{"id":253830,"date":"2024-08-08T22:11:00","date_gmt":"2024-08-08T14:11:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=253830"},"modified":"2024-08-08T22:11:00","modified_gmt":"2024-08-08T14:11:00","slug":"pepromene-bio-%e5%ae%a3%e5%b8%83%e7%a0%94%e7%a9%b6%ef%bc%8c%e9%a1%af%e7%a4%ba%e6%96%b0%e5%9e%8b%e5%b5%8c%e5%90%88%e6%8a%97%e5%8e%9f%e5%8f%97%e9%ab%94-car-t-%e7%b4%b0%e8%83%9e%e5%85%b7%e6%9c%89","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=253830","title":{"rendered":"PeProMene Bio \u5ba3\u5e03\u7814\u7a76\uff0c\u986f\u793a\u65b0\u578b\u5d4c\u5408\u6297\u539f\u53d7\u9ad4 (CAR) T \u7d30\u80de\u5177\u6709\u5f37\u5927\u7684\u591a\u529f\u80fd\u6027"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i>CAR T \u7d30\u80de\u7642\u6cd5\u6301\u7e8c\u7de9\u89e3\u75c5\u4eba\u9ad4\u5167\u816b\u7624\u9054 18 \u500b\u6708\uff0c\u591a\u529f\u80fd\u6027\u662f\u95dc\u9375<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u6b50\u6587<\/span><span class=\"legendSpanClass\">2024\u5e748\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8 <a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4227538-1&amp;h=1110971699&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4227538-1%26h%3D2494654772%26u%3Dhttps%253A%252F%252Fpepromenebio.com%252F%26a%3DPeproMene%2BBio%252C%2BInc.&amp;a=PePromene+Bio%2C+Inc.\" target=\"_blank\" rel=\"nofollow noopener\">PePromene Bio, Inc.<\/a> \u4eca\u5929\u5ba3\u5e03\u7531 City of Hope \u958b\u767c\u7684 BAFF-R CAR T\uff0c\u7a31\u70ba PMB-CT01\u3002\u6839\u64da\u767c\u8868\u5728<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4227538-1&amp;h=2681942836&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4227538-1%26h%3D1345489832%26u%3Dhttps%253A%252F%252Fauthors.elsevier.com%252Fsd%252Farticle%252FS2473952924003732%26a%3DBlood%2BAdvances&amp;a=%E3%80%8ABlood+Advances%E3%80%8B\" target=\"_blank\" rel=\"nofollow noopener\">\u300aBlood Advances\u300b<\/a>\u7684\u76f8\u95dc\u7814\u7a76\u6307\u51fa\uff0cPMB-CT01 \u6bd4 CD19 CAR T \u7d30\u80de\uff08\u7528\u65bc\u76ee\u524d\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u6838\u51c6\u7684 CAR T \u7d30\u80de\u7642\u6cd5\uff09\u986f\u793a\u51fa\u66f4\u597d\u7684\u591a\u529f\u80fd\u6027\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u4e86\u55ae\u7d30\u80de\u5e73\u53f0\uff0c\u767c\u73fe PMB-CT01 CAR T \u7d30\u80de\uff0c\u6bd4 CD 19 CAR T \u7d30\u80de\u5177\u6709\u66f4\u591a\u7684\u591a\u529f\u80fd\u6027\uff0c\u5373 T \u7d30\u80de\u540c\u6642\u57f7\u884c\u591a\u9805\u529f\u80fd\u7684\u80fd\u529b\u3002PMB-CT01 \u7d30\u80de\u9084\u7522\u751f\u66f4\u591a\u7684\u523a\u6fc0\u6027\u7d30\u80de\u56e0\u5b50\uff0c\u53ef\u4ee5\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\uff0c\u4ee5\u53ca\u6709\u6548\u7d30\u80de\u56e0\u5b50\uff0c\u53ef\u4ee5\u76f4\u63a5\u6bba\u6b7b\u764c\u7d30\u80de\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u7531 