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1\u4f8b\u9251\u8010\u85e5\u7684\u60a3\u8005\u7372\u5f97\u78ba\u8a8d\u7684PR\uff0c1\u4f8bPD\u3002\u57284\u4f8b\u78ba\u8a8d\u7684PR\u53d7\u8a66\u8005\u4e2d\uff0c3\u4f8b\u4ecd\u5728\u63a5\u53d7IBI363\u6cbb\u7642\uff0c1\u4f8b\u982d\u9838\u9c57\u764c\u60a3\u8005\u63a5\u53d7\u4e86\u6839\u6cbb\u6027\u5207\u9664\u624b\u8853\u3002<\/li>\n<\/ul>\n<p><b>\u798f\u5efa\u7701\u816b\u7624\u91ab\u9662\u9673\u8b7d\u6559\u6388<\/b>\u8868\u793a<b>\uff1a<\/b>\u300c\u9ed1\u8272\u7d20\u7624\u5728\u570b\u5167\u5c6c\u65bc\u5c11\u898b\u816b\u7624\uff0c\u4e14\u4e2d\u570b\u4eba\u7fa4\u4ee5\u514d\u75ab\u6cbb\u7642\u4e0d\u654f\u611f\u7684\u80a2\u7aef\u578b\u548c\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\u70ba\u4e3b\uff08\u7d04\u536060%~70%\uff09\u3002IL-2\u4f5c\u70ba\u6fc0\u6d3b\u816b\u7624\u7279\u7570\u6027CD8+T\u7d30\u80de\u7684\u91cd\u8981\u7d30\u80de\u56e0\u5b50\uff0c\u5728\u6a5f\u5236\u4e0a\u8207\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e92\u88dc\uff0c\u53ef\u4ee5\u626d\u8f49\u816b\u7624\u6297\u539f\u7279\u7570\u6027T\u7d30\u80de\u8017\u7aed\uff0c\u662f\u5728\u9ed1\u8272\u7d20\u7624\u7d93\u904e\u5145\u5206\u9a57\u8b49\u7684\u9776\u9ede\u3002IBI363\u4f5c\u70baPD-1\/IL-2\u96d9\u7279\u7570\u6027\u5206\u5b50\uff0c\u521d\u6b65\u7814\u7a76\u7d50\u679c\u63d0\u793a\u5728\u514d\u75ab\u8010\u85e5\u7684\u9ed1\u8272\u7d20\u7624\u5177\u6709\u986f\u8457\u512a\u65bc\u73fe\u6709\u6a19\u6e96\u6cbb\u7642\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u76ee\u524d\u5df2\u6709\u7684\u81e8\u5e8a\u6578\u64da\u63d0\u793aIBI363\u5728\u9ed1\u8272\u7d20\u7624\u4eba\u7fa4\u5177\u6709\u5145\u5206\u7684\u958b\u767c\u524d\u666f\uff0c\u5f8c\u7e8c\u5c07\u7e7c\u7e8c\u958b\u5c55\u81e8\u5e8a\u7814\u7a76\u9032\u4e00\u6b65\u660e\u78baIBI363\u5728\u9ed1\u8272\u7d20\u7624\u4eba\u7fa4\u7684\u81e8\u5e8a\u50f9\u503c\u3002\u300d<\/p>\n<p><b>\u6d59\u6c5f\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u6881\u5ef7\u6ce2\u6559\u6388<\/b>\u8868\u793a<b>\uff1a<\/b>\u300c\u7d50\u76f4\u8178\u764c\u662f\u5168\u7403\u7b2c\u4e09\u5927\u5e38\u898b\u7684\u764c\u75c7\u548c\u7b2c\u4e8c\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0<sup>[1]<\/sup>\uff0c50%~60%\u7684\u60a3\u8005\u6703\u767c\u751f\u9060\u8655\u8f49\u79fb\uff0c\u800c\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u7684\u9810\u5f8c\u8f03\u5dee\uff0c5\u5e74\u751f\u5b58\u7387\u4e0d\u8db320%<sup>[2]<\/sup>\u3002\u5c0d\u65bc\u6a19\u6e96\u5316\u7642\u5931\u6557\u7684\u665a\u671f\u7d50\u76f4\u8178\u764c\u53d7\u8a66\u8005\uff0c\u73fe\u6709\u6cbb\u7642\u7684ORR\u50c5\u70ba1%~4.7%\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u50c5\u70ba6~9\u500b\u6708<sup>[3]<\/sup>\u3002IBI363\u5728\u665a\u671f\u7d50\u76f4\u8178\u764c\u53d7\u8a66\u8005\u4e2d\u8868\u73fe\u51fa\u826f\u597d\u7684\u7642\u6548\uff0c\u7279\u5225\u662f\u5c0d\u65bcPD-L1 CPS\u22651\u7684\u53d7\u8a66\u8005\uff0c\u540c\u6642\u5b89\u5168\u6027\u53ef\u63a7\u3002\u6211\u5011\u975e\u5e38\u671f\u5f85IBI363\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u5728\u665a\u671f\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7814\u7a76\u7d50\u679c\uff0c\u5e0c\u671b\u80fd\u70ba\u66f4\u591a\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>IBI363\uff08PD-1\/IL-2<sup>\u03b1<\/sup>\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767d\uff09<\/b><\/p>\n<p>IBI363\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u5275PD-1\/IL-2\u96d9\u7279\u7570\u6027\u878d\u5408\u86cb\u767d\uff0c\u540c\u6642\u5177\u6709\u963b\u65b7PD-1\/PD-L1\u901a\u8def\u548c\u6fc0\u6d3bIL-2\u901a\u8def\u5169\u9805\u529f\u80fd\u3002IBI363\u7684IL-2\u81c2\u7d93\u904e\u4e86\u8a2d\u8a08\u6539\u9020\uff0c\u4fdd\u7559\u4e86\u5176\u5c0dIL-2\u03b1\u7684\u89aa\u548c\u529b\uff0c\u4f46\u524a\u5f31\u4e86\u5c0dIL-2R\u03b2\u548cIL-2R\u03b3\u7684\u7d50\u5408\u80fd\u529b\uff0c\u4ee5\u6b64\u964d\u4f4e\u6bd2\u6027\uff1b\u800cPD-1\u7d50\u5408\u81c2\u53ef\u4ee5\u540c\u6642\u5be6\u73fe\u5c0dPD-1\u7684\u963b\u65b7\u548cIL-2\u7684\u9078\u64c7\u6027\u905e\u9001\u3002\u7531\u65bc\u65b0\u6fc0\u6d3b