{"id":222321,"date":"2024-03-07T10:11:00","date_gmt":"2024-03-07T02:11:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=222321"},"modified":"2024-03-07T10:11:00","modified_gmt":"2024-03-07T02:11:00","slug":"%e7%b6%a0%e8%91%89%e8%a3%bd%e8%97%a5%e5%89%b5%e6%96%b0%e8%97%a5zepzelca%e5%9c%a8%e9%a6%99%e6%b8%af%e5%92%8c%e6%be%b3%e9%96%80%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=222321","title":{"rendered":"\u7da0\u8449\u88fd\u85e5\u5275\u65b0\u85e5Zepzelca\u00ae\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02"},"content":{"rendered":"
\n

\u5c0f\u7d30\u80de\u80ba\u764c\u4e8c\u7dda\u6cbb\u7642\u8fce\u4f86\u65b0\u7a81\u7834<\/b><\/p>\n

\u9999\u6e2f\u548c\u6fb3\u9580<\/span>2024\u5e743\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0\u7531\u9999\u6e2f\u816b\u7624\u6cbb\u7642\u5b78\u6703\u4e3b\u8fa6\u3001\u7da0\u8449\u88fd\u85e5\u96c6\u5718\u652f\u6301\u7684\u300c\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u6cbb\u7642\u65b0\u6a21\u5f0f\u300d\u5b78\u8853\u7814\u8a0e\u6703\u65bc3\u67086\u65e5\u5728\u9999\u6e2f\u5713\u6eff\u53ec\u958b\u3002\u7da0\u8449\u88fd\u85e5\u5728\u6703\u4e0a\u5ba3\u4f48\uff1a\u6cbb\u7642\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u5275\u65b0\u85e5Zepzelca\u00ae<\/sup>\uff08lurbinectedin\uff09\u6b63\u5f0f\u5728\u4e2d\u570b\u9999\u6e2f\u5730\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u5730\u5340\u4e0a\u5e02\u3002<\/p>\n

\n

Zepzelca\u00ae(lurbinectedin)\u4e0a\u5e02\u5100\u5f0f<\/span><\/p>\n<\/p><\/div>\n

Lurbinectedin\u662f\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\uff0c\u65bc2023\u5e7411\u6708\u548c2023\u5e7412\u6708\u5206\u5225\u5728\u6fb3\u9580\u548c\u9999\u6e2f\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u5728\u542b\u9251\u985e\u5316\u7642\u904e\u7a0b\u4e2d\u6216\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027SCLC\u6210\u4eba\u60a3\u8005\u3002\u8a72\u85e5\u7269\u4ea6\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u6210\u70ba\u81ea1997\u5e74\u81f3\u4eca\u7684\u8fd127\u5e74\u4f86\u3001\u552f\u4e00\u7372\u5f97\u7f8e\u570bFDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002<\/p>\n

Lurbinectedin<\/b>\u6253\u7834<\/b>SCLC<\/b>\u4e8c\u7dda\u6cbb\u7642\u74f6\u9838<\/b><\/p>\n

SCLC\u662f\u6700\u5177\u4fb5\u8972\u6027\u7684\u80ba\u764c\u4e4b\u4e00\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u50c5\u70ba7%[1]<\/sup>\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7642\u5f8c\u51fa\u73fe\u8010\u85e5\u53ca\u5fa9\u767c\uff0c\u5728\u63a5\u53d7\u9032\u4e00\u6b65\u7684\u5316\u7642\u5f8cmOS\uff08\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff09\u50c5\u70ba4~5\u500b\u6708[2]<\/sup>\u3002<\/p>\n

