{"id":243401,"date":"2024-06-19T10:46:00","date_gmt":"2024-06-19T02:46:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=243401"},"modified":"2024-06-19T10:46:00","modified_gmt":"2024-06-19T02:46:00","slug":"%e7%82%ba%e7%94%9f%e5%91%bd%ef%bc%8c%e5%89%b5%e7%84%a1%e6%ad%a2%e5%a2%83-%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e8%85%ab%e7%98%a4%e7%ae%a1%e7%b7%9a%e8%87%a8%e5%ba%8a%e6%95%b8%e6%93%9a%e6%9c%80","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=243401","title":{"rendered":"\u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883 | \u4fe1\u9054\u751f\u7269\u816b\u7624\u7ba1\u7dda\u81e8\u5e8a\u6578\u64da\u6700\u65b0\u89e3\u8b80\u5206\u4eab"},"content":{"rendered":"<div>\n<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5728\u4eca\u5e74\u591a\u500b\u570b\u969b\u816b\u7624\u5b78\u5e74\u6703\u4e0a\uff0c\u4fe1\u9054\u751f\u7269\u4ee510\u9805\u53e3\u982d\u5831\u544a\u548c15\u9805\u58c1\u5831\u5f62\u5f0f\uff0c\u5c55\u793a\u4e86\u591a\u6b3e\u816b\u7624\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u6578\u64da\u30026\u670817\u65e5\uff0c\u4fe1\u9054\u751f\u7269\u53ec\u958b\u6295\u8cc7\u8005\u96fb\u8a71\u6703\uff0c\u8a73\u7d30\u89e3\u8b80\u7522\u54c1\u81e8\u5e8a\u6578\u64da\uff0c\u540c\u6642\u4ecb\u7d39\u4e86\u516c\u53f8\u76ee\u524d\u805a\u7126\u5168\u7403\u5275\u65b0\u7684\u7814\u767c\u7b56\u7565\uff0c\u4ee5\u53ca\u91cd\u9ede\u63a8\u9032\u7684\u591a\u6b3e\u4e2d\u65e9\u671f\u5206\u5b50\u5dee\u7570\u5316\u7684\u65e9\u7814\u6a5f\u5236\u3001\u958b\u767c\u7b56\u7565\u548c\u958b\u767c\u65b9\u5411\u3002\u4fe1\u9054\u751f\u7269\u9996\u5e2d\u8ca1\u52d9\u5b98\u7531\u98db\u5973\u58eb\u3001\u816b\u7624\u958b\u767c\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u3001\u816b\u7624\u751f\u7269\u5b78\u8207ADC\u85e5\u7269\u7814\u7a76\u526f\u7e3d\u88c1\u4f55\u958b\u5091\u535a\u58eb\u53c3\u52a0\u6703\u8b70\u4e26\u9032\u884c\u532f\u5831\u3002<\/p>\n<p>\uff08\u8a73\u7d30\u5206\u4eab\u6750\u6599\u53ef\u5728\u516c\u53f8\u5b98\u7db2\u9032\u884c\u4e0b\u8f09\uff0c\u93c8\u63a5\uff1ahttps:\/\/investor.innoventbio.com\/cn\/investors\/webcasts-and-presentations\/\uff09<\/p>\n<p><b>\u816b\u7624\u958b\u767c\u7b56\u7565\uff1a\u6df1\u5ea6\u4f48\u5c40<\/b><b>IO+ADC\uff0c\u89e3\u6c7a\u5168\u7403\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42<\/b><\/p>\n<p>\u79d1\u5b78\u6280\u8853\u7684\u9032\u6b65\uff0c\u8b93\u816b\u7624\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u751f\u547d\u8cea\u91cf\u4e0d\u65b7\u63d0\u5347\u3002\u4f46\u816b\u7624\u6cbb\u7642\u9084\u5b58\u5728\u5f88\u591a\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5982\u4ee5PD-1\u70ba\u4ee3\u8868\u7684\u514d\u75ab\u7642\u6cd5\u97ff\u61c9\u7387\u6709\u9650\uff0c\u4e14\u7d55\u5927\u591a\u6578\u75be\u75c5\u97ff\u61c9\u6700\u7d42\u90fd\u6703\u9032\u5c55\uff1b\u7576\u524d\u4e3b\u8981\u6cbb\u7642\u624b\u6bb5\uff08\u5982\u6297\u8840\u7ba1\u751f\u6210\u85e5\u7269\uff09\u7684\u7642\u6548\u6709\u9650\u7b49\u3002<\/p>\n<p>\u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 <span>\u300c<\/span> \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)<span>\u300d<\/span> \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda<span>\u300c<\/span> \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883<span>\u300d<\/span> \u7684\u54c1\u724c\u5b9a\u4f4d\u3002<\/p>\n<p><b>\u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1a<\/b><b>PoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b<\/b><\/p>\n<p>\u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002<\/p>\n<p><b>IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe<\/b><\/p>\n<p>IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002<\/li>\n<li>IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002<\/li>\n<li>\u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002<\/li>\n<li>\u57fa\u65bc\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u9032\u4e00\u6b65\u62d3\u5c55IBI363\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5305\u62ec\u9032\u4e00\u6b65\u8ddf\u9032\u9ad8\u5291\u91cf3mg\/kg\u7684\u81e8\u5e8a\u7d50\u679c\u4ee5\u6c7a\u5b9a\u5f8c\u7e8c\u958b\u767c\u5291\u91cf\u3001\u958b\u5c55\u7f8e\u570b2\u671f\u81e8\u5e8a\u3001\u4ee5\u53ca\u63a2\u7d22\u66f4\u591a\u7684\u806f\u5408\u7528\u85e5\u6a5f\u6703\u3002<\/li>\n<\/ul>\n<p><b>\u5169\u6b3e\u57fa\u65bc<\/b><b>CLDN18.2\u9776\u9ede\u7684\u5275\u65b0\u6280\u8853\u5f62\u614bIBI343\u548cIBI389\u5c55\u73fe\u51fa\u7a81\u7834\u7642\u6548<\/b><\/p>\n<p><b>IBI343\uff1a\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff0c\u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7a81\u7834\u7642\u6548\u7684ADC \u85e5\u7269<\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u5168\u7403\u9818\u5148\u7684\u5275\u65b0\u578b<\/b><b>TOPO1i CLDN18.2 ADC<\/b>\uff1aIBI343\u63a1\u7528\u512a\u7570\u7684\u5206\u5b50\u8a2d\u8a08\uff0c\u57fa\u65bc\u4e16\u754c\u9818\u5148\u7684\u7cd6\u57fa\u5316\u5b9a\u9ede\u5076\u806f\u6280\u8853\uff0c\u9ad4\u5167\u7a69\u5b9a\u6027\u9ad8\uff1b\u4f7f\u7528\u5f37\u529b\u7684\u6709\u6548\u8f09\u8377\uff08\u4f0a\u559c\u66ff\u5eb7\uff09\u4e26\u5177\u6709\u5f37\u5927\u7684\u65c1\u89c0\u8005\u6bba\u50b7\u4f5c\u7528\uff1bFc\u6c89\u9ed8\u6548\u61c9\u78ba\u4fdd\u7121ADCC\u4ecb\u5c0e\u7684\u80c3\u8178\u9053\u6bd2\u6027\u4ee5\u4fdd\u8b49\u9ad8\u9ad4\u5167\u5b89\u5168\u6027\uff1b\u4ee5\u53ca\u5168\u4eba\u6e90\u548c\u9ad8\u5167\u541e\u6027\u7684CLDN18.2\u6297\u9ad4\u5e36\u4f86\u7684\u5f37\u5927\u9776\u5411\u6548\u679c\u3002<\/li>\n<li><b>\u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7642\u6548\u7a81\u7834\u7684<\/b><b>ADC\u85e5\u7269<\/b>\uff1aIBI343\u7528\u65bc\u81f3\u5c11\u63a5\u53d7\u904e1\u7dda\u6cbb\u7642\u7684\u80f0\u817a\u764c\u60a3\u8005\u7684I\u671f\u521d\u6b65\u6578\u64da\u986f\u793a\uff0c\u5728\u63a5\u53d76 mg\/kg IBI343\u6cbb\u7642\u7684CLDN18.2 IHC1\/2\/3+\u226560%\u80f0\u817a\u764c\u53d7\u8a66\u8005\uff08n=10\uff09\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba 40%\u3002<\/li>\n<li><b>\u9664<\/b><b>PDAC\u5916\uff0cIBI343\u5728\u5f8c\u7dda\u80c3\u764c\u6cbb\u7642\u5c55\u73fe\u51fa\u660e\u78ba\u7684\u6cbb\u7642\u6548\u679c<\/b>\uff0c\u5176MRCT\u81e8\u5e8a3\u671f\u6b63\u5728\u7c4c\u5099\u4e2d\u3002<\/li>\n<\/ul>\n<p><b>IBI389\uff1a\u5168\u7403\u9996\u5275\u6297CLDN18.2\/CD3\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u9996\u500b\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\u7684T\u7d30\u80de\u9023\u63a5\u5668<\/b><\/p>\n<ul type=\"disc\">\n<li>IBI389\u662f\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u5206\u5b50\uff0c\u901a\u904e\u540c\u6642\u7d50\u5408\u816b\u7624\u7d30\u80de\u4e0a\u8868\u9054\u7684CLDN18.2\u548cT\u7d30\u80de\u4e0a\u7684CD3\uff0c\u5c07T\u7d30\u80de\u91cd\u5b9a\u5411\u5230\u816b\u7624\u7d30\u80de\uff0c\u8a98\u5c0eT\u7d30\u80de\u5c0d\u816b\u7624\u7d30\u80de\u7684\u6bba\u50b7\u3002\u81e8\u5e8a\u524d\u7d50\u679c\u8868\u660e\uff0c\u5373\u4f7f\u5728CLDN18.2\u4f4e\u8868\u9054\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cIBI389\u4ecd\u80fd\u8207\u816b\u7624\u7d30\u80de\u7d50\u5408\uff0c\u8868\u73fe\u51fa\u660e\u986f\u7684\u6297\u816b\u7624\u6548\u529b\u3002<\/li>\n<li>IBI389\u5728\u5305\u62ecCLDN18.2\u4e2d\u4f4e\u8868\u9054\u4eba\u7fa4\u5728\u5167\u7684\u665a\u671f\u80c3\u764c\u548c\u80f0\u817a\u764c\u5747\u5c55\u73fe\u51fa\u6709\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\u3002\u7279\u5225\u662f\uff0c\u4f5c\u70ba\u5168\u7403\u9996\u500b\u516c\u4f48\u81e8\u5e8a\u6578\u64da\u7684\u9776\u5411CLDN18.2\/CD3\u96d9\u6297\uff0cIBI389\u5728\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\uff0c\u5be6\u73fe\u4e86\u8a72\u5275\u65b0\u85e5\u7269\u5f62\u5f0f\u5728\u96e3\u6cbb\u764c\u7a2e\u9818\u57df\u7684\u7a81\u7834\u3002<\/li>\n<li>ASCO\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0c\u572827\u4f8b\u63a5\u53d7\u4e86600\u03bcg\/kg IBI389\u6cbb\u7642\u4e26\u81f3\u5c11\u9032\u884c\u4e86\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\u7684\u80f0\u817a\u764c\u53d7\u8a66\u8005\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba29.6%\uff0c\u78ba\u8a8d\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08cORR\uff09\u70ba25.9%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u905470.4%\u3002\u5728CLDN18.2 IHC 2\/3+\u226540%\u768418\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0c cORR\u905438.9%\uff0895%CI\uff1a17.3-64.3\uff09\u3002<\/li>\n<li>\u57fa\u65bcIBI343\u8207IBI389\u5728\u65e9\u671f\u81e8\u5e8a\u53ca\u81e8\u5e8a\u958b\u767c\u4e2d\u5c55\u73fe\u51fa\u4f86\u7684\u7368\u7279\u512a\u52e2\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u63a8\u9032\u958b\u767cIBI343\u7528\u65bc\u80c3\u764c\u6cbb\u7642\u7684MRCT 3\u671f\u81e8\u5e8a\uff0c\u4e26\u63a8\u9032\u63a2\u7d22IBI343\u548cIBI389\u65bc\u96e3\u6cbb\u816b\u7624\u80f0\u817a\u764c\u7684\u9a57\u8b49\u6027\u81e8\u5e8a\u3002<\/li>\n<\/ul>\n<p>\u5c55\u671b\u672a\u4f86\uff0c\u4fe1\u9054\u751f\u7269\u5c07\u7e7c\u7e8c\u9ad8\u8cea\u91cf\u63a8\u9032\u816b\u7624\u7522\u54c1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5728 <span>\u300c<\/span> IO + ADC<span>\u300d<\/span> \u6230\u7565\u6307\u5f15\u4e0b\uff0c\u63a2\u7d22\u764c\u75c7\u6cbb\u7642\u9818\u57df\u672a\u88ab\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\uff0c\u4e26\u63a8\u52d5\u5168\u7403\u5275\u65b0\u3002<b>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u816b\u7624\u958b\u767c\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb<\/b>\u8868\u793a\uff1a<span>\u300c<\/span> \u4f5c\u70ba\u5c11\u6578\u517c\u5177IO\u548cADC\u9818\u57df\u9818\u5148\u7814\u767c\u80fd\u529b\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u6211\u5011\u5c07\u5728\u816b\u7624\u6cbb\u7642\u7684\u4e0b\u4e00\u4ee3\u5275\u65b0\u65b9\u9762\u5177\u5099\u7368\u7279\u7684\u7af6\u722d\u512a\u52e2\uff0c\u5805\u5b88\u79c9\u627f\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\u9019\u4e00\u4f7f\u547d\uff0c\u60e0\u53ca\u66f4\u591a\u60a3\u8005\uff0c\u52a9\u529b\u5065\u5eb7\u4e2d\u570b2030\u6230\u7565\u843d\u5730\u3002<span>\u300d<\/span>\u00a0<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p><span>\u300c<\/span> \u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c<span>\u300d<\/span> \uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670910\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09*\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09*\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<sup>\u00ae<\/sup>\uff09\u548c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<sup>\u00ae<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67094\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88<span>\u300c<\/span> \u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3<span>\u300d<\/span> \uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fInnovent Biologics\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8072\u660e\uff1a\u4fe1\u9054\u751f\u7269\u4e0d\u63a8\u85a6\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u7684\u4f7f\u7528\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">*\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\uff09\u548c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\uff09\u7531\u79ae\u4f86\u516c\u53f8\u7814\u767c\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u524d\u77bb\u6027\u8072\u660e<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528<span>\u300c<\/span> \u9810\u671f<span>\u300d<\/span> \u3001<span>\u300c<\/span> \u76f8\u4fe1<span>\u300d<\/span> \u3001<span>\u300c<\/span> \u9810\u6e2c<span>\u300d<\/span> \u3001<span>\u300c<\/span> \u671f\u671b<span>\u300d<\/span> \u3001<span>\u300c<\/span> \u6253\u7b97<span>\u300d<\/span> \u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u5747\u5c6c\u65bc\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/p>\n<p>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u662f\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u662f\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-243401","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883 | \u4fe1\u9054\u751f\u7269\u816b\u7624\u7ba1\u7dda\u81e8\u5e8a\u6578\u64da\u6700\u65b0\u89e3\u8b80\u5206\u4eab - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5728\u4eca\u5e74\u591a\u500b\u570b\u969b\u816b\u7624\u5b78\u5e74\u6703\u4e0a\uff0c\u4fe1\u9054\u751f\u7269\u4ee510\u9805\u53e3\u982d\u5831\u544a\u548c15\u9805\u58c1\u5831\u5f62\u5f0f\uff0c\u5c55\u793a\u4e86\u591a\u6b3e\u816b\u7624\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u6578\u64da\u30026\u670817\u65e5\uff0c\u4fe1\u9054\u751f\u7269\u53ec\u958b\u6295\u8cc7\u8005\u96fb\u8a71\u6703\uff0c\u8a73\u7d30\u89e3\u8b80\u7522\u54c1\u81e8\u5e8a\u6578\u64da\uff0c\u540c\u6642\u4ecb\u7d39\u4e86\u516c\u53f8\u76ee\u524d\u805a\u7126\u5168\u7403\u5275\u65b0\u7684\u7814\u767c\u7b56\u7565\uff0c\u4ee5\u53ca\u91cd\u9ede\u63a8\u9032\u7684\u591a\u6b3e\u4e2d\u65e9\u671f\u5206\u5b50\u5dee\u7570\u5316\u7684\u65e9\u7814\u6a5f\u5236\u3001\u958b\u767c\u7b56\u7565\u548c\u958b\u767c\u65b9\u5411\u3002\u4fe1\u9054\u751f\u7269\u9996\u5e2d\u8ca1\u52d9\u5b98\u7531\u98db\u5973\u58eb\u3001\u816b\u7624\u958b\u767c\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u3001\u816b\u7624\u751f\u7269\u5b78\u8207ADC\u85e5\u7269\u7814\u7a76\u526f\u7e3d\u88c1\u4f55\u958b\u5091\u535a\u58eb\u53c3\u52a0\u6703\u8b70\u4e26\u9032\u884c\u532f\u5831\u3002 \uff08\u8a73\u7d30\u5206\u4eab\u6750\u6599\u53ef\u5728\u516c\u53f8\u5b98\u7db2\u9032\u884c\u4e0b\u8f09\uff0c\u93c8\u63a5\uff1ahttps:\/\/investor.innoventbio.com\/cn\/investors\/webcasts-and-presentations\/\uff09 \u816b\u7624\u958b\u767c\u7b56\u7565\uff1a\u6df1\u5ea6\u4f48\u5c40IO+ADC\uff0c\u89e3\u6c7a\u5168\u7403\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42 \u79d1\u5b78\u6280\u8853\u7684\u9032\u6b65\uff0c\u8b93\u816b\u7624\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u751f\u547d\u8cea\u91cf\u4e0d\u65b7\u63d0\u5347\u3002\u4f46\u816b\u7624\u6cbb\u7642\u9084\u5b58\u5728\u5f88\u591a\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5982\u4ee5PD-1\u70ba\u4ee3\u8868\u7684\u514d\u75ab\u7642\u6cd5\u97ff\u61c9\u7387\u6709\u9650\uff0c\u4e14\u7d55\u5927\u591a\u6578\u75be\u75c5\u97ff\u61c9\u6700\u7d42\u90fd\u6703\u9032\u5c55\uff1b\u7576\u524d\u4e3b\u8981\u6cbb\u7642\u624b\u6bb5\uff08\u5982\u6297\u8840\u7ba1\u751f\u6210\u85e5\u7269\uff09\u7684\u7642\u6548\u6709\u9650\u7b49\u3002 \u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002   \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002  IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002  \u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002  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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u662f\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u662f\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 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property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5728\u4eca\u5e74\u591a\u500b\u570b\u969b\u816b\u7624\u5b78\u5e74\u6703\u4e0a\uff0c\u4fe1\u9054\u751f\u7269\u4ee510\u9805\u53e3\u982d\u5831\u544a\u548c15\u9805\u58c1\u5831\u5f62\u5f0f\uff0c\u5c55\u793a\u4e86\u591a\u6b3e\u816b\u7624\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u6578\u64da\u30026\u670817\u65e5\uff0c\u4fe1\u9054\u751f\u7269\u53ec\u958b\u6295\u8cc7\u8005\u96fb\u8a71\u6703\uff0c\u8a73\u7d30\u89e3\u8b80\u7522\u54c1\u81e8\u5e8a\u6578\u64da\uff0c\u540c\u6642\u4ecb\u7d39\u4e86\u516c\u53f8\u76ee\u524d\u805a\u7126\u5168\u7403\u5275\u65b0\u7684\u7814\u767c\u7b56\u7565\uff0c\u4ee5\u53ca\u91cd\u9ede\u63a8\u9032\u7684\u591a\u6b3e\u4e2d\u65e9\u671f\u5206\u5b50\u5dee\u7570\u5316\u7684\u65e9\u7814\u6a5f\u5236\u3001\u958b\u767c\u7b56\u7565\u548c\u958b\u767c\u65b9\u5411\u3002\u4fe1\u9054\u751f\u7269\u9996\u5e2d\u8ca1\u52d9\u5b98\u7531\u98db\u5973\u58eb\u3001\u816b\u7624\u958b\u767c\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u3001\u816b\u7624\u751f\u7269\u5b78\u8207ADC\u85e5\u7269\u7814\u7a76\u526f\u7e3d\u88c1\u4f55\u958b\u5091\u535a\u58eb\u53c3\u52a0\u6703\u8b70\u4e26\u9032\u884c\u532f\u5831\u3002 \uff08\u8a73\u7d30\u5206\u4eab\u6750\u6599\u53ef\u5728\u516c\u53f8\u5b98\u7db2\u9032\u884c\u4e0b\u8f09\uff0c\u93c8\u63a5\uff1ahttps:\/\/investor.innoventbio.com\/cn\/investors\/webcasts-and-presentations\/\uff09 \u816b\u7624\u958b\u767c\u7b56\u7565\uff1a\u6df1\u5ea6\u4f48\u5c40IO+ADC\uff0c\u89e3\u6c7a\u5168\u7403\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42 \u79d1\u5b78\u6280\u8853\u7684\u9032\u6b65\uff0c\u8b93\u816b\u7624\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u751f\u547d\u8cea\u91cf\u4e0d\u65b7\u63d0\u5347\u3002\u4f46\u816b\u7624\u6cbb\u7642\u9084\u5b58\u5728\u5f88\u591a\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5982\u4ee5PD-1\u70ba\u4ee3\u8868\u7684\u514d\u75ab\u7642\u6cd5\u97ff\u61c9\u7387\u6709\u9650\uff0c\u4e14\u7d55\u5927\u591a\u6578\u75be\u75c5\u97ff\u61c9\u6700\u7d42\u90fd\u6703\u9032\u5c55\uff1b\u7576\u524d\u4e3b\u8981\u6cbb\u7642\u624b\u6bb5\uff08\u5982\u6297\u8840\u7ba1\u751f\u6210\u85e5\u7269\uff09\u7684\u7642\u6548\u6709\u9650\u7b49\u3002 \u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002   \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002  IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002  \u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002  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\uff08\u8a73\u7d30\u5206\u4eab\u6750\u6599\u53ef\u5728\u516c\u53f8\u5b98\u7db2\u9032\u884c\u4e0b\u8f09\uff0c\u93c8\u63a5\uff1ahttps:\\\/\\\/investor.innoventbio.com\\\/cn\\\/investors\\\/webcasts-and-presentations\\\/\uff09 \u816b\u7624\u958b\u767c\u7b56\u7565\uff1a\u6df1\u5ea6\u4f48\u5c40IO+ADC\uff0c\u89e3\u6c7a\u5168\u7403\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42 \u79d1\u5b78\u6280\u8853\u7684\u9032\u6b65\uff0c\u8b93\u816b\u7624\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u751f\u547d\u8cea\u91cf\u4e0d\u65b7\u63d0\u5347\u3002\u4f46\u816b\u7624\u6cbb\u7642\u9084\u5b58\u5728\u5f88\u591a\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5982\u4ee5PD-1\u70ba\u4ee3\u8868\u7684\u514d\u75ab\u7642\u6cd5\u97ff\u61c9\u7387\u6709\u9650\uff0c\u4e14\u7d55\u5927\u591a\u6578\u75be\u75c5\u97ff\u61c9\u6700\u7d42\u90fd\u6703\u9032\u5c55\uff1b\u7576\u524d\u4e3b\u8981\u6cbb\u7642\u624b\u6bb5\uff08\u5982\u6297\u8840\u7ba1\u751f\u6210\u85e5\u7269\uff09\u7684\u7642\u6548\u6709\u9650\u7b49\u3002 \u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\\\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002 \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002 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\u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002   \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002  IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002  \u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002  \u57fa\u65bc\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u9032\u4e00\u6b65\u62d3\u5c55IBI363\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5305\u62ec\u9032\u4e00\u6b65\u8ddf\u9032\u9ad8\u5291\u91cf3mg\/kg\u7684\u81e8\u5e8a\u7d50\u679c\u4ee5\u6c7a\u5b9a\u5f8c\u7e8c\u958b\u767c\u5291\u91cf\u3001\u958b\u5c55\u7f8e\u570b2\u671f\u81e8\u5e8a\u3001\u4ee5\u53ca\u63a2\u7d22\u66f4\u591a\u7684\u806f\u5408\u7528\u85e5\u6a5f\u6703\u3002  \u5169\u6b3e\u57fa\u65bcCLDN18.2\u9776\u9ede\u7684\u5275\u65b0\u6280\u8853\u5f62\u614bIBI343\u548cIBI389\u5c55\u73fe\u51fa\u7a81\u7834\u7642\u6548 IBI343\uff1a\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff0c\u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7a81\u7834\u7642\u6548\u7684ADC \u85e5\u7269   \u5168\u7403\u9818\u5148\u7684\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff1aIBI343\u63a1\u7528\u512a\u7570\u7684\u5206\u5b50\u8a2d\u8a08\uff0c\u57fa\u65bc\u4e16\u754c\u9818\u5148\u7684\u7cd6\u57fa\u5316\u5b9a\u9ede\u5076\u806f\u6280\u8853\uff0c\u9ad4\u5167\u7a69\u5b9a\u6027\u9ad8\uff1b\u4f7f\u7528\u5f37\u529b\u7684\u6709\u6548\u8f09\u8377\uff08\u4f0a\u559c\u66ff\u5eb7\uff09\u4e26\u5177\u6709\u5f37\u5927\u7684\u65c1\u89c0\u8005\u6bba\u50b7\u4f5c\u7528\uff1bFc\u6c89\u9ed8\u6548\u61c9\u78ba\u4fdd\u7121ADCC\u4ecb\u5c0e\u7684\u80c3\u8178\u9053\u6bd2\u6027\u4ee5\u4fdd\u8b49\u9ad8\u9ad4\u5167\u5b89\u5168\u6027\uff1b\u4ee5\u53ca\u5168\u4eba\u6e90\u548c\u9ad8\u5167\u541e\u6027\u7684CLDN18.2\u6297\u9ad4\u5e36\u4f86\u7684\u5f37\u5927\u9776\u5411\u6548\u679c\u3002  \u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7642\u6548\u7a81\u7834\u7684ADC\u85e5\u7269\uff1aIBI343\u7528\u65bc\u81f3\u5c11\u63a5\u53d7\u904e1\u7dda\u6cbb\u7642\u7684\u80f0\u817a\u764c\u60a3\u8005\u7684I\u671f\u521d\u6b65\u6578\u64da\u986f\u793a\uff0c\u5728\u63a5\u53d76 mg\/kg IBI343\u6cbb\u7642\u7684CLDN18.2 IHC1\/2\/3+\u226560%\u80f0\u817a\u764c\u53d7\u8a66\u8005\uff08n=10\uff09\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba 40%\u3002  \u9664PDAC\u5916\uff0cIBI343\u5728\u5f8c\u7dda\u80c3\u764c\u6cbb\u7642\u5c55\u73fe\u51fa\u660e\u78ba\u7684\u6cbb\u7642\u6548\u679c\uff0c\u5176MRCT\u81e8\u5e8a3\u671f\u6b63\u5728\u7c4c\u5099\u4e2d\u3002  IBI389\uff1a\u5168\u7403\u9996\u5275\u6297CLDN18.2\/CD3\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u9996\u500b\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\u7684T\u7d30\u80de\u9023\u63a5\u5668   IBI389\u662f\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u5206\u5b50\uff0c\u901a\u904e\u540c\u6642\u7d50\u5408\u816b\u7624\u7d30\u80de\u4e0a\u8868\u9054\u7684CLDN18.2\u548cT\u7d30\u80de\u4e0a\u7684CD3\uff0c\u5c07T\u7d30\u80de\u91cd\u5b9a\u5411\u5230\u816b\u7624\u7d30\u80de\uff0c\u8a98\u5c0eT\u7d30\u80de\u5c0d\u816b\u7624\u7d30\u80de\u7684\u6bba\u50b7\u3002\u81e8\u5e8a\u524d\u7d50\u679c\u8868\u660e\uff0c\u5373\u4f7f\u5728CLDN18.2\u4f4e\u8868\u9054\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cIBI389\u4ecd\u80fd\u8207\u816b\u7624\u7d30\u80de\u7d50\u5408\uff0c\u8868\u73fe\u51fa\u660e\u986f\u7684\u6297\u816b\u7624\u6548\u529b\u3002  