\u7684\u816b\u7624\u7279\u7570\u6027T\u7d30\u80de\u540c\u6642\u8868\u9054PD-1\u548cIL-2\u03b1\uff0c\u9019\u4e00\u5dee\u7570\u6027\u7b56\u7565\u53ef\u4ee5\u66f4\u7cbe\u78ba\u548c\u6709\u6548\u5730\u5be6\u73fe\u5c0d\u8a72T\u7d30\u80de\u4e9e\u7fa4\u7684\u9776\u5411\u548c\u6fc0\u6d3b\u3002IBI363\u4e0d\u50c5\u5728\u591a\u7a2e\u8377\u7624\u85e5\u7406\u5b78\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u4e86\u826f\u597d\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5728PD-1\u8010\u85e5\u548c\u8f49\u79fb\u6a21\u578b\u4e2d\u4e5f\u8868\u73fe\u51fa\u4e86\u7a81\u51fa\u7684\u6291\u7624\u6548\u529b\u3002\u5f9e\u81e8\u5e8a\u8feb\u5207\u9700\u6c42\u51fa\u767c\uff0c\u4fe1\u9054\u751f\u7269\u6b63\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u958b\u5c55\u81e8\u5e8a\u7814\u7a76\u63a2\u7d22IBI363\u5728\u91dd\u5c0d\u5404\u7a2e\u665a\u671f\u60e1\u6027\u816b\u7624\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u67094\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u00a0<\/p>\n<p>\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"https:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a> 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(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c3\u8003\u6587\u737b<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0CA Cancer J Clin. 2024 May-Jun;74(3):229-263.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0JAMA. 2021 Feb 16;325(7):669-685.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u00a0doi: 10.1016\/S0140-6736(12)61900-X. doi: 10.1056\/NEJMoa1414325. DOI: 10.1001\/jama.2018.7855<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-240336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002          \u53c3\u8003\u6587\u737b         \u00a0CA Cancer J Clin. 2024 May-Jun;74(3):229-263.         \u00a0JAMA. 2021 Feb 16;325(7):669-685.         \u00a0doi: 10.1016\/S0140-6736(12)61900-X. doi: 10.1056\/NEJMoa1414325. DOI: 10.1001\/jama.2018.7855         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=240336\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u516c\u4f48\u5168\u7403\u9996\u5275PD-1\/IL-2\u03b1\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767d\uff08IBI363\uff09\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\u3001\u7d50\u76f4\u8178\u764c\u7b49\u816b\u7624\u7684I\u671f\u81e8\u5e8a\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u67082\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u5168\u7403\u9996\u5275\uff08First-in-class\uff09PD-1\/IL-2\u03b1\u96d9\u7279\u7570\u6027\u6297\u9ad4\u878d\u5408\u86cb\u767d\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI363\uff09\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\u3001\u7d50\u76f4\u8178\u764c\u7b49\u816b\u7624\u7684I\u671f\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff08\u7814\u7a76\u767b\u8a18\u865f\uff1aNCT05460767\uff09\u3002\u95dc\u65bcIBI363\u5728\u665a\u671f\u80ba\u764c\u53ca\u66f4\u591a\u7684I\u671f\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u5c07\u5728\u540c\u6708\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5168\u9ad4\u6703\u8b70\uff08ESMO Virtual Plenary\uff09\u4e0a\u4ee5\u53e3\u982d\u5f62\u5f0f\u5831\u544a\u3002 \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u8868\u793a\uff1a\u300c\u5f88\u9ad8\u8208\u80fd\u5920\u5728ASCO\u5e74\u6703\u4e0a\u9996\u6b21\u5206\u4eabIBI363\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u3002IL-2\u662f\u6700\u65e9\u88ab\u6279\u51c6\u7528\u65bc\u6297\u816b\u7624\u6cbb\u7642\u7684\u514d\u75ab\u7642\u6cd5\u4e4b\u4e00\uff0c\u7136\u800c\u4e00\u76f4\u4ee5\u4f86\uff0cIL-2\u7642\u6cd5\u7684\u5b89\u5168\u6027\u8207\u6709\u6548\u6027\u5747\u672a\u80fd\u4ee4\u4eba\u6eff\u610f\u3002IBI363\u901a\u904eIL-2R\u03b1 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002          \u53c3\u8003\u6587\u737b         \u00a0CA Cancer J Clin. 2024 May-Jun;74(3):229-263.         \u00a0JAMA. 2021 Feb 16;325(7):669-685.         \u00a0doi: 10.1016\/S0140-6736(12)61900-X. doi: 10.1056\/NEJMoa1414325. 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