{"id":220353,"date":"2024-02-26T18:00:00","date_gmt":"2024-02-26T10:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=220353"},"modified":"2024-02-26T18:00:00","modified_gmt":"2024-02-26T10:00:00","slug":"%e7%99%be%e6%bf%9f%e7%a5%9e%e5%b7%9e%ef%bc%88beigene%ef%bc%89%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%96%ae%e6%8a%97%e7%8d%b2%e5%be%97%e6%ad%90%e6%b4%b2%e8%97%a5%e5%93%81%e7%ae%a1%e7%90%86%e5%b1%80","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=220353","title":{"rendered":"\u767e\u6fdf\u795e\u5dde\uff08BeiGene\uff09\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u5f97\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\u7a4d\u6975\u610f\u898b\uff0c\u652f\u6301\u5176\u7528\u65bc\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005"},"content":{"rendered":"<div>\n<p class=\"prntac\"><i>\u8a72\u63a8\u85a6\u57fa\u65bc\u4e09\u9805<\/i><i>3<\/i><i>\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0c\u5176\u6578\u64da\u8b49\u660e\u4e86\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u4e00\u7dda\u548c\u4e8c\u7dda\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6cbb\u7642\u65b9\u6848\u7684\u81e8\u5e8a\u7372\u76ca<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e2d\u570b\u5317\u4eac\u3001\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e<\/span><span class=\"legendSpanClass\">2024\u5e742\u670826\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u767e\u6fdf\u795e\u5dde\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1a BGNE\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u78bc\uff1a688235\uff09\u662f\u4e00\u5bb6\u5168\u7403\u816b\u7624\u5275\u65b0\u516c\u53f8\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\uff08CHMP\uff09\u767c\u4f48\u5176\u63a8\u85a6\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u5f97\u4e0a\u5e02\u8a31\u53ef\u7684\u7a4d\u6975\u610f\u898b\uff0c\u5efa\u8b70\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u4e09\u9805\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u9069\u61c9\u75c7\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u6216\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7d50\u5408\u578b\uff09\u548c\u5361\u9251\u7528\u65bc\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u806f\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u9251\u985e\u5316\u7642\u7528\u65bcPD-L1\u8868\u9054\u226550%\u4e14\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4\uff08EGFR\uff09\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u7a81\u8b8a\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u85e5\u7269\u6cbb\u7642\u5f8c\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u8b8a\u967d\u6027\u6216ALK\u7a81\u8b8a\u967d\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u524d\u61c9\u7576\u5df2\u63a5\u53d7\u904e\u9776\u5411\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p>\u767e\u6fdf\u795e\u5dde\u5be6\u9ad4\u816b\u7624\u9996\u5e2d\u91ab\u5b78\u5b98Mark Lanasa\u91ab\u5b78\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5305\u62ec\u6b50\u76df\u5730\u5340\uff0c\u5171\u5165\u7d44\u8fd11,500\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u986f\u793a\u51fa\u80fd\u5920\u6709\u6548\u6cbb\u7642\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u3002CHMP\u4eca\u5929\u767c\u4f48\u7684\u7a4d\u6975\u610f\u898b\u8b93\u6211\u5011\u6709\u6a5f\u6703\u66f4\u5feb\u70ba\u6b50\u6d32\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u9805\u91cd\u8981\u7684\u6cbb\u7642\u9078\u64c7\u3002\u80ba\u764c\u662f\u6b50\u6d32\u5730\u5340\u6700\u5e38\u898b\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u764c\u75c7\u4e4b\u4e00\u3002\u300d<\/p>\n<p>\u6b64\u6b21NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08MAA\uff09\u662f\u57fa\u65bc\u5171\u5165\u7d441,499\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u665a\u671f\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 307\u7814\u7a76\u7d50\u679c\u548c\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 304\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u5728<a href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2777901\" target=\"_blank\" rel=\"nofollow noopener\"><i>JAMA Oncology<\/i><\/a>\u548c<a href=\"https:\/\/www.jto.org\/article\/S1556-0864(21)02176-6\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\"><i>Journal of Thoracic Oncology<\/i><\/a>\u00a0\u96dc\u8a8c\u4e0a\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u7528\u65bc\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u4e8c\u7dda\u6cbb\u7642\u7684RATIONALE 303\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728<a href=\"https:\/\/www.jto.org\/article\/S1556-0864(22)01803-2\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\"><i>Journal of Thoracic