{"id":242568,"date":"2024-06-14T08:59:00","date_gmt":"2024-06-14T00:59:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=242568"},"modified":"2024-06-14T08:59:00","modified_gmt":"2024-06-14T00:59:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e6%ad%90%e6%b4%b2%e8%85%ab%e7%98%a4%e5%85%a7%e7%a7%91%e5%ad%b8%e6%9c%83%ef%bc%88esmo%ef%bc%89%e5%85%ad%e6%9c%88%e5%85%a8%e9%ab%94%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=242568","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u516d\u6708\u5168\u9ad4\u5927\u6703\u53e3\u982d\u5831\u544a\u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767dIBI363\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7b49\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u6578\u64da"},"content":{"rendered":"<div>\n<p id=\"temp_ReleaseStart\"><span class=\"legendSpanClass\">\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e746\u670814\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u57282024\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u516d\u6708\u5168\u9ad4\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u5168\u7403\u9996\u5275\uff08First-in-class\uff09PD-1\/IL-2<sup>\u03b1-bias<\/sup>\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767dIBI363\u6cbb\u7642\u591a\u7a2e\u665a\u671f\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u6578\u64da\uff08\u7814\u7a76\u767b\u8a18\u865f\uff1aNCT05460767\uff09\u3002<a href=\"https:\/\/www.esmo.org\/meeting-calendar\/esmo-virtual-plenary-june-2024\" rel=\"nofollow noopener\" target=\"_blank\">[\u93c8\u63a5]<\/a><\/p>\n<p class=\"prntaj\"><strong>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u300cIBI363\u4f5c\u70baFIC\u5206\u5b50\uff0c\u4ee3\u8868\u4e86\u4fe1\u9054\u751f\u7269\u5728IO\u9818\u57df\u6301\u7e8c\u4e0d\u65b7\u7684\u7814\u767c\u548c\u5275\u65b0\u3002\u5206\u5b50\u8a2d\u8a08\u65b9\u9762\uff0c\u5275\u9020\u6027\u63a1\u7528\u03b1\u504f\u5411\u53ca\u6e1b\u5f31\u03b2\u3001\u03b3\u7684\u7368\u7279\u601d\u8def\uff0c\u6975\u5927\u63d0\u5347\u4e86IL-2\u7684\u6cbb\u7642\u7a97\u53e3\uff1b\u901a\u904ePD-1\u7684\u7279\u7570\u6027\u727d\u5f15\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u523a\u6fc0\u548c\u64f4\u589e\u816b\u7624\u5167\u540c\u6642\u8868\u9054PD-1\u548cCD25\u7684T\u7d30\u80de\uff0c\u5f9e\u800c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002IBI363\u5c55\u73fe\u51fa\u4e86\u6975\u4f73\u7684\u6210\u85e5\u6027\uff0c\u5177\u6709\u6297\u9ad4\u985e\u4f3c\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08IgG-like PK\uff09\u548c\u4f4e\u514d\u75ab\u539f\u6027\u3002\u5728ASCO\u6578\u64da\u5831\u9053\u57fa\u790e\u4e0a\uff0c\u672c\u6b21ESMO\u5168\u9ad4\u5927\u6703\u6211\u5011\u5c55\u793a\u4e86\u66f4\u591a\u6578\u64da\u3002\u5c24\u5176\u662f\u5728IO\u7d93\u6cbb\u7684\u9c57\u72c0NSCLC\u4e2d\uff0cIBI363\u5c55\u73fe\u4e86\u5f37\u5927\u7684\u6297\u816b\u7624\u4f5c\u7528\uff0c\u6709\u671b\u5e36\u4f86\u7a81\u7834\u6027\u7684\u7814\u7a76\u7d50\u679c\u3002\u6b64\u5916\uff0cIBI363\u5728\u672a\u7d93\u816b\u7624\u514d\u75ab\u6cbb\u7642\uff08IO