{"id":278358,"date":"2024-11-22T10:14:00","date_gmt":"2024-11-22T02:14:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=278358"},"modified":"2024-11-22T10:14:00","modified_gmt":"2024-11-22T02:14:00","slug":"%e8%80%90%e7%ab%8b%e5%85%8b%e6%b5%b7%e5%a4%96%e8%87%a8%e5%ba%8a%e9%80%b2%e5%b1%95%e6%a6%ae%e7%99%bb%e5%9c%8b%e9%9a%9b%e6%ac%8a%e5%a8%81%e6%9c%9f%e5%88%8a%e3%80%8ajama-oncology%e3%80%8b%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=278358","title":{"rendered":"\u8010\u7acb\u514b\u00ae\u6d77\u5916\u81e8\u5e8a\u9032\u5c55\u69ae\u767b\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300aJAMA Oncology\u300b\uff0c\u518d\u8b49\u53ef\u6709\u6548\u514b\u670dPonatinib\u548cAsciminib\u8010\u85e5"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e7411\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae<\/sup>\uff09\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684Ib\u671f\u6d77\u5916\u81e8\u5e8a\u7814\u7a76\uff08NCT04260022\uff09\u6578\u64da\uff0c\u5df2\u57282024\u5e7411\u6708\u671f\u7684\u300aJAMA Oncology\u300b\u6210\u529f\u767c\u8868\uff0c\u518d\u4e00\u6b21\u9ad4\u73fe\u570b\u969b\u8840\u6db2\u5b78\u754c\u5c0d\u5967\u96f7\u5df4\u66ff\u5c3c\u9019\u4e00\u5168\u7403\u5c64\u9762best-in-class\u6f5b\u529b\u85e5\u7269\u7684\u9ad8\u5ea6\u8a8d\u53ef\u3002<\/p>\n

\n<\/p><\/div>\n

\u300aJAMA Oncology\u300b\u662f\u5728\u5168\u7403\u816b\u7624\u5b78\u9818\u57df\u6975\u5177\u5f71\u97ff\u529b\u7684\u9818\u5148\u5b78\u8853\u671f\u520a\uff0c2023\u5e74\u7684\u5f71\u97ff\u56e0\u5b50\uff08IF\uff09\u70ba28.4\u3002\u8a72\u671f\u520a\u5728\u81e8\u5e8a\u816b\u7624\u9818\u57df\u7684\u8b80\u8005\u5ee3\u6cdb\uff0c\u6bcf\u5e74\u7684\u539f\u59cb\u4e0b\u8f09\u6216\u95b1\u89bd\u91cf\u9054640\u842c\u6b21\u30022023\u5e74\uff0c\u8a72\u671f\u520a\u6536\u5230\u76842223\u7bc7\u7814\u7a76\u8ad6\u6587\u6295\u7a3f\u4e2d\u50c5\u6709155\u7bc7\uff087%\uff09\u7372\u5f97\u767c\u8868\u3002<\/p>\n

\u5c0dTKI\u8010\u85e5\u548c\u4e0d\u8010\u53d7\u4ecd\u7136\u662fCML\u6cbb\u7642\u4e2d\u5b58\u5728\u7684\u5168\u7403\u6027\u6311\u6230\uff0c\u773e\u591aCML\u60a3\u8005\u56e0\u6b64\u9762\u81e8\u8457\u5de8\u5927\u7684\u751f\u6d3b\u56f0\u5883\u53ca\u7d93\u6fdf\u58d3\u529b\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5df2\u63a5\u53d7\u591a\u7dda\u6cbb\u7642\u4e14\u6548\u679c\u4e0d\u4f73\u7684\u60a3\u8005\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u4e9b\u4e8c\u4ee3\u548c\u4e09\u4ee3TKI\u85e5\u7269\u7684\u6cbb\u7642\u4e2d\uff0c\u52d5\u8108\u9589\u585e\u4e8b\u4ef6\uff08AOE\uff09\u5c31\u662f\u4e00\u986f\u8457\u5b89\u5168\u6027\u6311\u6230\uff0c\u5e38\u5c0e\u81f4\u5291\u91cf\u53d7\u9650\u3002\u7b2c\u4e09\u4ee3BCR::ABL1\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\u5247\u6709\u671b\u6eff\u8db3\u9019\u90e8\u5206\u60a3\u8005\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n

