{"id":228468,"date":"2024-04-02T13:00:00","date_gmt":"2024-04-02T05:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=228468"},"modified":"2024-04-02T13:00:00","modified_gmt":"2024-04-02T05:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e8%88%87%e5%92%8c%e9%bb%83%e9%86%ab%e8%97%a5%e5%ae%a3%e4%bd%88%e4%bf%a1%e8%bf%aa%e5%88%a9%e5%96%ae%e6%8a%97%e8%81%af%e5%90%88%e5%a4%ab%e5%a5%8e%e6%9b%bf%e5%b0%bc","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=228468","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u8207\u548c\u9ec3\u91ab\u85e5\u5ba3\u4f48\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u592b\u594e\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5b50\u5bae\u5167\u819c\u764c\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u53d7\u7406\u4e26\u7372\u7d0d\u5165\u512a\u5148\u5be9\u8a55"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e744\u67082\u65e5<\/span> <span>\/<\/span><span>\u7f8e\u901a\u793e<\/span><span>\/ &#8212; <\/span><span>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a<\/span><span>01801<\/span><span>\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u8207\u548c\u9ec3\u91ab\u85e5\uff08\u4e2d\u570b\uff09\u6709\u9650\u516c\u53f8\uff08\u7c21\u7a31<\/span><span>\u300c<\/span><span>\u548c\u9ec3\u91ab\u85e5<\/span><span>\u300d<\/span><span>\u6216\u300c<\/span><span>HUTCHMED\u300d<\/span><span>\uff09\uff08\u7d0d\u65af\u9054\u514b<\/span><span>\/<\/span><span>\u502b\u6566\u8b49\u4ea4\u6240\uff1a<\/span><span>HCM<\/span><span>\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a<\/span><span>13<\/span><span>\uff09\u4eca\u65e5\u806f\u5408\u5ba3\u4f48\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u8207\u592b\u594e\u66ff\u5c3c\u7684\u806f\u5408\u7642\u6cd5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7cfb\u7d71\u6027\u6297\u816b\u7624\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u4e14\u4e0d\u9069\u5408\u9032\u884c\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\u6216\u6839\u6cbb\u6027\u653e\u7642\u7684\u665a\u671f\u932f\u914d\u4fee\u5fa9\u5b8c\u6574\uff08<\/span><span>pMMR<sup>[1]<\/sup><\/span><span>\uff09\u6216\u975e\u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\uff08\u975e<\/span><span>MSI-H<sup>[2]<\/sup><\/span><span>\uff09\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/span><span>NMPA<\/span><span>\uff09\u53d7\u7406\u4e26\u4e88\u4ee5\u512a\u5148\u5be9\u8a55\u3002<\/span><\/p>\n<p><span>FRUSICA-1<\/span><span>\u7814\u7a76\u7684\u6578\u64da\u652f\u6301\u4e86\u6b64\u9805\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002<\/span><span>FRUSICA-1<\/span><span>\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c64\u7684<\/span><span>II<\/span><span>\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u5b50\u5bae\u5167\u819c\u764c\u8a3b\u518a\u968a\u5217\uff0c\u65e8\u5728\u8a55\u4f30\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u592b\u594e\u66ff\u5c3c\u6cbb\u7642\u542b\u9251\u96d9\u85e5\u5316\u7642\u6cbb\u7642\u5f8c\u75be\u75c5\u5fa9\u767c\u3001\u75be\u75c5\u9032\u5c55\u6216\u51fa\u73fe\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u662f\u7368\u7acb\u5be9\u67e5\u59d4\u54e1\u6703\uff08<\/span><span>IRC<\/span><span>\uff09\u8a55\u4f30\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08<\/span><span>ORR<\/span><span>\uff09\uff0c\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u75be\u75c5\u63a7\u5236\u7387\uff08<\/span><span>DCR<\/span><span>\uff09\u3001\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08<\/span><span>DOR)<\/span><span>\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08<\/span><span>PFS<\/span><span>\uff09\u3001\u7e3d\u751f\u5b58\u671f\uff08<\/span><span>OS<\/span><span>\uff09\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u8a55\u4f30\u3002<\/span><span>FRUSICA-1 <\/span><span>\u7814\u7a76\u7684\u6578\u64da\u5c07\u63d0\u4ea4\u65bc\u8fd1\u671f\u7684\u5b78\u8853\u6703\u8b70\u4e0a\u767c\u8868\u3002\u8a72\u9805\u7814\u7a76\u7684\u5176\u4ed6\u8a73\u60c5\u53ef\u767b\u9304<\/span><span>clinicaltrials.gov<\/span><span>\uff0c\u6aa2\u7d22\u8a3b\u518a\u865f<\/span><span><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03903705\" target=\"_blank\" rel=\"nofollow noopener\">NCT03903705<\/a><\/span><span>\u67e5\u770b\u3002<\/span><\/p>\n<p><b><span>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb<\/span><\/b><span>\u8868\u793a\uff1a<\/span><span>\u300c<\/span><span>\u9054\u4f2f\u8212<\/span><sup>\u00ae\u00a0<\/sup><span>\uff08\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\u4f5c\u70ba\u514d\u75ab\u816b\u7624\u9818\u57df\u7684\u57fa\u77f3\u7642\u6cd5\uff0c\u8207\u6297\u8840\u7ba1\u751f\u6210\u85e5\u7269\u806f\u5408\u4f7f\u7528\uff0c\u6709\u671b\u6539\u5584\u4e2d\u570b\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684\u9810\u5f8c\u3002\u6211\u5011\u5c0d\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u53d7\u7406\u4e26\u4e88\u4ee5\u512a\u5148\u5be9\u8a55\u611f\u5230\u8208\u596e\uff0c\u9019\u589e\u52a0\u4e86\u6211\u5011\u70ba\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u7684\u6f5b\u529b\uff0c\u540c\u6642\u4e5f\u5c07\u978f\u56fa\u9054\u4f2f\u8212<\/span><sup>\u00ae <\/sup><span>\u5728\u4e2d\u570b\u7684\u9818\u5c0e\u5730\u4f4d\u3002<\/span><span>\u300d<\/span><\/p>\n<p><b><span>\u548c\u9ec3\u91ab\u85e5\u7814\u767c\u8ca0\u8cac\u4eba\u53ca\u9996\u5e2d\u91ab\u5b78\u5b98\u77f3\u660e\u535a\u58eb<\/span><\/b><span>\u8868\u793a\uff1a<\/span><span>\u300c<\/span><span>\u9019\u662f\u592b\u594e\u66ff\u5c3c\u548c\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u7642\u6cd5\u7684\u9996\u500b\u76e3\u7ba1\u8a3b\u518a\u7533\u8acb\u3002<\/span> <span>\u9019\u4e5f\u6a19\u8a8c\u8457\u5728\u4e2d\u570b\u6211\u5011\u5728\u6539\u5beb\u9019\u7a2e\u5177\u6709\u6311\u6230\u6027\u7684\u75be\u75c5\u7684\u6cbb\u7642\u683c\u5c40\u7684\u9053\u8def\u4e0a\u53c8\u9081\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\u3002\u5b50\u5bae\u5167\u819c\u764c\u4ecd\u7136\u662f\u6700\u5e38\u898b\u7684\u5a66\u79d1\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u3002<\/span> <span>\u6211\u5011\u671f\u5f85\u70ba\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u5e36\u4f86\u9019\u4e00\u7ff9\u9996\u4ee5\u76fc\u7684\u6cbb\u7642\u9032\u5c55\uff0c\u4ee5\u6539\u5584\u4ed6\u5011\u7684\u6cbb\u7642\u7d50\u679c\u3002<\/span><span>\u300d<\/span><\/p>\n<p><span>\u4fe1\u8fea\u5229\u55ae\u6297\u8207\u592b\u594e\u66ff\u5c3c\u7684\u806f\u5408\u7642\u6cd5\u65bc<\/span><span>2023<\/span><span>\u5e74<\/span><span>7<\/span><span>\u6708\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u7528\u65bc\u6b64\u9805\u6f5b\u5728\u9069\u61c9\u75c7\u3002\u570b\u5bb6\u85e5\u76e3\u5c40\u5c07\u8a72\u806f\u5408\u7642\u6cd5\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u4f5c\u70ba\u7528\u65bc\u9632\u6cbb\u56b4\u91cd\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\uff0c\u4e14\u5c1a\u7121\u6709\u6548\u9632\u6cbb\u624b\u6bb5\u6216\u8207\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u76f8\u6bd4\u5177\u6709\u660e\u986f\u81e8\u5e8a\u512a\u52e2\u7684\u5275\u65b0\u85e5\u7269\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u5b50\u5bae\u5167\u819c\u764c<\/span><\/b><\/p>\n<p><span>\u5b50\u5bae\u5167\u819c\u764c\u662f\u4e00\u7a2e\u59cb\u65bc\u5b50\u5bae\u7684\u764c\u75c7\u3002\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c<\/span><span>2020<\/span><span>\u5e74\u4f30\u8a08\u65b0\u589e<\/span><span> 