{"id":224802,"date":"2024-03-19T08:00:00","date_gmt":"2024-03-19T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=224802"},"modified":"2024-03-19T08:00:00","modified_gmt":"2024-03-19T00:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88ibi302%ef%bc%88%e6%8a%97vegf-%e8%a3%9c%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%96%b0%e7%94%9f%e8%a1%80%e7%ae%a1%e6%80%a7%e5%b9%b4%e9%bd%a1%e7%9b%b8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=224802","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI302\uff08\u6297VEGF\/\u88dc\u9ad4\uff09\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u7b2c\u4e8c\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e743\u670819\u65e5<\/span> <span>\/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u4eba\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-\u6297\u9ad4-\u4eba\u88dc\u9ad4\u53d7\u9ad41 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI302\uff09\u5728\u4e2d\u570b\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u7b2c\u4e8c\u9805IBI302 (\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002<\/span><\/p>\n<p><span>\u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85<\/span><span>360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002<\/span><\/p>\n<p><span>\u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728<\/span><span>nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002<\/span><\/p>\n<p><span>\u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c<\/span><span>40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002<\/span><\/p>\n<p><span>\u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c<\/span><span>40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002<\/span><\/p>\n<p><span>\u6b64\u5916\uff0c<\/span>6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09<span id=\"spanHghlt60b6\"><sup>[<\/sup><sup>1]<\/sup><\/span>\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA<span>\u8a66\u9a57<\/span><span>&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09<sup><span id=\"spanHghltc0aa\">[2]<\/span><\/sup>\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002<\/span><\/p>\n<p><span>\u7814\u7a76\u671f\u9593<\/span><span>IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e<\/span><span>2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002<\/span><\/p>\n<p><b><span>\u8a72\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u5b6b\u66c9\u6771\u6559\u6388<\/span><\/b><span>\u8868\u793a\uff1a\u300c\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04\u6297<\/span><span>VEGF\u985e\u85e5\u7269\u662f\u7576\u524d\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u983b\u7e41\u6ce8\u5c04\u3001\u96a8\u8a2a\u4e2d\u8996\u529b\u7372\u76ca\u9010\u6f38\u4e1f\u5931\u7b49\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u9577\u9593\u9694\u7d66\u85e5\u548c\u6297\u9ec3\u6591\u840e\u7e2e\u662f\u85e5\u7269\u7814\u767c\u7684\u65b0\u8da8\u52e2\u3002IBI302\u662f\u5168\u7403\u9996\u5275\u6297VEGF-\u6297\u88dc\u9ad4\u96d9\u9776\u9ede\u5206\u5b50\uff0c\u4f5c\u70baIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5291\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76ee\u6a19\u4e26\u5c55\u73fe\u51fa\u9577\u9593\u9694\u7d66\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u8207\u4f4e\u5291\u91cfIBI302\u7684II\u671f\u7d50\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u9a5a\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u9019\u4e9b\u7d50\u679c\u80fd\u9032\u4e00\u6b65\u5728IBI302\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5f97\u5230\u9a57\u8b49\uff0c\u70banAMD\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002\u300d<\/span><\/p>\n<p><b><span>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb<\/span><\/b><span>\u8868\u793a\uff1a\u300c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u548c\u6e1b\u5c11\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\uff0c\u662f\u76ee\u524d<\/span><span>nAMD\u85e5\u7269\u7814\u767c\u7684\u5169\u5927\u65b9\u5411\u8207\u8da8\u52e2\u3002\u5728\u5169\u9805\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7d50\u679c\u4e2d\uff0cIBI302\u5c55\u73fe\u51fa\u986f\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec3\u6591\u6c34\u816b\uff0c\u660e\u986f\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u4e14\u5177\u6709\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u767c\u751f\u7684\u6f5b\u529b\u3002\u63a5\u4e0b\u4f86\u6211\u5011\u5c07\u5728III\u671f\u81e8\u5e8a\u7814\u7a76STAR\u4e2d\u9032\u4e00\u6b65\u63a2\u7d22\u9ad8\u5291\u91cfIBI302\u9577\u9593\u9694\u7d66\u85e5\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7d66nAMD\u60a3\u8005\u5e36\u4f86\u65b0\u4e00\u4ee3\u6297VEGF\u85e5\u7269\u3002\u300d<\/span><\/p>\n<p