\u5728\u8a72\u7814\u7a76( NCT04260022) \u4e2d\uff0c80\u4f8bCML\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+<\/sup> ALL\uff09\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u7d44\uff0c\u63a5\u53d7\u9694\u5929\u4e00\u6b21\u53e3\u670d30\u300140\u621650mg\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u3002\u5165\u7d44\u60a3\u8005\u5747\u5728\u65e2\u5f80\u5df2\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\uff1a\u7d0418%\u7684\u60a3\u8005\u66fe\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\uff0c28%\u7684\u60a3\u8005\u63a5\u53d7\u904e\u4e09\u7a2e\uff0c54%\u63a5\u53d7\u904e\u81f3\u5c11\u56db\u7a2e\u300246\u4f8b\uff0857.5%\uff09\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904ePonatinib\u6cbb\u7642\uff0c25\u4f8b\uff0831.3%\uff09\u63a5\u53d7\u904eAsciminib\u6cbb\u7642\uff0c11\u4f8b\uff0813.8%\uff09\u63a5\u53d7\u904e\u9019\u5169\u7a2e\u85e5\u7269\u6cbb\u7642\u3002[1]<\/sup><\/p>\n

\u5728\u6240\u6709\u53ef\u8a55\u4f30\u7684\u6162\u6027\u671fCML\uff08CP-CML\uff09\u60a3\u8005\u4e2d\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u7d04\u70ba61%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u7d04\u70ba42%\u3002\u7121\u8ad6\u60a3\u8005\u662f\u5426\u651c\u5e36\u53ef\u5c0e\u81f4\u4f0a\u99ac\u66ff\u5c3c\u53ca\u6240\u6709\u7b2c\u4e8c\u4ee3TKI\u85e5\u7269\u8010\u85e5\u7684T315I\u7a81\u8b8a\uff0c\u7d30\u80de\u907a\u50b3\u5b78\u548c\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u90fd\u8f03\u70ba\u63a5\u8fd1\u3002[1]<\/sup><\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u7d93Ponatinib\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u7d04\u670958%\u7372\u5f97\u4e86CCyR\uff0c\u7d0437%\u7372\u5f97\u4e86MMR\u3002\u800c\u5728\u5c0dAsciminib\u8010\u85e5\u7684\u60a3\u8005\u4e2d\uff0cCCyR\u7387\u70ba50%\uff1bMMR\u7387\u70ba33%\u3002[1]<\/sup><\/p>\n

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\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a<\/b>\uff1a\u300c\u6211\u5011\u975e\u5e38\u9ad8\u8208\u770b\u5230\u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u7684\u6cbb\u7642\u6f5b\u529b\u548c\u81e8\u5e8a\u9032\u5c55\u518d\u6b21\u7372\u570b\u969b\u816b\u7624\u5b78\u754c\u7684\u95dc\u6ce8\u548c\u8a8d\u53ef\u3002\u591a\u5e74\u4f86\uff0c\u4e9e\u76db\u91ab\u85e5\u59cb\u7d42\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u7684\u4f7f\u547d\uff0c\u4e26\u57fa\u65bc\u6b64\u6253\u9020\u4e86\u8c50\u5bcc\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u8986\u84cb\u591a\u7a2e\u60e1\u6027\u816b\u7624\u3002\u63a5\u4e0b\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5168\u529b\u63a8\u9032\u9019\u4e9b\u81e8\u5e8a\u958b\u767c\u9805\u76ee\uff0c\u65e9\u65e5\u9020\u798f\u5168\u7403\u60a3\u8005\uff0c\u63d0\u4f9b\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n