Oncology<\/i><\/a>\u96dc\u8a8c\u4e0a\u3002<\/p>\n<p>Lanasa\u535a\u58eb\u88dc\u5145\u9053\uff1a\u300c\u6211\u5011\u6b63\u5728\u4e0d\u65b7\u52a0\u5f37\u5728\u5be6\u9ad4\u7624\u9818\u57df\u7684\u5168\u7403\u7522\u54c1\u7d44\u5408\u3002\u6b64\u6b21CHMP\u767c\u4f48\u7a4d\u6975\u610f\u898b\u8ddd\u96e2\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7372\u6279\u7528\u65bc\u6cbb\u7642\u665a\u671f\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u50c5\u76f8\u9694\u5e7e\u500b\u6708\uff0c\u6210\u70ba\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u9075\u5faa\u79d1\u5b78\u548c\u6578\u64da\uff0c\u63a8\u9032\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u53ca\u806f\u5408\u7528\u85e5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u300d<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA<b><sup>\u00ae<\/sup><\/b>\uff09\u4e8e2023\u5e74\u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5316\u7642\u5f8c\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\uff0c\u76ee\u524d\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5728\u9032\u884c\u5be9\u8a55\u4e2d\u3002FDA\u4e5f\u6b63\u5728\u5be9\u8a55\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u3001\u5fa9\u767c\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u767e\u6fdf\u795e\u5dde\u5df2\u555f\u52d5\u8d85\u904e17\u9805\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6f5b\u5728\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u8fc4\u4eca\u5df2\u5165\u7d4413,000\u591a\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d15\u9805\u7814\u7a76\u5df2\u767c\u4f48\u7a4d\u6975\u7684\u6578\u64da\u7d50\u679c\u3002\u901a\u904e\u9019\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u5728\u5ee3\u6cdb\u7624\u7a2e\uff08\u4e14\u5728\u5f88\u591a\u60c5\u6cc1\u4e0b\u4e0d\u5340\u5206PD-\uff08L\uff091\u8868\u9054\u6c34\u6e96\uff09\u7684\u55ae\u85e5\u6216\u806f\u5408\u7528\u85e5\u6cbb\u7642\u4e2d\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u60e0\u53ca\u8d85\u904e90\u842c\u4f8b\u60a3\u8005\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>RATIONALE 307<\/b><\/p>\n<p>RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 [95%CI:0.326-0.619]; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 [95% CI:0.308-0.60]; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>RATIONALE 304<\/b><\/p>\n<p>RATIONALE 304\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03663205?term=NCT03663205&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT03663205<\/a>\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684PFS\u76f8\u6bd4\u5316\u7642\u7372\u5f97\u4e86\u7d71\u8a08\u5b78\u4e0a\u7684\u986f\u8457\u6539\u5584\uff08HR 0.65 [95% CI\uff1a0.47-0.91]; P=0.0054\uff09\uff0c\u540c\u6642\u7de9\u89e3\u7387\u66f4\u9ad8\uff0c\u4e14\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u66f4\u9577\u3002\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a9.8\u500b\u6708\u6642\uff0c\u5728\u7e3d\u9ad4\u4eba\u7fa4\u548cPD-L1\u226550%\u4eba\u7fa4\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u9251\u985e\u85e5\u7269\uff08\u5361\u9251\u6216\u9806\u9251\uff09\u548c\u57f9\u7f8e\u66f2\u585e\u7684\u4e2d\u4f4dPFS\u70ba9.7\u500b\u6708\uff0c\u800c\u9251\u985e\u85e5\u7269\u806f\u5408\u57f9\u7f8e\u66f2\u585e\u70ba7.6\u500b\u6708\uff1b\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u70ba14.6\u500b\u6708\uff0c\u50c5\u5316\u7642\u6cbb\u7642\u70ba4.6\u500b\u6708\uff08\u5206\u5c64HR 0.31 [95% CI\uff1a0.178-0.547]\uff09\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u8207\u5316\u7642\u76f8\u95dc\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>RATIONALE 303<\/b><\/p>\n<p>RATIONALE 303\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03358875?term=NCT03358875&amp;rank=1\" target=\"_blank\" rel=\"nofollow noopener\">NCT03358875<\/a>\uff09\u662f\u4e00\u9805\u6bd4\u8f03\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u8207\u591a\u897f\u4ed6\u8cfd\u7684\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44805\u4f8b\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u672c\u7814\u7a76\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u5728\u610f\u5411\u6027\u6cbb\u7642\u4eba\u7fa4\u4e2d\uff0c\u7121\u8ad6\u60a3\u8005PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u4e8c\u7dda\u6216\u4e09\u7dda\u6cbb\u7642\u7684\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u76f8\u6bd4\u591a\u897f\u4ed6\u8cfd\u5177\u6709\u7d71\u8a08\u5b78\u548c\u81e8\u5e8a\u610f\u7fa9\u4e0a\u7684\u6539\u5584\uff08HR\uff1a0.66 [95% CI\uff1a0.56-0.79]\uff1bP&lt;0.0001\uff09\u3002\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7684\u4e2d\u4f4dOS\u70ba16.9\u500b\u6708\uff0c\u800c\u591a\u897f\u4ed6\u8cfd\u7684\u4e2d\u4f4dOS\u70ba11.9\u500b\u6708\u3002\u6700\u7d42\u5206\u6790\u6642\uff0c\u5728PD-L1\u967d\u6027\u4eba\u7fa4\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7d44\u7684OS\u4e5f\u986f\u8457\u6539\u5584\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4e2d\u4f4dOS\u70ba19.3\u500b\u6708\uff0c\u591a\u897f\u4ed6\u8cfd\u4e2d\u4f4dOS\u70ba11.5\u500b\u6708\uff0cHR\uff1a0.53 [95% CI\uff1a0.41-0.70]\uff1bP&lt;0.0001\uff09\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u611f\u67d3\u6027\u80ba\u708e\u3001\u8ca7\u8840\u548c\u547c\u5438\u56f0\u96e3\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>NSCLC<\/b><\/p>\n<p>\u80ba\u764c\u662f\u7b2c\u4e8c\u5927\u5e38\u898b\u7684\u764c\u75c7\u985e\u578b\uff0c\u4e5f\u662f\u5168\u7403\u764c\u75c7\u76f8\u95dc\u6b7b\u4ea1\u7684\u4e3b\u8981\u75c5\u56e0<sup><span