class=\"prntaj\"><b><span>\u95dc\u65bc\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08<\/span><\/b><b><span>nAMD<\/span><\/b><b><span>\uff09<\/span><\/b><\/p>\n<p><span>\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08<\/span><span>AMD\uff09\u662f\u7d2f\u53ca\u9ec3\u6591\u5340\u8996\u7db2\u819c\uff0c\u5c0e\u81f4\u4e2d\u592e\u8996\u529b\u640d\u5bb3\u7684\u9032\u5c55\u6027\u773c\u90e8\u75be\u75c5\uff0c\u767c\u75c5\u7387\u96a8\u5e74\u9f61\u589e\u52a0\u800c\u5347\u9ad8\u3002\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u662fAMD\u7684\u4e3b\u8981\u985e\u578b\u4e4b\u4e00\uff0c\u5360\u6240\u6709AMD\u60a3\u8005\u768415%~20%\uff0c\u4e5f\u662f\u9020\u621065\u6b72\u4ee5\u4e0a\u7684AMD\u60a3\u8005\u4e2d\u5fc3\u8996\u529b\u55aa\u5931\u7684\u6700\u4e3b\u8981\u539f\u56e0<sup><span id=\"spanHghltc0aa\">[3]<\/span><\/sup>\u3002AMD\u5728\u6211\u570b\u767c\u75c5\u7387\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8da8\u52e2\uff0c\u73fe\u5df2\u8e8d\u5c45\u6211\u570b\u7b2c\u4e09\u5927\u81f4\u76f2\u539f\u56e0\u3002<\/span><\/p>\n<p><span>AMD\u7684\u75c5\u7406\u6a5f\u5236\u4e26\u6c92\u6709\u5b8c\u5168\u95e1\u660e\uff0c\u76ee\u524d\u666e\u904d\u8a8d\u53efVEGF\u8868\u9054\u589e\u52a0\u8a98\u5c0e\u7684\u8840\u7ba1\u65b0\u751f\u662fnAMD\u767c\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u88dc\u9ad4\u7570\u5e38\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u4e5f\u88ab\u8a8d\u70ba\u662fAMD\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u773c\u7528\u6297VEGF\u85e5\u7269\u5e36\u4f86\u4e86\u986f\u8457\u7684\u8996\u529b\u7372\u76ca\u4e26\u6539\u8b8a\u4e86nAMD\u7684\u75c5\u7a0b\uff0c\u4f46\u76ee\u524d\u983b\u7e41\u7684\u7d66\u85e5\uff08\u6bcf4\u5468\u62168\u9031\u4e00\u6b21\uff09\u7d66\u60a3\u8005\u3001\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u6b64\u5916\uff0c\u6297VEGF\u85e5\u7269\u6cbb\u7642\u7684\u8996\u529b\u7372\u76ca\u6703\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\u9010\u5e74\u4e1f\u5931\u3002\u5728\u7d042\/3\u7684\u96a8\u8a2a7\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u6297VEGF\u6cbb\u7642\u5e36\u4f86\u7684\u8996\u529b\u7372\u76ca\u6703\u5927\u5927\u55aa\u5931<sup><span id=\"spanHghltc0aa\">[4]<\/span><\/sup>\u3002\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u662f\u9577\u671f\u6297VEGF\u6cbb\u7642\u5f8c\u8996\u529b\u7372\u76ca\u4e1f\u5931\u7684\u91cd\u8981\u539f\u56e0\u3002\u76ee\u524d\u91dd\u5c0dnAMD\u7684\u85e5\u7269\u958b\u767c\u4e3b\u8981\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u91dd\u5c0d\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u7684\u5728\u7814\u85e5\u7269\u8f03\u5c11\u3002\u800c\u91dd\u5c0d\u5e72\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\u6240\u81f4\u7684\u5730\u5716\u6a23\u840e\u7e2e\uff0c\u5df2\u67092\u6b3e\u9776\u5411\u88dc\u9ad4\u7684\u85e5\u7269\u65bc2023\u5e74\u7372\u7f8e\u570bFDA\u6279\u51c6\u4e0a\u5e02<sup><span id=\"spanHghltc0aa\">[5,6]<\/span><\/sup>\u3002<\/span><\/p>\n<p class=\"prntaj\"><b><span>\u95dc<\/span><\/b><b><span>\u65bc<\/span><\/b><b><span>Efdamrofusp Alfa\uff08<\/span><\/b><b><span>IBI302<\/span><\/b><b><span>\uff09<\/span><\/b><\/p>\n<p><span>IBI302\u662f\u4fe1\u9054\u751f\u7269\u64c1\u6709\u5168\u7403\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u96d9\u7279\u7570\u6027\u91cd\u7d44\u5168\u4eba\u6e90\u878d\u5408\u86cb\u767d\u3002N\u7aef\u70baVEGF\u7d50\u5408\u57df\uff0c\u80fd\u5920\u8207VEGF\u5bb6\u65cf\u7d50\u5408\u963b\u65b7VEGF\u4ecb\u5c0e\u7684\u4fe1\u865f\u901a\u8def\uff0c\u6291\u5236\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u7684\u751f\u5b58\u3001\u589e\u6b96\uff0c\u5f9e\u800c\u6291\u5236\u8840\u7ba1\u65b0\u751f\uff0c\u964d\u4f4e\u8840\u7ba1\u6ef2\u900f\u6027\uff0c\u6e1b\u5c11\u8840\u7ba1\u6ef2\u6f0f\uff1bC\u7aef\u70ba\u88dc\u9ad4\u7d50\u5408\u57df\uff0c\u80fd\u5920\u901a\u904e\u7279\u7570\u6027\u7d50\u5408C3b\u548cC4b\uff0c\u6291\u5236\u88dc\u9ad4\u7d93\u5178\u9014\u5f91\u548c\u65c1\u8def\u9014\u7d93\u7684\u6fc0\u6d3b\uff0c\u6e1b\u8f15\u88dc\u9ad4\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u3002IBI302\u6f5b\u5728\u901a\u904e\u540c\u6642\u6291\u5236VEGF\u4ecb\u5c0e\u7684\u65b0\u751f\u8840\u7ba1\u751f\u6210\u548c\u88dc\u9ad4\u6d3b\u5316\u901a\u8def\uff0c\u767c\u63ee\u6cbb\u7642\u4f5c\u7528\u3002<\/span><\/p>\n<p class=\"prntaj\"><b><span>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/span><\/b><\/p>\n<p class=\"prntaj\"><span>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc<\/span><span>2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c5\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson\u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002 <\/span><\/p>\n<p class=\"prntaj\"><span>\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/span><\/p>\n<p class=\"prntaj\"><span>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<\/span><span>www.