{"id":259288,"date":"2024-09-03T18:00:00","date_gmt":"2024-09-03T10:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=259288"},"modified":"2024-09-03T18:00:00","modified_gmt":"2024-09-03T10:00:00","slug":"%e4%b9%9d%e5%a4%a9%e7%94%9f%e7%89%a9aav%e5%9f%ba%e5%9b%a0%e7%99%82%e6%b3%95skg1108%e6%b2%bb%e7%99%82%e8%a6%96%e7%b6%b2%e8%86%9c%e8%89%b2%e7%b4%a0%e8%ae%8a%e6%80%a7%e7%8d%b2fda%e5%ad%a4%e5%85%92","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=259288","title":{"rendered":"\u4e5d\u5929\u751f\u7269AAV\u57fa\u56e0\u7642\u6cd5SKG1108\u6cbb\u7642\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u7372FDA\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a"},"content":{"rendered":"<div>\n<p>\u4e0a\u6d772024\u5e749\u67083\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4e5d\u5929\u751f\u7269\uff08Skyline 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Therapeutics\uff09\u81ea\u4e3b\u7814\u767c\u7684\u817a\u76f8\u95dc\u75c5\u6bd2\uff08AAV\uff09\u57fa\u56e0\u6cbb\u7642\u85e5\u7269SKG1108\uff0c\u4e00\u6b3e\u7528\u65bc\u6cbb\u7642\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\uff08Retinitis Pigmentosa\uff0cRP\uff09\u7684\u7a81\u7834\u6027\u57fa\u56e0\u7642\u6cd5\uff0c\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff08ODD\uff09\u3002\u9019\u4e00\u8a8d\u5b9a\u6a19\u8a8c\u8457SKG1108\u9019\u4e00\u5275\u65b0AAV\u8f09\u9ad4\u5728\u6cbb\u7642RP\u65b9\u9762\u7684\u6f5b\u529b\u5f97\u5230\u4e86FDA\u7684\u8a8d\u53ef\uff0c\u4e26\u4f7f\u5176\u5728\u672a\u4f86\u7684\u958b\u767c\u3001\u4e0a\u5e02\u904e\u7a0b\u4e2d\u53ca\u4e0a\u5e02\u5f8c\u6709\u8cc7\u683c\u4eab\u53d7\u4e00\u7cfb\u5217\u6fc0\u52f5\u653f\u7b56\uff0c\u7372\u5f97FDA\u7684\u6301\u7e8c\u652f\u6301\u3002 SKG1108\u662f\u4e00\u6b3e\u5b8c\u5168\u5275\u65b0\u8a2d\u8a08\u7684AAV\u8f09\u9ad4\uff0c\u5305\u542b\u7528\u65bc\u73bb\u7483\u9ad4\u5167\u6ce8\u5c04\u7684\u5275\u65b0\u8863\u6bbcAAV.0106\uff0c\u5c07\u63a1\u7528\u524d\u6cbf\u8a2d\u8a08\u7684\u7de8\u78bc\u5177\u6709\u7368\u7279\u7d50\u69cb\u548c\u529f\u80fd\u7684\u5168\u65b0\u86cb\u767d\u7684\u57fa\u56e0\u76f4\u63a5\u905e\u9001\u81f3\u8996\u7db2\u819c\uff0c\u901a\u904e\u7279\u5b9a\u7684\u57fa\u56e0\u5143\u7d20\u8abf\u63a7\u5728\u8996\u7db2\u819c\u9776\u7d30\u80de\u4e2d\u8868\u9054\u7279\u6b8a\u5149\u654f\u86cb\u767d\uff0c\u5f9e\u800c\u7522\u751f\u65b0\u7684\u5149\u611f\u53d7\u5668\u4f86\u6539\u5584\u548c\u6062\u5fa9\u60a3\u8005\u8996\u89ba\u529f\u80fd\u3002 \u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u662f\u4e00\u7a2e\u9ad8\u81f4\u76f2\u6027\u907a\u50b3\u6027\u8996\u7db2\u819c\u9000\u884c\u6027\u75c5\u8b8a\uff08Inherited Retinal