\u300cSCLC\u662f\u60e1\u6027\u7a0b\u5ea6\u6700\u9ad8\u4e14\u6975\u6613\u5fa9\u767c\u7684\u4e00\u985e\u80ba\u764c\u4e9e\u578b\uff0c\u5176\u5fa9\u767c\u5f8c\u7684\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u548c\u751f\u5b58\u671f\u63d0\u5347\u5728\u904e\u5f8020\u591a\u5e74\u88e1\u5747\u7121\u5be6\u8cea\u9032\u5c55\uff0c\u300d\u6b64\u6b21\u7814\u8a0e\u6703\u7684\u5927\u6703\u4e3b\u5e2d\u3001\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u81e8\u5e8a\u816b\u7624\u5b78\u7cfb\u526f\u6559\u6388\u3001\u9999\u6e2f\u816b\u7624\u6cbb\u7642\u5b78\u6703\u7406\u4e8b\u6703\u6210\u54e1\u9f8d\u6d69\u92d2\u91ab\u751f\u6307\u51fa\uff1a\u300c\u6709\u5225\u65bc\u50b3\u7d71\u5316\u7642\u85e5\u7269\uff0clurbinectedin\u662f\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728SCLC\u4e2d\u5177\u6709\u986f\u8457\u6d3b\u6027\u3002\u6211\u5011\u671f\u5f85\u8a72\u6cbb\u7642\u65b9\u6848\u80fd\u5920\u6210\u70baSCLC\u4e8c\u7dda\u6cbb\u7642\u65b0\u6a19\u6e96\uff0c\u6539\u5584\u60a3\u8005\u7684\u751f\u5b58\u7372\u76ca\u3002\u300d<\/p>\n

\u81e8\u5e8a\u7814\u7a76\u63d0\u793a\u4e2d\u570b\u4eba\u7fa4\u7372\u76ca\u986f\u8457<\/b><\/p>\n

Lurbinectedin\u5728\u5305\u62ec\u7f8e\u570b\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u7b49\u570b\u5bb6\u548c\u5730\u5340\u7684\u7372\u6279\u4e3b\u8981\u57fa\u65bc\u5176\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2<\/sup>\u30011\u5c0f\u6642\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09105\u4f8b\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology<\/i>\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u63d0\u793a\uff1a\u63a5\u53d7lurbinectedin\u6cbb\u7642\u7684\u6240\u6709\u60a3\u8005ORR\uff08\u7e3d\u6709\u6548\u7387\uff09\u70ba35.2%\uff0cmDoR\uff08\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff09\u70ba5.3\u500b\u6708\uff0cmOS\u70ba9.3\u500b\u6708[3]<\/sup>\u3002<\/p>\n

\u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0clurbinectedin\u7684\u6578\u64da\u512a\u65bc\u7576\u524d\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e14\u5c0d\u65bc\u9251\u654f\u611f\u548c\u9251\u8010\u85e5\u7684SCLC\u60a3\u8005\u5747\u986f\u793a\u51fa\u826f\u597d\u7642\u6548\u3002\u300d\u897f\u73ed\u7259Gregorio Mara\u00f1\u00f3n\u5927\u5b78\u7d9c\u5408\u91ab\u9662\u91ab\u5b78\u816b\u7624\u79d1Antonio Calles\u91ab\u751f\u8868\u793a\uff1a\u300c\u9664\u4e86\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642\uff0c\u6211\u5011\u4e5f\u671f\u5f85\u8a72\u85e5\u5728\u806f\u5408\u5316\u7642\u3001\u514d\u75ab\u6cbb\u7642\u7b49\u806f\u7528\u7d44\u5408\u65b9\u9762\u62d3\u5bec\u61c9\u7528\u5ee3\u5ea6\uff0c\u767c\u63ee\u66f4\u5927\u7684\u6cbb\u7642\u50f9\u503c\u548c\u6f5b\u529b\u3002\u300d<\/p>\n

Lurbinectedin\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u2160\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767c\u6027SCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a\u63a5\u53d7lurbinectedin\u4e8c\u7dda\u6cbb\u7642\uff08FDA\u7372\u6279\u5291\u91cf\uff0c\u53733.2 mg\/m2<\/sup>, 1\u5c0f\u6642\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002<\/p>\n

\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u816b\u7624\u79d1\u4e3b\u4efb\u91ab\u5e2b\u8449\u5347\u6559\u6388\u5728\u6703\u4e0a\u6307\u51fa\uff1a\u300c\u8a72\u9805\u7814\u7a76\u5728\u4e2d\u570b\u4eba\u7fa4\u4e2d\u63a2\u7d22\u4e86lurbinectedin\u7684\u521d\u6b65\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u6211\u5011\u5f88\u9ad8\u8208\u5730\u770b\u5230\uff0cFDA\u7372\u6279\u5291\u91cf\u7684lurbinectedin\u5728\u4e00\u7dda\u542b\u9251\u5316\u7642\u51fa\u73fe\u9032\u5c55\u7684\u4e2d\u570b\u5fa9\u767cSCLC\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u570b\u5916\u2161\u671f\u7c43\u5b50\u8a66\u9a57SCLC\u968a\u5217\u7684\u7642\u6548\u7d50\u679c\u6709\u53ef\u6bd4\u6027\uff0c\u4e26\u50be\u5411\u65bc\u7372\u5f97\u66f4\u597d\u7684\u6709\u6548\u7387\u548c\u751f\u5b58\u671f\uff0c\u6709\u671b\u70ba\u4e2d\u570bSCLC\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n

