{"id":221057,"date":"2024-03-01T08:00:00","date_gmt":"2024-03-01T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=221057"},"modified":"2024-03-01T08:00:00","modified_gmt":"2024-03-01T00:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88ibi3002%ef%bc%88%e6%8a%97il-4r%ce%b1-tslp%e9%9b%99%e7%89%b9%e7%95%b0%e6%80%a7%e6%8a%97%e9%ab%94%ef%bc%89%e8%87%a8%e5%ba%8ai%e6%9c%9f%e7%a0%94","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=221057","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI3002\uff08\u6297IL-4R\u03b1\/TSLP\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff09\u81e8\u5e8aI\u671f\u7814\u7a76\u5728\u6fb3\u5927\u5229\u4e9e\u5b8c\u6210\u9996\u4f8b\u53d7\u8a66\u8005\u7d66\u85e5"},"content":{"rendered":"
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\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e743\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48IBI3002\u7684\u9996\u6b21\u4eba\u9ad4\uff08FIH\uff09\u81e8\u5e8aI\u671f\u7814\u7a76\u5df2\u5728\u6fb3\u5927\u5229\u4e9e\u5b8c\u6210\u9996\u4f8b\u53d7\u8a66\u8005\u7d66\u85e5\u3002IBI3002\u662f\u4e00\u7a2e\u5168\u7403\u9996\u5275\uff08first-in-class\uff09\u7684\u9776\u5411\u767d\u7d30\u80de\u4ecb\u7d204\u53d7\u9ad4\u03b1\uff08IL-4R\u03b1\uff09\u548c\u80f8\u817a\u57fa\u8cea\u6dcb\u5df4\u7d30\u80de\u751f\u6210\u7d20\uff08TSLP\uff09\u7684\u96d9\u7279\u7570\u6027\u6297\u9ad4\u3002<\/p>\n

\u672c\u9805FIH\u7814\u7a76\uff08NCT06213844\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u55ae\u6b21\u7d66\u85e5\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30IBI3002\u5728\u5065\u5eb7\u53d7\u8a66\u8005\u548c\u8f15\u4e2d\u5ea6\u54ee\u5598\u53d7\u8a66\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u548c\u85e5\u6548\u5b78\uff08PD\uff0c\u50c5\u5728\u54ee\u5598\u53d7\u8a66\u8005\u4e2d\uff09\uff0c\u4ee5\u652f\u6301IBI3002\u5f8c\u7e8c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u3002<\/p>\n

IBI3002\u662f\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u4eba\u6e90\u5316\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u9776\u5411\u7d30\u80de\u8868\u9762IL-4R\u03b1\u548c\u8b66\u5831\u7d20\u7d30\u80de\u56e0\u5b50TSLP\uff0c\u7528\u65bc\u6cbb\u7642\u5305\u62ec\u54ee\u5598\u5728\u5167\u7684\u708e\u75c7\u6027\u75be\u75c5\u3002IL-4\u53d7\u9ad4\u4ecb\u5c0e\u4e86IL-4\u4fe1\u865f\u901a\u8def\uff081\u578b\u548c2\u578b\uff09\u548cIL-13\u4fe1\u865f\u901a\u8def\uff082\u578b\uff09\uff0c\u5169\u7a2e\u7d30\u80de\u56e0\u5b50\u4fe1\u865f\u901a\u8def\u57282\u578b\u708e\u75c7\u6027\u75be\u75c5\u7684\u75c5\u7406\u751f\u7406\u5b78\u4e2d\u5747\u8d77\u95dc\u9375\u4f5c\u7528[1]<\/sup>\u3002TSLP\u662f\u4e00\u7a2e\u4e0a\u76ae\u7d30\u80de\u4f86\u6e90\u7684\u8b66\u5831\u7d20\u7d30\u80de\u56e0\u5b50\uff0c\u53ef\u89f8\u767c\u54ee\u5598\u4e2d\u76842\u578b\u548c\u975e2\u578b\u708e\u75c7[2]<\/sup>\u3002<\/p>\n