Diseases, IRDs\uff09\uff0c\u8207\u8d85\u904e\u4e0a\u767e\u7a2e\u4e0d\u540c\u57fa\u56e0\u7a81\u8b8a\u76f8\u95dc\u3002\u5118\u7ba1\u767c\u75c5\u5e74\u9f61\u5b58\u5728\u5dee\u7570\uff0c\u5927\u591a\u6578\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u60a3\u8005\u572840\u6b72\u5de6\u53f3\u5df2\u9054\u5230\u6cd5\u5b9a\u5931\u660e\u7684\u7a0b\u5ea6\u3002\u8a72\u75be\u75c5\u9032\u5c55\u521d\u671f\u51fa\u73fe\u8996\u687f\u7d30\u80de\u9000\u5316\uff0c\u96a8\u5f8c\u8996\u9310\u7d30\u80de\u9010\u6f38\u55aa\u5931\uff0c\u76f4\u81f3\u5149\u611f\u53d7\u5668\u7d30\u80de\u5e7e\u4e4e\u5b8c\u5168\u51cb\u4ea1\uff0c\u8996\u89ba\u529f\u80fd\u4e0d\u53ef\u9006\u5730\u53d7\u640d\uff0c\u6700\u7d42\u5c0e\u81f4\u5931\u660e\u3002\u76ee\u524d\uff0c\u5168\u7403\u5c1a\u7121\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\u80fd\u5920\u963b\u6b62\u6216\u9006\u8f49\u5149\u611f\u53d7\u5668\u7d30\u80de\u7684\u9000\u5316\u3002\u73fe\u6709\u7684\u57fa\u56e0\u7279\u7570\u6027\u6cbb\u7642\u65b9\u6cd5\u50c5\u91dd\u5c0d\u6975\u5c11\u6578\u7279\u5b9a\u57fa\u56e0\u7a81\u8b8a\uff0c\u4e0d\u9069\u7528\u65bc\u5927\u591a\u6578\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u60a3\u8005\u3002SKG1108\u57fa\u56e0\u6cbb\u7642\u63a1\u7528\u5275\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\uff0c\u4e0d\u53d7\u9650\u65bc\u7279\u5b9a\u57fa\u56e0\u7a81\u8b8a\uff0c\u901a\u904e\u751f\u6210\u65b0\u7684\u5149\u611f\u53d7\u5668\u4f86\u88dc\u511f\u8996\u687f\u7d30\u80de\u548c\u8996\u9310\u7d30\u80de\u7684\u9000\u8b8a\u8207\u55aa\u5931\u3001\u6539\u5584\u548c\u6062\u5fa9\u8996\u89ba\u529f\u80fd\uff0c\u5f9e\u800c\u6709\u6548\u6cbb\u7642\u56b4\u91cd\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\uff0c\u60e0\u53ca\u66f4\u591a\u6025\u9700\u6cbb\u7642\u7684\u60a3\u8005\u3002 \u95dc\u65bc\u5b64\u5152\u85e5\u8a8d\u5b9a\uff08ODD\uff09 \u5b64\u5152\u85e5\u8a8d\u5b9a\uff08ODD\uff09\uff0c\u662f\u7f8e\u570bFDA\u6388\u4e88\u7b26\u5408\u689d\u4ef6\u7684\u7528\u65bc\u9810\u9632\u3001\u8a3a\u65b7\u6216\u6cbb\u7642\u7f55\u898b\u75c5\u7684\u85e5\u7269\u6216\u751f\u7269\u88fd\u54c1\u7684\u4e00\u7a2e\u8cc7\u683c\u8a8d\u5b9a\uff0c\u65e8\u5728\u9f13\u52f5\u7814\u767c\u6a5f\u69cb\u70ba\u7f55\u898b\u75c5\u958b\u767c\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u3002\u7372\u5f97ODD\u8a8d\u5b9a\u610f\u5473\u8457\u8a72\u85e5\u7269\u5c0d\u65bc\u6cbb\u7642\u67d0\u7a2e\u7f55\u898b\u75c5\u7684\u6f5b\u529b\u5f97\u5230\u4e86FDA\u7684\u8a8d\u53ef\u3002\u7372\u5f97ODD\u8cc7\u683c\u7684\u85e5\u7269\u53ef\u4ee5\u4eab\u53d7\u4e00\u7cfb\u5217\u7684\u6fc0\u52f5\u653f\u7b56\uff0c\u5305\u62ec\u4e0a\u5e02\u5f8c7\u5e74\u7684\u5e02\u5834\u7368\u4f54\u671f\u3001\u81e8\u5e8a\u8a66\u9a57\u8cbb\u7528\u7684\u7a05\u6536\u62b5\u514d\u3001\u514d\u9664\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u8cbb\u4ee5\u53ca\u7372\u5f97\u81e8\u5e8a\u8a66\u9a57\u8cc7\u52a9\u7b49\u512a\u60e0\u653f\u7b56\u3002 \u95dc\u65bc\u4e5d\u5929\u751f\u7269 \u4e5d\u5929\u751f\u7269\u662f\u4e00\u5bb6\u4ee5\u5275\u65b0\u70ba\u9a45\u52d5\u7684\u5168\u7403\u6027\u81e8\u5e8a\u968e\u6bb5\u57fa\u56e0\u6cbb\u7642\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u548c\u751f\u7522\u7a81\u7834\u6027\u57fa\u56e0\u6cbb\u7642\u85e5\u7269\uff0c\u81f4\u529b\u65bc\u89e3\u6c7a\u7f55\u898b\u548c\u56b4\u91cd\u75be\u75c5\u9818\u57df\u60a3\u8005\u7684\u672a\u6eff\u8db3\u9700\u6c42\u3002\u6191\u501f\u81ea\u4e3b\u5275\u5efa\u7684\u5c16\u7aef\u817a\u76f8\u95dc\u75c5\u6bd2(AAV)\u57fa\u56e0\u6cbb\u7642\u6280\u8853\u5e73\u53f0\uff0c\u4e5d\u5929\u751f\u7269\u5728\u8863\u6bbc\u767c