{"id":241967,"date":"2024-06-11T11:14:00","date_gmt":"2024-06-11T03:14:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=241967"},"modified":"2024-06-11T11:14:00","modified_gmt":"2024-06-11T03:14:00","slug":"%e5%af%a6%e9%ab%94%e7%98%a4%e9%a0%98%e5%9f%9f%e9%87%8d%e5%a4%a7%e9%87%8c%e7%a8%8b%e7%a2%91%ef%bc%81%e8%80%90%e7%ab%8b%e5%85%8b%e6%b2%bb%e7%99%82sdh%e7%bc%ba%e9%99%b7%e5%9e%8bgist%e6%82%a3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=241967","title":{"rendered":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02<\/span>2024\u5e746\u670811\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae<\/sup>\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002<\/p>\n

\n<\/p><\/div>\n

\u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae<\/sup>\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n

GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1<\/sup>\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3<\/sup>\u3002<\/p>\n

SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5<\/sup>\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4<\/sup>\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002<\/p>\n

\u8010\u7acb\u514b\u00ae<\/sup>\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002<\/p>\n

\u8010\u7acb\u514b\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae<\/sup>\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae<\/sup>\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/u><\/b><\/p>\n

    \n
  1. Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559.<\/li>\n
  2. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/<\/a>(2019, accessed 4 May 2022<\/span>).<\/li>\n
  3. Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278.<\/li>\n
  4. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528.<\/li>\n
  5. Mullassery D, Weldon CB. Pediatric\/”Wildtype” gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310.<\/li>\n<\/ol>\n

    \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/span><\/u><\/b><\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002<\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

    \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae<\/sup>\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n