IBI3002\u5177\u6709\u9ad8\u6548\u7684IL-4R\u03b1\u548cTSLP\u5171\u540c\u963b\u65b7\u529f\u80fd\u3002\u9ad4\u5916\u529f\u80fd\u5b78\u5be6\u9a57\u986f\u793a\u6bd4\u540c\u9776\u9ede\u7684\u5df2\u4e0a\u5e02\u55ae\u514b\u9686\u6297\u9ad4\u66f4\u512a\u3002\u901a\u904e\u540c\u6642\u9776\u5411IL-4R\u03b1\u548cTSLP\uff0cIBI3002\u5177\u6709\u6291\u52362\u578b\u548c\u975e2\u578b\u708e\u75c7\u7684\u6f5b\u529b\uff0c\u5728\u6291\u52362\u578b\u708e\u75c7\u65b9\u9762\u5177\u6709\u6f5b\u5728\u7684\u5354\u540c\u4f5c\u7528\uff0c\u6709\u671b\u5728\u6cbb\u76422\u578b\u708e\u75c7\u6027\u75be\u75c5\u4e2d\u5c55\u73fe\u512a\u6548\u6027\u3002<\/p>\n

\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u958b\u767c\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u5728\u904e\u53bb\u7684\u5e7e\u5341\u5e74\u88e1\uff0c\u91ab\u7642\u754c\u5c0d\u54ee\u5598\u7684\u75c5\u7406\u751f\u7406\u6a5f\u5236\/\u8868\u578b\u548c\u6cbb\u7642\u9078\u64c7\u7684\u8a8d\u77e5\u6709\u4e86\u986f\u8457\u589e\u52a0\uff0c\u7279\u5225\u662f\u901a\u904e\u5f15\u5165\u751f\u7269\u5236\u5291\u6cbb\u7642\u91cd\u5ea6\u54ee\u5598\u9019\u4e00\u7cbe\u6e96\u6cbb\u7642\u7684\u7b56\u7565\uff0c\u70ba\u54ee\u5598\u7ba1\u7406\u5e36\u4f86\u9769\u547d\u6027\u7684\u8b8a\u9769\u3002\u9ad8\u9078\u64c7\u6027\u85e5\u7269\u901a\u904e\u9776\u5411\u514d\u75ab\u708e\u75c7\u7d1a\u806f\u7684\u7279\u5b9a\u6b65\u9a5f\uff0c\u6709\u6f5b\u529b\u9032\u4e00\u6b65\u7a81\u7834\u5ee3\u5927\u56b4\u91cd\u54ee\u5598\u60a3\u8005\u7684\u6cbb\u7642\u5c40\u9650\uff0c\u4e26\u6709\u671b\u5728\u591a\u7a2e\u91cd\u5ea6\u54ee\u5598\u708e\u75c7\u8868\u578b\u4e2d\u5be6\u73fe\u6700\u4f73\u75be\u75c5\u63a7\u5236\uff1b\u540c\u6642\uff0c\u6211\u5011\u4e5f\u671f\u5f85\u63a8\u9032\u8a72\u5206\u5b50\u672a\u4f86\u5728\u54ee\u5598\u548c\u5176\u4ed6\u591a\u7a2e\u708e\u75c7\u6027\u75be\u75c5\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002\u300d<\/p>\n

\u95dc\u65bc\u54ee\u5598<\/b><\/p>\n

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\u95dc\u65bc<\/b>IBI3002<\/b><\/p>\n

IBI3002\u662f\u4e00\u6b3e\u5168\u7403\u9996\u5275\u9776\u5411\u7d30\u80de\u8868\u9762IL-4R\u03b1\u548c\u8b66\u5831\u7d20\u7d30\u80de\u56e0\u5b50TSLP\u7684\u96d9\u7279\u7570\u6027\u6297\u9ad4\u3002\u8a72\u5206\u5b50\u5177\u6709\u9ad8\u6548\u7684IL-4R\u03b1\u548cTSLP\u5171\u540c\u963b\u65b7\u529f\u80fd\u3002\u9ad4\u5916\u529f\u80fd\u5b78\u5be6\u9a57\u986f\u793a\u6bd4\u540c\u9776\u9ede\u7684\u5df2\u4e0a\u5e02\u55ae\u514b\u9686\u6297\u9ad4\u66f4\u512a\u3002\u901a\u904e\u540c\u6642\u9776\u5411IL-4R\u03b1\u548cTSLP\uff0cIBI3002\u5177\u6709\u6cbb\u7642\u5305\u62ec\u54ee\u5598\u5728\u5167\u591a\u7a2e\u708e\u75c7\u6027\u75be\u75c5\u7684\u6f5b\u529b\u3002<\/p>\n