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/\u3002<\/span><\/p>\n<p><span>\u8072\u660e\uff1a<i>\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1<\/i><\/span><i><span>\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/span><\/i><\/p>\n<p class=\"prntaj\"><b><span>\u524d\u77bb\u6027\u8072\u660e<\/span><\/b><\/p>\n<p class=\"prntaj\"><span>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/span><\/p>\n<p class=\"prntaj\"><span>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/span><\/p>\n<p class=\"prntaj\"><span>\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prnsbtb0 prnrbrb0 prnsbbb0 prnsblb0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u00a0 \u00a0<a href=\"https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375<\/a><br \/>[2] \u00a0 \u00a0Heier, Jeffrey S et al. &#8220;Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.&#8221; Lancet (London, England) vol. 399,10326 (2022): 729-740.<br \/>[3] \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283.<br \/>[4] \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046.<br \/>[5] \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023.<br \/>[6] \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"prntaj\">\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-224802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI302\uff08\u6297VEGF\/\u88dc\u9ad4\uff09\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u7b2c\u4e8c\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u4eba\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-\u6297\u9ad4-\u4eba\u88dc\u9ad4\u53d7\u9ad41 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI302\uff09\u5728\u4e2d\u570b\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u7b2c\u4e8c\u9805IBI302 (\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002 \u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002 \u8a72\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u5b6b\u66c9\u6771\u6559\u6388\u8868\u793a\uff1a\u300c\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04\u6297VEGF\u985e\u85e5\u7269\u662f\u7576\u524d\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u983b\u7e41\u6ce8\u5c04\u3001\u96a8\u8a2a\u4e2d\u8996\u529b\u7372\u76ca\u9010\u6f38\u4e1f\u5931\u7b49\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u9577\u9593\u9694\u7d66\u85e5\u548c\u6297\u9ec3\u6591\u840e\u7e2e\u662f\u85e5\u7269\u7814\u767c\u7684\u65b0\u8da8\u52e2\u3002IBI302\u662f\u5168\u7403\u9996\u5275\u6297VEGF-\u6297\u88dc\u9ad4\u96d9\u9776\u9ede\u5206\u5b50\uff0c\u4f5c\u70baIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5291\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76ee\u6a19\u4e26\u5c55\u73fe\u51fa\u9577\u9593\u9694\u7d66\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u8207\u4f4e\u5291\u91cfIBI302\u7684II\u671f\u7d50\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u9a5a\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u9019\u4e9b\u7d50\u679c\u80fd\u9032\u4e00\u6b65\u5728IBI302\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5f97\u5230\u9a57\u8b49\uff0c\u70banAMD\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u548c\u6e1b\u5c11\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\uff0c\u662f\u76ee\u524dnAMD\u85e5\u7269\u7814\u767c\u7684\u5169\u5927\u65b9\u5411\u8207\u8da8\u52e2\u3002\u5728\u5169\u9805\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7d50\u679c\u4e2d\uff0cIBI302\u5c55\u73fe\u51fa\u986f\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec3\u6591\u6c34\u816b\uff0c\u660e\u986f\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u4e14\u5177\u6709\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u767c\u751f\u7684\u6f5b\u529b\u3002\u63a5\u4e0b\u4f86\u6211\u5011\u5c07\u5728III\u671f\u81e8\u5e8a\u7814\u7a76STAR\u4e2d\u9032\u4e00\u6b65\u63a2\u7d22\u9ad8\u5291\u91cfIBI302\u9577\u9593\u9694\u7d66\u85e5\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7d66nAMD\u60a3\u8005\u5e36\u4f86\u65b0\u4e00\u4ee3\u6297VEGF\u85e5\u7269\u3002\u300d 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\u95dc\u65bc\u4fe1\u9054\u751f\u7269 \u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c5\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson\u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002  \u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002 \u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/\u3002 \u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002 \u524d\u77bb\u6027\u8072\u660e 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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 \u53c3\u8003\u6587\u737b\uff1a   \u00a0 \u00a0https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. &quot;Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.&quot; Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.    \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=224802\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI302\uff08\u6297VEGF\/\u88dc\u9ad4\uff09\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u7b2c\u4e8c\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u4eba\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-\u6297\u9ad4-\u4eba\u88dc\u9ad4\u53d7\u9ad41 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI302\uff09\u5728\u4e2d\u570b\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u7b2c\u4e8c\u9805IBI302 (\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002 \u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002 \u8a72\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u5b6b\u66c9\u6771\u6559\u6388\u8868\u793a\uff1a\u300c\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04\u6297VEGF\u985e\u85e5\u7269\u662f\u7576\u524d\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u983b\u7e41\u6ce8\u5c04\u3001\u96a8\u8a2a\u4e2d\u8996\u529b\u7372\u76ca\u9010\u6f38\u4e1f\u5931\u7b49\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u9577\u9593\u9694\u7d66\u85e5\u548c\u6297\u9ec3\u6591\u840e\u7e2e\u662f\u85e5\u7269\u7814\u767c\u7684\u65b0\u8da8\u52e2\u3002IBI302\u662f\u5168\u7403\u9996\u5275\u6297VEGF-\u6297\u88dc\u9ad4\u96d9\u9776\u9ede\u5206\u5b50\uff0c\u4f5c\u70baIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5291\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76ee\u6a19\u4e26\u5c55\u73fe\u51fa\u9577\u9593\u9694\u7d66\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u8207\u4f4e\u5291\u91cfIBI302\u7684II\u671f\u7d50\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u9a5a\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u9019\u4e9b\u7d50\u679c\u80fd\u9032\u4e00\u6b65\u5728IBI302\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5f97\u5230\u9a57\u8b49\uff0c\u70banAMD\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u548c\u6e1b\u5c11\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\uff0c\u662f\u76ee\u524dnAMD\u85e5\u7269\u7814\u767c\u7684\u5169\u5927\u65b9\u5411\u8207\u8da8\u52e2\u3002\u5728\u5169\u9805\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7d50\u679c\u4e2d\uff0cIBI302\u5c55\u73fe\u51fa\u986f\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec3\u6591\u6c34\u816b\uff0c\u660e\u986f\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u4e14\u5177\u6709\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u767c\u751f\u7684\u6f5b\u529b\u3002\u63a5\u4e0b\u4f86\u6211\u5011\u5c07\u5728III\u671f\u81e8\u5e8a\u7814\u7a76STAR\u4e2d\u9032\u4e00\u6b65\u63a2\u7d22\u9ad8\u5291\u91cfIBI302\u9577\u9593\u9694\u7d66\u85e5\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7d66nAMD\u60a3\u8005\u5e36\u4f86\u65b0\u4e00\u4ee3\u6297VEGF\u85e5\u7269\u3002\u300d \u95dc\u65bc\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09 \u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08AMD\uff09\u662f\u7d2f\u53ca\u9ec3\u6591\u5340\u8996\u7db2\u819c\uff0c\u5c0e\u81f4\u4e2d\u592e\u8996\u529b\u640d\u5bb3\u7684\u9032\u5c55\u6027\u773c\u90e8\u75be\u75c5\uff0c\u767c\u75c5\u7387\u96a8\u5e74\u9f61\u589e\u52a0\u800c\u5347\u9ad8\u3002\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u662fAMD\u7684\u4e3b\u8981\u985e\u578b\u4e4b\u4e00\uff0c\u5360\u6240\u6709AMD\u60a3\u8005\u768415%~20%\uff0c\u4e5f\u662f\u9020\u621065\u6b72\u4ee5\u4e0a\u7684AMD\u60a3\u8005\u4e2d\u5fc3\u8996\u529b\u55aa\u5931\u7684\u6700\u4e3b\u8981\u539f\u56e0\u3002AMD\u5728\u6211\u570b\u767c\u75c5\u7387\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8da8\u52e2\uff0c\u73fe\u5df2\u8e8d\u5c45\u6211\u570b\u7b2c\u4e09\u5927\u81f4\u76f2\u539f\u56e0\u3002 AMD\u7684\u75c5\u7406\u6a5f\u5236\u4e26\u6c92\u6709\u5b8c\u5168\u95e1\u660e\uff0c\u76ee\u524d\u666e\u904d\u8a8d\u53efVEGF\u8868\u9054\u589e\u52a0\u8a98\u5c0e\u7684\u8840\u7ba1\u65b0\u751f\u662fnAMD\u767c\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u88dc\u9ad4\u7570\u5e38\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u4e5f\u88ab\u8a8d\u70ba\u662fAMD\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u773c\u7528\u6297VEGF\u85e5\u7269\u5e36\u4f86\u4e86\u986f\u8457\u7684\u8996\u529b\u7372\u76ca\u4e26\u6539\u8b8a\u4e86nAMD\u7684\u75c5\u7a0b\uff0c\u4f46\u76ee\u524d\u983b\u7e41\u7684\u7d66\u85e5\uff08\u6bcf4\u5468\u62168\u9031\u4e00\u6b21\uff09\u7d66\u60a3\u8005\u3001\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u6b64\u5916\uff0c\u6297VEGF\u85e5\u7269\u6cbb\u7642\u7684\u8996\u529b\u7372\u76ca\u6703\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\u9010\u5e74\u4e1f\u5931\u3002\u5728\u7d042\/3\u7684\u96a8\u8a2a7\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u6297VEGF\u6cbb\u7642\u5e36\u4f86\u7684\u8996\u529b\u7372\u76ca\u6703\u5927\u5927\u55aa\u5931\u3002\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u662f\u9577\u671f\u6297VEGF\u6cbb\u7642\u5f8c\u8996\u529b\u7372\u76ca\u4e1f\u5931\u7684\u91cd\u8981\u539f\u56e0\u3002\u76ee\u524d\u91dd\u5c0dnAMD\u7684\u85e5\u7269\u958b\u767c\u4e3b\u8981\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u91dd\u5c0d\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u7684\u5728\u7814\u85e5\u7269\u8f03\u5c11\u3002\u800c\u91dd\u5c0d\u5e72\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\u6240\u81f4\u7684\u5730\u5716\u6a23\u840e\u7e2e\uff0c\u5df2\u67092\u6b3e\u9776\u5411\u88dc\u9ad4\u7684\u85e5\u7269\u65bc2023\u5e74\u7372\u7f8e\u570bFDA\u6279\u51c6\u4e0a\u5e02\u3002 \u95dc\u65bcEfdamrofusp Alfa\uff08IBI302\uff09 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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 \u53c3\u8003\u6587\u737b\uff1a   \u00a0 \u00a0https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. &quot;Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.