\u9019\u9805\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78<\/b>MD<\/b>\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6559\u6388<\/b>Elias Jabbour<\/span><\/b>\u8868\u793a<\/b>\uff1a\u300c\u5967\u96f7\u5df4\u66ff\u5c3c\u4e4b\u6240\u4ee5\u80fd\u5728Ponatinib\u548cAsciminib\u8010\u85e5\u60a3\u8005\u4e2d\u7522\u751f\u826f\u597d\u7642\u6548\uff0c\u53ef\u80fd\u6e90\u65bc\u5b83\u5c0d\u591a\u7a2e\u7a81\u8b8a\u7684\u5ee3\u6cdb\u8986\u84cb\uff08\u6cdbBCR::ABL1<\/i>\u6fc0\u9176\u57df\uff09\u3002\u5728\u8fc4\u4eca\u70ba\u6b62\u7684\u7814\u7a76\u4e2d\uff0c\u8207\u5176\u5b83\u5df2\u7372\u6279\u7684TKIs\u548cSTAMP\u6291\u5236\u5291Asciminib\u76f8\u6bd4\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u5c0d\u65bc\u5b58\u5728\u5fa9\u5408\u7a81\u8b8a\uff08\u5373BCR::ABL1<\/i>\u878d\u5408\u57fa\u56e0\u7684\u540c\u4e00\u7b49\u4f4d\u57fa\u56e0\u4e0a\u51fa\u73fe\u5169\u500b\u6216\u591a\u500b\u7a81\u8b8a\uff09\u7684\u60a3\u8005\u7684\u654f\u611f\u5ea6\u66f4\u9ad8\uff0c\u7642\u6548\u4e5f\u66f4\u4f73\u3002\u300d<\/p>\n

\u9019\u9805\u7814\u7a76\u7684\u7d50\u679c\u5df2\u5728\u5168\u7403\u591a\u500b\u8840\u6db2\u5b78\u53ca\u816b\u7624\u5927\u6703\u4e0a\u7372\u5f97\u5c55\u793a\uff0c\u5305\u62ec\u65bc2024\u5e746\u670813-16\u65e5\u5728\u99ac\u5fb7\u88e1\u8209\u884c\u7684\u7b2c29\u5c46\u6b50\u6d32\u8840\u6db2\u5b78\u5354\u6703\u5e74\u6703\uff08EHA\u5e74\u6703\uff09\uff1b9\u67084-7\u65e5\u5728\u7f8e\u570b\u4f11\u65af\u9813\u8209\u884c\u7684\u7b2c12\u5c46\u8840\u6db2\u816b\u7624\u5354\u6703\u5e74\u6703\uff08SOHO\u5e74\u6703\uff09\uff1b\u4ee5\u53ca9\u670827-29\u65e5\u5728\u5e03\u62c9\u683c\u8209\u884c\u7684\u7b2c26\u5c46John Goldman\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08\u751f\u7269\u5b78\u53ca\u7642\u6cd5\uff09\u5927\u6703\u3002\u8a72\u7814\u7a76\u7684\u6700\u65b0\u7d50\u679c\u5c07\u65bc\u4eca\u5e7412\u67088\u65e5\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\u4ee5\u58c1\u5831\u5c55\u793a\u7684\u5f62\u5f0f\u516c\u5e03\uff08\u6458\u8981\u7de8\u865f\uff1a3151\uff09\u3002<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u8463\u4e8b\u9577\u3001<\/b>CEO<\/b>\u694a\u5927\u4fca\u535a\u58eb\u8868\u793a<\/b>\uff1a\u300c\u80fd\u5920\u5728\u6b0a\u5a01\u671f\u520a\u300aJAMA Oncology\u300b\u4e0a\u767c\u8868\u9019\u9805\u7814\u7a76\u6210\u679c\uff0c\u662f\u5967\u96f7\u5df4\u66ff\u5c3c\u81e8\u5e8a\u958b\u767c\u7684\u53c8\u4e00\u91cd\u5927\u88e1\u7a0b\u7891\u3002\u53e6\u5916\uff0c\u9019\u9805\u7814\u7a76\u9084\u78ba\u5b9a\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76POLARIS-2 [NCT06423911]\u7684\u63a8\u85a6\u4f7f\u7528\u5291\u91cf\u3002\u6211\u5011\u5341\u5206\u671f\u5f85\u5967\u96f7\u5df4\u66ff\u5c3c\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u5e0c\u671b\u4e0d\u9060\u7684\u672a\u4f86\uff0c\u4e9e\u76db\u91ab\u85e5\u80fd\u5920\u651c\u624b\u6b66\u7530\uff0c\u5c07\u9019\u4e00Best-in-class\u85e5\u7269\u76e1\u5feb\u5e36\u7d66\u5168\u7403\u4e9f\u9700\u65b0\u578b\u7642\u6cd5\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5c0d\u5176\u5b83\u85e5\u7269\u8010\u85e5\u6216\u4e0d\u8010\u53d7\u7684CML\u6216Ph+<\/sup> ALL\u60a3\u8005\u3002\u300d<\/p>\n