IL-4\u662f2\u578b\u6dcb\u5df4\u7d30\u80de\u5206\u5316\u7684\u4e2d\u5fc3\u4ecb\u8cea\uff1b\u5b83\u8a98\u5c0e\u7522\u751f2\u578b\u76f8\u95dc\u7d30\u80de\u56e0\u5b50\uff0c\u5982IL-5\u3001IL-9\u3001IL-13\u548c\/\u62162\u578b\u76f8\u95dc\u8da8\u5316\u56e0\u5b50\uff0c\u5982\u80f8\u817a\u548c\u6d3b\u5316\u8abf\u7bc0\u8da8\u5316\u56e0\u5b50(TARC\/CCL17)\u548c\u55dc\u9178\u6027\u7c92\u7d30\u80de\u8da8\u5316\u56e0\u5b50-3\u3002IL-4\u53c3\u8207\u8abf\u7bc0B\u7d30\u80de\u7684\u540c\u7a2e\u578b\u985e\u5225\u8f49\u63db\u4ee5\u7522\u751f\u8840\u6e05IgE\uff0c\u4e26\u901a\u904e\u91cb\u653eIL-5\u62db\u52df\u55dc\u9178\u6027\u7c92\u7d30\u80de\u3002\u5118\u7ba1IL-13\u5728\u9019\u4e9b\u4fc3\u708e\u904e\u7a0b\u4e2d\u986f\u793a\u51fa\u4e00\u4e9b\u5197\u4f59\u6027\uff0c\u4f46\u5b83\u5728\u4ecb\u5c0e\u676f\u72c0\u7d30\u80de\u589e\u751f\u3001\u7c98\u6db2\u7522\u751f\u3001\u5e73\u6ed1\u808c\u6536\u7e2e\u6027\u548c\u6c23\u9053\u9ad8\u53cd\u61c9\u6027\u65b9\u9762\u5177\u6709\u984d\u5916\u7684\u4f5c\u7528\u3002\u7e3d\u7684\u4f86\u8aaa\uff0cIL-4\u548cIL-13\u5171\u540c\u57282\u578b\u708e\u75c7\u4e2d\u8d77\u95dc\u9375\u4f5c\u7528[1]<\/sup>\u3002<\/p>\n

TSLP\u662f\u4e00\u7a2e\u4e0a\u76ae\u7d30\u80de\u4f86\u6e90\u7684\u8b66\u5831\u7d20\u7d30\u80de\u56e0\u5b50\uff0c\u5b83\u57282\u578b\u708e\u75c7\u8a98\u5c0e\u548c\u901a\u904eIL-4\u3001IL-5\u548cIL-13\u7522\u751f\u7684Th2\u7d30\u80de\u5206\u5316\u8207\u6210\u719f\u4e2d\u4f54\u64da\u4e0a\u6e38\u4f4d\u7f6e\u3002TSLP\u4e5f\u88ab\u8a8d\u70ba\u662f\u54ee\u5598\u4e2d\u975e2\u578b\u708e\u75c7\u7684\u89f8\u767c\u56e0\u7d20[2]<\/sup>\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n

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\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n

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\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1. Zhu J. T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production[J]. Cytokine, 2015, 75(1): 14-24.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2. Brusselle G G, Koppelman G H. Biologic therapies for severe asthma[J]. New England Journal of Medicine, 2022, 386(2): 157-171.<\/span><\/p>\n<\/td>\n<\/tr>\n

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3. Global Initiative for Asthma. 2023 GINA Report, Global Strategy for Asthma Management and Prevention. 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4. GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 [published correction appears in Lancet Respir Med. 2017 Oct;5(10 ):e30]. Lancet Respir Med. 2017;5(9):691-706.<\/span><\/p>\n<\/td>\n<\/tr>\n