\u73fe\u3001\u75c5\u6bd2\u8f09\u9ad4\u8a2d\u8a08\u548c\u69cb\u5efa\u3001\u5de5\u85dd\u958b\u767c\u53caGMP\u751f\u7522\u7b49\u65b9\u9762\u64c1\u6709\u5168\u9762\u7684\u5275\u65b0\u80fd\u529b\u548c\u9818\u5148\u512a\u52e2\u3002\u516c\u53f8\u7814\u767c\u7ba1\u7dda\u6db5\u84cb\u773c\u79d1\u3001\u795e\u7d93\u548c\u5fc3\u8840\u7ba1\u7b49\u9818\u57df\uff0c\u591a\u500b\u5275\u65b0\u9805\u76ee\u5df2\u7372\u5f97\u4e2d\u570b\u548c\u7f8e\u570b\u76e3\u7ba1\u6a5f\u69cb\u7684\u81e8\u5e8a\u8a66\u9a57\u6279\u51c6\u6216\u7279\u5225\u8cc7\u683c\u8a8d\u5b9a\uff0c\u4e26\u958b\u5c55\u4e86\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\uff0c\u4ee5\u5ee3\u6cdb\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u4e5d\u5929\u751f\u7269\u5728\u4e2d\u570b\u4e0a\u6d77\u3001\u676d\u5dde\u548c\u7f8e\u570b\u6ce2\u58eb\u9813\u8a2d\u6709\u7814\u767c\u53ca\u751f\u7522\u57fa\u5730\u3002www.skytx.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=259288\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e5d\u5929\u751f\u7269AAV\u57fa\u56e0\u7642\u6cd5SKG1108\u6cbb\u7642\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u7372FDA\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772024\u5e749\u67083\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4e5d\u5929\u751f\u7269\uff08Skyline Therapeutics\uff09\u81ea\u4e3b\u7814\u767c\u7684\u817a\u76f8\u95dc\u75c5\u6bd2\uff08AAV\uff09\u57fa\u56e0\u6cbb\u7642\u85e5\u7269SKG1108\uff0c\u4e00\u6b3e\u7528\u65bc\u6cbb\u7642\u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\uff08Retinitis Pigmentosa\uff0cRP\uff09\u7684\u7a81\u7834\u6027\u57fa\u56e0\u7642\u6cd5\uff0c\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff08ODD\uff09\u3002\u9019\u4e00\u8a8d\u5b9a\u6a19\u8a8c\u8457SKG1108\u9019\u4e00\u5275\u65b0AAV\u8f09\u9ad4\u5728\u6cbb\u7642RP\u65b9\u9762\u7684\u6f5b\u529b\u5f97\u5230\u4e86FDA\u7684\u8a8d\u53ef\uff0c\u4e26\u4f7f\u5176\u5728\u672a\u4f86\u7684\u958b\u767c\u3001\u4e0a\u5e02\u904e\u7a0b\u4e2d\u53ca\u4e0a\u5e02\u5f8c\u6709\u8cc7\u683c\u4eab\u53d7\u4e00\u7cfb\u5217\u6fc0\u52f5\u653f\u7b56\uff0c\u7372\u5f97FDA\u7684\u6301\u7e8c\u652f\u6301\u3002 SKG1108\u662f\u4e00\u6b3e\u5b8c\u5168\u5275\u65b0\u8a2d\u8a08\u7684AAV\u8f09\u9ad4\uff0c\u5305\u542b\u7528\u65bc\u73bb\u7483\u9ad4\u5167\u6ce8\u5c04\u7684\u5275\u65b0\u8863\u6bbcAAV.0106\uff0c\u5c07\u63a1\u7528\u524d\u6cbf\u8a2d\u8a08\u7684\u7de8\u78bc\u5177\u6709\u7368\u7279\u7d50\u69cb\u548c\u529f\u80fd\u7684\u5168\u65b0\u86cb\u767d\u7684\u57fa\u56e0\u76f4\u63a5\u905e\u9001\u81f3\u8996\u7db2\u819c\uff0c\u901a\u904e\u7279\u5b9a\u7684\u57fa\u56e0\u5143\u7d20\u8abf\u63a7\u5728\u8996\u7db2\u819c\u9776\u7d30\u80de\u4e2d\u8868\u9054\u7279\u6b8a\u5149\u654f\u86cb\u767d\uff0c\u5f9e\u800c\u7522\u751f\u65b0\u7684\u5149\u611f\u53d7\u5668\u4f86\u6539\u5584\u548c\u6062\u5fa9\u60a3\u8005\u8996\u89ba\u529f\u80fd\u3002 \u8996\u7db2\u819c\u8272\u7d20\u8b8a\u6027\u662f\u4e00\u7a2e\u9ad8\u81f4\u76f2\u6027\u907a\u50b3\u6027\u8996\u7db2\u819c\u9000\u884c\u6027\u75c5\u8b8a\uff08Inherited Retinal Diseases, 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