2024\u5e746\u670814\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u8207\u8de8\u570b\u5236\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u5967\u96f7\u5df4\u66ff\u5c3c\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae<\/sup>\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002<\/p>\n

\u76ee\u524d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u5df2\u5728\u4e2d\u570b\u7372\u6279\u5206\u5225\u7528\u65bc\u6cbb\u7642\uff1a\u4efb\u4f55TKI\u8010\u85e5\uff0c\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u671f\uff08CP-CML\uff09\u6216\u52a0\u901f\u671fCML\uff08AP-CML\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CP-CML\u6210\u5e74\u60a3\u8005\u3002<\/p>\n

\u53c3\u8003\u6587\u737b<\/b><\/p>\n

[1]<\/sup> Jabbour E, Oehler VG, Koller PB, et al. Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b<\/span> randomized clinical trial. JAMA Oncol<\/i> 2024. doi:10.1001\/jamaoncol.2024.5157<\/p>\n

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Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. 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Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e 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name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=278358\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u8010\u7acb\u514b\u00ae\u6d77\u5916\u81e8\u5e8a\u9032\u5c55\u69ae\u767b\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300aJAMA Oncology\u300b\uff0c\u518d\u8b49\u53ef\u6709\u6548\u514b\u670dPonatinib\u548cAsciminib\u8010\u85e5 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684Ib\u671f\u6d77\u5916\u81e8\u5e8a\u7814\u7a76\uff08NCT04260022\uff09\u6578\u64da\uff0c\u5df2\u57282024\u5e7411\u6708\u671f\u7684\u300aJAMA Oncology\u300b\u6210\u529f\u767c\u8868\uff0c\u518d\u4e00\u6b21\u9ad4\u73fe\u570b\u969b\u8840\u6db2\u5b78\u754c\u5c0d\u5967\u96f7\u5df4\u66ff\u5c3c\u9019\u4e00\u5168\u7403\u5c64\u9762best-in-class\u6f5b\u529b\u85e5\u7269\u7684\u9ad8\u5ea6\u8a8d\u53ef\u3002 \u300aJAMA Oncology\u300b\u662f\u5728\u5168\u7403\u816b\u7624\u5b78\u9818\u57df\u6975\u5177\u5f71\u97ff\u529b\u7684\u9818\u5148\u5b78\u8853\u671f\u520a\uff0c2023\u5e74\u7684\u5f71\u97ff\u56e0\u5b50\uff08IF\uff09\u70ba28.4\u3002\u8a72\u671f\u520a\u5728\u81e8\u5e8a\u816b\u7624\u9818\u57df\u7684\u8b80\u8005\u5ee3\u6cdb\uff0c\u6bcf\u5e74\u7684\u539f\u59cb\u4e0b\u8f09\u6216\u95b1\u89bd\u91cf\u9054640\u842c\u6b21\u30022023\u5e74\uff0c\u8a72\u671f\u520a\u6536\u5230\u76842223\u7bc7\u7814\u7a76\u8ad6\u6587\u6295\u7a3f\u4e2d\u50c5\u6709155\u7bc7\uff087%\uff09\u7372\u5f97\u767c\u8868\u3002 \u5c0dTKI\u8010\u85e5\u548c\u4e0d\u8010\u53d7\u4ecd\u7136\u662fCML\u6cbb\u7642\u4e2d\u5b58\u5728\u7684\u5168\u7403\u6027\u6311\u6230\uff0c\u773e\u591aCML\u60a3\u8005\u56e0\u6b64\u9762\u81e8\u8457\u5de8\u5927\u7684\u751f\u6d3b\u56f0\u5883\u53ca\u7d93\u6fdf\u58d3\u529b\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5df2\u63a5\u53d7\u591a\u7dda\u6cbb\u7642\u4e14\u6548\u679c\u4e0d\u4f73\u7684\u60a3\u8005\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u4e9b\u4e8c\u4ee3\u548c\u4e09\u4ee3TKI\u85e5\u7269\u7684\u6cbb\u7642\u4e2d\uff0c\u52d5\u8108\u9589\u585e\u4e8b\u4ef6\uff08AOE\uff09\u5c31\u662f\u4e00\u986f\u8457\u5b89\u5168\u6027\u6311\u6230\uff0c\u5e38\u5c0e\u81f4\u5291\u91cf\u53d7\u9650\u3002\u7b2c\u4e09\u4ee3BCR::ABL1\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\u5247\u6709\u671b\u6eff\u8db3\u9019\u90e8\u5206\u60a3\u8005\u7684\u8feb\u5207\u9700\u6c42\u3002 \u5728\u8a72\u7814\u7a76( NCT04260022) \u4e2d\uff0c80\u4f8bCML\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u7d44\uff0c\u63a5\u53d7\u9694\u5929\u4e00\u6b21\u53e3\u670d30\u300140\u621650mg\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u3002\u5165\u7d44\u60a3\u8005\u5747\u5728\u65e2\u5f80\u5df2\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\uff1a\u7d0418%\u7684\u60a3\u8005\u66fe\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\uff0c28%\u7684\u60a3\u8005\u63a5\u53d7\u904e\u4e09\u7a2e\uff0c54%\u63a5\u53d7\u904e\u81f3\u5c11\u56db\u7a2e\u300246\u4f8b\uff0857.5%\uff09\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904ePonatinib\u6cbb\u7642\uff0c25\u4f8b\uff0831.3%\uff09\u63a5\u53d7\u904eAsciminib\u6cbb\u7642\uff0c11\u4f8b\uff0813.8%\uff09\u63a5\u53d7\u904e\u9019\u5169\u7a2e\u85e5\u7269\u6cbb\u7642\u3002 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Goldman\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08\u751f\u7269\u5b78\u53ca\u7642\u6cd5\uff09\u5927\u6703\u3002\u8a72\u7814\u7a76\u7684\u6700\u65b0\u7d50\u679c\u5c07\u65bc\u4eca\u5e7412\u67088\u65e5\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\u4ee5\u58c1\u5831\u5c55\u793a\u7684\u5f62\u5f0f\u516c\u5e03\uff08\u6458\u8981\u7de8\u865f\uff1a3151\uff09\u3002 \u4e9e\u76db\u91ab\u85e5\u8463\u4e8b\u9577\u3001CEO\u694a\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u300c\u80fd\u5920\u5728\u6b0a\u5a01\u671f\u520a\u300aJAMA Oncology\u300b\u4e0a\u767c\u8868\u9019\u9805\u7814\u7a76\u6210\u679c\uff0c\u662f\u5967\u96f7\u5df4\u66ff\u5c3c\u81e8\u5e8a\u958b\u767c\u7684\u53c8\u4e00\u91cd\u5927\u88e1\u7a0b\u7891\u3002\u53e6\u5916\uff0c\u9019\u9805\u7814\u7a76\u9084\u78ba\u5b9a\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76POLARIS-2 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2024\u5e746\u670814\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u8207\u8de8\u570b\u5236\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u5967\u96f7\u5df4\u66ff\u5c3c\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002 \u76ee\u524d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u5df2\u5728\u4e2d\u570b\u7372\u6279\u5206\u5225\u7528\u65bc\u6cbb\u7642\uff1a\u4efb\u4f55TKI\u8010\u85e5\uff0c\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u671f\uff08CP-CML\uff09\u6216\u52a0\u901f\u671fCML\uff08AP-CML\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CP-CML\u6210\u5e74\u60a3\u8005\u3002 \u53c3\u8003\u6587\u737b Jabbour E, Oehler VG, Koller PB, et al. Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. JAMA Oncol 2024. doi:10.1001\/jamaoncol.2024.5157 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 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Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. 