{"id":240334,"date":"2024-06-02T08:00:00","date_gmt":"2024-06-02T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=240334"},"modified":"2024-06-02T08:00:00","modified_gmt":"2024-06-02T00:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e8%87%a8%e5%ba%8a%e8%85%ab%e7%98%a4%e5%ad%b8%e6%9c%83%ef%bc%88asco%ef%bc%89%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88%e5%89%b5","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=240334","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u516c\u4f48\u5275\u65b0\u578b\u6297CLDN18.2 ADC\uff08IBI343\uff09\u5728\u665a\u671f\u80f0\u817a\u764c\u6216\u81bd\u9053\u764c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u6578\u64da"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span><span 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type=\"disc\">\n<li>\u622a\u81f3 2024 \u5e74 1 \u6708 15 \u65e5\uff0c\u572825\u4f8b\u81f3\u5c11\u63a5\u53d7\u904e1\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\u7684\u53d7\u8a66\u8005\u4e2d\uff0c7 \u4f8b\u9054\u5230\u90e8\u5206\u7de9\u89e3 (PR)\uff0c \u5176\u4e2d5 \u4f8b\u70ba PDAC\u60a3\u8005\uff0c2\u4f8b\u70baBTC\u60a3\u8005\u3002\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba 28.0%\uff0895%CI\uff1a12.1-49.4\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba 80.0%\uff0895%CI\uff1a59.3-93.2\uff09\u3002<\/li>\n<li><b>\u5728<\/b><b> 6 mg\/kg\u5291\u91cf\u7d44\uff0c CLDN18.2 IHC1\/2\/3+\u226560%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c13\u4f8b\u81f3\u5c11\u9032\u884c\u4e861\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\uff0c\u5176\u4e2d5 \u4f8b\u53d7\u8a66\u8005\u9054\u5230PR\uff0cORR \u70ba 38.5%\uff0895%CI\uff1a13.9-68.4\uff09\uff0c DCR \u70ba 84.6%\uff0895%CI\uff1a54.6-98.1\uff09\u3002\u5728\u672c\u4e9e\u7d44\u4e2d\u768410 \u4f8b\u665a\u671fPDAC \u53d7\u8a66\u8005\u4e2d\uff0cORR \u70ba 40%\uff0895%CI\uff1a12.2-73.8\uff09\u3002<\/b> <b>DoR \u548c PFS \u6578\u64da\u5c1a\u672a\u6210\u719f\u3002<\/b><\/li>\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff0c80.0%\u53d7\u8a66\u8005\u767c\u751f\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6 (TRAE)\uff0c\u5e38\u898b\u7684TRAE\u70ba\u8ca7\u8840\uff0842.9%\uff09\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u6e1b\u5c11\uff0828.6%\uff09\u3001\u5641\u5fc3\uff0825.7%\uff09\u3001\u5614\u5410\uff0825.7%\uff09\u548c\u767d\u7d30\u80de\u8a08\u6578\u6e1b\u5c11\uff0822.9%\uff09\uff1b 25.7%\u53d7\u8a66\u8005\u767c\u751f\u22653 \u7d1aTRAE\uff1b\u672a\u767c\u751f\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u6b7b\u4ea1\u4e8b\u4ef6\u3002<\/li>\n<\/ul>\n<p><b>\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u91ab\u9662\u865e\u5148\u6fec\u6559\u6388<\/b>\u8868\u793a<b>\uff1a<\/b>\u300c\u665a\u671f\u80f0\u817a\u764c\u548c\u81bd\u9053\u764c\u9032\u5c55\u8fc5\u901f\u4f46\u8d77\u75c5\u96b1\u533f\uff0c\u591a\u6578\u60a3\u8005\u78ba\u8a3a\u6642\u5df2\u665a\u671f\uff0c\u9810\u5f8c\u5dee\u3002\u76ee\u524d\u91dd\u5c0d\u665a\u671f\u80f0\u817a\u764c\u53ca\u81bd\u9053\u764c\u7684\u4e00\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u4ecd\u4ee5\u5316\u7642\u70ba\u4e3b\uff0c\u5176\u4e2d\u4e8c\u7dda\u6cbb\u7642\u7684\u81e8\u5e8a\u9078\u64c7\u5c24\u70ba\u6709\u9650\uff0c\u7121\u6cd5\u70ba\u60a3\u8005\u5e36\u4f86\u986f\u8457\u7684\u81e8\u5e8a\u7372\u76ca\u3002FOLFOX\u65b9\u6848\u4f5c\u70ba\u665a\u671f\u81bd\u9053\u764c\u7684\u4e8c\u7dda\u6a19\u6e96\u6cbb\u7642\uff0cORR\u50c5\u70ba5%\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671fOS\u70ba6.2\u500b\u6708<sup>[1]<\/sup>\u3002\u800c\u5728\u80f0\u817a\u764c\u4e8c\u7dda\u6cbb\u7642\u4e2d\uff0c\u5316\u7642\u97ff\u61c9\u7387\u50c5\u70ba6-16%\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u5927\u7d04\u50c5\u67093~6\u500b\u6708<sup>[2]<\/sup>\u3002CLDN18.2\u4f5c\u70ba\u6297\u6d88\u5316\u9053\u816b\u7624\u6cbb\u7642\u5099\u53d7\u95dc\u6ce8\u7684\u9776\u9ede\uff0c\u5728\u80f0\u817a\u764c\u53ca\u81bd\u9053\u764c\u4e2d\u7684\u8868\u9054\u7387\u8f03\u9ad8\uff0c\u5728\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u7684\u8868\u9054\u7387\u70ba50%~70%<sup>[3]<\/sup>\uff0c\u81bd\u9053\u764c\u4e2d\u4e5f\u9054\u5230\u4e8652%<sup>[4]<\/sup>\u3002\u5275\u65b0\u578bTOPOi\u6297CLDN18.2 ADC