\u7da0\u8449\u88fd\u85e5\u52a9\u63a8\u5275\u65b0\u85e5\u7269\u60e0\u53ca\u66f4\u591a\u60a3\u8005<\/b><\/p>\n

\u622a\u81f3\u76ee\u524d\uff0clurbinectedin\u5171\u5728\u5168\u740316\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u53ca\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316lurbinectedin\uff0c\u4ee5\u671f\u5c07\u9019\u4e00\u81e8\u5e8a\u6025\u9700\u7684\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u60e0\u53ca\u4e2d\u570b\u60a3\u8005\u3002\u8a72\u85e5\u9664\u5df2\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u5730\u5340\u7372\u6279\u4e0a\u5e02\u5916\uff0c\u9084\u5728\u4e2d\u570b\u5167\u5730\u8655\u65bc\u4e0a\u5e02\u5be9\u8a55\u968e\u6bb5\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u54c1\u7a2e\u540d\u55ae\u3002<\/p>\n

\u300c\u5fa9\u767cSCLC\u6b77\u7d9320\u591a\u5e74\u6cbb\u7642\u74f6\u9838\u5f8c\u8fce\u4f86\u91cd\u8981\u7a81\u7834\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u4e45\u9055\u7684\u5e0c\u671b\uff0c\u6539\u5584\u5176\u81e8\u5e8a\u7372\u76ca\u3002\u96a8\u8457lurbinectedin\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u7684\u4e0a\u5e02\uff0c\u6211\u5011\u4e5f\u5728\u8207\u591a\u65b9\u7a4d\u6975\u5354\u4f5c\uff0c\u5171\u540c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u6211\u5011\u5e0c\u671b\u80fd\u5920\u5e6b\u52a9\u5230\u66f4\u591a\u60a3\u8005\u53ca\u6642\u7372\u76ca\u65bc\u9019\u4e00\u6cbb\u7642\u65b9\u6848\uff0c\u7372\u5f97\u66f4\u591a\u751f\u5b58\u6a5f\u6703\uff0c\u6e1b\u8f15\u5176\u6cbb\u7642\u8ca0\u64d4\u3002\u300d\u7da0\u8449\u88fd\u85e5\uff08\u570b\u969b\uff09\u4e9e\u592a\u5340\u526f\u7e3d\u88c1Andy Siow\u8868\u793a\u3002<\/span><\/p>\n

\u95dc\u65bc<\/u><\/b>Zepzelca<\/u><\/b>\u00ae<\/sup><\/u><\/b>(lurbinectedin)<\/u><\/b><\/p>\n

Zepzelca\u00ae<\/sup>\uff08lurbinectedin\uff09\u662f\u5f9e\u6d77\u9798Ecteinascidia turbinata<\/i>\u4e2d\u5206\u96e2\u51fa\u7684\u6d77\u6d0b\u5316\u5408\u7269ET-736\u7684\u884d\u751f\u7269\uff0cET-736\u4e2d\u7684\u6c2b\u539f\u5b50\u88ab\u7532\u6c27\u57fa\u53d6\u4ee3\u3002Lurbinectedin\u80fd\u5920\u9078\u64c7\u6027\u5730\u6291\u5236\u591a\u7a2e\u816b\u7624\u6240\u4f9d\u8cf4\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u3002\u9664\u4e86\u5176\u5c0d\u764c\u7d30\u80de\u7684\u76f4\u63a5\u4f5c\u7528\uff0clurbinectedin\u9084\u53ef\u4ee5\u9078\u64c7\u6027\u6291\u5236\u67d0\u4e9b\u4f86\u6e90\u65bc\u816b\u7624\u76f8\u95dc\u5de8\u566c\u7d30\u80de\u7684\u7d30\u80de\u56e0\u5b50\u7684\u8f49\u9304\u548c\u5206\u6ccc\uff0c\u5f9e\u800c\u5c0d\u816b\u7624\u5fae\u74b0\u5883\u7522\u751f\u986f\u8457\u5f71\u97ff\u3002<\/p>\n

