{"id":214960,"date":"2024-01-30T10:53:00","date_gmt":"2024-01-30T02:53:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=214960"},"modified":"2024-01-30T10:53:00","modified_gmt":"2024-01-30T02:53:00","slug":"%e9%bd%8a%e9%ad%af%e8%a3%bd%e8%97%a5%e4%bc%8a%e9%ad%af%e9%98%bf%e5%85%8biii%e6%9c%9finspire%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e7%99%bb%e4%b8%8a%e5%9c%8b%e9%9a%9b%e6%ac%8a%e5%a8%81%e6%9c%9f%e5%88%8a","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=214960","title":{"rendered":"\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514bIII\u671fINSPIRE\u7814\u7a76\u6210\u679c\u767b\u4e0a\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6fdf\u5357<\/span>2024\u5e741\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0c\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514b\u7247\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684III\u671fINSPIRE\u7814\u7a76\u4e2d\u671f\u5206\u6790\u7d50\u679c\u5728\u570b\u969b\u80ba\u764c\u7814\u7a76\u5354\u6703\u5b98\u65b9\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08Journal of Thoracic Oncology\uff0cIF=20.4\uff09\u767c\u8868\u3002\u4f0a\u9b6f\u963f\u514bINSPIRE\u7814\u7a76\u7d50\u679c\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520a\u7684\u767c\u8868\uff0c\u9ad4\u73fe\u4e86\u570b\u969b\u5b78\u8853\u754c\u5c0d\u65bc\u672c\u9805\u7814\u7a76\u6210\u679c\u81e8\u5e8a\u610f\u7fa9\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9032\u4e00\u6b65\u52a0\u6df1\u5b78\u754c\u5c0dINSPIRE\u7814\u7a76\u548c\u4f0a\u9b6f\u963f\u514b\u7684\u8a8d\u8b58\u3002<\/p>\n

\n<\/p><\/div>\n

\u4f0a\u9b6f\u963f\u514b\u662f\u65b0\u4e00\u4ee3ALK\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\uff0c\u5c0d\u91ce\u751f\u578b\u548c\u7a81\u8b8a\u578bALK\u878d\u5408\u57fa\u56e0\u5747\u6709\u6291\u5236\u4f5c\u7528\u3002\u9019\u9805\u7814\u7a76\u5728\u5168\u570b40\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u727d\u982d\u7814\u7a76\u8005\u70ba\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u77f3\u9060\u51f1\u6559\u6388\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u986f\u8457\u5ef6\u9577\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u540c\u6642\u986f\u793a\u51fa\u66f4\u512a\u7684\u9871\u5167\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n

INSPIRE\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4f0a\u9b6f\u963f\u514b\u8207\u514b\u5511\u66ff\u5c3c\u5c0d\u6bd4\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u904eALK\u6291\u5236\u5291\u6cbb\u7642\u7684ALK\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u6b64\u524d\uff0c\u90e8\u5206\u8cc7\u6599\u57282023\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u8868\u3002<\/p>\n

2019\u5e749\u67084\u65e5\u81f32020\u5e7412\u67082\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d44292\u4f8bALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec81\u4f8b\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u8f49\u79fb\u7684\u60a3\u8005\u3002<\/p>\n

\u57fa\u65bc\u6b64\u6b21\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u7684\u7d50\u679c\uff0c\u622a\u81f32022\u5e7411\u670813\u65e5\uff0cIRC\u8a55\u4f30\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u7684\u4e2d\u4f4dPFS\u5206\u5225\u70ba27.7\u500b\u6708\u548c14.6\u500b\u6708\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u70ba0.34\uff0898.02% \u7f6e\u4fe1\u5340\u9593CI, 0.23-0.52\uff09\u3002\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u8005\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8666\uff05\u3002\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u7d50\u679c\u8207IRC\u8a55\u4f30\u7d50\u679c\u4e00\u81f4\u3002\u81f3\u8cc7\u6599\u622a\u6b62\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44OS\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f26.7\u500b\u6708\uff0c\u5c0d\u7167\u7d44\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f25.9\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\u3002<\/p>\n