City of Hope \u958b\u767c\u7684\u6e2c\u8a66\uff0c\u6e2c\u8a66\u4e86\u4e00\u540d 57 \u6b72\u60a3\u6709\u5fa9\u767c\u7684\u5305\u88dd\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684 BAFF-R CAR T \u7d30\u80de\u7522\u54c1\u3002\u75c5\u4eba\u5148\u524d\u4f7f\u7528 CD19 CAR T \u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u7121\u9054\u5230\u7de9\u89e3\u6548\u679c\u3002\u5728 City of Hope \u7684<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4227538-1&amp;h=3741710376&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4227538-1%26h%3D690005826%26u%3Dhttps%253A%252F%252Fclinicaltrials.gov%252Fstudy%252FNCT05370430%253Ftab%253Dhistory%26a%3DPhase%2B1%2Btrial&amp;a=%E7%AC%AC%E4%B8%80%E6%9C%9F%E8%A9%A6%E9%A9%97\" target=\"_blank\" rel=\"nofollow noopener\">\u7b2c\u4e00\u671f\u8a66\u9a57<\/a>\u4e2d\uff0c\u4f7f\u7528 PMB-CT01 \u6ce8\u5c04\u4e00\u6b21\u5f8c\uff0c\u8a66\u9a57\u4e2d\u7537\u5b50\u5728 18 \u500b\u6708\u5167\u5be6\u73fe\u5b8c\u5168\u7de9\u89e3 (CR)\uff0c\u5c31\u7b97\u900f\u904e\u654f\u611f\u7684\u5fae\u5c0f\u6b98\u7559\u75be\u75c5\u5206\u5b50\u6aa2\u6e2c\uff0c\u4ecd\u6aa2\u6e2c\u4e0d\u5230\u764c\u75c7\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u5831\u544a\u4e86\u5f37\u5927\u7684\u591a\u529f\u80fd\u6027\u6307\u6a19\uff0c\u9019\u8207\u6ce8\u5c04 CAR T \u7d30\u80de\u5f8c\u7d30\u80de\u6210\u529f\u64f4\u589e\uff0c\u4ee5\u53ca\u75c5\u4eba\u7372\u5f97\u6301\u7e8c\u7de9\u89e3\u6709\u95dc\u3002\u7814\u7a76\u4eba\u54e1\u8a08\u5283\u4f7f\u7528\u9019\u7a2e\u6aa2\u6e2c\u65b9\u6cd5\uff0c\u4ee5\u6e2c\u8a66\u8a66\u9a57\u4e2d\u53e6\u5916\u4e94\u4f4d\u75c5\u4eba\u7684 CAR T \u7d30\u80de\u7522\u54c1\uff0c\u9019\u4e9b\u75c5\u4eba\u90fd\u7d93\u6b77\u4e86\u8207 PMB-CT01 \u985e\u4f3c\u7684\u7de9\u89e3\u3002<\/p>\n<p>City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3 (CCC) \u526f\u4e3b\u5e2d\u517c\u526f\u4e3b\u4efb\u3001PeproMene \u7684\u79d1\u5b78\u5275\u8fa6\u4eba\u517c Scientific Advisory Board \u53d7\u85aa\u4e3b\u5e2d <a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4227538-1&amp;h=851486972&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4227538-1%26h%3D3292574086%26u%3Dhttps%253A%252F%252Fwww.cityofhope.org%252Flarry-kwak%26a%3DLarry%2BW.%2BKwak&amp;a=Larry+W.+Kwak\" target=\"_blank\" rel=\"nofollow noopener\"><span class=\"xn-person\">Larry W. Kwak<\/span><\/a> \u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u958b\u767c\u4e86 BAFFR-CAR T \u7642\u6cd5\uff0c\u4f5c\u70ba\u5927\u91cf\u63a5\u53d7\u5546\u696d CD19 CAR T \u7d30\u80de\u6cbb\u7642\u5f8c\u5fa9\u767c\u7684\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u75c5\u4eba\u7684\u53e6\u4e00\u7a2e\u6cbb\u7642\u9078\u64c7\uff1b\u6211\u5011\u76ee\u524d\u7684\u7d50\u679c\uff0c\u662f\u6700\u5927\u7642\u6548\u548c\u6700\u5c0f\u6bd2\u6027\u7684\u7406\u60f3\u9ad4\u73fe\u3002Kwak \u5728 PeproMene \u6301\u6709\u80a1\u6b0a\u3002\u300c\u6211\u5011\u70ba CAR T \u7d30\u80de\u7522\u54c1\u958b\u767c\u4e86\u4e00\u7a2e\u5f37\u5927\u4e14\u53ef\u9760\u7684\u591a\u529f\u80fd\u5206\u6790\uff0c\u5177\u6709\u6f5b\u529b\u9810\u6e2c\u75c5\u4eba\u7d50\u679c\uff0c\u4e26\u52a0\u901f\u958b\u767c\u6709\u6548\u7684 CAR T \u7d30\u80de\u7642\u6cd5\u3002\u300d<\/p>\n<p>\u6b64\u6e2c\u8a66\u7684\u9996\u5e2d\u7814\u7a76\u54e1\u3001City of Hope \u7684\u8840\u6db2\u5b78\u548c\u9020\u8840\u7d30\u80de\u79fb\u690d\u526f\u6559\u6388\u3001\u517c\u514d\u75ab\u589e\u5f37\u7d30\u80de\u6cbb\u7642\u8a08\u5283\u7684\u57f7\u884c\u91ab\u7642\u7e3d\u76e3 <span class=\"xn-person\">Elizabeth Budde<\/span> \u535a\u58eb\uff0c\u5728American Society of Hematology 2023 \u5e74 12 \u6708\u7684\u6703\u8b70\u4e0a\uff0c\u5c55\u793a\u4e86\u521d\u6b65\u8a66\u9a57\u7d50\u679c\u3002<\/p>\n<p>Budde \u535a\u58eb\u8aaa\uff1a\u300c\u4ee4\u4eba\u8208\u596e\u7684\u662f\uff0c\u6709 5 \u4f4d\u975e\u970d\u5947\u91d1\u6c0f\u6dcb\u5df4\u7624 (Non-Hodgkin lymphoma) \u75c5\u4eba\u548c 1 \u4f4d\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5 (Acute Lymphoblastic Leukemia) \u75c5\u4eba\u63a5\u53d7\u4e86 PMB-CT01 \u7684\u6cbb\u7642\uff0c\u7576\u4e2d 100% \u90fd\u986f\u793a\u51fa\u6301\u4e45\u7684\u53cd\u61c9\u3002\u5728\u63a5\u53d7 CD19 CAR T \u6cbb\u7642\u5f8c\u548c\/\u6216\u5728 CD19 \u5448\u9670\u6027\u6642\uff0c\u8a31\u591a\u8a66\u9a57\u75c5\u4eba\u51fa\u73fe\u5fa9\u767c\u3002PMB-CT01 \u53ef\u4ee5\u70ba\u5176\u4ed6\u9762\u81e8\u9019\u7a2e\u56f0\u5883\u7684\u75c5\u4eba\u63d0\u4f9b\u4e00\u500b\u53ef\u884c\u7684\u9078\u64c7\u3002\u300d<\/p>\n<p>\u300c\u6b64\u6e2c\u8a66\u53ef\u4ee5\u61c9\u7528\u65bc\u76ee\u524d\u548c\u672a\u4f86\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u6307\u5c0e PMB-CT01 \u7684\u767c\u5c55\u3002PeProMene \u4ecd\u7136\u81f4\u529b\u65bc\u9019\u7a2e\u6f5b\u5728\u6709\u671b\u7684\u65b0\u7d30\u80de\u6cbb\u7642\u7684\u6301\u7e8c\u79d1\u5b78\u548c\u81e8\u5e8a\u958b\u767c\uff0c\u300dPeproMene Bio \u71df\u904b\u7e3d\u76e3 <span class=\"xn-person\">Hazel Cheng<\/span> \u535a\u58eb\u8868\u793a\u3002<\/p>\n<p><b>PMB-CT01 \u7c21\u4ecb<\/b><\/p>\n<p>PMB-CT01 \u662f\u4e00\u7a2e\u4e00\u6d41\u7684 BAFF-R \u91dd\u5c0d\u6027\u81ea\u9ad4 CAR T \u7d30\u80de\u6cbb\u7642\u3002BAFF-R\uff08B-\u7d30\u80de\u6d3b\u5316\u56e0\u5b50\u53d7\u9ad4\uff09\u662f\u816b\u7624\u58de\u6b7b\u56e0\u5b50\uff08TNF\uff09\u53d7\u9ad4\u8d85\u65cf\u7684\u6210\u54e1\uff0c\u662f BAFF \u7684\u4e3b\u8981\u53d7\u9ad4\uff0c\u5e7e\u4e4e\u50c5\u5728 B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u7531\u65bc BAFF-R \u4fe1\u865f\u4fc3\u9032\u6b63\u5e38 B \u7d30\u80de\u589e\u6b96\uff0c\u4e26\u4e14\u4f3c\u4e4e\u662f B \u7d30\u80de\u751f\u5b58\u6240\u9700\u7684\uff0c\u56e0\u6b64\u816b\u7624\u7d30\u80de\u4e0d\u592a\u53ef\u80fd\u901a\u904e\u4e1f\u5931 