&quot; Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.    \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=224802\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-19T00:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" 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(\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002 \u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002 \u8a72\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u5b6b\u66c9\u6771\u6559\u6388\u8868\u793a\uff1a\u300c\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04\u6297VEGF\u985e\u85e5\u7269\u662f\u7576\u524d\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u983b\u7e41\u6ce8\u5c04\u3001\u96a8\u8a2a\u4e2d\u8996\u529b\u7372\u76ca\u9010\u6f38\u4e1f\u5931\u7b49\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u9577\u9593\u9694\u7d66\u85e5\u548c\u6297\u9ec3\u6591\u840e\u7e2e\u662f\u85e5\u7269\u7814\u767c\u7684\u65b0\u8da8\u52e2\u3002IBI302\u662f\u5168\u7403\u9996\u5275\u6297VEGF-\u6297\u88dc\u9ad4\u96d9\u9776\u9ede\u5206\u5b50\uff0c\u4f5c\u70baIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5291\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76ee\u6a19\u4e26\u5c55\u73fe\u51fa\u9577\u9593\u9694\u7d66\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u8207\u4f4e\u5291\u91cfIBI302\u7684II\u671f\u7d50\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u9a5a\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u9019\u4e9b\u7d50\u679c\u80fd\u9032\u4e00\u6b65\u5728IBI302\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5f97\u5230\u9a57\u8b49\uff0c\u70banAMD\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u548c\u6e1b\u5c11\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\uff0c\u662f\u76ee\u524dnAMD\u85e5\u7269\u7814\u767c\u7684\u5169\u5927\u65b9\u5411\u8207\u8da8\u52e2\u3002\u5728\u5169\u9805\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7d50\u679c\u4e2d\uff0cIBI302\u5c55\u73fe\u51fa\u986f\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec3\u6591\u6c34\u816b\uff0c\u660e\u986f\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u4e14\u5177\u6709\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u767c\u751f\u7684\u6f5b\u529b\u3002\u63a5\u4e0b\u4f86\u6211\u5011\u5c07\u5728III\u671f\u81e8\u5e8a\u7814\u7a76STAR\u4e2d\u9032\u4e00\u6b65\u63a2\u7d22\u9ad8\u5291\u91cfIBI302\u9577\u9593\u9694\u7d66\u85e5\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7d66nAMD\u60a3\u8005\u5e36\u4f86\u65b0\u4e00\u4ee3\u6297VEGF\u85e5\u7269\u3002\u300d \u95dc\u65bc\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09 \u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08AMD\uff09\u662f\u7d2f\u53ca\u9ec3\u6591\u5340\u8996\u7db2\u819c\uff0c\u5c0e\u81f4\u4e2d\u592e\u8996\u529b\u640d\u5bb3\u7684\u9032\u5c55\u6027\u773c\u90e8\u75be\u75c5\uff0c\u767c\u75c5\u7387\u96a8\u5e74\u9f61\u589e\u52a0\u800c\u5347\u9ad8\u3002\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u662fAMD\u7684\u4e3b\u8981\u985e\u578b\u4e4b\u4e00\uff0c\u5360\u6240\u6709AMD\u60a3\u8005\u768415%~20%\uff0c\u4e5f\u662f\u9020\u621065\u6b72\u4ee5\u4e0a\u7684AMD\u60a3\u8005\u4e2d\u5fc3\u8996\u529b\u55aa\u5931\u7684\u6700\u4e3b\u8981\u539f\u56e0\u3002AMD\u5728\u6211\u570b\u767c\u75c5\u7387\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8da8\u52e2\uff0c\u73fe\u5df2\u8e8d\u5c45\u6211\u570b\u7b2c\u4e09\u5927\u81f4\u76f2\u539f\u56e0\u3002 AMD\u7684\u75c5\u7406\u6a5f\u5236\u4e26\u6c92\u6709\u5b8c\u5168\u95e1\u660e\uff0c\u76ee\u524d\u666e\u904d\u8a8d\u53efVEGF\u8868\u9054\u589e\u52a0\u8a98\u5c0e\u7684\u8840\u7ba1\u65b0\u751f\u662fnAMD\u767c\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u88dc\u9ad4\u7570\u5e38\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u4e5f\u88ab\u8a8d\u70ba\u662fAMD\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u773c\u7528\u6297VEGF\u85e5\u7269\u5e36\u4f86\u4e86\u986f\u8457\u7684\u8996\u529b\u7372\u76ca\u4e26\u6539\u8b8a\u4e86nAMD\u7684\u75c5\u7a0b\uff0c\u4f46\u76ee\u524d\u983b\u7e41\u7684\u7d66\u85e5\uff08\u6bcf4\u5468\u62168\u9031\u4e00\u6b21\uff09\u7d66\u60a3\u8005\u3001\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u6b64\u5916\uff0c\u6297VEGF\u85e5\u7269\u6cbb\u7642\u7684\u8996\u529b\u7372\u76ca\u6703\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\u9010\u5e74\u4e1f\u5931\u3002\u5728\u7d042\\\/3\u7684\u96a8\u8a2a7\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u6297VEGF\u6cbb\