417,000<\/span><span>\u4f8b\u5b50\u5bae\u5167\u819c\u764c\u65b0\u75c7\uff0c\u4e26\u9020\u6210\u7d04<\/span><span> 97,000 <\/span><span>\u4eba\u6b7b\u4ea1<\/span><sup>[3]<\/sup><span>\u3002\u5728\u4e2d\u570b\uff0c<\/span><span>2020<\/span><span>\u5e74\u4f30\u8a08\u65b0\u589e<\/span><span> 82,000<\/span><span>\u4f8b\u5b50\u5bae\u5167\u819c\u764c\u65b0\u75c7\uff0c\u4e26\u9020\u6210\u7d04<\/span><span> 17,000 <\/span><span>\u4eba\u6b7b\u4ea1<\/span><sup>[4]<\/sup><span>\u3002\u5118\u7ba1\u65e9\u671f\u5b50\u5bae\u5167\u819c\u764c\u53ef\u4ee5\u901a\u904e\u624b\u8853\u5207\u9664\uff0c\u4f46\u5fa9\u767c\u6027\u548c<\/span><span>\/<\/span><span>\u6216\u8f49\u79fb\u6027\u5b50\u5bae\u5167\u819c\u764c\u9818\u57df\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u672a\u6eff\u8db3\u7684\u9700\u6c42\uff0c\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u4e0d\u4f73\u4e14\u6cbb\u7642\u9078\u64c7\u6709\u9650<\/span><sup>[5],[6],[7]<\/sup><span>\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u4fe1\u8fea\u5229\u55ae\u6297<\/span><\/b><\/p>\n<p><span>\u4fe1\u8fea\u5229\u55ae\u6297\uff0c\u4e2d\u570b\u5546\u54c1\u540d\u70ba\u9054\u4f2f\u8212<\/span><sup>\u00ae <\/sup><span>\uff08\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u548c\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u5408\u4f5c\u7814\u767c\u7684\u5177\u6709\u570b\u969b\u8cea\u91cf\u7684\u5275\u65b0<\/span><span>PD-1<\/span><span>\u6291\u5236\u5291\u85e5\u7269\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u662f\u4e00\u7a2e\u4eba\u985e\u514d\u75ab\u7403\u86cb\u767d<\/span><span>G4<\/span><span>\uff08<\/span><span>IgG4<\/span><span>\uff09\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u80fd\u7279\u7570\u6027\u7d50\u5408<\/span><span>T<\/span><span>\u7d30\u80de\u8868\u9762\u7684<\/span><span>PD-1<\/span><span>\u5206\u5b50\uff0c\u5f9e\u800c\u963b\u65b7\u5c0e\u81f4\u816b\u7624\u514d\u75ab\u8010\u53d7\u7684<\/span><span> PD-1\/<\/span><span>\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u9ad4\u914d\u9ad4<\/span><span>1<\/span><span>\uff08<\/span><span>Programmed Death-Ligand 1, PD-L1<\/span><span>\uff09\u901a\u8def\uff0c\u91cd\u65b0\u555f\u52d5\u6dcb\u5df4\u7d30\u80de\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5f9e\u800c\u9054\u5230\u6cbb\u7642\u816b\u7624\u7684\u76ee\u7684<\/span><sup>[8]<\/sup><span>\u3002<\/span><\/p>\n<p><span>\u4fe1\u8fea\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e03\u9805\u9069\u61c9\u75c7\u4e26\u5168\u90e8\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff0c\u5354\u8b70\u671f\u5167\u91ab\u4fdd\u76ee\u9304\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u7bc4\u570d\u5305\u62ec\uff1a<\/span><\/p>\n<ul type=\"disc\">\n<li><span>\u81f3\u5c11\u7d93\u904e\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u7d93\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08<\/span><span>EGFR<\/span><span>\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176<\/span><span>(ALK)<\/span><span>\u9670\u6027\u3001<\/span> <span>\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/span><span>NSCLC<\/span><span>\uff09\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08<\/span><span>EGFR-TKI<\/span><span>\uff09<\/span> <span>\u6cbb\u7642\u5931\u6557\u7684<\/span><span> EGFR <\/span><span>\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/span><span>NSCLC<\/span><span>\uff09<\/span> <span>\u60a3\u8005\u7684\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/span><span>NSCLC<\/span><span>\uff09\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u809d\u7d30\u80de\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/span><\/li>\n<li><span>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002<\/span><\/li>\n<\/ul>\n<p><span>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u592b\u594e\u66ff\u5c3c\u7684\u806f\u5408\u7642\u6cd5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7cfb\u7d71\u6027\u6297\u816b\u7624\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u4e14\u4e0d\u9069\u5408\u9032\u884c\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\u6216\u6839\u6cbb\u6027\u653e\u7642\u7684\u665a\u671f\u932f\u914d\u4fee\u5fa9\u5b8c\u6574\uff08<\/span><span>pMMR<\/span><span>\uff09\u6216\u975e\u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\uff08\u975e<\/span><span>MSI-H<\/span><span>\uff09\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u4e26\u4e88\u4ee5\u512a\u5148\u5be9\u8a55\u3002<\/span><\/p>\n<p><span>\u4fe1\u8fea\u5229\u55ae\u6297\u53e6\u6709\u5169\u9805\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u7814\u7a76\u7d42\u9ede\uff0c\u5305\u62ec\uff1a<\/span><\/p>\n<ul type=\"disc\">\n<li><span>\u55ae\u85e5\u7528\u65bc\u665a\u671f<\/span><span>\/<\/span><span>\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u4e8c\u7dda\u6cbb\u7642\u7684<\/span><span>II<\/span><span>\u671f\u81e8\u5e8a\u7814\u7a76\uff1b<\/span><\/li>\n<li><span>\u55ae\u85e5\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u7684\u665a\u671f\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e8c\u7dda\u6cbb\u7642\u7684<\/span><span>III<\/span><span>\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/span><\/li>\n<\/ul>\n<p><i><span>\u8072\u660e\uff1a\u4fe1\u9054\u751f\u7269\u4e0d\u63a8\u85a6\u672a\u7372\u6279\u7684\u85e5\u54c1<\/span><\/i><i><span>\/<\/span><\/i><i><span>\u9069\u61c9\u75c7\u7684\u4f7f\u7528\u3002<\/span><\/i><\/p>\n<p><b><span>\u95dc\u65bc\u592b\u594e\u66ff\u5c3c<\/span><\/b><\/p>\n<p><span>\u592b\u594e\u66ff\u5c3c\u662f\u4e00\u7a2e\u9078\u64c7\u6027\u7684\u53e3\u670d\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08<\/span><span>VEGFR<\/span><span>\uff09<\/span><span>-1<\/span><span>\u3001<\/span><span>-2<\/span><span>\u53ca<\/span><span>-3<\/span><span>\u6291\u5236\u5291\u3002<\/span><span>VEGFR<\/span><span>\u6291\u5236\u5291\u5728\u6291\u5236\u816b\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\u3002\u592b\u594e\u66ff\u5c3c\u88ab\u8a2d\u8a08\u70ba\u64c1\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9078\u64c7\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u812b\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u5f9e\u800c\u5be6\u73fe\u66f4\u9ad8\u7684\u85e5\u7269\u66b4\u9732\u3001\u5c0d\u9776\u9ede\u7684\u6301\u7e8c\u8986\u84cb\u4ee5\u53ca\u7576\u6f5b\u5728\u4f5c\u70ba\u806f\u5408\u7642\u6cd5\u6642\u64c1\u6709\u66f4\u9ad8\u7684\u9748\u6d3b\u5ea6\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u592b\u594e\u66ff\u5c3c\u5c55\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u5176\u8207\u5176\u4ed6\u6297\u816b\u7624\u7642\u6cd5\u806f\u5408\u4f7f\u7528\u7684\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u592b\u594e\u66ff\u5c3c\u5728\u4e2d\u570b\u7372\u6279<\/span><\/b><\/p>\n<p><span>\u592b\u594e\u66ff\u5c3c\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u6c1f\u5c3f\u5627\u5576\u985e\u3001\u5967\u6c99\u5229\u9251\u548c\u4f0a\u7acb\u66ff\u5eb7\u70ba\u57fa\u790e\u7684\u5316\u7642\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u904e\u6216\u4e0d\u9069\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\uff08<\/span><span>VEGF<\/span><span>\uff09\u6cbb\u7642\u3001\u6297\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08<\/span><span>EGFR<\/span><span>\uff09\u6cbb\u7642\uff08<\/span><span>RAS<\/span><span>\u91ce\u751f\u578b\uff09\u7684\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\uff0c\u4e26\u7531\u548c\u9ec3\u91ab\u85e5\u53ca\u79ae\u4f86\u5408\u4f5c\u7814\u767c\u53ca\u4ee5\u5546\u54c1\u540d\u611b\u512a\u7279<\/span><sup>\u00ae <\/sup><span>\u4e0a\u5e02\u92b7\u552e\u3002\u5176\u65bc<\/span><span>2020<\/span><span>\u5e74<\/span><span>1<\/span><span>\u6708\u7372\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u3002\u5728\u4e2d\u570b<\/span><span>416<\/span><span>\u4f8b\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u592b\u594e\u66ff\u5c3c<\/span><span>III<\/span><span>\u671f\u95dc\u9375\u6027\u8a3b\u518a\u7814\u7a76<\/span><span>FRESCO<\/span><span>\u7684\u7814\u7a76\u652f\u6301\u4e86\u592b\u594e\u66ff\u5c3c\u5728\u4e2d\u570b\u7684\u7372\u6279\uff0c\u8a72\u7814\u7a76\u7684\u7d50\u679c\u5df2\u65bc\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\uff08<\/span><span>JAMA<\/span><span>\uff09\u300b\u4e0a<\/span><span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2685988\" target=\"_blank\" rel=\"nofollow noopener\"><span>\u767c\u8868<\/span><\/a><\/span><span>\u3002\u81ea\u592b\u594e\u66ff\u5c3c\u5728\u4e2d\u570b\u4e0a\u5e02\u4ee5\u4f86\uff0c\u622a\u81f3<\/span><span>2023<\/span><span>\u5e74\u5e74\u4e2d\u5df2\u7d93\u60e0\u53ca\u8d85\u904e<\/span><span>8<\/span><span>\u842c\u540d\u7d50\u76f4\u8178\u764c\u60a3\u8005\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u592b\u594e\u66ff\u5c3c\u5728\u7f8e\u570b\u7372\u6279<\/span><\/b><\/p>\n<p><span>\u592b\u594e\u66ff\u5c3c\u65bc<\/span><span>2023<\/span><span>\u5e74<\/span><span>11<\/span><span>\u6708\u65bc\u7f8e\u570b\u7372\u5f97\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u66fe\u63a5\u53d7\u904e\u6c1f\u5c3f\u5627\u5576\u985e\u3001\u5967\u6c99\u5229\u9251\u548c\u4f0a\u7acb\u66ff\u5eb7\u70ba\u57fa\u790e\u7684\u5316\u7642\u3001\u6297<\/span><span>VEGF<\/span><span>\u6cbb\u7642\uff0c\u4ee5\u53ca\u6297<\/span><span>EGFR<\/span><span>\u6cbb\u7642\uff08\u82e5\u5c6c<\/span><span>RAS<\/span><span>\u91ce\u751f\u578b\u53ca\u91ab\u5b78\u4e0a\u9069\u7528\uff09\u7684\u6210\u4eba\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\uff0c\u4e26\u7531\u6b66\u7530\u4ee5\u5546\u54c1\u540d<\/span><span>FRUZAQLA\u2122<\/span><span>\u4e0a\u5e02\u92b7\u552e\u3002\u592b\u594e\u66ff\u5c3c\u7684\u7f8e\u570b\u7372\u6279\u662f\u57fa\u65bc\u5169\u9805\u5927\u578b<\/span><span>III<\/span><span>\u671f\u7814\u7a76\u7684\u6578\u64da\uff0c\u5305\u62ec\u5df2\u65bc\u300a\u67f3\u8449\u5200<\/span><span> (The Lancet)<\/span><span>\u300b<\/span><span><a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)00772-9\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\"><span>\u767c\u8868<\/span><\/a><\/span><span>\u7d50\u679c\u7684\u570b\u969b\u591a\u4e2d\u5fc3<\/span><span>FRESCO-2<\/span><span>\u7814\u7a76\u4ee5\u53ca\u4e2d\u570b\u7684<\/span><span>FRESCO<\/span><span>\u7814\u7a76\u3002\u9019\u5169\u9805\u7814\u7a76\u63a2\u7d22\u4e86\u592b\u594e\u66ff\u5c3c\u806f\u5408\u6700\u4f73\u652f\u6301\u6cbb\u7642\u5c0d\u6bd4\u5b89\u6170\u5291\u806f\u5408\u6700\u4f73\u652f\u6301\u6cbb\u7642\u7528\u65bc\u6cbb\u7642\u7d93\u6cbb\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u3002<\/span><span>FRESCO<\/span><span>\u548c<\/span><span>FRESCO-2<\/span><span>\u7814\u7a76\u5747\u9054\u5230\u4e86\u5176\u4e3b\u8981\u7d42\u9ede\u53ca\u95dc\u9375\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff0c\u5728\u5171<\/span><span>734<\/span><span>\u540d\u63a5\u53d7\u4e86\u592b\u594e\u66ff\u5c3c\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u5c55\u793a\u51fa\u4e86\u4e00\u81f4\u7684\u7372\u76ca\u3002\u5404\u9805\u7814\u7a76\u5747\u5c55\u793a\u51fa\u4e86\u4e00\u81f4\u7684\u5b89\u5168\u6027\u7279\u5fb5\u3002\u6b66\u7530\u64c1\u6709\