na\u00efve\uff09\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u770b\u5230\u4e86\u4ee4\u4eba\u6b23\u559c\u7684\u7642\u6548\uff0c\u5728\u76f8\u5c0d\u51b7\u816b\u7624\u7684\u4eba\u7fa4\u4e2d\u770b\u5230\u9019\u6a23\u7684\u7d50\u679c\uff0c\u5c0d\u65bc\u6211\u5011\u4e0b\u4e00\u6b65\u62d3\u5c55IO na\u00efve\u4eba\u7fa4\u5e36\u4f86\u4fe1\u5fc3\uff0c\u4e5f\u9810\u793aIBI363\u7684\u5ee3\u6cdb\u958b\u767c\u6f5b\u529b\u3002\u300d<\/p>\n<p class=\"prntaj\"><strong>PD-1\/IL-2<sup>\u03b1-bia<\/sup><\/strong><strong><sup>s<\/sup><\/strong><strong>\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767d\uff08<\/strong><strong>IBI363<\/strong><strong>\uff09\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684\u7684<\/strong><strong>I<\/strong><strong>\u671f\u81e8\u5e8a\u6578\u64da<\/strong><\/p>\n<p class=\"prntaj\">\u672c\u9805\u7814\u7a76\u70baIa\/Ib\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30IBI363\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u53d7\u8a66\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u521d\u6b65\u6709\u6548\u6027\u3002<\/p>\n<p class=\"prntaj\"><strong>\u8d85\u904e<\/strong><strong>300<\/strong><strong>\u4f8b\u53d7\u8a66\u8005\u63a5\u53d7<\/strong><strong>IBI363<\/strong><strong>\u55ae\u85e5\u6cbb\u7642\uff0c\u7d66\u85e5\u5291\u91cf\u9054\u5230\u53f2\u7121\u524d\u4f8b\u7684\u6c34\u5e73\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u7a81\u7834<\/strong><strong>IL-2<\/strong><strong>\u7642\u6cd5\u7684\u5b89\u5168\u6027\u9867\u616e<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32024\u5e744\u670816\u65e5\uff0c\u5171347\u4f8b\u665a\u671f\u5be6\u9ad4\u7624\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u4e0d\u540c\u5291\u91cf\uff080.2 \u03bcg\/kg QW~3mg\/kg Q3W\uff09\u7684IBI363\u55ae\u85e5\u6cbb\u7642\u3002\u5176\u4e2d\u5305\u62ec100\u4f8b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u300189\u4f8b\u9ed1\u8272\u7d20\u7624\u3001102\u4f8b\u7d50\u76f4\u8178\u764c\u53ca56\u4f8b\u5176\u4ed6\u816b\u7624\u7684\u53d7\u8a66\u8005\u3002\u5176\u4e2d81.8%\u7684\u53d7\u8a66\u8005\u65e2\u5f80\u63a5\u53d7\u904e2\u7dda\u6216\u4ee5\u4e0a\u7684\u7cfb\u7d71\u6027\u6cbb\u7642\u3002\u5728\u9664\u7d50\u76f4\u8178\u764c\u4ee5\u5916\u7684245\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0c84.1%\u7684\u53d7\u8a66\u8005\u5165\u7d44\u524d\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u3002<\/li>\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6700\u5e38\u898b\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u662f\u95dc\u7bc0\u75db\u3001\u8ca7\u8840\u548c\u7532\u72c0\u817a\u529f\u80fd\u7570\u5e38\u3002\u4e09\u7d1a\u6216\u4ee5\u4e0aTRAE\u7684\u7e3d\u9ad4\u767c\u751f\u7387\u70ba23.9%\uff0c\u4e09\u7d1a\u6216\u4ee5\u4e0a\u514d\u75ab\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(irAE)\u7684\u7e3d\u9ad4\u767c\u751f\u7387\u70ba10.4%\u30023mg\/kg