\u4e9e\u7d44\u5206\u6790\u53ca\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\u4e5f\u652f\u6301\u4f0a\u9b6f\u963f\u514b\u7684\u512a\u7570\u7642\u6548\u3002\u4f0a\u9b6f\u963f\u514b\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u6240\u7522\u751f\u7684\u816b\u7624\u7de9\u89e3\u66f4\u6301\u4e45\uff08\u4e2d\u4f4dDoR, 26.8\u500b\u6708 vs. 12.9\u500b\u6708\uff1bHR\uff0c0.31\uff09\u3002\u5728\u57fa\u7dda\u6709CNS\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684CNS\u5ba2\u89c0\u7de9\u89e3\u7387\u66f4\u9ad8\uff08\u9871\u5167ORR\uff0c57.9% vs. 25.6%\uff1b\u9871\u5167CR\uff0c31.6% vs. 2.6%\uff09\uff1b\u5728\u57fa\u7dda\u6709\u53ef\u6e2c\u91cfCNS\u8f49\u79fb\u7076\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u9871\u5167ORR\u905490.9%\u3002<\/p>\n

\u5b89\u5168\u6027\u65b9\u9762\uff0c\u5118\u7ba1\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u60a3\u8005\u6bd4\u5c0d\u7167\u7d44\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u7684\u6642\u9593\u66f4\u9577\uff0823.9\u500b\u6708 vs. 12.9\u500b\u6708\uff09\uff0c\u5169\u7d44\u91cd\u5ea6\u4e0d\u826f\u53cd\u61c9\uff083\u7d1a\u62164\u7d1a\uff09\u7684\u767c\u751f\u7387\u76f8\u7576\uff0851.7% vs.49.7%\uff09\u3002<\/p>\n

\u57fa\u65bcINSPIRE\u7814\u7a76\u7684\u7d50\u679c\uff0c\u4f0a\u9b6f\u963f\u514b\u65bc\u4eca\u5e741\u6708\u88ab\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u55ae\u85e5\u7528\u65bcALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u76ee\u524d\u8a72\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u65b0\u7684\u8cc7\u6599\u5c07\u9678\u7e8c\u5728\u5404\u5927\u5b78\u8853\u6703\u8b70\u4e0a\u516c\u4f48\u3002<\/p>\n