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u9580\u4ee5\u5916\u9032\u4e00\u6b65\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u751f\u7522\u592b\u594e\u66ff\u5c3c\u7684\u5168\u7403\u7368\u5bb6\u8a31\u53ef\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/span><\/b><\/p>\n<p><span>\u300c<\/span><span>\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c<\/span><span>\u300d<\/span><span>\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc<\/span><span>2011<\/span><span>\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u6709<\/span><span>10<\/span><span>\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u6709<\/span><span>3<\/span><span>\u500b\u54c1\u7a2e\u5728<\/span><span>NMPA<\/span><span>\u5be9\u8a55\u4e2d\uff0c<\/span><span>5<\/span><span>\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165<\/span><span>III<\/span><span>\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u6709<\/span><span>18<\/span><span>\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001<\/span><span>Adimab<\/span><span>\u3001<\/span><span>Incyte<\/span><span>\u548c<\/span><span>MD Anderson <\/span><span>\u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u6210<\/span><span>30<\/span><span>\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002<\/span><span>\u00a0<\/span><\/p>\n<p><span>\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88<\/span><span>\u300c<\/span><span>\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3<\/span><span>\u300d<\/span><span>\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/span><\/p>\n<p><span>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<\/span><span><a href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow\">www.innoventbio.com<\/a><\/span><span>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u548c\u9ec3\u91ab\u85e5<\/span><\/b><\/p>\n<p><span>\u548c\u9ec3\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b<\/span><span>\/<\/span><span>\u502b\u6566\u8b49\u4ea4\u6240\uff1a<\/span><span>HCM<\/span><span>\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a<\/span><span>13<\/span><span>\uff09\u662f\u4e00\u5bb6\u8655\u65bc\u5546\u696d\u5316\u968e\u6bb5\u7684\u5275\u65b0\u578b\u751f\u7269\u91ab\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u3001\u5168\u7403\u958b\u767c\u548c\u5546\u696d\u5316\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u85e5\u7269\u548c\u514d\u75ab\u7642\u6cd5\u3002\u96c6\u5718\u65d7\u4e0b\u516c\u53f8\u5171\u6709\u7d04<\/span><span>5,000<\/span><span>\u540d\u54e1\u5de5\uff0c\u5176\u4e2d\u6838\u5fc3\u7684\u816b\u7624<\/span><span>\/<\/span><span>\u514d\u75ab\u696d\u52d9\u64c1\u6709\u7d04<\/span><span>1,800<\/span><span>\u4eba\u7684\u5718\u968a\u3002\u81ea\u6210\u7acb\u4ee5\u4f86\uff0c\u548c\u9ec3\u91ab\u85e5\u81f4\u529b\u65bc\u5c07\u81ea\u4e3b\u767c\u73fe\u7684\u6297\u816b\u7624\u5019\u9078\u85e5\u7269\u5e36\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u500b\u85e5\u7269\u73fe\u5df2\u5728\u4e2d\u570b\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u500b\u85e5\u7269\u4ea6\u65bc\u7f8e\u570b\u4e0a\u5e02\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u8a73\u60c5\uff0c\u8acb\u8a2a\u554f\uff1a<\/span><span>www.hutch med.com<\/span><span>\u6216\u95dc\u6ce8\u6211\u5011\u7684<\/span><span>LinkedIn<\/span><span>\u5c08\u9801\u3002<\/span><\/p>\n<p><b><span>\u524d\u77bb\u6027\u8072\u660e<\/span><\/b><\/p>\n<p><span>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528<\/span><span>\u300c<\/span><span>\u9810\u671f<\/span><span>\u300d<\/span><span>\u3001<\/span><span>\u300c<\/span><span>\u76f8\u4fe1<\/span><span>\u300d<\/span><span>\u3001<\/span><span>\u300c<\/span><span>\u9810\u6e2c<\/span><span>\u300d<\/span><span>\u3001<\/span><span>\u300c<\/span><span>\u671f\u671b<\/span><span>\u300d<\/span><span>\u3001<\/span><span>\u300c<\/span><span>\u6253\u7b97<\/span><span>\u300d<\/span><span>\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/span><\/p>\n<p><span>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/span><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c3\u8003\u6587\u737b<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0 <\/span><span class=\"prnews_span\">\u932f\u914d\u4fee\u5fa9\u5b8c\u6574<\/span><span class=\"prnews_span\"> (pMMR) =\u00a0 Mismatch Repair proficient.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0 <\/span><span class=\"prnews_span\">\u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a<\/span><span class=\"prnews_span\">\u00a0(MSI-H) =\u00a0 Microsatellite instability-high.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u00a0\u00a0<a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>,\u00a0<a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">World Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]\u00a0\u00a0<a href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">The Global Cancer Observatory<\/a>,\u00a0<a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">China Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]\u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0<i>J Clin Oncol.<\/i>\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]\u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0<i>ESMO Open<\/i>. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[7]\u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0<i>CA Cancer J Clin<\/i>. 2023;73(1):17-48. DOI:10.3322\/caac.21763.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[8] Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-228468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002          \u53c3\u8003\u6587\u737b         \u00a0 \u932f\u914d\u4fee\u5fa9\u5b8c\u6574 (pMMR) =\u00a0 Mismatch Repair proficient.         \u00a0 \u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\u00a0(MSI-H) =\u00a0 Microsatellite instability-high.         \u00a0\u00a0The Global Cancer Observatory,\u00a0World Fact Sheet. Accessed June 12, 2023.         \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023.         \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.         \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.         \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763.         Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.         \u00a0 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=228468\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u8207\u548c\u9ec3\u91ab\u85e5\u5ba3\u4f48\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u592b\u594e\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5b50\u5bae\u5167\u819c\u764c\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u53d7\u7406\u4e26\u7372\u7d0d\u5165\u512a\u5148\u5be9\u8a55 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" 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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002          \u53c3\u8003\u6587\u737b         \u00a0 \u932f\u914d\u4fee\u5fa9\u5b8c\u6574 (pMMR) =\u00a0 Mismatch Repair proficient.         \u00a0 \u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\u00a0(MSI-H) =\u00a0 Microsatellite instability-high.         \u00a0\u00a0The Global Cancer Observatory,\u00a0World Fact Sheet. Accessed June 12, 2023.         \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023.         \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.         \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.         \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763.         Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.         \u00a0 \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=228468\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-02T05:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" 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Accessed June 12, 2023. \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023. \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\\\/JCO.2023.41.16_suppl.e17613. \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\\\/j.esmoop.2022.100774. \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\\\/caac.21763. Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. \u00a0 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\u53c3\u8003\u6587\u737b         \u00a0 \u932f\u914d\u4fee\u5fa9\u5b8c\u6574 (pMMR) =\u00a0 Mismatch Repair proficient.         \u00a0 \u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\u00a0(MSI-H) =\u00a0 Microsatellite instability-high.         \u00a0\u00a0The Global Cancer Observatory,\u00a0World Fact Sheet. Accessed June 12, 2023.         \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023.         \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.         \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.         \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763.         Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.         \u00a0 \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=228468","og_locale":"zh_TW","og_type":"article","og_title":"\u4fe1\u9054\u751f\u7269\u8207\u548c\u9ec3\u91ab\u85e5\u5ba3\u4f48\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u592b\u594e\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5b50\u5bae\u5167\u819c\u764c\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u53d7\u7406\u4e26\u7372\u7d0d\u5165\u512a\u5148\u5be9\u8a55 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e744\u67082\u65e5 \/\u7f8e\u901a\u793e\/ -- 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\u53c3\u8003\u6587\u737b         \u00a0 \u932f\u914d\u4fee\u5fa9\u5b8c\u6574 (pMMR) =\u00a0 Mismatch Repair proficient.         \u00a0 \u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\u00a0(MSI-H) =\u00a0 Microsatellite instability-high.         \u00a0\u00a0The Global Cancer Observatory,\u00a0World Fact Sheet. Accessed June 12, 2023.         \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023.         \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.         \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.         \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763.         Wang J, Fei K, Jing H, et al. 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\u53c3\u8003\u6587\u737b \u00a0 \u932f\u914d\u4fee\u5fa9\u5b8c\u6574 (pMMR) =\u00a0 Mismatch Repair proficient. \u00a0 \u5fae\u885b\u661f\u9ad8\u5ea6\u4e0d\u7a69\u5b9a\u00a0(MSI-H) =\u00a0 Microsatellite instability-high. \u00a0\u00a0The Global Cancer Observatory,\u00a0World Fact Sheet. Accessed June 12, 2023. \u00a0\u00a0The Global Cancer Observatory,\u00a0China Fact Sheet. Accessed June 12, 2023. \u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0\u00a0J Clin Oncol.\u00a02023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613. \u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.\u00a0ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774. \u00a0 Siegel RL, et al. Cancer statistics, 2023.\u00a0CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763. Wang J, Fei K, Jing H, et al. 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