u7642\u5e36\u4f86\u7684\u8996\u529b\u7372\u76ca\u6703\u5927\u5927\u55aa\u5931\u3002\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u662f\u9577\u671f\u6297VEGF\u6cbb\u7642\u5f8c\u8996\u529b\u7372\u76ca\u4e1f\u5931\u7684\u91cd\u8981\u539f\u56e0\u3002\u76ee\u524d\u91dd\u5c0dnAMD\u7684\u85e5\u7269\u958b\u767c\u4e3b\u8981\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u91dd\u5c0d\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u7684\u5728\u7814\u85e5\u7269\u8f03\u5c11\u3002\u800c\u91dd\u5c0d\u5e72\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\u6240\u81f4\u7684\u5730\u5716\u6a23\u840e\u7e2e\uff0c\u5df2\u67092\u6b3e\u9776\u5411\u88dc\u9ad4\u7684\u85e5\u7269\u65bc2023\u5e74\u7372\u7f8e\u570bFDA\u6279\u51c6\u4e0a\u5e02\u3002 \u95dc\u65bcEfdamrofusp Alfa\uff08IBI302\uff09 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\u53c3\u8003\u6587\u737b\uff1a \u00a0 \u00a0https:\\\/\\\/investor.regeneron.com\\\/static-files\\\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. \\\"Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.\\\" Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\\\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023. 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corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002 \u8a72\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb\u5b6b\u66c9\u6771\u6559\u6388\u8868\u793a\uff1a\u300c\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04\u6297VEGF\u985e\u85e5\u7269\u662f\u7576\u524d\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u4ecd\u5b58\u5728\u9700\u8981\u983b\u7e41\u6ce8\u5c04\u3001\u96a8\u8a2a\u4e2d\u8996\u529b\u7372\u76ca\u9010\u6f38\u4e1f\u5931\u7b49\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\uff0c\u63a2\u7d22\u9577\u9593\u9694\u7d66\u85e5\u548c\u6297\u9ec3\u6591\u840e\u7e2e\u662f\u85e5\u7269\u7814\u767c\u7684\u65b0\u8da8\u52e2\u3002IBI302\u662f\u5168\u7403\u9996\u5275\u6297VEGF-\u6297\u88dc\u9ad4\u96d9\u9776\u9ede\u5206\u5b50\uff0c\u4f5c\u70baIBI302\u7cfb\u5217\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6211\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\u9ad8\u5291\u91cfIBI302\u5728II\u671f\u7814\u7a76\u4e2d\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76ee\u6a19\u4e26\u5c55\u73fe\u51fa\u9577\u9593\u9694\u7d66\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u8207\u4f4e\u5291\u91cfIBI302\u7684II\u671f\u7d50\u679c\u4e00\u81f4\uff0c\u975e\u5e38\u4ee4\u4eba\u9a5a\u559c\u3002\u6211\u975e\u5e38\u671f\u5f85\u9019\u4e9b\u7d50\u679c\u80fd\u9032\u4e00\u6b65\u5728IBI302\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5f97\u5230\u9a57\u8b49\uff0c\u70banAMD\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u548c\u6e1b\u5c11\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\uff0c\u662f\u76ee\u524dnAMD\u85e5\u7269\u7814\u767c\u7684\u5169\u5927\u65b9\u5411\u8207\u8da8\u52e2\u3002\u5728\u5169\u9805\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u4e8c\u671f\u7814\u7a76\u7d50\u679c\u4e2d\uff0cIBI302\u5c55\u73fe\u51fa\u986f\u8457\u6539\u5584nAMD\u60a3\u8005\u7684BCVA\u548c\u9ec3\u6591\u6c34\u816b\uff0c\u660e\u986f\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u4e14\u5177\u6709\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u767c\u751f\u7684\u6f5b\u529b\u3002\u63a5\u4e0b\u4f86\u6211\u5011\u5c07\u5728III\u671f\u81e8\u5e8a\u7814\u7a76STAR\u4e2d\u9032\u4e00\u6b65\u63a2\u7d22\u9ad8\u5291\u91cfIBI302\u9577\u9593\u9694\u7d66\u85e5\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u671f\u5f85\u7d66nAMD\u60a3\u8005\u5e36\u4f86\u65b0\u4e00\u4ee3\u6297VEGF\u85e5\u7269\u3002\u300d \u95dc\u65bc\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09 \u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08AMD\uff09\u662f\u7d2f\u53ca\u9ec3\u6591\u5340\u8996\u7db2\u819c\uff0c\u5c0e\u81f4\u4e2d\u592e\u8996\u529b\u640d\u5bb3\u7684\u9032\u5c55\u6027\u773c\u90e8\u75be\u75c5\uff0c\u767c\u75c5\u7387\u96a8\u5e74\u9f61\u589e\u52a0\u800c\u5347\u9ad8\u3002\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u662fAMD\u7684\u4e3b\u8981\u985e\u578b\u4e4b\u4e00\uff0c\u5360\u6240\u6709AMD\u60a3\u8005\u768415%~20%\uff0c\u4e5f\u662f\u9020\u621065\u6b72\u4ee5\u4e0a\u7684AMD\u60a3\u8005\u4e2d\u5fc3\u8996\u529b\u55aa\u5931\u7684\u6700\u4e3b\u8981\u539f\u56e0\u3002AMD\u5728\u6211\u570b\u767c\u75c5\u7387\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8da8\u52e2\uff0c\u73fe\u5df2\u8e8d\u5c45\u6211\u570b\u7b2c\u4e09\u5927\u81f4\u76f2\u539f\u56e0\u3002 