{"id":218899,"date":"2024-02-20T08:00:00","date_gmt":"2024-02-20T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=218899"},"modified":"2024-02-20T08:00:00","modified_gmt":"2024-02-20T00:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88ibi311%ef%bc%88%e6%8a%97igf-1r%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e7%94%b2%e7%8b%80%e8%85%ba%e7%9c%bc%e7%97%85%e7%9a%84iii%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=218899","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI311\uff08\u6297IGF-1R\u6297\u9ad4\uff09\u6cbb\u7642\u7532\u72c0\u817a\u773c\u75c5\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08RESTORE-1\uff09\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u8a08\u5283\u5c07\u905e\u4ea4\u4e0a\u5e02\u7533\u8acb"},"content":{"rendered":"
\n

2024\u5e742\u670820\u65e5\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u7814\u767c\u7684\u91cd\u7d44\u6297\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b501\u53d7\u9ad4\uff08IGF-1R\uff09\u6297\u9ad4\u6ce8\u5c04\u6db2\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI311\uff09\u5728\u4e2d\u570b\u7532\u72c0\u817a\u773c\u75c5\uff08Thyroid Eye Disease, TED\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08RESTORE-1\uff09\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002\u4fe1\u9054\u751f\u7269\u8a08\u5283\u5411\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u905e\u4ea4IBI311\u6cbb\u7642TED\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n

RESTORE-1\uff08CTR20223393\uff09\u662f\u4e00\u9805\u5728TED\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30IBI311\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u5b89\u6170\u5291\u5c0d\u7167\u7684II\/III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cRESTORE-1\u7684III\u671f\u968e\u6bb5\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u9806\u5229\u9054\u6210\uff1a\u7b2c24\u5468\u6642\uff0c\u63a5\u53d7IBI311\u6cbb\u7642\u7684\u53d7\u8a66\u8005\u7814\u7a76\u773c\u7684\u773c\u7403\u7a81\u51fa\u61c9\u7b54\u7387\uff08\u7814\u7a76\u773c\u76f8\u5c0d\u65bc\u57fa\u7dda\u7a81\u773c\u5ea6\u56de\u9000\u22652mm\uff0c\u4e14\u4e0d\u4f34\u6709\u5c0d\u5074\u773c\u7a81\u773c\u5ea6\u589e\u52a0\u22652mm\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\uff09\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\u7d44\uff1aIBI311\u7d44\u548c\u5b89\u6170\u5291\u7d44\u7814\u7a76\u773c\u7684\u773c\u7403\u7a81\u51fa\u61c9\u7b54\u7387\u5206\u5225\u70ba85.8%\u548c3.8%\uff0c\u5169\u7d44\u5dee\u7570\u70ba81.9%\uff0895%CI\uff1a69.8%-93.9%\uff0cP<0.0001\uff09\u3002<\/p>\n

\u6b64\u5916\uff0c \u7814\u7a76\u7684\u95dc\u9375\u6b21\u8981\u7814\u7a76\u7d42\u9ede\u5982\u7814\u7a76\u773c\u7684\u773c\u7403\u7e3d\u9ad4\u61c9\u7b54\u7387(\u7814\u7a76\u773c\u76f8\u5c0d\u65bc\u57fa\u7dda\u7a81\u773c\u5ea6\u56de\u9000\u22652mm\u53ca\u7814\u7a76\u773c\u81e8\u5e8a\u6d3b\u52d5\u6027\u8a55\u5206\u6539\u5584\u22652\u5206\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b)\u3001\u7814\u7a76\u773c\u81e8\u5e8a\u6d3b\u52d5\u6027\u8a55\u5206\uff08CAS\uff09\u70ba0\u62161\u7684\u53d7\u8a66\u8005\u767e\u5206\u6bd4\u3001\u7814\u7a76\u773c\u7684\u773c\u7403\u7a81\u51fa\u5ea6\u8f03\u57fa\u7dda\u7684\u6539\u8b8a\u7b49\u5747\u9806\u5229\u9054\u6210\uff0cIBI311\u5c0d\u4e0a\u8ff0\u6307\u6a19\u7684\u6539\u5584\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\u7d44\u3002<\/p>\n