\u7576\u524d\uff0clurbinectedin\u5df2\u7372\u5f97\u591a\u9805\u81e8\u5e8a\u6307\u5357\u7684\u63a8\u85a6\uff0c\u5176\u4e2d\u5305\u62ec\uff1a\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff082024.V2\uff09\u300b[4]<\/sup>\u63a8\u85a6\uff0c\u4f5c\u70ba\u7121\u5316\u7642\u9593\u9694\uff08CTFI\uff09\u22646\u500b\u6708\u5fa9\u767cSCLC\u60a3\u8005\u7684\u9996\u9078\u65b9\u6848\uff1b\u4e26\u53d7\u5230\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b[5]<\/sup>\uff082021\u5e74\u767c\u4f48\uff09\u3001\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023\u300b[2]<\/sup>\u63a8\u85a6\u7528\u65bc\u5fa9\u767cSCLC\u6cbb\u7642\u3002<\/p>\n

\u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718<\/u><\/b><\/p>\n

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\n\n\n\n\n\n\n\n
\n

[1] The data of lung cancer patients’ survival rates on the website of American Cancer Society (https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html<\/a>), accessed in March 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2]\u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3]\u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4]\u00a0NCCN Clinical Practice Guidelines in Oncology – Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462<\/a>), accessed in March, 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[5]\u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed<\/a>\u00a0in March, 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u00a0<\/p>\n