IBI343\u5728\u665a\u671f\u80f0\u817a\u764c\u53ca\u81bd\u9053\u764c\u53d7\u8a66\u8005\u4e2d\uff0c\u89c0\u5bdf\u5230\u6709\u6f5b\u529b\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u7279\u5225\u5728CLDN18.2\u8f03\u9ad8\u8868\u9054\u7684\u665a\u671f\u80f0\u817a\u764c\u53d7\u8a66\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u6027\u4fe1\u865f\uff0c\u540c\u6642\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u6709\u671b\u70ba\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u66f4\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>IBI343\uff08\u6297CLDN18.2 ADC\uff09<\/b><\/p>\n<p>IBI343\u662f\u91cd\u7d44\u4eba\u6e90\u6297CLDN18.2 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Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u00a0<\/p>\n<p>\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216<span id=\"spanHghlt451a\">\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"https:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow 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(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c3\u8003\u6587\u737b<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0Lamarca A, Palmer DH, Wasan HS, et al. Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4] Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. J Clin Pathol. 2024 Mar 28:jcp-2023-209268.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-240334","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u516c\u4f48\u5275\u65b0\u578b\u6297CLDN18.2 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002          \u53c3\u8003\u6587\u737b         \u00a0Lamarca A, Palmer DH, Wasan HS, et al. Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701.         Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801.         Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264.         Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. J Clin Pathol. 2024 Mar 28:jcp-2023-209268.         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=240334\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u516c\u4f48\u5275\u65b0\u578b\u6297CLDN18.2 ADC\uff08IBI343\uff09\u5728\u665a\u671f\u80f0\u817a\u764c\u6216\u81bd\u9053\u764c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u67082\u65e5 \/\u7f8e\u901a\u793e\/ -- 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Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701.         Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801.         Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264.         Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. 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Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701. Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801. Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264. Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. J Clin Pathol. 2024 Mar 28:jcp-2023-209268. 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002          \u53c3\u8003\u6587\u737b         \u00a0Lamarca A, Palmer DH, Wasan HS, et al. Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701.         Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801.         Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264.         Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. J Clin Pathol. 2024 Mar 28:jcp-2023-209268.         \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=240334","og_locale":"zh_TW","og_type":"article","og_title":"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u516c\u4f48\u5275\u65b0\u578b\u6297CLDN18.2 ADC\uff08IBI343\uff09\u5728\u665a\u671f\u80f0\u817a\u764c\u6216\u81bd\u9053\u764c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e746\u67082\u65e5 \/\u7f8e\u901a\u793e\/ -- 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002          \u53c3\u8003\u6587\u737b         \u00a0Lamarca A, Palmer DH, Wasan HS, et al. Advanced Biliary Cancer Working Group. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial. Lancet Oncol. 2021 May;22(5):690-701.         Vaccaro V, Sperduti I, Vari S, et al. Metastatic pancreatic cancer: Is there a light at the end of the tunnel?. World J Gastroenterol. 2015;21(16):4788-4801.         Wu YY, Fan L, Liao XH, et al. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol. 2022 Jul 15;14(7):1252-1264.         Yan P, Dong Y, Zhang F, Zhen T, Liang J, Shi H, Han A. Claudin18.2 expression and its clinicopathological feature in adenocarcinoma from various parts. 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