IBI389\u5728\u5305\u62ecCLDN18.2\u4e2d\u4f4e\u8868\u9054\u4eba\u7fa4\u5728\u5167\u7684\u665a\u671f\u80c3\u764c\u548c\u80f0\u817a\u764c\u5747\u5c55\u73fe\u51fa\u6709\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\u3002\u7279\u5225\u662f\uff0c\u4f5c\u70ba\u5168\u7403\u9996\u500b\u516c\u4f48\u81e8\u5e8a\u6578\u64da\u7684\u9776\u5411CLDN18.2\/CD3\u96d9\u6297\uff0cIBI389\u5728\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\uff0c\u5be6\u73fe\u4e86\u8a72\u5275\u65b0\u85e5\u7269\u5f62\u5f0f\u5728\u96e3\u6cbb\u764c\u7a2e\u9818\u57df\u7684\u7a81\u7834\u3002  ASCO\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0c\u572827\u4f8b\u63a5\u53d7\u4e86600\u03bcg\/kg IBI389\u6cbb\u7642\u4e26\u81f3\u5c11\u9032\u884c\u4e86\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\u7684\u80f0\u817a\u764c\u53d7\u8a66\u8005\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba29.6%\uff0c\u78ba\u8a8d\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08cORR\uff09\u70ba25.9%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u905470.4%\u3002\u5728CLDN18.2 IHC 2\/3+\u226540%\u768418\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0c cORR\u905438.9%\uff0895%CI\uff1a17.3-64.3\uff09\u3002  \u57fa\u65bcIBI343\u8207IBI389\u5728\u65e9\u671f\u81e8\u5e8a\u53ca\u81e8\u5e8a\u958b\u767c\u4e2d\u5c55\u73fe\u51fa\u4f86\u7684\u7368\u7279\u512a\u52e2\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u63a8\u9032\u958b\u767cIBI343\u7528\u65bc\u80c3\u764c\u6cbb\u7642\u7684MRCT 3\u671f\u81e8\u5e8a\uff0c\u4e26\u63a8\u9032\u63a2\u7d22IBI343\u548cIBI389\u65bc\u96e3\u6cbb\u816b\u7624\u80f0\u817a\u764c\u7684\u9a57\u8b49\u6027\u81e8\u5e8a\u3002  \u5c55\u671b\u672a\u4f86\uff0c\u4fe1\u9054\u751f\u7269\u5c07\u7e7c\u7e8c\u9ad8\u8cea\u91cf\u63a8\u9032\u816b\u7624\u7522\u54c1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5728 \u300c IO + ADC\u300d \u6230\u7565\u6307\u5f15\u4e0b\uff0c\u63a2\u7d22\u764c\u75c7\u6cbb\u7642\u9818\u57df\u672a\u88ab\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\uff0c\u4e26\u63a8\u52d5\u5168\u7403\u5275\u65b0\u3002\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u816b\u7624\u958b\u767c\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u8868\u793a\uff1a\u300c 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\u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002   \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002  IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002  \u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002  \u57fa\u65bc\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u9032\u4e00\u6b65\u62d3\u5c55IBI363\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5305\u62ec\u9032\u4e00\u6b65\u8ddf\u9032\u9ad8\u5291\u91cf3mg\/kg\u7684\u81e8\u5e8a\u7d50\u679c\u4ee5\u6c7a\u5b9a\u5f8c\u7e8c\u958b\u767c\u5291\u91cf\u3001\u958b\u5c55\u7f8e\u570b2\u671f\u81e8\u5e8a\u3001\u4ee5\u53ca\u63a2\u7d22\u66f4\u591a\u7684\u806f\u5408\u7528\u85e5\u6a5f\u6703\u3002  \u5169\u6b3e\u57fa\u65bcCLDN18.2\u9776\u9ede\u7684\u5275\u65b0\u6280\u8853\u5f62\u614bIBI343\u548cIBI389\u5c55\u73fe\u51fa\u7a81\u7834\u7642\u6548 IBI343\uff1a\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff0c\u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7a81\u7834\u7642\u6548\u7684ADC \u85e5\u7269   \u5168\u7403\u9818\u5148\u7684\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff1aIBI343\u63a1\u7528\u512a\u7570\u7684\u5206\u5b50\u8a2d\u8a08\uff0c\u57fa\u65bc\u4e16\u754c\u9818\u5148\u7684\u7cd6\u57fa\u5316\u5b9a\u9ede\u5076\u806f\u6280\u8853\uff0c\u9ad4\u5167\u7a69\u5b9a\u6027\u9ad8\uff1b\u4f7f\u7528\u5f37\u529b\u7684\u6709\u6548\u8f09\u8377\uff08\u4f0a\u559c\u66ff\u5eb7\uff09\u4e26\u5177\u6709\u5f37\u5927\u7684\u65c1\u89c0\u8005\u6bba\u50b7\u4f5c\u7528\uff1bFc\u6c89\u9ed8\u6548\u61c9\u78ba\u4fdd\u7121ADCC\u4ecb\u5c0e\u7684\u80c3\u8178\u9053\u6bd2\u6027\u4ee5\u4fdd\u8b49\u9ad8\u9ad4\u5167\u5b89\u5168\u6027\uff1b\u4ee5\u53ca\u5168\u4eba\u6e90\u548c\u9ad8\u5167\u541e\u6027\u7684CLDN18.2\u6297\u9ad4\u5e36\u4f86\u7684\u5f37\u5927\u9776\u5411\u6548\u679c\u3002  \u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7642\u6548\u7a81\u7834\u7684ADC\u85e5\u7269\uff1aIBI343\u7528\u65bc\u81f3\u5c11\u63a5\u53d7\u904e1\u7dda\u6cbb\u7642\u7684\u80f0\u817a\u764c\u60a3\u8005\u7684I\u671f\u521d\u6b65\u6578\u64da\u986f\u793a\uff0c\u5728\u63a5\u53d76 mg\/kg IBI343\u6cbb\u7642\u7684CLDN18.2 IHC1\/2\/3+\u226560%\u80f0\u817a\u764c\u53d7\u8a66\u8005\uff08n=10\uff09\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba 40%\u3002  \u9664PDAC\u5916\uff0cIBI343\u5728\u5f8c\u7dda\u80c3\u764c\u6cbb\u7642\u5c55\u73fe\u51fa\u660e\u78ba\u7684\u6cbb\u7642\u6548\u679c\uff0c\u5176MRCT\u81e8\u5e8a3\u671f\u6b63\u5728\u7c4c\u5099\u4e2d\u3002  IBI389\uff1a\u5168\u7403\u9996\u5275\u6297CLDN18.2\/CD3\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u9996\u500b\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\u7684T\u7d30\u80de\u9023\u63a5\u5668   IBI389\u662f\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u5206\u5b50\uff0c\u901a\u904e\u540c\u6642\u7d50\u5408\u816b\u7624\u7d30\u80de\u4e0a\u8868\u9054\u7684CLDN18.2\u548cT\u7d30\u80de\u4e0a\u7684CD3\uff0c\u5c07T\u7d30\u80de\u91cd\u5b9a\u5411\u5230\u816b\u7624\u7d30\u80de\uff0c\u8a98\u5c0eT\u7d30\u80de\u5c0d\u816b\u7624\u7d30\u80de\u7684\u6bba\u50b7\u3002\u81e8\u5e8a\u524d\u7d50\u679c\u8868\u660e\uff0c\u5373\u4f7f\u5728CLDN18.2\u4f4e\u8868\u9054\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cIBI389\u4ecd\u80fd\u8207\u816b\u7624\u7d30\u80de\u7d50\u5408\uff0c\u8868\u73fe\u51fa\u660e\u986f\u7684\u6297\u816b\u7624\u6548\u529b\u3002  IBI389\u5728\u5305\u62ecCLDN18.2\u4e2d\u4f4e\u8868\u9054\u4eba\u7fa4\u5728\u5167\u7684\u665a\u671f\u80c3\u764c\u548c\u80f0\u817a\u764c\u5747\u5c55\u73fe\u51fa\u6709\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\u3002\u7279\u5225\u662f\uff0c\u4f5c\u70ba\u5168\u7403\u9996\u500b\u516c\u4f48\u81e8\u5e8a\u6578\u64da\u7684\u9776\u5411CLDN18.2\/CD3\u96d9\u6297\uff0cIBI389\u5728\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\uff0c\u5be6\u73fe\u4e86\u8a72\u5275\u65b0\u85e5\u7269\u5f62\u5f0f\u5728\u96e3\u6cbb\u764c\u7a2e\u9818\u57df\u7684\u7a81\u7834\u3002  ASCO\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0c\u572827\u4f8b\u63a5\u53d7\u4e86600\u03bcg\/kg IBI389\u6cbb\u7642\u4e26\u81f3\u5c11\u9032\u884c\u4e86\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\u7684\u80f0\u817a\u764c\u53d7\u8a66\u8005\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba29.6%\uff0c\u78ba\u8a8d\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08cORR\uff09\u70ba25.9%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u905470.4%\u3002\u5728CLDN18.2 IHC 2\/3+\u226540%\u768418\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0c cORR\u905438.9%\uff0895%CI\uff1a17.3-64.3\uff09\u3002  \u57fa\u65bcIBI343\u8207IBI389\u5728\u65e9\u671f\u81e8\u5e8a\u53ca\u81e8\u5e8a\u958b\u767c\u4e2d\u5c55\u73fe\u51fa\u4f86\u7684\u7368\u7279\u512a\u52e2\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u63a8\u9032\u958b\u767cIBI343\u7528\u65bc\u80c3\u764c\u6cbb\u7642\u7684MRCT 3\u671f\u81e8\u5e8a\uff0c\u4e26\u63a8\u9032\u63a2\u7d22IBI343\u548cIBI389\u65bc\u96e3\u6cbb\u816b\u7624\u80f0\u817a\u764c\u7684\u9a57\u8b49\u6027\u81e8\u5e8a\u3002  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\u4fe1\u9054\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86\u4e00\u689d\u5305\u542b36\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u816b\u7624\u7522\u54c1\u7ba1\u7dda\u670922\u6b3e\u5019\u9078\u85e5\u7269\u3002\u901a\u904e\u767c\u63ee\u5168\u7403\u9818\u5148\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3001\u958b\u767c\u5dee\u7570\u5316\u7684\u9023\u63a5\u9ad4-\u6709\u6548\u8f09\u8377\uff08linker-payload\uff09\u548c\u5c0d\u816b\u7624\u79d1\u5b78\u7684\u6df1\u5ea6\u7406\u89e3\uff0c\u4fe1\u9054\u751f\u7269\u6df1\u5ea6\u4f48\u5c40 \u300c \u816b\u7624\u514d\u75ab (IO) + \u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u300d \uff0c\u4ee5\u5be6\u73fe\u5168\u7403\u5275\u65b0\u7684\u6230\u7565\u76ee\u6a19\u548c\u816b\u7624\u7ba1\u7dda\u300c \u70ba\u751f\u547d\uff0c\u5275\u7121\u6b62\u5883\u300d \u7684\u54c1\u724c\u5b9a\u4f4d\u3002 \u91cd\u78c5\u7522\u54c1\u9032\u5c55\uff1aPoC+MRCT\uff0c\u7a69\u6b65\u63a8\u9032\u5275\u65b0\u7522\u54c1\u5168\u7403\u5316\u9032\u7a0b \u516c\u53f8\u816b\u7624\u7522\u54c1\u7dda\u901a\u904e\u81e8\u5e8a\u9a57\u8b49\uff08Proof of Concept, PoC\uff09\u548c\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff08MRCT\uff09\u4f86\u63a8\u9032\u5275\u65b0\u85e5\u7269\u958b\u767c\uff0c\u76ee\u524d\u5df2\u6709\u591a\u500b\u9ad8\u6f5b\u529b\u5206\u5b50\u9032\u5165\u5230\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u5305\u62ec\u672c\u6b21\u9032\u884c\u8a73\u7d30\u89e3\u8b80\u7684\u4e09\u6b3e\u5168\u7403\u65b0\u5206\u5b50IBI363\uff0cIBI343\u548cIBI389\uff0c\u4e26\u64c1\u6709\u66f4\u591a\u96d9\u7279\u7570\u6027\u6297\u9ad4\u548cADC\u5275\u65b0\u5206\u5b50\u8655\u65bc\u65e9\u671f\u5168\u7403\u81e8\u5e8a\u958b\u767c\u904e\u7a0b\u7576\u4e2d\u3002 