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turbinata\u4e2d\u5206\u96e2\u51fa\u7684\u6d77\u6d0b\u5316\u5408\u7269ET-736\u7684\u884d\u751f\u7269\uff0cET-736\u4e2d\u7684\u6c2b\u539f\u5b50\u88ab\u7532\u6c27\u57fa\u53d6\u4ee3\u3002Lurbinectedin\u80fd\u5920\u9078\u64c7\u6027\u5730\u6291\u5236\u591a\u7a2e\u816b\u7624\u6240\u4f9d\u8cf4\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u3002\u9664\u4e86\u5176\u5c0d\u764c\u7d30\u80de\u7684\u76f4\u63a5\u4f5c\u7528\uff0clurbinectedin\u9084\u53ef\u4ee5\u9078\u64c7\u6027\u6291\u5236\u67d0\u4e9b\u4f86\u6e90\u65bc\u816b\u7624\u76f8\u95dc\u5de8\u566c\u7d30\u80de\u7684\u7d30\u80de\u56e0\u5b50\u7684\u8f49\u9304\u548c\u5206\u6ccc\uff0c\u5f9e\u800c\u5c0d\u816b\u7624\u5fae\u74b0\u5883\u7522\u751f\u986f\u8457\u5f71\u97ff\u3002 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\u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 The data of lung cancer patients' survival rates on the website of American Cancer Society (https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed\u00a0in March, 2024. \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=222321\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u7da0\u8449\u88fd\u85e5\u5275\u65b0\u85e5Zepzelca\u00ae\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" 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Lurbinectedin\u662f\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\uff0c\u65bc2023\u5e7411\u6708\u548c2023\u5e7412\u6708\u5206\u5225\u5728\u6fb3\u9580\u548c\u9999\u6e2f\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u5728\u542b\u9251\u985e\u5316\u7642\u904e\u7a0b\u4e2d\u6216\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684\u8f49\u79fb\u6027SCLC\u6210\u4eba\u60a3\u8005\u3002\u8a72\u85e5\u7269\u4ea6\u65bc2020\u5e74\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9644\u689d\u4ef6\u6279\u51c6\uff0c\u6210\u70ba\u81ea1997\u5e74\u81f3\u4eca\u7684\u8fd127\u5e74\u4f86\u3001\u552f\u4e00\u7372\u5f97\u7f8e\u570bFDA\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u5fa9\u767cSCLC\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\u3002 Lurbinectedin\u6253\u7834SCLC\u4e8c\u7dda\u6cbb\u7642\u74f6\u9838 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\u300cSCLC\u662f\u60e1\u6027\u7a0b\u5ea6\u6700\u9ad8\u4e14\u6975\u6613\u5fa9\u767c\u7684\u4e00\u985e\u80ba\u764c\u4e9e\u578b\uff0c\u5176\u5fa9\u767c\u5f8c\u7684\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u548c\u751f\u5b58\u671f\u63d0\u5347\u5728\u904e\u5f8020\u591a\u5e74\u88e1\u5747\u7121\u5be6\u8cea\u9032\u5c55\uff0c\u300d\u6b64\u6b21\u7814\u8a0e\u6703\u7684\u5927\u6703\u4e3b\u5e2d\u3001\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u81e8\u5e8a\u816b\u7624\u5b78\u7cfb\u526f\u6559\u6388\u3001\u9999\u6e2f\u816b\u7624\u6cbb\u7642\u5b78\u6703\u7406\u4e8b\u6703\u6210\u54e1\u9f8d\u6d69\u92d2\u91ab\u751f\u6307\u51fa\uff1a\u300c\u6709\u5225\u65bc\u50b3\u7d71\u5316\u7642\u85e5\u7269\uff0clurbinectedin\u662f\u9078\u64c7\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u6291\u5236\u5291\uff0c\u5728SCLC\u4e2d\u5177\u6709\u986f\u8457\u6d3b\u6027\u3002\u6211\u5011\u671f\u5f85\u8a72\u6cbb\u7642\u65b9\u6848\u80fd\u5920\u6210\u70baSCLC\u4e8c\u7dda\u6cbb\u7642\u65b0\u6a19\u6e96\uff0c\u6539\u5584\u60a3\u8005\u7684\u751f\u5b58\u7372\u76ca\u3002\u300d \u81e8\u5e8a\u7814\u7a76\u63d0\u793a\u4e2d\u570b\u4eba\u7fa4\u7372\u76ca\u986f\u8457 Lurbinectedin\u5728\u5305\u62ec\u7f8e\u570b\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u7b49\u570b\u5bb6\u548c\u5730\u5340\u7684\u7372\u6279\u4e3b\u8981\u57fa\u65bc\u5176\u55ae\u85e5\u6cbb\u7642\uff083.2mg\/m2\u30011\u5c0f\u6642\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09105\u4f8b\u63a5\u53d7\u9251\u985e\u85e5\u7269\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684SCLC\u6210\u4eba\u60a3\u8005\uff08\u5305\u62ec\u9251\u985e\u654f\u611f\u548c\u8010\u85e5\u60a3\u8005\uff09\u7684\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u55ae\u81c2\u7814\u7a76\uff08\u2161\u671f\u7c43\u5b50\u8a66\u9a57\uff09\u3002\u8a72\u8a66\u9a57\u7814\u7a76\u7d50\u679c\u4ea6\u767c\u8868\u65bcThe