Q3W\u5291\u91cf\u7d44\u768438\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0c13.2%\u7684\u60a3\u8005\u767c\u751f\u4e86\u4e09\u7d1a\u6216\u4ee5\u4e0aTRAE\uff0c\u5b89\u5168\u8b5c\u8207\u7e3d\u9ad4\u4eba\u7fa4\u985e\u4f3c\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u98a8\u96aa\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><strong>\u5c55\u73fe\u51fa\u8de8\u7624\u7a2e\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u5291\u91cf\u722c\u5347\u64f4\u5c55\u81f3<\/strong><strong>3mg\/kg<\/strong><strong>\u7642\u6548\u6301\u7e8c\u63d0\u5347<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u6709\u6548\u6027\u65b9\u9762\uff0c\u5728\u22650.1mg\/kg\u5291\u91cf\u7bc4\u570d\u5167\uff0c\u5171300\u4f8b\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c\u5176\u4e2d\u67093\u4f8b\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u548c49\u4f8b\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\u3002\u622a\u6b62\u65e5\u671f\u524d\uff0c38\u4f8b\u53d7\u8a66\u8005\u4ecd\u672a\u767c\u751f\u75be\u75c5\u9032\u5c55\uff08PD\uff09\uff0cDoR\u5c1a\u672a\u6210\u719f\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684204\u4f8b\u53d7\u8a66\u8005\u4e2d\uff0cORR\u9054\u523017.6%\u3002<\/li>\n<li><strong>\u5728<\/strong><strong>3mg\/kg<\/strong><strong>\u5291\u91cf\u7d44\uff0c\u5171<\/strong><strong>15<\/strong><strong>\u4f8b\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c\u5176\u4e2d<\/strong><strong>ORR<\/strong><strong>\u9054\u5230<\/strong><strong>46.7%, DCR 80.0%<\/strong><strong>\u3002<\/strong><\/li>\n<\/ul>\n<p class=\"prntaj\"><strong>\u5728\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u89c0\u5bdf\u5230\u4ee4\u4eba\u6b23\u559c\u7684\u7642\u6548\u4fe1\u865f<\/strong><\/p>\n<ul type=\"disc\">\n<li>70\u4f8b\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u22650.3mg\/kg IBI363\u6cbb\u7642\u4e26\u81f3\u5c11\u63a5\u53d7\u4e86\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c\u5176\u4e2d77%\u65e2\u5f80\u63a5\u53d7\u904e2\u7dda\u6216\u4ee5\u4e0a\u7cfb\u7d71\u6027\u6cbb\u7642\uff0c\u50c51\u4f8b\u60a3\u8005\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u3002\u7e3d\u9ad4ORR\u70ba27.1%\uff0cDCR\u70ba72.9%\u3002<\/li>\n<li><strong>\u5728<\/strong><strong>37<\/strong><strong>\u4f8b\u63a5\u53d7\u2265<\/strong><strong>0.3mg\/kg IBI363<\/strong><strong>\u7684\u80ba\u9c57\u764c\u53d7\u8a66\u8005\u4e2d\uff08\u5176\u4e2d<\/strong><strong>36<\/strong><strong>\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e<\/strong><strong>PD-(L)1<\/strong><strong>\u6cbb\u7642<\/strong><strong>\uff0c1<\/strong><strong>\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e<\/strong><strong>TCE<\/strong><strong>\u6cbb\u7642\uff09\uff0c<\/strong><strong>13<\/strong><strong>\u4f8b\u60a3\u8005\u7372\u5f97<\/strong><strong>PR<\/strong><strong>\uff0c<\/strong><strong>ORR<\/strong><strong>\u9054\u5230<\/strong><strong>35.1%<\/strong><strong>\uff0c<\/strong><strong>DCR<\/strong><strong>\u70ba<\/strong><strong>75.7%<\/strong><strong>\u3002\u622a\u6b62\u65e5\u671f\u6642\uff0c\u80ba\u9c57\u764c\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba<\/strong><strong>5.7<\/strong><strong>\u500b\u6708\uff0c\u4e2d\u4f4d<\/strong><strong>PFS<\/strong><strong>\u70ba<\/strong><strong>5.5<\/strong><strong>\u500b\u6708\uff08<\/strong><strong>95% CI, 