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\u4e2d\uff0c80\u4f8bCML\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u7d44\uff0c\u63a5\u53d7\u9694\u5929\u4e00\u6b21\u53e3\u670d30\u300140\u621650mg\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u3002\u5165\u7d44\u60a3\u8005\u5747\u5728\u65e2\u5f80\u5df2\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\uff1a\u7d0418%\u7684\u60a3\u8005\u66fe\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\uff0c28%\u7684\u60a3\u8005\u63a5\u53d7\u904e\u4e09\u7a2e\uff0c54%\u63a5\u53d7\u904e\u81f3\u5c11\u56db\u7a2e\u300246\u4f8b\uff0857.5%\uff09\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904ePonatinib\u6cbb\u7642\uff0c25\u4f8b\uff0831.3%\uff09\u63a5\u53d7\u904eAsciminib\u6cbb\u7642\uff0c11\u4f8b\uff0813.8%\uff09\u63a5\u53d7\u904e\u9019\u5169\u7a2e\u85e5\u7269\u6cbb\u7642\u3002 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\u9019\u9805\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6559\u6388Elias 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\u9019\u9805\u7814\u7a76\u7684\u7d50\u679c\u5df2\u5728\u5168\u7403\u591a\u500b\u8840\u6db2\u5b78\u53ca\u816b\u7624\u5927\u6703\u4e0a\u7372\u5f97\u5c55\u793a\uff0c\u5305\u62ec\u65bc2024\u5e746\u670813-16\u65e5\u5728\u99ac\u5fb7\u88e1\u8209\u884c\u7684\u7b2c29\u5c46\u6b50\u6d32\u8840\u6db2\u5b78\u5354\u6703\u5e74\u6703\uff08EHA\u5e74\u6703\uff09\uff1b9\u67084-7\u65e5\u5728\u7f8e\u570b\u4f11\u65af\u9813\u8209\u884c\u7684\u7b2c12\u5c46\u8840\u6db2\u816b\u7624\u5354\u6703\u5e74\u6703\uff08SOHO\u5e74\u6703\uff09\uff1b\u4ee5\u53ca9\u670827-29\u65e5\u5728\u5e03\u62c9\u683c\u8209\u884c\u7684\u7b2c26\u5c46John Goldman\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08\u751f\u7269\u5b78\u53ca\u7642\u6cd5\uff09\u5927\u6703\u3002\u8a72\u7814\u7a76\u7684\u6700\u65b0\u7d50\u679c\u5c07\u65bc\u4eca\u5e7412\u67088\u65e5\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\u4ee5\u58c1\u5831\u5c55\u793a\u7684\u5f62\u5f0f\u516c\u5e03\uff08\u6458\u8981\u7de8\u865f\uff1a3151\uff09\u3002 \u4e9e\u76db\u91ab\u85e5\u8463\u4e8b\u9577\u3001CEO\u694a\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u300c\u80fd\u5920\u5728\u6b0a\u5a01\u671f\u520a\u300aJAMA Oncology\u300b\u4e0a\u767c\u8868\u9019\u9805\u7814\u7a76\u6210\u679c\uff0c\u662f\u5967\u96f7\u5df4\u66ff\u5c3c\u81e8\u5e8a\u958b\u767c\u7684\u53c8\u4e00\u91cd\u5927\u88e1\u7a0b\u7891\u3002\u53e6\u5916\uff0c\u9019\u9805\u7814\u7a76\u9084\u78ba\u5b9a\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76POLARIS-2 \u7684\u63a8\u85a6\u4f7f\u7528\u5291\u91cf\u3002\u6211\u5011\u5341\u5206\u671f\u5f85\u5967\u96f7\u5df4\u66ff\u5c3c\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u5e0c\u671b\u4e0d\u9060\u7684\u672a\u4f86\uff0c\u4e9e\u76db\u91ab\u85e5\u80fd\u5920\u651c\u624b\u6b66\u7530\uff0c\u5c07\u9019\u4e00Best-in-class\u85e5\u7269\u76e1\u5feb\u5e36\u7d66\u5168\u7403\u4e9f\u9700\u65b0\u578b\u7642\u6cd5\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5c0d\u5176\u5b83\u85e5\u7269\u8010\u85e5\u6216\u4e0d\u8010\u53d7\u7684CML\u6216Ph+ ALL\u60a3\u8005\u3002\u300d 2024\u5e746\u670814\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u8207\u8de8\u570b\u5236\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u5967\u96f7\u5df4\u66ff\u5c3c\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002 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Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. 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Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. 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Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: a phase 1b randomized clinical trial. 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