Lancet Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u63d0\u793a\uff1a\u63a5\u53d7lurbinectedin\u6cbb\u7642\u7684\u6240\u6709\u60a3\u8005ORR\uff08\u7e3d\u6709\u6548\u7387\uff09\u70ba35.2%\uff0cmDoR\uff08\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff09\u70ba5.3\u500b\u6708\uff0cmOS\u70ba9.3\u500b\u6708\u3002 \u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0clurbinectedin\u7684\u6578\u64da\u512a\u65bc\u7576\u524d\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e14\u5c0d\u65bc\u9251\u654f\u611f\u548c\u9251\u8010\u85e5\u7684SCLC\u60a3\u8005\u5747\u986f\u793a\u51fa\u826f\u597d\u7642\u6548\u3002\u300d\u897f\u73ed\u7259Gregorio Mara\u00f1\u00f3n\u5927\u5b78\u7d9c\u5408\u91ab\u9662\u91ab\u5b78\u816b\u7624\u79d1Antonio Calles\u91ab\u751f\u8868\u793a\uff1a\u300c\u9664\u4e86\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642\uff0c\u6211\u5011\u4e5f\u671f\u5f85\u8a72\u85e5\u5728\u806f\u5408\u5316\u7642\u3001\u514d\u75ab\u6cbb\u7642\u7b49\u806f\u7528\u7d44\u5408\u65b9\u9762\u62d3\u5bec\u61c9\u7528\u5ee3\u5ea6\uff0c\u767c\u63ee\u66f4\u5927\u7684\u6cbb\u7642\u50f9\u503c\u548c\u6f5b\u529b\u3002\u300d Lurbinectedin\u4ea6\u91dd\u5c0d\u4e2d\u570b\u4eba\u7fa4\u958b\u5c55\u4e86\u4e00\u9805\u55ae\u81c2\u3001\u5305\u542b\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7684\u2160\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u8a72\u85e5\u5728\u5305\u62ec\u5fa9\u767c\u6027SCLC\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u570b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u7279\u5fb5\u548c\u521d\u6b65\u7642\u6548\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a\u63a5\u53d7lurbinectedin\u4e8c\u7dda\u6cbb\u7642\uff08FDA\u7372\u6279\u5291\u91cf\uff0c\u53733.2 mg\/m2, 1\u5c0f\u6642\u975c\u8108\u8f38\u6ce8\u3001\u6bcf3\u54681\u6b21\uff09SCLC\u7684ORR\u70ba45.5%\u3001mDoR\u70ba4.2\u500b\u6708\u3001mOS\u70ba11.0\u500b\u6708\u3002 \u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u816b\u7624\u79d1\u4e3b\u4efb\u91ab\u5e2b\u8449\u5347\u6559\u6388\u5728\u6703\u4e0a\u6307\u51fa\uff1a\u300c\u8a72\u9805\u7814\u7a76\u5728\u4e2d\u570b\u4eba\u7fa4\u4e2d\u63a2\u7d22\u4e86lurbinectedin\u7684\u521d\u6b65\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u6211\u5011\u5f88\u9ad8\u8208\u5730\u770b\u5230\uff0cFDA\u7372\u6279\u5291\u91cf\u7684lurbinectedin\u5728\u4e00\u7dda\u542b\u9251\u5316\u7642\u51fa\u73fe\u9032\u5c55\u7684\u4e2d\u570b\u5fa9\u767cSCLC\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u570b\u5916\u2161\u671f\u7c43\u5b50\u8a66\u9a57SCLC\u968a\u5217\u7684\u7642\u6548\u7d50\u679c\u6709\u53ef\u6bd4\u6027\uff0c\u4e26\u50be\u5411\u65bc\u7372\u5f97\u66f4\u597d\u7684\u6709\u6548\u7387\u548c\u751f\u5b58\u671f\uff0c\u6709\u671b\u70ba\u4e2d\u570bSCLC\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d \u7da0\u8449\u88fd\u85e5\u52a9\u63a8\u5275\u65b0\u85e5\u7269\u60e0\u53ca\u66f4\u591a\u60a3\u8005 \u622a\u81f3\u76ee\u524d\uff0clurbinectedin\u5171\u5728\u5168\u740316\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u7da0\u8449\u88fd\u85e5\u7372\u6b0a\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u53ca\u6fb3\u9580\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316lurbinectedin\uff0c\u4ee5\u671f\u5c07\u9019\u4e00\u81e8\u5e8a\u6025\u9700\u7684\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u60e0\u53ca\u4e2d\u570b\u60a3\u8005\u3002\u8a72\u85e5\u9664\u5df2\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u5730\u5340\u7372\u6279\u4e0a\u5e02\u5916\uff0c\u9084\u5728\u4e2d\u570b\u5167\u5730\u8655\u65bc\u4e0a\u5e02\u5be9\u8a55\u968e\u6bb5\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u54c1\u7a2e\u540d\u55ae\u3002 \u300c\u5fa9\u767cSCLC\u6b77\u7d9320\u591a\u5e74\u6cbb\u7642\u74f6\u9838\u5f8c\u8fce\u4f86\u91cd\u8981\u7a81\u7834\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u4e45\u9055\u7684\u5e0c\u671b\uff0c\u6539\u5584\u5176\u81e8\u5e8a\u7372\u76ca\u3002\u96a8\u8457lurbinectedin\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u7684\u4e0a\u5e02\uff0c\u6211\u5011\u4e5f\u5728\u8207\u591a\u65b9\u7a4d\u6975\u5354\u4f5c\uff0c\u5171\u540c\u63d0\u5347\u60a3\u8005\u7684\u7528\u85e5\u53ef\u53ca\u6027\u3002\u6211\u5011\u5e0c\u671b\u80fd\u5920\u5e6b\u52a9\u5230\u66f4\u591a\u60a3\u8005\u53ca\u6642\u7372\u76ca\u65bc\u9019\u4e00\u6cbb\u7642\u65b9\u6848\uff0c\u7372\u5f97\u66f4\u591a\u751f\u5b58\u6a5f\u6703\uff0c\u6e1b\u8f15\u5176\u6cbb\u7642\u8ca0\u64d4\u3002\u300d\u7da0\u8449\u88fd\u85e5\uff08\u570b\u969b\uff09\u4e9e\u592a\u5340\u526f\u7e3d\u88c1Andy Siow\u8868\u793a\u3002 \u95dc\u65bcZepzelca\u00ae(lurbinectedin) Zepzelca\u00ae\uff08lurbinectedin\uff09\u662f\u5f9e\u6d77\u9798Ecteinascidia turbinata\u4e2d\u5206\u96e2\u51fa\u7684\u6d77\u6d0b\u5316\u5408\u7269ET-736\u7684\u884d\u751f\u7269\uff0cET-736\u4e2d\u7684\u6c2b\u539f\u5b50\u88ab\u7532\u6c27\u57fa\u53d6\u4ee3\u3002Lurbinectedin\u80fd\u5920\u9078\u64c7\u6027\u5730\u6291\u5236\u591a\u7a2e\u816b\u7624\u6240\u4f9d\u8cf4\u7684\u81f4\u764c\u57fa\u56e0\u8f49\u9304\u3002\u9664\u4e86\u5176\u5c0d\u764c\u7d30\u80de\u7684\u76f4\u63a5\u4f5c\u7528\uff0clurbinectedin\u9084\u53ef\u4ee5\u9078\u64c7\u6027\u6291\u5236\u67d0\u4e9b\u4f86\u6e90\u65bc\u816b\u7624\u76f8\u95dc\u5de8\u566c\u7d30\u80de\u7684\u7d30\u80de\u56e0\u5b50\u7684\u8f49\u9304\u548c\u5206\u6ccc\uff0c\u5f9e\u800c\u5c0d\u816b\u7624\u5fae\u74b0\u5883\u7522\u751f\u986f\u8457\u5f71\u97ff\u3002 \u7576\u524d\uff0clurbinectedin\u5df2\u7372\u5f97\u591a\u9805\u81e8\u5e8a\u6307\u5357\u7684\u63a8\u85a6\uff0c\u5176\u4e2d\u5305\u62ec\uff1a\u5df2\u7372\u5f97\u300aNCCN\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff082024.V2\uff09\u300b\u63a8\u85a6\uff0c\u4f5c\u70ba\u7121\u5316\u7642\u9593\u9694\uff08CTFI\uff09\u22646\u500b\u6708\u5fa9\u767cSCLC\u60a3\u8005\u7684\u9996\u9078\u65b9\u6848\uff1b\u4e26\u53d7\u5230\u300aESMO\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u300b\uff082021\u5e74\u767c\u4f48\uff09\u3001\u300aCSCO\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023\u300b\u63a8\u85a6\u7528\u65bc\u5fa9\u767cSCLC\u6cbb\u7642\u3002 \u95dc\u65bc\u7da0\u8449\u88fd\u85e5\u96c6\u5718 \u7da0\u8449\u88fd\u85e5\u96c6\u5718\u662f\u81f4\u529b\u65bc\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u7684\u570b\u969b\u5316\u88fd\u85e5\u516c\u53f8\u3002\u7da0\u8449\u88fd\u85e5\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u8a2d\u6709\u7814\u767c\u4e2d\u5fc3\uff0c\u64c1\u6709\u8d85\u904e30\u500b\u4e2d\u570b\u5728\u7814\u85e5\u7269\u548c10\u591a\u500b\u6d77\u5916\u5728\u7814\u85e5\u7269\u3002\u7da0\u8449\u88fd\u85e5\u5728\u5fae\u7403\u3001\u8102\u8cea\u9ad4\u3001\u900f\u76ae\u91cb\u85e5\u7b49\u5148\u9032\u85e5\u7269\u905e\u9001\u6280\u8853\u9818\u57df\u9054\u5230\u570b\u969b\u5148\u9032\u6c34\u5e73\uff0c\u5728\u65b0\u5206\u5b50\u5be6\u9ad4\u3001\u751f\u7269\u6297\u9ad4\u9818\u57df\u6536\u7a6b\u591a\u9805\u5275\u65b0\u6210\u679c\uff0c\u4e26\u5728\u7d30\u80de\u6cbb\u7642\u3001\u57fa\u56e0\u6cbb\u7642\u7b49\u9818\u57df\u9032\u884c\u4e86\u7a4d\u6975\u4f48\u5c40\u548c\u958b\u767c\u3002 \u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 The data of lung cancer patients' survival rates on the website of American Cancer Society (https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed\u00a0in March, 2024. \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=222321\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-07T02:11:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/03\/Zepzelca__lurbinectedin.jpg\" 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(https:\\\/\\\/www.cancer.org\\\/cancer\\\/types\\\/lung-cancer\\\/detection-diagnosis-staging\\\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\\\/\\\/www.nccn.org\\\/guidelines\\\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\\\/\\\/www.esmo.org\\\/guidelines\\\/guidelines-by-topic\\\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\\\/small-cell-lung-cancer), accessed\u00a0in March, 2024. 