id=\"spanHghlt99e3\">[1]<\/span><\/sup>\u3002\u80ba\u764c\u662f\u6b50\u6d32\u7b2c\u4e09\u5927\u5e38\u898b\u764c\u75c7\uff1bNSCLC\u5360\u6240\u6709\u80ba\u764c\u768485-90%<sup><span id=\"spanHghltd177\">[2]<\/span><\/sup>\u30022020\u5e74\uff0c\u6b50\u6d32\u65b0\u8a3a\u65b7\u80ba\u764c\u75c5\u4f8b\u6578\u4f30\u8a08\u70ba477,534\u4f8b<span id=\"spanHghlt1218\"><sup>[3]<\/sup>\u3002<\/span><\/p>\n<p><b>\u95dc\u65bc\u66ff\u96f7\u5229\u73e0\u55ae\u6297<\/b><\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u767e\u6fa4\u5b89<sup>\u00ae<\/sup>\uff0c\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA<sup>\u00ae<\/sup>\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297PD-1\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5c0dPD-1\u5177\u6709\u9ad8\u89aa\u548c\u529b\u548c\u7d50\u5408\u7279\u7570\u6027\uff0c\u8a2d\u8a08\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u8207\u5de8\u566c\u7d30\u80de\u4e2d\u7684Fc\u03b3\u53d7\u9ad4\u7d50\u5408\uff0c\u5e6b\u52a9\u4eba\u9ad4\u514d\u75ab\u7d30\u80de\u8b58\u5225\u4e26\u6bba\u50b7\u816b\u7624\u7d30\u80de\u3002<\/p>\n<p><b>\u95dc\u65bc\u767e\u6fdf\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6fdf\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u816b\u7624\u5275\u65b0\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u70ba\u5168\u4e16\u754c\u7684\u764c\u75c7\u60a3\u8005\u7814\u767c\u5275\u65b0\u6297\u816b\u7624\u85e5\u7269\u3002\u901a\u904e\u5f37\u5927\u7684\u81ea\u4e3b\u7814\u767c\u80fd\u529b\u548c\u5916\u90e8\u6230\u7565\u5408\u4f5c\uff0c\u6211\u5011\u4e0d\u65b7\u52a0\u901f\u958b\u767c\u591a\u5143\u3001\u5275\u65b0\u7684\u85e5\u7269\u7ba1\u7dda\u548c\u7522\u54c1\u7d44\u5408\uff0c\u81f4\u529b\u65bc\u70ba\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u63d0\u5347\u85e5\u7269\u53ef\u53ca\u6027\u548c\u53ef\u8ca0\u64d4\u6027\u3002\u5728\u5168\u7403\u4e94\u5927\u6d32\uff0c\u6211\u5011\u6709\u8d85\u904e10,000\u4eba\u7684\u5718\u968a\uff0c\u4e26\u5728\u4e2d\u570b\u5317\u4eac\u3001\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e\u8a2d\u7acb\u4e86\u4e3b\u8981\u8fa6\u4e8b\u8655\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<a href=\"https:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.beigene.com.cn<\/a>; <a href=\"https:\/\/www.beigene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.beigene.com<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u806f\u90a6\u8b49\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u8072\u660e\uff0c\u5305\u62ec\u95dc\u65bc\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u6cbb\u7642\u9078\u64c7\u7684\u6709\u6548\u6027\uff0c\u91dd\u5c0d\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u800c\u9032\u884c\u7684\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u672a\u4f86\u958b\u767c\u8a08\u756b\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u70ba\u60a3\u8005\u5e36\u4f86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u5728\u300c\u95dc\u65bc\u767e\u6fdf\u795e\u5dde\u300d\u6a19\u984c\u4e0b\u63d0\u53ca\u7684\u767e\u6fdf\u795e\u5dde\u8a08\u756b\u3001\u627f\u8afe\u3001\u9858\u671b\u548c\u76ee\u6a19\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u7d50\u679c\u5b58\u5728\u5be6\u8cea\u6027\u5dee\u7570\u3002\u9019\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6fdf\u795e\u5dde\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u4e0a\u5e02\u5be9\u6279\uff1b\u85e5\u653f\u90e8\u9580\u7684\u884c\u52d5\u53ef\u80fd\u6703\u5f71\u97ff\u5230\u81e8\u5e8a\u8a66\u9a57\u7684\u555f\u52d5\u3001\u6642\u9593\u8868\u548c\u9032\u5c55\u4ee5\u53ca\u85e5\u7269\u4e0a\u5e02\u5be9\u6279\uff1b\u767e\u6fdf\u795e\u5dde\u7684\u4e0a\u5e02\u85e5\u7269\u53ca\u5019\u9078\u85e5\u7269\uff08\u5982\u80fd\u7372\u6279\uff09\u7372\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u7372\u5f97\u548c\u7dad\u8b77\u5c0d\u5176\u85e5\u7269\u548c\u6280\u8853\u7684\u667a\u6167\u8ca1\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u4f9d\u8cf4\u5354\u529b\u5ee0\u5546\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u670d\u52d9\u7684\u60c5\u6cc1\uff1b\u767e\u6fdf\u795e\u5dde\u53d6\u5f97\u76e3\u7ba1\u5be9\u6279\u548c\u5546\u696d\u5316\u91ab\u85e5\u7522\u54c1\u7684\u6709\u9650\u7d93\u9a57\uff0c\u53ca\u5176\u7372\u5f97\u9032\u4e00\u6b65\u7684\u71df\u904b\u8cc7\u91d1\u4ee5\u5b8c\u6210\u5019\u9078\u85e5\u7269\u958b\u767c\u53ca\u5be6\u73fe\u4e26\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u5831\u544a\u7684 10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] Globocan 2020. <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">900-world-fact-sheets.pdf (iarc.fr)<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? <a href=\"https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8a72\u63a8\u85a6\u57fa\u65bc\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-220353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u85e5\u7269\u6cbb\u7642\u5f8c\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u8b8a\u967d\u6027\u6216ALK\u7a81\u8b8a\u967d\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u524d\u61c9\u7576\u5df2\u63a5\u53d7\u904e\u9776\u5411\u6cbb\u7642\u3002 \u767e\u6fdf\u795e\u5dde\u5be6\u9ad4\u816b\u7624\u9996\u5e2d\u91ab\u5b78\u5b98Mark Lanasa\u91ab\u5b78\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5305\u62ec\u6b50\u76df\u5730\u5340\uff0c\u5171\u5165\u7d44\u8fd11,500\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u986f\u793a\u51fa\u80fd\u5920\u6709\u6548\u6cbb\u7642\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u3002CHMP\u4eca\u5929\u767c\u4f48\u7684\u7a4d\u6975\u610f\u898b\u8b93\u6211\u5011\u6709\u6a5f\u6703\u66f4\u5feb\u70ba\u6b50\u6d32\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u9805\u91cd\u8981\u7684\u6cbb\u7642\u9078\u64c7\u3002\u80ba\u764c\u662f\u6b50\u6d32\u5730\u5340\u6700\u5e38\u898b\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u764c\u75c7\u4e4b\u4e00\u3002\u300d 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Oncology\u96dc\u8a8c\u4e0a\u3002 Lanasa\u535a\u58eb\u88dc\u5145\u9053\uff1a\u300c\u6211\u5011\u6b63\u5728\u4e0d\u65b7\u52a0\u5f37\u5728\u5be6\u9ad4\u7624\u9818\u57df\u7684\u5168\u7403\u7522\u54c1\u7d44\u5408\u3002\u6b64\u6b21CHMP\u767c\u4f48\u7a4d\u6975\u610f\u898b\u8ddd\u96e2\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7372\u6279\u7528\u65bc\u6cbb\u7642\u665a\u671f\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u50c5\u76f8\u9694\u5e7e\u500b\u6708\uff0c\u6210\u70ba\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u9075\u5faa\u79d1\u5b78\u548c\u6578\u64da\uff0c\u63a8\u9032\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u53ca\u806f\u5408\u7528\u85e5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u300d 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\u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 ; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002 \u95dc\u65bcRATIONALE 304 RATIONALE 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10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002   Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr).    European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf.    Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.    \u00a0 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=220353\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u767e\u6fdf\u795e\u5dde\uff08BeiGene\uff09\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u5f97\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\u7a4d\u6975\u610f\u898b\uff0c\u652f\u6301\u5176\u7528\u65bc\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u8a72\u63a8\u85a6\u57fa\u65bc\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0c\u5176\u6578\u64da\u8b49\u660e\u4e86\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u4e00\u7dda\u548c\u4e8c\u7dda\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6cbb\u7642\u65b9\u6848\u7684\u81e8\u5e8a\u7372\u76ca \u4e2d\u570b\u5317\u4eac\u3001\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e2024\u5e742\u670826\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u767e\u6fdf\u795e\u5dde\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1a 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\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u6216\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7d50\u5408\u578b\uff09\u548c\u5361\u9251\u7528\u65bc\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b  \u806f\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u9251\u985e\u5316\u7642\u7528\u65bcPD-L1\u8868\u9054\u226550%\u4e14\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4\uff08EGFR\uff09\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u7a81\u8b8a\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b  \u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u85e5\u7269\u6cbb\u7642\u5f8c\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u8b8a\u967d\u6027\u6216ALK\u7a81\u8b8a\u967d\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u524d\u61c9\u7576\u5df2\u63a5\u53d7\u904e\u9776\u5411\u6cbb\u7642\u3002 \u767e\u6fdf\u795e\u5dde\u5be6\u9ad4\u816b\u7624\u9996\u5e2d\u91ab\u5b78\u5b98Mark Lanasa\u91ab\u5b78\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5305\u62ec\u6b50\u76df\u5730\u5340\uff0c\u5171\u5165\u7d44\u8fd11,500\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u986f\u793a\u51fa\u80fd\u5920\u6709\u6548\u6cbb\u7642\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u3002CHMP\u4eca\u5929\u767c\u4f48\u7684\u7a4d\u6975\u610f\u898b\u8b93\u6211\u5011\u6709\u6a5f\u6703\u66f4\u5feb\u70ba\u6b50\u6d32\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u9805\u91cd\u8981\u7684\u6cbb\u7642\u9078\u64c7\u3002\u80ba\u764c\u662f\u6b50\u6d32\u5730\u5340\u6700\u5e38\u898b\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u764c\u75c7\u4e4b\u4e00\u3002\u300d \u6b64\u6b21NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08MAA\uff09\u662f\u57fa\u65bc\u5171\u5165\u7d441,499\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u665a\u671f\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 307\u7814\u7a76\u7d50\u679c\u548c\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 304\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u5728JAMA