3.2-6.9<\/strong><strong>\uff09\uff0c<\/strong><strong>13<\/strong><strong>\u4f8b<\/strong><strong>PR<\/strong><strong>\u60a3\u8005\u4e2d\u6709<\/strong><strong>11<\/strong><strong>\u4f8b\u4ecd\u8655\u65bc\u7de9\u89e3\u72c0\u614b\u3002<\/strong><\/li>\n<li><strong>\u5171<\/strong><strong>9<\/strong><strong>\u4f8b\u80ba\u764c\u60a3\u8005\uff08\u5176\u4e2d<\/strong><strong>8<\/strong><strong>\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e<\/strong><strong>PD-(L)1<\/strong><strong>\u6cbb\u7642<\/strong><strong>,1<\/strong><strong>\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e<\/strong><strong>TCE<\/strong><strong>\u6cbb\u7642\uff09\u63a5\u53d7\u4e86<\/strong><strong>3mg\/kg IBI363<\/strong><strong>\u7d66\u85e5\u4e14\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c<\/strong>\u542b6\u4f8b\u80ba\u9c57\u764c\u548c3\u4f8b\u9a45\u52d5\u57fa\u56e0\u91ce\u751f\u578b\u80ba\u817a\u764c\uff0c<strong>\u5176\u4e2d<\/strong><strong>6<\/strong><strong>\u4f8b\u80ba\u9c57\u764c\u53ca<\/strong><strong>1<\/strong><strong>\u4f8b\u80ba\u817a\u764c\u7372\u5f97<\/strong><strong>PR<\/strong><strong>\uff0c<\/strong><strong>ORR<\/strong><strong>\u5206\u5225\u70ba<\/strong><strong>100%<\/strong><strong>\u548c<\/strong><strong>33.3%<\/strong><strong>\uff0c<\/strong><strong>DCR<\/strong><strong>\u5747\u70ba<\/strong><strong>100%<\/strong><strong>\u3002<\/strong><\/li>\n<\/ul>\n<p class=\"prntaj\"><strong>\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u7624\u4ee5\u53ca\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u53d7\u8a66\u8005\u4e2d\u5747\u89c0\u5bdf\u5230\u4ee4\u4eba\u6b23\u559c\u7684\u7642\u6548\u4fe1\u865f<\/strong><\/p>\n<ul type=\"disc\">\n<li><strong>37<\/strong><strong>\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/strong>\u63a5\u53d7\u4e861mg\/kg IBI363\u6cbb\u7642\u4e26\u81f3\u5c11\u63a5\u53d7\u4e86\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c11\u4f8b\u60a3\u8005\u7372\u5f97\u4e86\u5ba2\u89c0\u7de9\u89e3\uff0c\u5305\u62ec1\u4f8bCR\u548c10\u4f8bPR\uff0c<strong>ORR<\/strong><strong>\u548c<\/strong><strong>DCR<\/strong><strong>\u5206\u5225\u70ba<\/strong><strong>29.7%<\/strong><strong>\u548c<\/strong><strong>73.0%<\/strong><strong>\u3002<\/strong><\/li>\n<li><strong>8<\/strong><strong>\u4f8b\u65e2\u5f80\u672a\u7d93\u904e\u514d\u75ab\u6cbb\u7642\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u53d7\u8a66\u8005\u4e2d\uff0c<\/strong>6\u4f8b\u53d7\u8a66\u8005\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u5176\u4e2d1\u4f8b\u53d7\u8a66\u8005\u6700\u4f73\u7642\u6548\u70baCR\uff0c5\u4f8b\u53d7\u8a66\u8005\u6700\u4f73\u7642\u6548\u70baPR\uff0c<strong>\u7e3d\u9ad4<\/strong><strong>ORR<\/strong><strong>\u9054\u5230<\/strong><strong>75.0%<\/strong><strong>\uff0c<\/strong><strong>DCR<\/strong><strong>\u70ba<\/strong><strong>100%<\/strong><strong>\u3002<\/strong><\/li>\n<\/ul>\n<p class=\"prntaj\">\u6b64\u5916\uff0c\u672c\u9805I\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7d50\u76f4\u8178\u764c\u968a\u5217\u7684\u6578\u64da\u6b64\u524d\u5728ASCO\u767c\u8868\u3002\u9452\u65bcIBI363\u55ae\u85e5\u5c55\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u4fe1\u865f\u53ca\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672c\u7814\u7a76\u6b63\u5728\u7e7c\u7e8c\u63a8\u9032\u4e2d\uff0c\u4ee5\u9032\u4e00\u6b65\u63a2\u7d22IBI363\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u7d50\u76f4\u8178\u764c\u7b49\u816b\u7624\u4e2d\u7684\u524d\u666f\uff0c\u76f8\u95dc\u6578\u64da\u548c\u5206\u6790\u5c07\u5728\u672a\u4f86\u5b78\u8853\u6703\u8b70\u6216\u671f\u520a\u4e0a\u7e7c\u7e8c\u66f4\u65b0\u3002<\/p>\n<p