\u539f\u6587\u9023\u7d50\uff1ahttps:\/\/www.jto.org\/article\/S1556-0864(24)00033-9\/fulltext<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6fdf\u53572024\u5e741\u670830\u65e5 \/\u7f8e…<\/p>\n","protected":false},"author":16,"featured_media":214961,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-214960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514bIII\u671fINSPIRE\u7814\u7a76\u6210\u679c\u767b\u4e0a\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u6fdf\u53572024\u5e741\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u8fd1\u65e5\uff0c\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514b\u7247\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684III\u671fINSPIRE\u7814\u7a76\u4e2d\u671f\u5206\u6790\u7d50\u679c\u5728\u570b\u969b\u80ba\u764c\u7814\u7a76\u5354\u6703\u5b98\u65b9\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08Journal of Thoracic Oncology\uff0cIF=20.4\uff09\u767c\u8868\u3002\u4f0a\u9b6f\u963f\u514bINSPIRE\u7814\u7a76\u7d50\u679c\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520a\u7684\u767c\u8868\uff0c\u9ad4\u73fe\u4e86\u570b\u969b\u5b78\u8853\u754c\u5c0d\u65bc\u672c\u9805\u7814\u7a76\u6210\u679c\u81e8\u5e8a\u610f\u7fa9\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9032\u4e00\u6b65\u52a0\u6df1\u5b78\u754c\u5c0dINSPIRE\u7814\u7a76\u548c\u4f0a\u9b6f\u963f\u514b\u7684\u8a8d\u8b58\u3002 \u4f0a\u9b6f\u963f\u514b\u662f\u65b0\u4e00\u4ee3ALK\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\uff0c\u5c0d\u91ce\u751f\u578b\u548c\u7a81\u8b8a\u578bALK\u878d\u5408\u57fa\u56e0\u5747\u6709\u6291\u5236\u4f5c\u7528\u3002\u9019\u9805\u7814\u7a76\u5728\u5168\u570b40\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u727d\u982d\u7814\u7a76\u8005\u70ba\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u77f3\u9060\u51f1\u6559\u6388\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u986f\u8457\u5ef6\u9577\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u540c\u6642\u986f\u793a\u51fa\u66f4\u512a\u7684\u9871\u5167\u6297\u816b\u7624\u6d3b\u6027\u3002 INSPIRE\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4f0a\u9b6f\u963f\u514b\u8207\u514b\u5511\u66ff\u5c3c\u5c0d\u6bd4\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u904eALK\u6291\u5236\u5291\u6cbb\u7642\u7684ALK\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u6b64\u524d\uff0c\u90e8\u5206\u8cc7\u6599\u57282023\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u8868\u3002 2019\u5e749\u67084\u65e5\u81f32020\u5e7412\u67082\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d44292\u4f8bALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec81\u4f8b\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u8f49\u79fb\u7684\u60a3\u8005\u3002 \u57fa\u65bc\u6b64\u6b21\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u7684\u7d50\u679c\uff0c\u622a\u81f32022\u5e7411\u670813\u65e5\uff0cIRC\u8a55\u4f30\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u7684\u4e2d\u4f4dPFS\u5206\u5225\u70ba27.7\u500b\u6708\u548c14.6\u500b\u6708\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u70ba0.34\uff0898.02% \u7f6e\u4fe1\u5340\u9593CI, 0.23-0.52\uff09\u3002\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u8005\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8666\uff05\u3002\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u7d50\u679c\u8207IRC\u8a55\u4f30\u7d50\u679c\u4e00\u81f4\u3002\u81f3\u8cc7\u6599\u622a\u6b62\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44OS\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f26.7\u500b\u6708\uff0c\u5c0d\u7167\u7d44\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f25.9\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\u3002 \u4e9e\u7d44\u5206\u6790\u53ca\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\u4e5f\u652f\u6301\u4f0a\u9b6f\u963f\u514b\u7684\u512a\u7570\u7642\u6548\u3002\u4f0a\u9b6f\u963f\u514b\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u6240\u7522\u751f\u7684\u816b\u7624\u7de9\u89e3\u66f4\u6301\u4e45\uff08\u4e2d\u4f4dDoR, 26.8\u500b\u6708 vs. 12.9\u500b\u6708\uff1bHR\uff0c0.31\uff09\u3002\u5728\u57fa\u7dda\u6709CNS\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684CNS\u5ba2\u89c0\u7de9\u89e3\u7387\u66f4\u9ad8\uff08\u9871\u5167ORR\uff0c57.9% vs. 25.6%\uff1b\u9871\u5167CR\uff0c31.6% vs. 2.6%\uff09\uff1b\u5728\u57fa\u7dda\u6709\u53ef\u6e2c\u91cfCNS\u8f49\u79fb\u7076\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u9871\u5167ORR\u905490.9%\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5118\u7ba1\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u60a3\u8005\u6bd4\u5c0d\u7167\u7d44\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u7684\u6642\u9593\u66f4\u9577\uff0823.9\u500b\u6708 vs. 