Oncology\u548cJournal of Thoracic Oncology\u00a0\u96dc\u8a8c\u4e0a\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u7528\u65bc\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u4e8c\u7dda\u6cbb\u7642\u7684RATIONALE 303\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728Journal of Thoracic Oncology\u96dc\u8a8c\u4e0a\u3002 Lanasa\u535a\u58eb\u88dc\u5145\u9053\uff1a\u300c\u6211\u5011\u6b63\u5728\u4e0d\u65b7\u52a0\u5f37\u5728\u5be6\u9ad4\u7624\u9818\u57df\u7684\u5168\u7403\u7522\u54c1\u7d44\u5408\u3002\u6b64\u6b21CHMP\u767c\u4f48\u7a4d\u6975\u610f\u898b\u8ddd\u96e2\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7372\u6279\u7528\u65bc\u6cbb\u7642\u665a\u671f\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u50c5\u76f8\u9694\u5e7e\u500b\u6708\uff0c\u6210\u70ba\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u9075\u5faa\u79d1\u5b78\u548c\u6578\u64da\uff0c\u63a8\u9032\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u53ca\u806f\u5408\u7528\u85e5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u300d \u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA\u00ae\uff09\u4e8e2023\u5e74\u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5316\u7642\u5f8c\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\uff0c\u76ee\u524d\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5728\u9032\u884c\u5be9\u8a55\u4e2d\u3002FDA\u4e5f\u6b63\u5728\u5be9\u8a55\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u3001\u5fa9\u767c\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u767e\u6fdf\u795e\u5dde\u5df2\u555f\u52d5\u8d85\u904e17\u9805\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6f5b\u5728\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u8fc4\u4eca\u5df2\u5165\u7d4413,000\u591a\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d15\u9805\u7814\u7a76\u5df2\u767c\u4f48\u7a4d\u6975\u7684\u6578\u64da\u7d50\u679c\u3002\u901a\u904e\u9019\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u5728\u5ee3\u6cdb\u7624\u7a2e\uff08\u4e14\u5728\u5f88\u591a\u60c5\u6cc1\u4e0b\u4e0d\u5340\u5206PD-\uff08L\uff091\u8868\u9054\u6c34\u6e96\uff09\u7684\u55ae\u85e5\u6216\u806f\u5408\u7528\u85e5\u6cbb\u7642\u4e2d\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u60e0\u53ca\u8d85\u904e90\u842c\u4f8b\u60a3\u8005\u3002 \u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 ; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002 \u95dc\u65bcRATIONALE 304 RATIONALE 304\uff08NCT03663205\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684PFS\u76f8\u6bd4\u5316\u7642\u7372\u5f97\u4e86\u7d71\u8a08\u5b78\u4e0a\u7684\u986f\u8457\u6539\u5584\uff08HR 0.65 ; 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\u95dc\u65bcRATIONALE 303 RATIONALE 303\uff08NCT03358875\uff09\u662f\u4e00\u9805\u6bd4\u8f03\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u8207\u591a\u897f\u4ed6\u8cfd\u7684\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44805\u4f8b\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u5316\u7642\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u672c\u7814\u7a76\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u5728\u610f\u5411\u6027\u6cbb\u7642\u4eba\u7fa4\u4e2d\uff0c\u7121\u8ad6\u60a3\u8005PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u4e8c\u7dda\u6216\u4e09\u7dda\u6cbb\u7642\u7684\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u76f8\u6bd4\u591a\u897f\u4ed6\u8cfd\u5177\u6709\u7d71\u8a08\u5b78\u548c\u81e8\u5e8a\u610f\u7fa9\u4e0a\u7684\u6539\u5584\uff08HR\uff1a0.66 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1995\uff09\u4ee5\u53ca\u5176\u4ed6\u806f\u90a6\u8b49\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u8072\u660e\uff0c\u5305\u62ec\u95dc\u65bc\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u6cbb\u7642\u9078\u64c7\u7684\u6709\u6548\u6027\uff0c\u91dd\u5c0d\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u800c\u9032\u884c\u7684\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u672a\u4f86\u958b\u767c\u8a08\u756b\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u70ba\u60a3\u8005\u5e36\u4f86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u5728\u300c\u95dc\u65bc\u767e\u6fdf\u795e\u5dde\u300d\u6a19\u984c\u4e0b\u63d0\u53ca\u7684\u767e\u6fdf\u795e\u5dde\u8a08\u756b\u3001\u627f\u8afe\u3001\u9858\u671b\u548c\u76ee\u6a19\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u7d50\u679c\u5b58\u5728\u5be6\u8cea\u6027\u5dee\u7570\u3002\u9019\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6fdf\u795e\u5dde\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u4e0a\u5e02\u5be9\u6279\uff1b\u85e5\u653f\u90e8\u9580\u7684\u884c\u52d5\u53ef\u80fd\u6703\u5f71\u97ff\u5230\u81e8\u5e8a\u8a66\u9a57\u7684\u555f\u52d5\u3001\u6642\u9593\u8868\u548c\u9032\u5c55\u4ee5\u53ca\u85e5\u7269\u4e0a\u5e02\u5be9\u6279\uff1b\u767e\u6fdf\u795e\u5dde\u7684\u4e0a\u5e02\u85e5\u7269\u53ca\u5019\u9078\u85e5\u7269\uff08\u5982\u80fd\u7372\u6279\uff09\u7372\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u7372\u5f97\u548c\u7dad\u8b77\u5c0d\u5176\u85e5\u7269\u548c\u6280\u8853\u7684\u667a\u6167\u8ca1\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u4f9d\u8cf4\u5354\u529b\u5ee0\u5546\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u670d\u52d9\u7684\u60c5\u6cc1\uff1b\u767e\u6fdf\u795e\u5dde\u53d6\u5f97\u76e3\u7ba1\u5be9\u6279\u548c\u5546\u696d\u5316\u91ab\u85e5\u7522\u54c1\u7684\u6709\u9650\u7d93\u9a57\uff0c\u53ca\u5176\u7372\u5f97\u9032\u4e00\u6b65\u7684\u71df\u904b\u8cc7\u91d1\u4ee5\u5b8c\u6210\u5019\u9078\u85e5\u7269\u958b\u767c\u53ca\u5be6\u73fe\u4e26\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u5831\u544a\u7684 10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002   Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr).    