class=\"prntaj\"><strong>\u6d59\u6c5f\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u767d\u96ea\u8389\u6559\u6388<\/strong>\u8868\u793a<strong>\uff1a<\/strong>\u300c\u80ba\u764c\u662f\u5168\u7403\u7b2c\u4e00\u5927\u81f4\u6b7b\u6027\u816b\u7624\uff0c\u5176\u4e2d\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u5927\u7d04\u5360\u6bd480%<sup>[1]<\/sup>\u3002\u8fd1\u5e74\u4f86\uff0cPD-1\/PD-L1\u6291\u5236\u5291\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u5c55\u73fe\u51fa\u4e86\u4ee4\u4eba\u6b23\u559c\u7684\u7642\u6548\u3002\u7136\u800c\uff0c\u591a\u6578\u60a3\u8005\u5728\u6cbb\u7642\u5f8c\u5c0d\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u8868\u73fe\u51fa\u539f\u767c\u6027\u6216\u7e7c\u767c\u6027\u8010\u85e5\u3002\u514d\u75ab\u8010\u85e5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u624b\u6bb5\uff0c\u5316\u7642\uff08\u5982\u591a\u897f\u4ed6\u8cfd\uff09\u7684ORR\u50c5\u7d0410%\uff0c\u4e2d\u4f4dPFS\u4e0d\u52304\u500b\u6708<sup>[2]<\/sup>\u3002IL-2\u4f5c\u70ba\u6fc0\u6d3b\u816b\u7624\u7279\u7570\u6027CD8+T\u7d30\u80de\u7684\u91cd\u8981\u7d30\u80de\u56e0\u5b50\uff0c\u5728\u6a5f\u5236\u4e0a\u8207\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e92\u88dc\uff0c\u53ef\u4ee5\u626d\u8f49T\u7d30\u80de\u8017\u7aed\uff0c\u5f9e\u800c\u514b\u670d\u514d\u75ab\u8010\u85e5\u3002IBI363\u4f5c\u70baPD-1\/IL-2<sup>\u03b1<\/sup><sup>-bias<\/sup>\u96d9\u7279\u7570\u6027\u5206\u5b50\uff0c\u5728\u514d\u75ab\u8010\u85e5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u8868\u73fe\u51fa\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5728ORR\u548cPFS\u4e0a\u90fd\u986f\u793a\u51fa\u81e8\u5e8a\u7372\u76ca\uff1b\u540c\u6642\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u9ad8\u5291\u91cf\u6c34\u5e73\u521d\u6b65\u986f\u793a\u51fa\u66f4\u9ad8\u7684\u97ff\u61c9\u7387\u4e14\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u98a8\u96aa\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u63a2\u7d22\u3002\u300d<\/p>\n<p class=\"prntaj\"><strong>\u798f\u5efa\u7701\u816b\u7624\u91ab\u9662\u9673\u8b7d\u6559\u6388<\/strong>\u8868\u793a<strong>\uff1a<\/strong>\u300c\u9ed1\u8272\u7d20\u7624\u5728\u4e2d\u570b\u4eba\u7fa4\u4e2d\uff0c\u4ee5\u514d\u75ab\u6cbb\u7642\u4e0d\u654f\u611f\u7684\u80a2\u7aef\u578b\u548c\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u70ba\u4e3b\uff08\u7d04\u536060%~70%<sup>[3]<\/sup>\uff09\u3002IL-2\u4f5c\u70ba\u6fc0\u6d3b\u816b\u7624\u7279\u7570\u6027CD8+T\u7d30\u80de\u7684\u91cd\u8981\u7d30\u80de\u56e0\u5b50\uff0c\u5728\u6a5f\u5236\u4e0a\u8207\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e92\u88dc\uff0c\u53ef\u4ee5\u626d\u8f49T\u7d30\u80de\u8017\u7aed\uff0c\u662f\u5728\u9ed1\u8272\u7d20\u7624\u7d93\u904e\u5145\u5206\u9a57\u8b49\u7684\u9776\u9ede\u3002IBI363\u4f5c\u70