IBI363: \u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u5c0d\u514d\u75ab\u7d93\u6cbb\u53ca\u51b7\u816b\u7624\u7684\u8de8\u816b\u7624\u7642\u6548\uff0c\u65b0\u4e00\u4ee3IO\u7642\u6cd5\u6f5b\u529b\u521d\u73fe IBI363\u4f5c\u70ba\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u85e5\u7269\uff0c\u4ee3\u8868\u4e86\u516c\u53f8\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\uff0c\u672c\u6b21\u516c\u53f8\u9996\u6b21\u5831\u544a\u4e86\u5176\u5168\u7403\u65b0\u7684\u4f5c\u7528\u6a5f\u7406\u548c\u81e8\u5e8a\u958b\u767c\u9032\u5c55\u3002 \u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002 IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u9019\u4f7f\u5f97IBI363\u7684\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834IL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e\u3002 \u5728\u5171\u5165\u7d44\u8d85\u904e300\u53d7\u8a66\u8005\u7684\u81e8\u5e8a1\u671f\u4e2d\uff0cIBI363\u5728\u5404\u9805\u4ee3\u8868\u6027\u7684\u7624\u7a2e\u4e2d\u5747\u770b\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u3001\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u548c\u51b7\u816b\u7624\u8178\u764c, \u986f\u793a\u4e86IBI363\u7684\u5ee3\u8b5c\u6297\u7624\u4f5c\u7528\u3002 \u57fa\u65bc\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u9032\u4e00\u6b65\u62d3\u5c55IBI363\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5305\u62ec\u9032\u4e00\u6b65\u8ddf\u9032\u9ad8\u5291\u91cf3mg\/kg\u7684\u81e8\u5e8a\u7d50\u679c\u4ee5\u6c7a\u5b9a\u5f8c\u7e8c\u958b\u767c\u5291\u91cf\u3001\u958b\u5c55\u7f8e\u570b2\u671f\u81e8\u5e8a\u3001\u4ee5\u53ca\u63a2\u7d22\u66f4\u591a\u7684\u806f\u5408\u7528\u85e5\u6a5f\u6703\u3002 \u5169\u6b3e\u57fa\u65bcCLDN18.2\u9776\u9ede\u7684\u5275\u65b0\u6280\u8853\u5f62\u614bIBI343\u548cIBI389\u5c55\u73fe\u51fa\u7a81\u7834\u7642\u6548 IBI343\uff1a\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff0c\u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7a81\u7834\u7642\u6548\u7684ADC \u85e5\u7269 \u5168\u7403\u9818\u5148\u7684\u5275\u65b0\u578bTOPO1i CLDN18.2 ADC\uff1aIBI343\u63a1\u7528\u512a\u7570\u7684\u5206\u5b50\u8a2d\u8a08\uff0c\u57fa\u65bc\u4e16\u754c\u9818\u5148\u7684\u7cd6\u57fa\u5316\u5b9a\u9ede\u5076\u806f\u6280\u8853\uff0c\u9ad4\u5167\u7a69\u5b9a\u6027\u9ad8\uff1b\u4f7f\u7528\u5f37\u529b\u7684\u6709\u6548\u8f09\u8377\uff08\u4f0a\u559c\u66ff\u5eb7\uff09\u4e26\u5177\u6709\u5f37\u5927\u7684\u65c1\u89c0\u8005\u6bba\u50b7\u4f5c\u7528\uff1bFc\u6c89\u9ed8\u6548\u61c9\u78ba\u4fdd\u7121ADCC\u4ecb\u5c0e\u7684\u80c3\u8178\u9053\u6bd2\u6027\u4ee5\u4fdd\u8b49\u9ad8\u9ad4\u5167\u5b89\u5168\u6027\uff1b\u4ee5\u53ca\u5168\u4eba\u6e90\u548c\u9ad8\u5167\u541e\u6027\u7684CLDN18.2\u6297\u9ad4\u5e36\u4f86\u7684\u5f37\u5927\u9776\u5411\u6548\u679c\u3002 \u5168\u7403\u9996\u500b\u5728\u80f0\u817a\u764c\u4e0a\u5c55\u73fe\u7642\u6548\u7a81\u7834\u7684ADC\u85e5\u7269\uff1aIBI343\u7528\u65bc\u81f3\u5c11\u63a5\u53d7\u904e1\u7dda\u6cbb\u7642\u7684\u80f0\u817a\u764c\u60a3\u8005\u7684I\u671f\u521d\u6b65\u6578\u64da\u986f\u793a\uff0c\u5728\u63a5\u53d76 mg\/kg IBI343\u6cbb\u7642\u7684CLDN18.2 IHC1\/2\/3+\u226560%\u80f0\u817a\u764c\u53d7\u8a66\u8005\uff08n=10\uff09\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba 40%\u3002 \u9664PDAC\u5916\uff0cIBI343\u5728\u5f8c\u7dda\u80c3\u764c\u6cbb\u7642\u5c55\u73fe\u51fa\u660e\u78ba\u7684\u6cbb\u7642\u6548\u679c\uff0c\u5176MRCT\u81e8\u5e8a3\u671f\u6b63\u5728\u7c4c\u5099\u4e2d\u3002 IBI389\uff1a\u5168\u7403\u9996\u5275\u6297CLDN18.2\/CD3\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u9996\u500b\u80f0\u817a\u764c\u4e2d\u89c0\u5bdf\u5230\u660e\u986f\u7372\u76ca\u4fe1\u865f\u7684T\u7d30\u80de\u9023\u63a5\u5668 IBI389\u662f\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275\u5206\u5b50\uff0c\u901a\u904e\u540c\u6642\u7d50\u5408\u816b\u7624\u7d30\u80de\u4e0a\u8868\u9054\u7684CLDN18.2\u548cT\u7d30\u80de\u4e0a\u7684CD3\uff0c\u5c07T\u7d30\u80de\u91cd\u5b9a\u5411\u5230\u816b\u7624\u7d30\u80de\uff0c\u8a98\u5c0eT\u7d30\u80de\u5c0d\u816b\u7624\u7d30\u80de\u7684\u6bba\u50b7\u3002\u81e8\u5e8a\u524d\u7d50\u679c\u8868\u660e\uff0c\u5373\u4f7f\u5728CLDN18.2\u4f4e\u8868\u9054\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cIBI389\u4ecd\u80fd\u8207\u816b\u7624\u7d30\u80de\u7d50\u5408\uff0c\u8868\u73fe\u51fa\u660e\u986f\u7684\u6297\u816b\u7624\u6548\u529b\u3002 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