European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf.    Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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--\u00a0\u767e\u6fdf\u795e\u5dde\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1a BGNE\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u78bc\uff1a688235\uff09\u662f\u4e00\u5bb6\u5168\u7403\u816b\u7624\u5275\u65b0\u516c\u53f8\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\uff08CHMP\uff09\u767c\u4f48\u5176\u63a8\u85a6\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u5f97\u4e0a\u5e02\u8a31\u53ef\u7684\u7a4d\u6975\u610f\u898b\uff0c\u5efa\u8b70\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u4e09\u9805\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u9069\u61c9\u75c7\uff1a \u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u6216\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7d50\u5408\u578b\uff09\u548c\u5361\u9251\u7528\u65bc\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b \u806f\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u9251\u985e\u5316\u7642\u7528\u65bcPD-L1\u8868\u9054\u226550%\u4e14\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4\uff08EGFR\uff09\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u7a81\u8b8a\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u6216\u4e0d\u9069\u5408\u542b\u9251\u653e\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b \u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u85e5\u7269\u6cbb\u7642\u5f8c\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u8b8a\u967d\u6027\u6216ALK\u7a81\u8b8a\u967d\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u524d\u61c9\u7576\u5df2\u63a5\u53d7\u904e\u9776\u5411\u6cbb\u7642\u3002 \u767e\u6fdf\u795e\u5dde\u5be6\u9ad4\u816b\u7624\u9996\u5e2d\u91ab\u5b78\u5b98Mark Lanasa\u91ab\u5b78\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5305\u62ec\u6b50\u76df\u5730\u5340\uff0c\u5171\u5165\u7d44\u8fd11,500\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u986f\u793a\u51fa\u80fd\u5920\u6709\u6548\u6cbb\u7642\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u3002CHMP\u4eca\u5929\u767c\u4f48\u7684\u7a4d\u6975\u610f\u898b\u8b93\u6211\u5011\u6709\u6a5f\u6703\u66f4\u5feb\u70ba\u6b50\u6d32\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u9805\u91cd\u8981\u7684\u6cbb\u7642\u9078\u64c7\u3002\u80ba\u764c\u662f\u6b50\u6d32\u5730\u5340\u6700\u5e38\u898b\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u764c\u75c7\u4e4b\u4e00\u3002\u300d \u6b64\u6b21NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08MAA\uff09\u662f\u57fa\u65bc\u5171\u5165\u7d441,499\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u665a\u671f\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 307\u7814\u7a76\u7d50\u679c\u548c\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 304\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u5728JAMA Oncology\u548cJournal of Thoracic Oncology\u00a0\u96dc\u8a8c\u4e0a\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u7528\u65bc\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u4e8c\u7dda\u6cbb\u7642\u7684RATIONALE 303\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728Journal of Thoracic Oncology\u96dc\u8a8c\u4e0a\u3002 Lanasa\u535a\u58eb\u88dc\u5145\u9053\uff1a\u300c\u6211\u5011\u6b63\u5728\u4e0d\u65b7\u52a0\u5f37\u5728\u5be6\u9ad4\u7624\u9818\u57df\u7684\u5168\u7403\u7522\u54c1\u7d44\u5408\u3002\u6b64\u6b21CHMP\u767c\u4f48\u7a4d\u6975\u610f\u898b\u8ddd\u96e2\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7372\u6279\u7528\u65bc\u6cbb\u7642\u665a\u671f\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u50c5\u76f8\u9694\u5e7e\u500b\u6708\uff0c\u6210\u70ba\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u9075\u5faa\u79d1\u5b78\u548c\u6578\u64da\uff0c\u63a8\u9032\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u53ca\u806f\u5408\u7528\u85e5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u300d \u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA\u00ae\uff09\u4e8e2023\u5e74\u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5316\u7642\u5f8c\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\uff0c\u76ee\u524d\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5728\u9032\u884c\u5be9\u8a55\u4e2d\u3002FDA\u4e5f\u6b63\u5728\u5be9\u8a55\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u3001\u5fa9\u767c\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u767e\u6fdf\u795e\u5dde\u5df2\u555f\u52d5\u8d85\u904e17\u9805\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6f5b\u5728\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u8fc4\u4eca\u5df2\u5165\u7d4413,000\u591a\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d15\u9805\u7814\u7a76\u5df2\u767c\u4f48\u7a4d\u6975\u7684\u6578\u64da\u7d50\u679c\u3002\u901a\u904e\u9019\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u5728\u5ee3\u6cdb\u7624\u7a2e\uff08\u4e14\u5728\u5f88\u591a\u60c5\u6cc1\u4e0b\u4e0d\u5340\u5206PD-\uff08L\uff091\u8868\u9054\u6c34\u6e96\uff09\u7684\u55ae\u85e5\u6216\u806f\u5408\u7528\u85e5\u6cbb\u7642\u4e2d\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u60e0\u53ca\u8d85\u904e90\u842c\u4f8b\u60a3\u8005\u3002 \u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\\\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 ; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002 \u95dc\u65bcRATIONALE 304 RATIONALE 304\uff08NCT03663205\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684PFS\u76f8\u6bd4\u5316\u7642\u7372\u5f97\u4e86\u7d71\u8a08\u5b78\u4e0a\u7684\u986f\u8457\u6539\u5584\uff08HR 0.65 ; 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10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002 Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr). European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\\\/\\\/www.esmo.org\\\/content\\\/download\\\/7252\\\/143219\\\/file\\\/en-non-small-cell-lung-cancer-guide-for-patients.pdf. Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. \u00a0 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\u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; 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10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002   Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr).    European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf.    Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.    \u00a0 \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=220353","og_locale":"zh_TW","og_type":"article","og_title":"\u767e\u6fdf\u795e\u5dde\uff08BeiGene\uff09\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u5f97\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\u7a4d\u6975\u610f\u898b\uff0c\u652f\u6301\u5176\u7528\u65bc\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u8a72\u63a8\u85a6\u57fa\u65bc\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0c\u5176\u6578\u64da\u8b49\u660e\u4e86\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u4e00\u7dda\u548c\u4e8c\u7dda\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6cbb\u7642\u65b9\u6848\u7684\u81e8\u5e8a\u7372\u76ca 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\u6b64\u6b21NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08MAA\uff09\u662f\u57fa\u65bc\u5171\u5165\u7d441,499\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u665a\u671f\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 307\u7814\u7a76\u7d50\u679c\u548c\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 304\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u5728JAMA Oncology\u548cJournal of Thoracic Oncology\u00a0\u96dc\u8a8c\u4e0a\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u7528\u65bc\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u4e8c\u7dda\u6cbb\u7642\u7684RATIONALE 303\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728Journal of Thoracic 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\u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 ; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002 \u95dc\u65bcRATIONALE 304 RATIONALE 304\uff08NCT03663205\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684PFS\u76f8\u6bd4\u5316\u7642\u7372\u5f97\u4e86\u7d71\u8a08\u5b78\u4e0a\u7684\u986f\u8457\u6539\u5584\uff08HR 0.65 ; 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10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002   Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr).    European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf.    Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u542b\u9251\u85e5\u7269\u6cbb\u7642\u5f8c\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u3002EGFR\u7a81\u8b8a\u967d\u6027\u6216ALK\u7a81\u8b8a\u967d\u6027\u7684NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u524d\u61c9\u7576\u5df2\u63a5\u53d7\u904e\u9776\u5411\u6cbb\u7642\u3002 \u767e\u6fdf\u795e\u5dde\u5be6\u9ad4\u816b\u7624\u9996\u5e2d\u91ab\u5b78\u5b98Mark Lanasa\u91ab\u5b78\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5305\u62ec\u6b50\u76df\u5730\u5340\uff0c\u5171\u5165\u7d44\u8fd11,500\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u986f\u793a\u51fa\u80fd\u5920\u6709\u6548\u6cbb\u7642\u521d\u6cbb\u548c\u96e3\u6cbbNSCLC\u60a3\u8005\u3002CHMP\u4eca\u5929\u767c\u4f48\u7684\u7a4d\u6975\u610f\u898b\u8b93\u6211\u5011\u6709\u6a5f\u6703\u66f4\u5feb\u70ba\u6b50\u6d32\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u9805\u91cd\u8981\u7684\u6cbb\u7642\u9078\u64c7\u3002\u80ba\u764c\u662f\u6b50\u6d32\u5730\u5340\u6700\u5e38\u898b\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u764c\u75c7\u4e4b\u4e00\u3002\u300d \u6b64\u6b21NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08MAA\uff09\u662f\u57fa\u65bc\u5171\u5165\u7d441,499\u4f8b\u60a3\u8005\u7684\u4e09\u98053\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u665a\u671f\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 307\u7814\u7a76\u7d50\u679c\u548c\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u806f\u5408\u7528\u85e5\u7528\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u4e00\u7dda\u6cbb\u7642\u7684RATIONALE 304\u7814\u7a76\u7d50\u679c\u5206\u5225\u767c\u8868\u5728JAMA Oncology\u548cJournal of Thoracic Oncology\u00a0\u96dc\u8a8c\u4e0a\u3002\u8a55\u50f9\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u7528\u65bc\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u4e8c\u7dda\u6cbb\u7642\u7684RATIONALE 303\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728Journal of Thoracic Oncology\u96dc\u8a8c\u4e0a\u3002 Lanasa\u535a\u58eb\u88dc\u5145\u9053\uff1a\u300c\u6211\u5011\u6b63\u5728\u4e0d\u65b7\u52a0\u5f37\u5728\u5be6\u9ad4\u7624\u9818\u57df\u7684\u5168\u7403\u7522\u54c1\u7d44\u5408\u3002\u6b64\u6b21CHMP\u767c\u4f48\u7a4d\u6975\u610f\u898b\u8ddd\u96e2\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7372\u6279\u7528\u65bc\u6cbb\u7642\u665a\u671f\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u50c5\u76f8\u9694\u5e7e\u500b\u6708\uff0c\u6210\u70ba\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5728\u6b50\u76df\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u9075\u5faa\u79d1\u5b78\u548c\u6578\u64da\uff0c\u63a8\u9032\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u4f5c\u70ba\u55ae\u85e5\u53ca\u806f\u5408\u7528\u85e5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u89e3\u6c7a\u5168\u7403\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u3002\u300d \u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aTEVIMBRA\u00ae\uff09\u4e8e2023\u5e74\u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5316\u7642\u5f8c\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\uff0c\u76ee\u524d\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5728\u9032\u884c\u5be9\u8a55\u4e2d\u3002FDA\u4e5f\u6b63\u5728\u5be9\u8a55\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u3001\u5fa9\u767c\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u767e\u6fdf\u795e\u5dde\u5df2\u555f\u52d5\u8d85\u904e17\u9805\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6f5b\u5728\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u8fc4\u4eca\u5df2\u5165\u7d4413,000\u591a\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d15\u9805\u7814\u7a76\u5df2\u767c\u4f48\u7a4d\u6975\u7684\u6578\u64da\u7d50\u679c\u3002\u901a\u904e\u9019\u4e9b\u7814\u7a76\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u5728\u5ee3\u6cdb\u7624\u7a2e\uff08\u4e14\u5728\u5f88\u591a\u60c5\u6cc1\u4e0b\u4e0d\u5340\u5206PD-\uff08L\uff091\u8868\u9054\u6c34\u6e96\uff09\u7684\u55ae\u85e5\u6216\u806f\u5408\u7528\u85e5\u6cbb\u7642\u4e2d\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u6539\u5584\u548c\u751f\u6d3b\u54c1\u8cea\u63d0\u5347\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5df2\u60e0\u53ca\u8d85\u904e90\u842c\u4f8b\u60a3\u8005\u3002 \u95dc\u65bcRATIONALE 307 RATIONALE\u00a0307\uff08NCT03594747\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44360\u4f8b\u665a\u671f\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u6e96\u5982\u4f55\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u5747\u53ef\u7372\u5f97\u7d71\u8a08\u5b78\u986f\u8457\u6539\u5584\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u7279\u5fb5\u3002\u5728\u4e2d\u4f4d\u7814\u7a76\u96a8\u8a2a8.6\u500b\u6708\u6642\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba7.7\u500b\u6708\uff08\u98a8\u96aa\u6bd4HR\uff1a0.45 ; P&lt;0.001\uff09\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u767d\u86cb\u767d\u7d50\u5408\u578b\u7d2b\u6749\u9187\u548c\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba9.6\u500b\u6708\uff08HR\uff1a0.43 ; P&lt;0.001\uff09\uff0c\u800c\u7d2b\u6749\u9187\u806f\u5408\u5361\u9251\u7684\u4e2d\u4f4dPFS\u70ba5.5\u500b\u6708\u3002\u6700\u5e38\u898b\u76843\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u548c\u767d\u7d30\u80de\u6e1b\u5c11\u75c7\u3002 \u95dc\u65bcRATIONALE 304 RATIONALE 304\uff08NCT03663205\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u30013\u671f\u8a66\u9a57\uff0c\u5171\u5165\u7d44334\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684PFS\u76f8\u6bd4\u5316\u7642\u7372\u5f97\u4e86\u7d71\u8a08\u5b78\u4e0a\u7684\u986f\u8457\u6539\u5584\uff08HR 0.65 ; 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10-Q \u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002 Globocan 2020. 900-world-fact-sheets.pdf (iarc.fr). European Society of Medical Oncology. What is Non-Small-Cell Lung Cancer? https:\/\/www.esmo.org\/content\/download\/7252\/143219\/file\/en-non-small-cell-lung-cancer-guide-for-patients.pdf. Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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