6bd4\u66ff\u5b9a\uff09\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/281154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=281154"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/281154\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/199219"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=281154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=281154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=281154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}