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\u95dc\u65bc\u7532\u72c0\u817a\u773c\u75c5\uff08<\/b>TED<\/b>\uff09<\/b><\/p>\n

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TED\u7684\u5e74\u767c\u75c5\u7387\u9810\u4f30\u70ba16\/100,000\u4eba\uff08\u5973\u6027\uff09\u548c2.9\/100,000\u4eba\uff08\u7537\u6027\uff091<\/sup>\uff0c\u60a3\u75c5\u7387\u70ba0.1-0.3%2<\/sup> \u3002\u6309\u7167\u75be\u75c5\u56b4\u91cd\u7a0b\u5ea6\uff0c\u53ef\u5206\u70ba\u8f15\u5ea6\u3001\u4e2d\u91cd\u5ea6\u548c\u6975\u91cd\u5ea6\u3002\u96d6\u7136TED\u66f4\u5e38\u767c\u751f\u65bc\u5973\u6027\uff0c\u4f46\u91cd\u5ea6\u75c5\u4f8b\u66f4\u5e38\u767c\u751f\u65bc\u7537\u6027\u3002TED\u6700\u5e38\u898b\u65bc30~50\u6b72\u7684\u60a3\u8005\uff0c\u56b4\u91cdTED\u75c5\u4f8b\u66f4\u5e38\u767c\u751f\u65bc50\u6b72\u4ee5\u4e0a\u7684\u60a3\u80057<\/sup>\u3002\u76ee\u524d\uff0cTED\u7684\u767c\u75c5\u6a5f\u5236\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff0c\u4f46\u591a\u9805\u7814\u7a76\u8868\u660e\uff0c\u5b58\u5728\u65bc\u808c\u7e96\u7dad\u3001\u773c\u7736\u7e96\u7dad\u7d50\u7de0\u7d44\u7e54\u9593\u9699\u4e2d\u7684OFs\u662f\u5c0e\u81f4TED\u773c\u7736\u8edf\u7d44\u7e54\u589e\u751f\u7684\u95dc\u9375\u56e0\u7d208<\/sup>\u3002<\/p>\n

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\u76ee\u524d\uff0c\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027TED\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\u70ba\u7cd6\u76ae\u8cea\u6fc0\u7d20\u975c\u8108\u885d\u64ca\u6cbb\u7642\uff0c\u5b58\u5728\u7a81\u773c\u6539\u5584\u4e0d\u7406\u60f3\u4ee5\u53ca\u6fc0\u7d20\u76f8\u95dc\u7684\u5168\u8eab\u526f\u4f5c\u7528\u7b49\u554f\u984c\uff0c\u4ecd\u5b58\u5728\u8f03\u5927\u7684\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u4e8c\u7dda\u6cbb\u7642\u5305\u62ec\u518d\u6b21\u6fc0\u7d20\u885d\u64ca\u6216\u806f\u5408\u773c\u7736\u653e\u7642\u6216\u5176\u4ed6\u514d\u75ab\u8abf\u7bc0\u5291\u3002\u66ff\u59a5\u5c24\u55ae\u6297\uff08Teprotumumab\uff09\u3001\u6258\u73e0\u55ae\u6297\uff08TociIizumab\uff09\u548c\u5229\u59a5\u6614\u55ae\u6297\uff08Rituximab\uff09\u7b49\u751f\u7269\u5236\u5291\u4e5f\u88abEUGOGO \u6307\u53573<\/sup>\u548c\u4e2d\u570b\u7532\u72c0\u817a\u773c\u75c5\u81e8\u5e8a\u8a3a\u65b7\u548c\u6cbb\u7642\u6307\u5357\uff082022\u5e74\uff094<\/sup>\u548c\u7f8e\u570b\u7532\u72c0\u817a\u5b78\u6703\u548c\u6b50\u6d32\u7532\u72c0\u817a\u5b78\u6703\u7684\u7532\u72c0\u817a\u773c\u75c5\u5171\u8b585<\/sup>\u63a8\u85a6\u70ba\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027TED\u7684\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u3002\u5c24\u5176\u662f\u5c0d\u65bc\u5408\u4f75\u986f\u8457\u7a81\u773c\u7684TED\uff0c\u9776\u5411IGF-1R\u7684\u66ff\u59a5\u5c24\u55ae\u6297\u53ef\u4f5c\u70ba\u9996\u9078\u3002<\/p>\n