AMD\u7684\u75c5\u7406\u6a5f\u5236\u4e26\u6c92\u6709\u5b8c\u5168\u95e1\u660e\uff0c\u76ee\u524d\u666e\u904d\u8a8d\u53efVEGF\u8868\u9054\u589e\u52a0\u8a98\u5c0e\u7684\u8840\u7ba1\u65b0\u751f\u662fnAMD\u767c\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u88dc\u9ad4\u7570\u5e38\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u4e5f\u88ab\u8a8d\u70ba\u662fAMD\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u773c\u7528\u6297VEGF\u85e5\u7269\u5e36\u4f86\u4e86\u986f\u8457\u7684\u8996\u529b\u7372\u76ca\u4e26\u6539\u8b8a\u4e86nAMD\u7684\u75c5\u7a0b\uff0c\u4f46\u76ee\u524d\u983b\u7e41\u7684\u7d66\u85e5\uff08\u6bcf4\u5468\u62168\u9031\u4e00\u6b21\uff09\u7d66\u60a3\u8005\u3001\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u6b64\u5916\uff0c\u6297VEGF\u85e5\u7269\u6cbb\u7642\u7684\u8996\u529b\u7372\u76ca\u6703\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\u9010\u5e74\u4e1f\u5931\u3002\u5728\u7d042\/3\u7684\u96a8\u8a2a7\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u6297VEGF\u6cbb\u7642\u5e36\u4f86\u7684\u8996\u529b\u7372\u76ca\u6703\u5927\u5927\u55aa\u5931\u3002\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u662f\u9577\u671f\u6297VEGF\u6cbb\u7642\u5f8c\u8996\u529b\u7372\u76ca\u4e1f\u5931\u7684\u91cd\u8981\u539f\u56e0\u3002\u76ee\u524d\u91dd\u5c0dnAMD\u7684\u85e5\u7269\u958b\u767c\u4e3b\u8981\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0c\u91dd\u5c0d\u9ec3\u6591\u840e\u7e2e\u6216\u8996\u7db2\u819c\u7e96\u7dad\u5316\u7684\u5728\u7814\u85e5\u7269\u8f03\u5c11\u3002\u800c\u91dd\u5c0d\u5e72\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\u6240\u81f4\u7684\u5730\u5716\u6a23\u840e\u7e2e\uff0c\u5df2\u67092\u6b3e\u9776\u5411\u88dc\u9ad4\u7684\u85e5\u7269\u65bc2023\u5e74\u7372\u7f8e\u570bFDA\u6279\u51c6\u4e0a\u5e02\u3002 \u95dc\u65bcEfdamrofusp Alfa\uff08IBI302\uff09 IBI302\u662f\u4fe1\u9054\u751f\u7269\u64c1\u6709\u5168\u7403\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u96d9\u7279\u7570\u6027\u91cd\u7d44\u5168\u4eba\u6e90\u878d\u5408\u86cb\u767d\u3002N\u7aef\u70baVEGF\u7d50\u5408\u57df\uff0c\u80fd\u5920\u8207VEGF\u5bb6\u65cf\u7d50\u5408\u963b\u65b7VEGF\u4ecb\u5c0e\u7684\u4fe1\u865f\u901a\u8def\uff0c\u6291\u5236\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u7684\u751f\u5b58\u3001\u589e\u6b96\uff0c\u5f9e\u800c\u6291\u5236\u8840\u7ba1\u65b0\u751f\uff0c\u964d\u4f4e\u8840\u7ba1\u6ef2\u900f\u6027\uff0c\u6e1b\u5c11\u8840\u7ba1\u6ef2\u6f0f\uff1bC\u7aef\u70ba\u88dc\u9ad4\u7d50\u5408\u57df\uff0c\u80fd\u5920\u901a\u904e\u7279\u7570\u6027\u7d50\u5408C3b\u548cC4b\uff0c\u6291\u5236\u88dc\u9ad4\u7d93\u5178\u9014\u5f91\u548c\u65c1\u8def\u9014\u7d93\u7684\u6fc0\u6d3b\uff0c\u6e1b\u8f15\u88dc\u9ad4\u6d3b\u5316\u4ecb\u5c0e\u7684\u708e\u75c7\u53cd\u61c9\u3002IBI302\u6f5b\u5728\u901a\u904e\u540c\u6642\u6291\u5236VEGF\u4ecb\u5c0e\u7684\u65b0\u751f\u8840\u7ba1\u751f\u6210\u548c\u88dc\u9ad4\u6d3b\u5316\u901a\u8def\uff0c\u767c\u63ee\u6cbb\u7642\u4f5c\u7528\u3002 \u95dc\u65bc\u4fe1\u9054\u751f\u7269 \u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c5\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson\u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002  \u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002 \u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/\u3002 \u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 \u53c3\u8003\u6587\u737b\uff1a   \u00a0 \u00a0https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. \"Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.\" Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.    \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=224802","og_locale":"zh_TW","og_type":"article","og_title":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI302\uff08\u6297VEGF\/\u88dc\u9ad4\uff09\u6cbb\u7642\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08nAMD\uff09\u7684\u7b2c\u4e8c\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u4eba\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-\u6297\u9ad4-\u4eba\u88dc\u9ad4\u53d7\u9ad41 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI302\uff09\u5728\u4e2d\u570b\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u7b2c\u4e8c\u9805IBI302 (\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002 \u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u76f8\u4f3c\u3002IBI302\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u8a73\u7d30\u7814\u7a76\u6578\u64da\u5c07\u9032\u4e00\u6b65\u5206\u6790\u767c\u4f48\u3002 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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 \u53c3\u8003\u6587\u737b\uff1a   \u00a0 \u00a0https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. \"Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.\" Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. IZERVAY (avacincaptad pegol intravitreal solution).2023.    \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=224802","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-03-19T00:00:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 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- \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=224802#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=224802#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","datePublished":"2024-03-19T00:00:00+00:00","description":"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u4eba\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08VEGFR\uff09-\u6297\u9ad4-\u4eba\u88dc\u9ad4\u53d7\u9ad41 (CR1) \u878d\u5408\u86cb\u767dEfdamrofusp alfa\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI302\uff09\u5728\u4e2d\u570b\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08neovascular age-related macular degeneration, nAMD\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u7b2c\u4e8c\u9805IBI302 (\u9ad8\u5291\u91cf)\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002 \u5df2\u958b\u5c55\u7684\u5171\u5165\u7d44\u8d85360\u4f8b\u53d7\u8a66\u8005\u7684\u5169\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u63d0\u793a\uff0c\u76f8\u8f03\u963f\u67cf\u897f\u666e\uff0cIBI302\u53ef\u5728\u9577\u9593\u9694\u7d66\u85e5\uff083\u500b\u6708\u53ca\u4ee5\u4e0a\uff09\u4e0b\u5e36\u4f86\u7a69\u5b9a\u7684\u8996\u529b\u7372\u76ca\u548c\u89e3\u5256\u5b78\u7642\u6548\u6539\u5584\uff0c\u4e26\u89c0\u5bdf\u5230\u5c0d\u9ec3\u6591\u840e\u7e2e\u7684\u6f5b\u5728\u6539\u5584\u4f5c\u7528\u3002\u6b64\u524d\uff0c\u4fe1\u9054\u751f\u7269\u5df2\u65bc2023\u5e7410\u6708\u555f\u52d5\u4e86IBI302 8mg\u7528\u65bc\u6cbb\u7642nAMD\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u3002 \u672c\u6b21\u9054\u5230\u7d42\u9ede\u7684\u662f\u4e00\u9805\u5728nAMD\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u9577\u9593\u9694\u73bb\u7483\u9ad4\u8154\u6ce8\u5c04IBI302\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u6d3b\u6027\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05403749\uff09\u3002132\u4f8b\u53d7\u8a66\u8005\u4ee51:1:1\u96a8\u6a5f\u5206\u914d\u81f3IBI302 6.4 mg\u7d44\u3001IBI302 8.0mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0mg\u7d44\u3002IBI302 6.4 mg\u7d44\u548c8.0 mg\u7d44\u5728\u8ca0\u8377\u6cbb\u7642\u968e\u6bb5\u5f8c\u6839\u64da\u6cbb\u7642\u53cd\u61c9\u8abf\u6574\u81f3\u6bcf8\u5468\uff08Q8W\uff09\u6216\u6bcf12\u5468\uff08Q12W\uff09\u7d66\u85e51\u6b21\u3002\u963f\u67cf\u897f\u666e2.0mg\u7d44\u8ca0\u8377\u6cbb\u7642\u5f8c\uff0c\u6309\u7167Q8W\u6cbb\u7642\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u70ba\u5728\u7b2c40\u5468\u6642\uff0c\u7814\u7a76\u773c\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08best corrected visual acuity, BCVA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u3002\u7814\u7a76\u7e3d\u9031\u671f\u70ba52\u5468\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\u9806\u5229\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff1a\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u7814\u7a76\u773cBCVA\u8f03\u57fa\u7dda\u6539\u5584\u503c\u975e\u52a3\u6548\u65bc\u963f\u67cf\u897f\u666e2.0 mg\u7d44\u3002\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u3001IBI302 8.0 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2.0 mg\u7d44BCVA\u8f03\u57fa\u7dda\u63d0\u9ad8\u7684\u5747\u503c\u5206\u5225\u70ba10.5\u300111.0\u30019.8\u500bETDRS\u5b57\u6bcd\u6578\u3002 \u5728\u89e3\u5256\u5b78\u7642\u6548\u7d42\u9ede\u4e0a\uff0c\u7b2c40\u5468\u6642\uff0cIBI302 6.4 mg\u7d44\u82078.0 mg\u7d44\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08central subfield thickness, CST\uff09\u8f03\u57fa\u7dda\u6539\u5584\u7684\u5747\u503c\u5206\u5225\u70ba-163.19 \u03bcm\u3001-184.46 \u03bcm\uff0c\u963f\u67cf\u897f\u666e 2.0 mg\u7d44\u70ba-108.23 \u03bcm\u3002 \u6b64\u5916\uff0c6.4mg IBI302\u7d44\u82078.0mg IBI302\u7d44\u7dad\u6301Q12W\u7d66\u85e5\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba81%\u300188%\u3002\u9593\u63a5\u6bd4\u8f03\uff0c\u8207\u963f\u67cf\u897f\u666e 8.0 mg\uff08PULSAR\u8a66\u9a57\u70ba83%\uff09\u548c\u6cd5\u745e\u897f\u55ae\u6297\uff08TENAYA\u8a66\u9a57&amp;LUCERNE\u8a66\u9a57\u5206\u5225\u70ba79.7%\uff0c77.8%\uff09\u7684Q12W\u53ca\u4ee5\u4e0a\u9593\u9694\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u57fa\u65bcII\u671f\u4e2d\u512a\u7570\u7684\u9577\u9593\u9694\u7d66\u85e5\u6548\u679c\uff0c\u5728III\u671f\u81e8\u5e8a\u7814\u7a76\uff08STAR\uff09\u589e\u52a0\u4e86IBI302\u7dad\u6301Q16W\u7d66\u85e5\u9593\u9694\u7684\u6cbb\u7642\u968a\u5217\u3002 \u7814\u7a76\u671f\u9593IBI302\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u8207\u963f\u67cf\u897f\u666e2.0 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\u53c3\u8003\u6587\u737b\uff1a \u00a0 \u00a0https:\/\/investor.regeneron.com\/static-files\/e3307e7d-d495-438c-b8bb-c62cdacdb375 \u00a0 \u00a0Heier, Jeffrey S et al. \"Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.\" Lancet (London, England) vol. 399,10326 (2022): 729-740. \u00a0 \u00a0Sassa Y, Hata Y. Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor. Clinical Ophthalmology (Auckland, N.Z.). 2010;4:275-283. \u00a0 \u00a0Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292-2299. doi:10.1016\/j.ophtha.2013.03.046. \u00a0 \u00a0FDA. SYFOVRE(pegcetacoplan injection). 2023. \u00a0 \u00a0FDA. 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