{"id":262708,"date":"2024-09-19T17:08:00","date_gmt":"2024-09-19T09:08:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=262708"},"modified":"2024-09-19T17:08:00","modified_gmt":"2024-09-19T09:08:00","slug":"%e8%81%96%e8%ab%be%e9%86%ab%e8%97%a5%e5%9c%a8%e3%80%8a%e7%be%8e%e5%ae%b9%e7%9a%ae%e8%86%9a%e5%ad%b8%e3%80%8b%e9%9b%9c%e5%bf%97%e4%b8%8a%e7%99%bc%e8%a1%a8%e8%ab%96%e6%96%87%e6%8f%ad%e7%a4%ba%e5%85%b6","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=262708","title":{"rendered":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e749\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <b>Sirnaomics Ltd. <\/b>\uff08\u300c<b>\u672c\u516c\u53f8<\/b>\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c<b>\u672c\u96c6\u5718<\/b>\u300d\u6216\u300c<b>Sirnaomics <\/b><b>\u8056\u8afe\u91ab\u85e5<\/b>\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c<i>\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411<\/i><i>TGF-\u03b21<\/i><i>\u548c<\/i><i>\u00a0COX-2<\/i><i>\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76<\/i><i>I<\/i><i>\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d<\/i>\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002<\/p>\n<p>STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002<\/p>\n<p>\u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d<\/p>\n<p><b>\u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb<\/b>\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d<\/p>\n<p><b><u>\u95dc\u65bc\u8056\u8afe\u91ab\u85e5<\/u><\/b><\/p>\n<p>Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-262708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=262708\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=262708\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-19T09:08:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406\",\"datePublished\":\"2024-09-19T09:08:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708\"},\"wordCount\":61,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708\",\"name\":\"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"datePublished\":\"2024-09-19T09:08:00+00:00\",\"description\":\"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\\\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":\"3000\",\"height\":\"1990\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=262708#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=262708","og_locale":"zh_TW","og_type":"article","og_title":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=262708","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-09-19T09:08:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406","datePublished":"2024-09-19T09:08:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708"},"wordCount":61,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=262708","url":"https:\/\/pingtungtimes.com.tw\/?p=262708","name":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","datePublished":"2024-09-19T09:08:00+00:00","description":"\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2024\u5e749\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics \u8056\u8afe\u91ab\u85e5\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u4f48\uff0c\u516c\u53f8\u7814\u767c\u5718\u968a\u8207\u4f5b\u7f85\u91cc\u9054\u5dde\u9081\u963f\u5bc6\u81e8\u5e8a\u548c\u7f8e\u5bb9\u7814\u7a76\u4e2d\u5fc3\u7684Mark