\u95dc<\/b>\u65bc<\/b>IBI311<\/b><\/p>\n

IBI311\u662f\u4fe1\u9054\u751f\u7269\u7814\u767c\u7684\u91cd\u7d44\u6297\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b501\u53d7\u9ad4\uff08IGF-1R\uff09\u6297\u9ad4\uff0c\u7528\u65bc\u6cbb\u7642TED\u3002IGF-1R\u662f\u4e00\u7a2e\u8de8\u819c\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u9ad4\uff0c\u5728\u767c\u80b2\u3001\u4ee3\u8b1d\u53ca\u514d\u75ab\u8abf\u7bc0\u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u4e26\u5728TED\u60a3\u8005\u7684OFs\u3001B\u7d30\u80de\u3001T\u7d30\u80de\u4e2d\u904e\u8868\u905411<\/sup>\u3002IBI311\u53ef\u963b\u65b7IGF-1\u7b49\u76f8\u95dc\u914d\u9ad4\u6216\u6fc0\u52d5\u578b\u6297\u9ad4\u4ecb\u5c0e\u7684IGF-1R\u4fe1\u865f\u901a\u8def\u6fc0\u6d3b\uff0c\u6e1b\u5c11\u4e0b\u6e38\u708e\u75c7\u56e0\u5b50\u7684\u8868\u9054\uff0c\u5f9e\u800c\u6291\u5236OFs\u6d3b\u5316\u5c0e\u81f4\u7684\u900f\u660e\u8cea\u9178\u548c\u5176\u4ed6\u7cd6\u80fa\u805a\u7cd6\u5408\u6210\uff0c\u6e1b\u8f15\u708e\u75c7\u53cd\u61c9\uff1b\u6291\u5236OFs\u5206\u5316\u70ba\u8102\u80aa\u7d30\u80de\u6216\u808c\u6210\u7e96\u7dad\u7d30\u80de\uff0c\u9032\u800c\u6e1b\u8f15TED\u60a3\u8005\u7684\u75be\u75c5\u6d3b\u52d5\u5ea6\uff0c\u6539\u5584\u7a81\u773c\u3001\u5fa9\u8996\u3001\u773c\u90e8\u5145\u8840\u6c34\u816b\u7b49\u75c7\u72c0\u548c\u9ad4\u5f81\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u00a0\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u6b3e\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670919\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u8207\u6d77\u5167\u5916\u85e5\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u85e5\u7269\u5275\u65b0\uff0c\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002<\/p>\n

\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u958b\u767c\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u00a0\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/\u3002<\/p>\n

\u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1<\/i>\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/i><\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n

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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/p>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartley G. The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota<\/span>. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588.<\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves’ ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60.<\/p>\n

3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy. Eur J Endocrinol. 2021;185(4):G43-G67.<\/p>\n

4.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u4e2d\u83ef\u91ab\u5b78\u6703\u773c\u79d1\u5b78\u5206\u6703\u773c\u6574\u5f62\u773c\u7736\u75c5\u5b78\u7d44, \u4e2d\u83ef\u91ab\u5b78\u6703\u5167\u5206\u6ccc\u5b78\u5206\u6703\u7532\u72c0\u817a\u5b78\u7d44. \u4e2d\u570b\u7532\u72c0\u817a\u76f8\u95dc\u773c\u75c5\u8a3a\u65b7\u548c\u6cbb\u7642\u6307\u5357 \uff082022\u5e74\uff09.\u4e2d\u83ef\u773c\u79d1\u96dc\u8a8c. 2022;58(9).<\/p>\n