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5. Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118-127.<\/span><\/p>\n<\/td>\n<\/tr>\n

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6. Israel E, Reddel H K. Severe and difficult-to-treat asthma in adults[J]. New England Journal of Medicine, 2017, 377(10): 965-976.<\/span><\/p>\n<\/td>\n<\/tr>\n

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7. Settipane RA, Kreindler JL, Chung Y, Tkacz J. Evaluating direct costs and productivity losses of patients with asthma receiving GINA 4\/5 therapy in the United States. Ann Allergy Asthma Immunol 2019; 123(6): 564-572.e3.<\/span><\/p>\n<\/td>\n<\/tr>\n

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8. Caminati M, Vaia R, Furci F, Guarnieri G, Senna G. Uncontrolled Asthma: Unmet Needs in the Management of Patients. J Asthma Allergy. 2021;14:457-466.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u53c3\u8003\u6587\u737b\uff1a 1. Zhu J. T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine, 2015, 75(1): 14-24. 2. Brusselle G G, Koppelman G H. Biologic therapies for severe asthma. New England Journal of Medicine, 2022, 386(2): 157-171. 3. Global Initiative for Asthma. 2023 GINA Report, Global Strategy for Asthma Management and Prevention. 2023. 4. GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 . Lancet Respir Med. 2017;5(9):691-706. 5. Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118-127. 6. Israel E, Reddel H K. Severe and difficult-to-treat asthma in adults. New England Journal of Medicine, 2017, 377(10): 965-976. 7. Settipane RA, Kreindler JL, Chung Y, Tkacz J. Evaluating direct costs and productivity losses of patients with asthma receiving GINA 4\/5 therapy in the United States. Ann Allergy Asthma Immunol 2019; 123(6): 564-572.e3. 8. Caminati M, Vaia R, Furci F, Guarnieri G, Senna G. Uncontrolled Asthma: Unmet Needs in the Management of Patients. J Asthma Allergy. 2021;14:457-466. \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=221057\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI3002\uff08\u6297IL-4R\u03b1\/TSLP\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff09\u81e8\u5e8aI\u671f\u7814\u7a76\u5728\u6fb3\u5927\u5229\u4e9e\u5b8c\u6210\u9996\u4f8b\u53d7\u8a66\u8005\u7d66\u85e5 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2024\u5e743\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- 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\u53c3\u8003\u6587\u737b\uff1a 1. 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\u53c3\u8003\u6587\u737b\uff1a 1. Zhu J. T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine, 2015, 75(1): 14-24. 2. Brusselle G G, Koppelman G H. Biologic therapies for severe asthma. New England Journal of Medicine, 2022, 386(2): 157-171. 3. Global Initiative for Asthma. 2023 GINA Report, Global Strategy for Asthma Management and Prevention. 2023. 4. GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 . Lancet Respir Med. 2017;5(9):691-706. 5. Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118-127. 6. Israel E, Reddel H K. Severe and difficult-to-treat asthma in adults. New England Journal of Medicine, 2017, 377(10): 965-976. 7. Settipane RA, Kreindler JL, Chung Y, Tkacz J. Evaluating direct costs and productivity losses of patients with asthma receiving GINA 4\/5 therapy in the United States. Ann Allergy Asthma Immunol 2019; 123(6): 564-572.e3. 8. Caminati M, Vaia R, Furci F, Guarnieri G, Senna G. Uncontrolled Asthma: Unmet Needs in the Management of Patients. 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\u53c3\u8003\u6587\u737b\uff1a 1. 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Severe and difficult-to-treat asthma in adults. New England Journal of Medicine, 2017, 377(10): 965-976. 7. Settipane RA, Kreindler JL, Chung Y, Tkacz J. Evaluating direct costs and productivity losses of patients with asthma receiving GINA 4\/5 therapy in the United States. Ann Allergy Asthma Immunol 2019; 123(6): 564-572.e3. 8. Caminati M, Vaia R, Furci F, Guarnieri G, Senna G. Uncontrolled Asthma: Unmet Needs in the Management of Patients. 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\u53c3\u8003\u6587\u737b\uff1a 1. 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