BAFF-R \u6297\u539f\u4f86\u9003\u812b\u6cbb\u7642\u3002\u9019\u7a2e\u7368\u7279\u7279\u6027\uff0c\u4f7f BAFFR CAR T \u7642\u6cd5\u6210\u70ba\u6cbb\u7642 B \u7d30\u80de\u60e1\u6027\u816b\u7624\u975e\u5e38\u6709\u524d\u9014\u7684\u9078\u64c7\u3002BAFFR CAR \u4f7f\u7528\u6297 BAFF-R \u55ae\u93c8\u7247\u6bb5\u8b8a\u7570 (scFv) \u6297\u9ad4\u548c\u7b2c\u4e8c\u4ee3\u4fe1\u865f\u57df CD3\u03b6 \u53ca 4-1BB \u5efa\u69cb\u800c\u6210\u3002\u6211\u5011\u7684\u7814\u7a76\u8868\u660e\uff0cBAFFR-CAR T \u7d30\u80de\u5728\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u4e2d\uff0c\u80fd\u5920\u6709\u6548\u6bba\u6b7b\u4eba\u985e\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u3002PeproMene Bio \u5df2\u5411 City of Hope \u6388\u6b0a PMB-CT01 \u7684\u77e5\u8b58\u7522\u6b0a\u3002<\/p>\n<p><b>PeproMene Bio \u7c21\u4ecb<\/b><\/p>\n<p>PeProMene Bio, Inc. \u662f\u4e00\u9593\u4f4d\u65bc\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u6b50\u6587\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u958b\u767c\u5275\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\u4ee5\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u969c\u7919\u3002PeproMene \u7684\u4e3b\u8981\u5019\u9078\u85e5\u7269 PMB-CT01 (BAFFR-CAR T cells) \u76ee\u524d\u6b63\u9032\u884c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u6cbb\u7642\u5fa9\u767c\u53ca\u96e3\u4ee5\u6839\u6cbb\u7684 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (B-ALL\uff1bNCT04690595) \u53ca B \u7d30\u80de\u975e\u4f55\u6770\u91d1\u6dcb\u5df4\u7624 (B-NHL\uff1bNCT05370430)\u3002PeproMene Bio \u9084\u6b63\u958b\u767c BAFFR \u96d9\u7279\u7570\u6027T\u7d30\u80de\u929c\u63a5\u7cfb\u7d71 (bispecific T-cell engager\uff0cBiTE) \u548c BAFFR-CAR NK \u7d30\u80de\u3002<\/p>\n<p>\u806f\u7d61\u65b9\u6cd5\uff1aJohn Fry\uff0c<a href=\"mailto:john.fry@pepromenebio.com\" target=\"_blank\" rel=\"nofollow noopener\">john.fry@pepromenebio.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>CAR T 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Fry\uff0cjohn.fry@pepromenebio.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=253830\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PeProMene Bio \u5ba3\u5e03\u7814\u7a76\uff0c\u986f\u793a\u65b0\u578b\u5d4c\u5408\u6297\u539f\u53d7\u9ad4 (CAR) T \u7d30\u80de\u5177\u6709\u5f37\u5927\u7684\u591a\u529f\u80fd\u6027 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"CAR T \u7d30\u80de\u7642\u6cd5\u6301\u7e8c\u7de9\u89e3\u75c5\u4eba\u9ad4\u5167\u816b\u7624\u9054 18 \u500b\u6708\uff0c\u591a\u529f\u80fd\u6027\u662f\u95dc\u9375 \u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u6b50\u65872024\u5e748\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8 PePromene Bio, Inc. 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