baPD-1\/IL-2<sup>\u03b1<\/sup><sup>-bias<\/sup>\u96d9\u7279\u7570\u6027\u5206\u5b50\uff0c\u521d\u6b65\u7814\u7a76\u7d50\u679c\u63d0\u793a\u5728\u514d\u75ab\u8010\u85e5\u7684\u9ed1\u8272\u7d20\u7624\u5177\u6709\u986f\u8457\u512a\u65bc\u76ee\u524d\u6a19\u6e96\u6cbb\u7642\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff0c\u4e26\u4e14\u7de9\u89e3\u6301\u4e45\u3002\u5728\u514d\u75ab\u6cbb\u7642\u5e7e\u4e4e\u7121\u61c9\u7b54\u7684\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u66f4\u662f\u89c0\u5bdf\u5230\u4e86\u9f13\u821e\u4eba\u5fc3\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u548c\u75be\u75c5\u63a7\u5236\u7387\u3002IBI363\u6cbb\u7642\u5728\u9ed1\u8272\u7d20\u7624\u4eba\u7fa4\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u98a8\u96aa\u53ef\u63a7\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u76ee\u524d\u5df2\u6709\u7684\u81e8\u5e8a\u6578\u64da\u63d0\u793aIBI363\u5728\u9ed1\u8272\u7d20\u7624\u4eba\u7fa4\u5177\u6709\u5145\u5206\u7684\u958b\u767c\u524d\u666f\uff0c\u5f8c\u7e8c\u5c07\u7e7c\u7e8c\u958b\u5c55\u81e8\u5e8a\u7814\u7a76\u9032\u4e00\u6b65\u63a2\u7d22IBI363\u5728\u9ed1\u8272\u7d20\u7624\u4eba\u7fa4\u7684\u81e8\u5e8a\u50f9\u503c\u3002\u300d<\/p>\n<p class=\"prntaj\"><strong>\u95dc\u65bc<\/strong><strong>IBI363<\/strong><strong>\uff08<\/strong><strong>PD-1\/IL-2<\/strong><strong><sup>\u03b1<\/sup><\/strong><strong><sup>-bias<\/sup><\/strong><strong>\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767d\uff09<\/strong><\/p>\n<p class=\"prntaj\">IBI363\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275PD-1\/IL-2\u96d9\u7279\u7570\u6027\u878d\u5408\u86cb\u767d\uff0c\u540c\u6642\u5177\u6709\u963b\u65b7PD-1\/PD-L1\u901a\u8def\u548c\u6fc0\u6d3bIL-2\u901a\u8def\u5169\u9805\u529f\u80fd\u3002IBI363\u7684IL-2\u81c2\u7d93\u904e\u4e86\u8a2d\u8a08\u6539\u9020\uff0c\u4fdd\u7559\u4e86\u5176\u5c0dIL-2 R\u03b1\u7684\u89aa\u548c\u529b\uff0c\u4f46\u524a\u5f31\u4e86\u5c0dIL-2R\u03b2\u548cIL-2R\u03b3\u7684\u7d50\u5408\u80fd\u529b\uff0c\u4ee5\u6b64\u964d\u4f4e\u6bd2\u6027\uff1b\u800cPD-1\u7d50\u5408\u81c2\u53ef\u4ee5\u540c\u6642\u5be6\u73fe\u5c0dPD-1\u7684\u963b\u65b7\u548cIL-2\u7684\u9078\u64c7\u6027\u905e\u9001\u3002\u7531\u65bc\u65b0\u6fc0\u6d3b\u7684\u816b\u7624\u7279\u7570\u6027T\u7d30\u80de\u540c\u6642\u8868\u9054PD-1\u548cIL-2\u03b1\uff0c\u9019\u4e00\u5dee\u7570\u6027\u7b56\u7565\u53ef\u4ee5\u66f4\u7cbe\u78ba\u548c\u6709\u6548\u5730\u5be6\u73fe\u5c0d\u8a72T\u7d30\u80de\u4e9e\u7fa4\u7684\u9776\u5411\u548c\u6fc0\u6d3b\u3002IBI363\u4e0d\u50c5\u5728\u591a\u7a2e\u8377\u7624\u85e5\u7406\u5b78\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u4e86\u826f\u597d\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5728PD-1\u8010\u85e5\u548c\u8f49\u79fb\u6a21\u578b\u4e2d\u4e5f\u8868\u73fe\u51fa\u4e86\u7a81\u51fa\u7684\u6291\u7624\u6548\u529b\u3002\u5f9e\u81e8\u5e8a\u8feb\u5207\u9700\u6c42\u51fa\u767c\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u958b\u5c55\u81e8\u5e8a\u7814\u7a76\u63a2\u7d22IBI363\u5728\u91dd\u5c0d\u5404\u7a2e\u665a\u671f\u60e1\u6027\u816b\u7624\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p