Nestor\u535a\u58eb\u5718\u968a\u5408\u4f5c\uff0c\u5171\u540c\u767c\u8868\u4e86\u5176\u65b0\u578bsiRNA\u85e5\u7269\u7684\u7a81\u7834\u6027\u9032\u5c55\uff0c\u63ed\u793a\u4e86\u8a72\u85e5\u7269\u5728\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7372\u5f97\u8102\u80aa\u7d44\u7e54\u986f\u8457\u6e1b\u5c11\u7684\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u3002\u9019\u9805\u958b\u5275\u6027\u5de5\u4f5c\u7684\u6a19\u984c\u70ba\uff1a\u300c\u7528\u65bc\u5c40\u90e8\u6e1b\u8102\u9776\u5411TGF-\u03b21\u548c\u00a0COX-2\u7684\u65b0\u578b\u591a\u80bd\u6838\u9178\u7d0d\u7c73\u6ce8\u5c04\u5291\u7814\u7a76I\uff1a\u81e8\u5e8a\u524d\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u8cc7\u6599\u5206\u6790\u300d\uff0c\u767c\u8868\u65bc\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\uff082024\u5e7400:1-11\uff09\u4e0a\uff0c\u7232\u516c\u53f8\u57fa\u65bcRNAi\u7684\u5c40\u90e8\u6eb6\u8102\u85e5\u7269\u62d3\u5c55\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002 STP705\u662f\u4e00\u7a2e\u6ce8\u5c04\u5291\u85e5\u7269\uff0c\u542b\u6709\u5c01\u88dd\u5728\u7d44\u6c28\u9178-\u8cf4\u6c28\u9178\u591a\u80bd\uff08HKP\uff09\u7d0d\u7c73\u9846\u7c92\u4e2d\u7684siRNA\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9776\u5411\u8f49\u5316\u751f\u9577\u56e0\u6578\u03b21\uff08TGF-\u03b21\uff09\u548c\u74b0\u6c27\u5408\u9176-2\uff08COX-2\uff09\uff0c\u6291\u5236\u5176\u5728\u8102\u80aa\u7d30\u80de\uff08Adipocytes\uff09\u5206\u5316\u548c\u8102\u80aa\u7d44\u7e54\uff08Adipose Tissue\uff09\u4fdd\u5b58\u7684\u95dc\u9375\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u901a\u904e\u4f7f\u7528\u5c0f\u9f20\u524d\u8102\u80aa\u7d30\u80de\uff08preadipocytes\uff09\u7684\u9ad4\u5916\u5be6\u9a57\uff0c\u4ee5\u53ca\u4f7f\u7528\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u548c\u5c24\u5361\u5766\u5c0f\u578b\u8c6c\u7684\u9ad4\u5167\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86STP705\u7684\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cSTP705\u6709\u6548\u964d\u4f4e\u4e86TGF-\u03b21\u548cCOX-2\u7684\u8868\u9054\uff0c\u5c0e\u81f4\u8102\u80aa\u7d30\u80de\u9ad4\u7a4d\u548c\u8102\u8cea\u542b\u91cf\u986f\u8457\u964d\u4f4e\uff0c\u540c\u6642\u7121\u660e\u986f\u7684\u4e0d\u826f\u5168\u8eab\u53cd\u61c9\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u9019\u500bHKP-siRNA\u8907\u5408\u7269\u8868\u73fe\u51fa\u5c0d\u6ce8\u5c04\u8102\u80aa\u7d44\u7e54\u7684\u7cbe\u78ba\u5b9a\u4f4d\uff0c\u4e26\u5728\u7d66\u85e5\u5f8c\u9577\u905414\u5929\u5167\u4fdd\u6301\u986f\u8457\u7684\u57fa\u56e0\u6c89\u9ed8\u548c\u00a0siRNA\u7684\u53ef\u6aa2\u6e2c\u6c34\u5e73\u3002\u5c0f\u578b\u8c6c\u7684\u6578\u64da\u9032\u4e00\u6b65\u986f\u793a\uff0c\u7d66\u85e5\u5f8c56\u5929\u5167\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u539a\u5ea6\u986f\u8457\u6e1b\u5c11\u3002\u7d50\u679c\u8868\u660e\uff0c\u9019\u4e9b\u7814\u7a76\u652f\u6301\u4f7f\u7528\u5c08\u9580\u91dd\u5c0dTGF-\u03b21\u548cCOX-2\u7684\u9776\u5411siRNA\u85e5\u7269\u9032\u884c\u5c40\u90e8\u6eb6\u8102\u6cbb\u7642\uff0c\u7232\u7576\u524d\u6e1b\u8102\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u5fae\u5275\u66ff\u4ee3\u65b9\u6848\u3002 \u81e8\u5e8a\u76ae\u819a\u75c5\u5b78\u548c\u7f8e\u5bb9\u91ab\u5b78\u81e8\u5e8a\u7814\u7a76\u9818\u57df\u7684\u570b\u969b\u516c\u8a8d\u5c08\u5bb6\uff0cMark Nestor\u91ab\u5b78\u548c\u54f2\u5b78\u535a\u58eb\uff0c\u662f\u9081\u963f\u5bc6\u5927\u5b78\u7c73\u52d2\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u5b78\u548c\u76ae\u819a\u5916\u79d1\u7cfb\u4ee5\u53ca\u5916\u79d1\/\u6574\u5f62\u5916\u79d1\u7cfb\u7684\u5fd7\u9858\u6559\u6388\uff1b\u540c\u6642\u662f\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5ddeAventura\u5e02\u7684\u81e8\u5e8a\u548c\u5316\u599d\u54c1\u7814\u7a76\u4e2d\u5fc3\u548c\u7f8e\u5bb9\u589e\u5f37\u4e2d\u5fc3\u7684\u4e3b\u4efb\uff1b\u4e5f\u662f\u672c\u9805\u7814\u7a76\u5831\u544a\u7684\u9996\u5e2d\u4f5c\u8005\uff0c\u8a55\u8ad6\u9053\uff1a\u300c\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\u7684\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0cSTP705\u4f5c\u7232\u4e00\u7a2e\u5b89\u5168\u6709\u6548\u7684\u6e1b\u5c11\u5c40\u90e8\u8102\u80aa\u5806\u7a4d\u7684\u65b9\u6cd5\u5177\u6709\u5de8\u5927\u6f5b\u529b\uff0c\u4e26\u7232\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8a\u8def\u5f91\u5960\u5b9a\u4e86\u57fa\u790e\u3002\u300d \u8056\u8afe\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8a55\u8ad6\u9053\uff1a\u300c\u6700\u65b0\u767c\u8868\u7684\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8868\u660e\uff0c\u8056\u8afe\u91ab\u85e5\u9818\u5148\u7684\u5019\u9078\u85e5\u7269STP705\u8868\u73fe\u51fa\u4e00\u7a2e\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027\u6c89\u9ed8\u76ae\u4e0b\u8102\u80aa\u7d44\u7e54\u4e2d\u7684TGF-\u03b21\u548cCOX-2\uff0c\u5c0e\u81f4\u5c40\u90e8\u8102\u80aa\u6e1b\u5c11\u3002\u9019\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e0d\u50c5\u986f\u793a\u4e86\u8a72\u85e5\u7269\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u800c\u4e14\u5728\u8a98\u5c0e\u8102\u80aa\u7d30\u80de\u51cb\u4ea1\u548c\u8102\u80aa\u7d44\u7e54\u91cd\u5851\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u521d\u6b65\u7642\u6548\uff0c\u8868\u73fe\u51fa\u4e86\u91dd\u5c0d\u73fe\u6709\u6e1b\u8102\u7642\u6cd5\u66f4\u5b89\u5168\u6709\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u6216\u8f14\u52a9\u624b\u6bb5\u3002\u300d \u95dc\u65bc\u8056\u8afe\u91ab\u85e5 Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5176\u5019\u9078\u7523\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u6709\u91ab\u7642\u9700\u6c42\u548c\u5de8\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u7b2c\u4e00\u5bb6\u5728\u4e9e\u6d32\u548c\u7f8e\u570b\u90fd\u6709\u5f37\u5927\u5f71\u97ff\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u00a0RNA \u6cbb\u7642\u516c\u53f8\u3002\u57fa\u65bc\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a\u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u5236\u5291\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u806f\uff0c\u672c\u96c6\u5718\u5efa\u7acb\u4e86\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002Sirnaomics\u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u5b78\u00a0RNAi \u7642\u6cd5\u61c9\u7528\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u5176\u00a0STP705\uff08IIa \u671f\u3001IIb \u671f\uff09\u548c\u00a0STP707\uff08I \u671f\uff09\u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u4e86\u591a\u9805\u6210\u529f\u3002\u6b63\u5728\u9032\u884c\u7684\u00a0STP122G I \u671f\u7814\u7a76\u4ee3\u8868\u4e86\u00a0GalAhead\u2122 \u6280\u8853\u7684\u7b2c\u4e00\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6cbb\u7642\u6548\u679c\u548c\u5b89\u5168\u6027\u6578\u64da\u3002\u77ad\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=262708"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":"3000","height":"1990"},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=262708#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u8056\u8afe\u91ab\u85e5\u5728\u300a\u7f8e\u5bb9\u76ae\u819a\u5b78\u300b\u96dc\u5fd7\u4e0a\u767c\u8868\u8ad6\u6587\u63ed\u793a\u5176\u6838\u9178\u5e72\u64fe\u5275\u65b0\u85e5\u7528\u65bc\u5c40\u90e8\u6eb6\u8102\u7684\u4f5c\u7528\u6a5f\u7406"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/262708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=262708"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/262708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/199219"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=262708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=262708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=262708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}