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\u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 The data of lung cancer patients' survival rates on the website of American Cancer Society (https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed\u00a0in March, 2024. \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=222321","og_locale":"zh_TW","og_type":"article","og_title":"\u7da0\u8449\u88fd\u85e5\u5275\u65b0\u85e5Zepzelca\u00ae\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02 - 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\u7da0\u8449\u88fd\u85e5\u6df1\u5ea6\u4f48\u5c40\u5168\u7403\u4f9b\u61c9\u93c8\u9ad4\u7cfb\uff0c\u5df2\u5728\u5168\u7403\u5efa\u67098\u5927\u751f\u7522\u57fa\u5730\uff0c\u8d85\u904e30\u689d\u751f\u7522\u7dda\uff0c\u4e26\u5efa\u7acb\u4e86\u8207\u570b\u969b\u63a5\u8ecc\u7684GMP\u8cea\u91cf\u7ba1\u7406\u548c\u63a7\u5236\u9ad4\u7cfb\u3002\u516c\u53f8\u73fe\u670930\u9918\u500b\u4e0a\u5e02\u7522\u54c1\uff0c\u7522\u54c1\u8986\u84cb\u816b\u7624\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3001\u5fc3\u8840\u7ba1\u3001\u6d88\u5316\u8207\u4ee3\u8b1d\u7b49\u6cbb\u7642\u9818\u57df\uff1b\u696d\u52d9\u904d\u53ca\u5168\u740380\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c\u7b49\u5168\u7403\u4e3b\u8981\u91ab\u85e5\u5e02\u5834\uff0c\u4ee5\u53ca\u9ad8\u901f\u589e\u9577\u7684\u5404\u5730\u65b0\u8208\u5e02\u5834\u3002 The data of lung cancer patients' survival rates on the website of American Cancer Society (https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed\u00a0in March, 2024. 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Oncology\uff08\u300a\u67f3\u8449\u5200-\u816b\u7624\u5b78\u300b\uff09\u5b78\u8853\u671f\u520a\uff0c\u63d0\u793a\uff1a\u63a5\u53d7lurbinectedin\u6cbb\u7642\u7684\u6240\u6709\u60a3\u8005ORR\uff08\u7e3d\u6709\u6548\u7387\uff09\u70ba35.2%\uff0cmDoR\uff08\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff09\u70ba5.3\u500b\u6708\uff0cmOS\u70ba9.3\u500b\u6708\u3002 \u300c\u5728\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u65b9\u9762\uff0clurbinectedin\u7684\u6578\u64da\u512a\u65bc\u7576\u524d\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u7684\u6b77\u53f2\u6578\u64da\uff0c\u4e14\u5c0d\u65bc\u9251\u654f\u611f\u548c\u9251\u8010\u85e5\u7684SCLC\u60a3\u8005\u5747\u986f\u793a\u51fa\u826f\u597d\u7642\u6548\u3002\u300d\u897f\u73ed\u7259Gregorio Mara\u00f1\u00f3n\u5927\u5b78\u7d9c\u5408\u91ab\u9662\u91ab\u5b78\u816b\u7624\u79d1Antonio 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(https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html), accessed in March 2024. \u00a0\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u6307\u5357\u5de5\u4f5c\u59d4\u54e1\u6703. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u53572023. \u4eba\u6c11\u885b\u751f\u51fa\u7248\u793e. 2023 \u00a0Trigo J, et al. Lancet Oncol. 2020; 21:645-54 \u00a0NCCN Clinical Practice Guidelines in Oncology - Small Cell Lung Cancer (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1462), accessed in March, 2024. \u00a0Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\uff1a(https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/small-cell-lung-cancer), accessed\u00a0in March, 2024. \u00a0","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=222321#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=222321"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=222321#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/03\/Zepzelca__lurbinectedin.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2024\/03\/Zepzelca__lurbinectedin.jpg","width":400,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=222321#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u7da0\u8449\u88fd\u85e5\u5275\u65b0\u85e5Zepzelca\u00ae\u5728\u9999\u6e2f\u548c\u6fb3\u9580\u4e0a\u5e02"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/222321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=222321"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/222321\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/222322"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=222321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=222321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=222321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}