5.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Burch HB, et al. Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association. Eur Thyroid J. 2022;11(6):e220189.<\/p>\n

6.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Li Z, Cestari D M, Fortin E. Thyroid eye disease: what is new to know? Curr Opin Ophthalmol. 2018;29(6):528-534.<\/p>\n

7.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Edsel I. Thyroid Associated Orbitopathy. Retrieved June 7<\/span>, 2011,\u00a0from Medscape Reference: http:\/\/emedicine.medscape.com\/article\/1218444-overview#a1<\/a><\/p>\n

8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ali F, Chorsiya A, Anjum V, Ali A. Teprotumumab (TEPEZZA): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment. Int Ophthalmol. 2021;41(4):1549-1561.\u00a0<\/p>\n

9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dolman P J. Evaluating Graves’ orbitopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):229-248.<\/p>\n

10.\u00a0\u00a0 Bahn R S. Graves’ ophthalmopathy. N Engl J Med. 2010;362(8):726-738.<\/p>\n

11.\u00a0\u00a0 Douglas\u00a0RS, Naik V, Hwang CJ, et al. B cells from patients with Graves’ disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol 2008;181:5768-5774.<\/p>\n

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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. Eur J Endocrinol. 2021;185(4):G43-G67. 4.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u4e2d\u83ef\u91ab\u5b78\u6703\u773c\u79d1\u5b78\u5206\u6703\u773c\u6574\u5f62\u773c\u7736\u75c5\u5b78\u7d44, \u4e2d\u83ef\u91ab\u5b78\u6703\u5167\u5206\u6ccc\u5b78\u5206\u6703\u7532\u72c0\u817a\u5b78\u7d44. \u4e2d\u570b\u7532\u72c0\u817a\u76f8\u95dc\u773c\u75c5\u8a3a\u65b7\u548c\u6cbb\u7642\u6307\u5357 \uff082022\u5e74\uff09.\u4e2d\u83ef\u773c\u79d1\u96dc\u8a8c. 2022;58(9). 5.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Burch HB, et al. Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association. Eur Thyroid J. 2022;11(6):e220189. 6.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Li Z, Cestari D M, Fortin E. Thyroid eye disease: what is new to know? Curr Opin Ophthalmol. 2018;29(6):528-534. 7.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Edsel I. Thyroid Associated Orbitopathy. Retrieved June 7, 2011,\u00a0from Medscape Reference: http:\/\/emedicine.medscape.com\/article\/1218444-overview#a1 8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ali F, Chorsiya A, Anjum V, Ali A. Teprotumumab (TEPEZZA): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment. Int Ophthalmol. 2021;41(4):1549-1561.\u00a0 9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dolman P J. Evaluating Graves' orbitopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):229-248. 10.\u00a0\u00a0 Bahn R S. Graves' ophthalmopathy. N Engl J Med. 2010;362(8):726-738. 11.\u00a0\u00a0 Douglas\u00a0RS, Naik V, Hwang CJ, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol 2008;181:5768-5774. \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=218899\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI311\uff08\u6297IGF-1R\u6297\u9ad4\uff09\u6cbb\u7642\u7532\u72c0\u817a\u773c\u75c5\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08RESTORE-1\uff09\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u8a08\u5283\u5c07\u905e\u4ea4\u4e0a\u5e02\u7533\u8acb - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"2024\u5e742\u670820\u65e5\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde \/\u7f8e\u901a\u793e\/ -- 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. 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Retrieved June 7, 2011,\u00a0from Medscape Reference: http:\/\/emedicine.medscape.com\/article\/1218444-overview#a1 8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ali F, Chorsiya A, Anjum V, Ali A. Teprotumumab (TEPEZZA): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment. Int Ophthalmol. 