    \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002<\/p>\n

    \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e<\/u><\/b><\/p>\n

    \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e…<\/p>\n","protected":false},"author":16,"featured_media":241968,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-241967","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\/"Wildtype" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=241967\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\/"Wildtype" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=241967\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-11T03:14:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"77\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef\",\"datePublished\":\"2024-06-11T03:14:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967\"},\"wordCount\":194,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Ascentage_Pharma_Logo.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967\",\"name\":\"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Ascentage_Pharma_Logo.jpg\",\"datePublished\":\"2024-06-11T03:14:00+00:00\",\"description\":\"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\\\/10\u842c-1.5\\\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\\\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\\\/\\\/liferaftgroup.org\\\/2019\\\/08\\\/treatmentresponses-in-sdh-deficient-gist-2\\\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\\\/\\\"Wildtype\\\" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Ascentage_Pharma_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Ascentage_Pharma_Logo.jpg\",\"width\":400,\"height\":77},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=241967#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\/\"Wildtype\" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=241967","og_locale":"zh_TW","og_type":"article","og_title":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\/\"Wildtype\" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=241967","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-06-11T03:14:00+00:00","og_image":[{"width":400,"height":77,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef","datePublished":"2024-06-11T03:14:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967"},"wordCount":194,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=241967","url":"https:\/\/pingtungtimes.com.tw\/?p=241967","name":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg","datePublished":"2024-06-11T03:14:00+00:00","description":"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e022024\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff1b\u7814\u767c\u4ee3\u865f\uff1aHQP1351\uff09\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u7269\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u958b\u5c55\u5176\u91dd\u5c0d\u7cfb\u7d71\u6027\u5168\u8eab\u6cbb\u7642\u5931\u6557\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9593\u8cea\u7624\uff08gastrointestinal stromal tumor, GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u3001\u958b\u653e\u6027\u95dc\u9375\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002CDE\u5df2\u540c\u610f\u8a72\u9805\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u7d50\u679c\u5c07\u652f\u6301\u672a\u4f86SDH\u7f3a\u9677\u578bGIST\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u3002 GIST\u662f\u6d88\u5316\u9053\u6700\u5e38\u898b\u7684\u8edf\u7d44\u7e54\u8089\u7624\uff0c\u5168\u7403\u767c\u75c5\u7387\u7d04\u6bcf\u5e741\/10\u842c-1.5\/10\u842c 1\u3002KIT\u53caPDGFRA\u662fGIST\u4e3b\u8981\u7684\u81f4\u764c\u9a45\u52d5\u57fa\u56e0\uff0c\u5176\u4e2d85%\uff5e90%\u7684GIST\u60a3\u8005\u6709KIT\u6216PDGFRA\u7a81\u8b8a\u3002\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985eGIST\u60a3\u8005\u7684\u9810\u5f8c\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u7d0485%\u7684\u5152\u7ae5GIST\u548c10%-15\u7684\u6210\u4ebaGIST\u60a3\u8005\u4e26\u4e0d\u651c\u5e36KIT\u6216PDGFRA\u7a81\u8b8a\uff0c\u7a31\u70ba\u91ce\u751f\u578bGIST\u3002\u6839\u64daSDH\u8868\u9054\u662f\u5426\u7f3a\u5931\uff0c\u91ce\u751f\u578bGIST\u53ef\u5206\u70baSDH\u7f3a\u9677\u578bGIST\u548c\u975eSDH\u7f3a\u9677\u578bGIST 2-3\u3002 SDH\u7f3a\u9677\u578bGIST\u5177\u6709\u7368\u7279\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u3002\u6587\u737b\u5831\u544a\u4e2d\u4f4d\u8a3a\u65b7\u5e74\u9f61\u70ba21\u6b72\uff0c\u5973\u6027\u591a\u898b\uff0c\u597d\u767c\u90e8\u4f4d\u70ba\u80c3\u90e8\uff0c\u5bb9\u6613\u8f49\u79fb\uff0c\u514d\u75ab\u7d44\u5316\u8868\u73fe\u70baSDHB\u86cb\u767d\u8868\u9054\u7f3a\u5931\u3002\u65e9\u671f\u5c40\u9650\u578b\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u6703\u5fa9\u767c\u3002\u5fa9\u767c\u548c\u665a\u671f\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u76ee\u524d\u7121\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u4e00\u822c\u8a8d\u70ba\u4f0a\u99ac\u66ff\u5c3c\u6cbb\u7642\u7121\u6548\uff0c\u5176\u4ed6TKI\u7684\u7642\u6548\u4e5f\u96e3\u4ee5\u4ee4\u4eba\u6eff\u610f 2-5\uff0c5\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\uff08EFS\uff09\u7387\u50c5\u70ba24% 4\u3002SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u767c\u75c5\u5e74\u8f15\uff0c\u56b4\u91cd\u5f71\u97ff\u751f\u5b58\u8cea\u91cf\uff0c\u4e14\u660e\u986f\u7e2e\u77ed\u751f\u5b58\u671f\uff0c\u9019\u4e00\u5b58\u5728\u7dca\u8feb\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u9818\u57df\u4e9f\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3TKI\u3002\u6b64\u524d\uff0c\u8a72\u54c1\u7a2e\u5df2\u7372CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u3002\u4f5c\u70ba\u591a\u9776\u9edeTKI\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u5176\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u81ea2022\u5e74\u8d77\uff0c\u5df2\u9023\u7e8c\u4e09\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\uff0c\u4e26\u5728\u672c\u6708\u8209\u8fa6\u7684\u7b2c60\u5c46ASCO\u5e74\u6703\u4e0a\u53e3\u982d\u5831\u544a\u4e86\u6700\u65b0\u9032\u5c55\u3002\u6578\u64da\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905492.3%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u76ee\u524d\u5df2\u6709\u5169\u9805\u9069\u61c9\u75c7\u7372\u6279\uff0c\u5206\u5225\u70ba\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08-CP\uff09\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u548c\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u7d93\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u6b64\u6b21\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7684\u7372\u6279\u8b93\u6211\u5011\u6df1\u53d7\u9f13\u821e\uff01\u9019\u4e0d\u50c5\u610f\u5473\u8457\u8010\u7acb\u514b\u00ae\u6709\u671b\u70ba\u53c8\u4e00\u500b\u7121\u85e5\u53ef\u91ab\u7684\u9069\u61c9\u75c7\u5e36\u4f86\u6cbb\u7642\u7a81\u7834\uff0c\u66f4\u662f\u4e9e\u76db\u91ab\u85e5\u5728\u5be6\u9ad4\u7624\u9818\u57df\u81e8\u5e8a\u958b\u767c\u7684\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u79c9\u627f\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559. Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/(2019, accessed 4 May 2022). Nannini M, Rizzo A, Indio V, et al.\u00a0Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278. Weldon CB, Madenci AL, Boikos SA,\u00a0et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528. Mullassery D, Weldon CB. Pediatric\/\"Wildtype\" gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002 \u4e9e\u76db\u91ab\u85e5\u64c1\u6709\u81ea\u4e3b\u69cb\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u85e5\u7269\u8a2d\u8a08\u5e73\u53f0\uff0c\u8655\u65bc\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u85e5\u7814\u767c\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u64c1\u67099\u500b\u5df2\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u76841\u985e\u5c0f\u5206\u5b50\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d6\u9805\u70ba\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u7528\u65bc\u6cbb\u7642\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u7a2e\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u66fe\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u65b0\u85e5\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u548c\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4e26\u5df2\u5728\u4e2d\u570b\u7372\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u500b\u4e0a\u5e02\u54c1\u7a2e\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff082022\u5e74\uff09\u300b\u3002\u8a72\u54c1\u7a2e\u9084\u7372\u5f97\u4e86\u7f8e\u570bFDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u3001\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3001\u4ee5\u53ca\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u500b\u5728\u7814\u65b0\u85e5\u7372\u5f9716\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u516c\u53f8\u5148\u5f8c\u627f\u64d4\u591a\u9805\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\uff0c\u5176\u4e2d\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u98055\u9805\uff0c\u5305\u62ec1\u9805\u300c\u4f01\u696d\u5275\u65b0\u85e5\u7269\u5b75\u5316\u57fa\u5730\u300d\u53ca4\u9805\u300c\u5275\u65b0\u85e5\u7269\u7814\u767c\u300d\uff0c\u53e6\u5916\u627f\u64d4\u300c\u91cd\u5927\u50b3\u67d3\u75c5\u9632\u6cbb\u300d\u5c08\u98051\u9805\u3002 \u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207UNITY\u3001MD Anderson\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u7b49\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u53ca\u91ab\u85e5\u516c\u53f8\u3001\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u8c50\u5bcc\u7684\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u540c\u6642\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6a19\u6e96\u6253\u9020\u5f8c\u671f\u7684\u5546\u696d\u5316\u751f\u7522\u53ca\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u4e9e\u76db\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=241967"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/06\/Ascentage_Pharma_Logo.jpg","width":400,"height":77},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=241967#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u5be6\u9ad4\u7624\u9818\u57df\u91cd\u5927\u91cc\u7a0b\u7891\uff01\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u7372CDE\u81e8\u5e8a\u8a31\u53ef"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/241967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=241967"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/241967\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/241968"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=241967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=241967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=241967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}