class=\"prntaj\"><strong>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/strong><\/p>\n<p class=\"prntaj\">\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670910\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09<sup>2<\/sup>\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09<sup>2<\/sup>\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<sup>\u00ae<\/sup>\uff09\u548c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<sup>\u00ae<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67094\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p class=\"prntaj\">\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson 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class=\"prntaj\">\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"https:\/\/www.innoventbio.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow noopener\" target=\"_blank\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p class=\"prntaj\">\u8072\u660e\uff1a<em>\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1<\/em><em>\/<\/em><em>\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/em><\/p>\n<p class=\"prntaj\"><strong>\u524d\u77bb\u6027\u8072\u660e<\/strong><\/p>\n<p 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class=\"prntal\">\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9\uff1b\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<div>\n<table class=\"prnbcc\" border=\"0\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c3\u8003\u6587\u737b<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: a cancer journal for clinicians, 2021, 71(3): 209-249.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0TROPION-Lung01 ESMO 2023<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u00a0Clin Cancer Res 2020;26:4250\u20139. doi: 10.1158\/1078-0432.CCR-19-3922; BMC Cancer (2023) 23:121.\u00a0<a class=\"prnews_a\" href=\"https:\/\/doi.org\/10.1186\/s12885-022-10473-y\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12885-022-10473-y<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-242568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 2021, 71(3): 209-249.     \u00a0TROPION-Lung01 ESMO 2023     \u00a0Clin Cancer Res 2020;26:4250\u20139. doi: 10.1158\/1078-0432.CCR-19-3922; BMC Cancer (2023) 23:121.\u00a0https:\/\/doi.org\/10.1186\/s12885-022-10473-y.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=242568\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u516d\u6708\u5168\u9ad4\u5927\u6703\u53e3\u982d\u5831\u544a\u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1-bias\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767dIBI363\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7b49\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u6578\u64da - 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9\uff1b\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002      \u53c3\u8003\u6587\u737b     \u00a0Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9\uff1b\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b \u00a0Sung H, Ferlay J, Siegel R L, et al. 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