2021;41(4):1549-1561.\u00a0 9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dolman P J. Evaluating Graves' orbitopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):229-248. 10.\u00a0\u00a0 Bahn R S. Graves' ophthalmopathy. N Engl J Med. 2010;362(8):726-738. 11.\u00a0\u00a0 Douglas\u00a0RS, Naik V, Hwang CJ, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol 2008;181:5768-5774. \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=218899","og_locale":"zh_TW","og_type":"article","og_title":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48IBI311\uff08\u6297IGF-1R\u6297\u9ad4\uff09\u6cbb\u7642\u7532\u72c0\u817a\u773c\u75c5\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08RESTORE-1\uff09\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u8a08\u5283\u5c07\u905e\u4ea4\u4e0a\u5e02\u7533\u8acb - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"2024\u5e742\u670820\u65e5\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde \/\u7f8e\u901a\u793e\/ -- 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. Eur J Endocrinol. 2021;185(4):G43-G67. 4.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u4e2d\u83ef\u91ab\u5b78\u6703\u773c\u79d1\u5b78\u5206\u6703\u773c\u6574\u5f62\u773c\u7736\u75c5\u5b78\u7d44, \u4e2d\u83ef\u91ab\u5b78\u6703\u5167\u5206\u6ccc\u5b78\u5206\u6703\u7532\u72c0\u817a\u5b78\u7d44. \u4e2d\u570b\u7532\u72c0\u817a\u76f8\u95dc\u773c\u75c5\u8a3a\u65b7\u548c\u6cbb\u7642\u6307\u5357 \uff082022\u5e74\uff09.\u4e2d\u83ef\u773c\u79d1\u96dc\u8a8c. 2022;58(9). 5.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Burch HB, et al. Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association. Eur Thyroid J. 2022;11(6):e220189. 6.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Li Z, Cestari D M, Fortin E. Thyroid eye disease: what is new to know? Curr Opin Ophthalmol. 2018;29(6):528-534. 7.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Edsel I. Thyroid Associated Orbitopathy. Retrieved June 7, 2011,\u00a0from Medscape Reference: http:\/\/emedicine.medscape.com\/article\/1218444-overview#a1 8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ali F, Chorsiya A, Anjum V, Ali A. Teprotumumab (TEPEZZA): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment. Int Ophthalmol. 2021;41(4):1549-1561.\u00a0 9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dolman P J. Evaluating Graves' orbitopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):229-248. 10.\u00a0\u00a0 Bahn R S. Graves' ophthalmopathy. N Engl J Med. 2010;362(8):726-738. 11.\u00a0\u00a0 Douglas\u00a0RS, Naik V, Hwang CJ, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. 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The epidemiological characteristics and clinical course of ophthalmology\u00a0associated with autoimmune thyroid disease in Olmsted Country, Minnesota. Trans Am\u00a0Ophthalmol Soc 1994;92:477-588. 2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hiromatsu Y, Eguchi H, Tani J, Kasaoka M, Teshima Y. Graves' ophthalmopathy: epidemiology and natural history. Intern Med. 2014;53(5):353-60. 3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy. 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Retrieved June 7, 2011,\u00a0from Medscape Reference: http:\/\/emedicine.medscape.com\/article\/1218444-overview#a1 8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ali F, Chorsiya A, Anjum V, Ali A. Teprotumumab (TEPEZZA): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment. Int Ophthalmol. 2021;41(4):1549-1561.\u00a0 9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dolman P J. Evaluating Graves' orbitopathy. Best Pract Res Clin Endocrinol Metab.2012;26(3):229-248. 10.\u00a0\u00a0 Bahn R S. Graves' ophthalmopathy. N Engl J Med. 2010;362(8):726-738. 11.\u00a0\u00a0 Douglas\u00a0RS, Naik V, Hwang CJ, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. 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