12.9\u500b\u6708\uff09\uff0c\u5169\u7d44\u91cd\u5ea6\u4e0d\u826f\u53cd\u61c9\uff083\u7d1a\u62164\u7d1a\uff09\u7684\u767c\u751f\u7387\u76f8\u7576\uff0851.7% vs.49.7%\uff09\u3002 \u57fa\u65bcINSPIRE\u7814\u7a76\u7684\u7d50\u679c\uff0c\u4f0a\u9b6f\u963f\u514b\u65bc\u4eca\u5e741\u6708\u88ab\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u55ae\u85e5\u7528\u65bcALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u76ee\u524d\u8a72\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u65b0\u7684\u8cc7\u6599\u5c07\u9678\u7e8c\u5728\u5404\u5927\u5b78\u8853\u6703\u8b70\u4e0a\u516c\u4f48\u3002 \u539f\u6587\u9023\u7d50\uff1ahttps:\/\/www.jto.org\/article\/S1556-0864(24)00033-9\/fulltext\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=214960\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514bIII\u671fINSPIRE\u7814\u7a76\u6210\u679c\u767b\u4e0a\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u6fdf\u53572024\u5e741\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u8fd1\u65e5\uff0c\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514b\u7247\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684III\u671fINSPIRE\u7814\u7a76\u4e2d\u671f\u5206\u6790\u7d50\u679c\u5728\u570b\u969b\u80ba\u764c\u7814\u7a76\u5354\u6703\u5b98\u65b9\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08Journal of Thoracic Oncology\uff0cIF=20.4\uff09\u767c\u8868\u3002\u4f0a\u9b6f\u963f\u514bINSPIRE\u7814\u7a76\u7d50\u679c\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520a\u7684\u767c\u8868\uff0c\u9ad4\u73fe\u4e86\u570b\u969b\u5b78\u8853\u754c\u5c0d\u65bc\u672c\u9805\u7814\u7a76\u6210\u679c\u81e8\u5e8a\u610f\u7fa9\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9032\u4e00\u6b65\u52a0\u6df1\u5b78\u754c\u5c0dINSPIRE\u7814\u7a76\u548c\u4f0a\u9b6f\u963f\u514b\u7684\u8a8d\u8b58\u3002 \u4f0a\u9b6f\u963f\u514b\u662f\u65b0\u4e00\u4ee3ALK\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\uff0c\u5c0d\u91ce\u751f\u578b\u548c\u7a81\u8b8a\u578bALK\u878d\u5408\u57fa\u56e0\u5747\u6709\u6291\u5236\u4f5c\u7528\u3002\u9019\u9805\u7814\u7a76\u5728\u5168\u570b40\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u727d\u982d\u7814\u7a76\u8005\u70ba\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u77f3\u9060\u51f1\u6559\u6388\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u986f\u8457\u5ef6\u9577\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u540c\u6642\u986f\u793a\u51fa\u66f4\u512a\u7684\u9871\u5167\u6297\u816b\u7624\u6d3b\u6027\u3002 INSPIRE\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4f0a\u9b6f\u963f\u514b\u8207\u514b\u5511\u66ff\u5c3c\u5c0d\u6bd4\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u904eALK\u6291\u5236\u5291\u6cbb\u7642\u7684ALK\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u6b64\u524d\uff0c\u90e8\u5206\u8cc7\u6599\u57282023\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u8868\u3002 2019\u5e749\u67084\u65e5\u81f32020\u5e7412\u67082\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d44292\u4f8bALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec81\u4f8b\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u8f49\u79fb\u7684\u60a3\u8005\u3002 \u57fa\u65bc\u6b64\u6b21\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u7684\u7d50\u679c\uff0c\u622a\u81f32022\u5e7411\u670813\u65e5\uff0cIRC\u8a55\u4f30\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u7684\u4e2d\u4f4dPFS\u5206\u5225\u70ba27.7\u500b\u6708\u548c14.6\u500b\u6708\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u70ba0.34\uff0898.02% \u7f6e\u4fe1\u5340\u9593CI, 0.23-0.52\uff09\u3002\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u8005\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8666\uff05\u3002\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u7d50\u679c\u8207IRC\u8a55\u4f30\u7d50\u679c\u4e00\u81f4\u3002\u81f3\u8cc7\u6599\u622a\u6b62\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44OS\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f26.7\u500b\u6708\uff0c\u5c0d\u7167\u7d44\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f25.9\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\u3002 \u4e9e\u7d44\u5206\u6790\u53ca\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\u4e5f\u652f\u6301\u4f0a\u9b6f\u963f\u514b\u7684\u512a\u7570\u7642\u6548\u3002\u4f0a\u9b6f\u963f\u514b\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u6240\u7522\u751f\u7684\u816b\u7624\u7de9\u89e3\u66f4\u6301\u4e45\uff08\u4e2d\u4f4dDoR, 26.8\u500b\u6708 vs. 12.9\u500b\u6708\uff1bHR\uff0c0.31\uff09\u3002\u5728\u57fa\u7dda\u6709CNS\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684CNS\u5ba2\u89c0\u7de9\u89e3\u7387\u66f4\u9ad8\uff08\u9871\u5167ORR\uff0c57.9% vs. 25.6%\uff1b\u9871\u5167CR\uff0c31.6% vs. 2.6%\uff09\uff1b\u5728\u57fa\u7dda\u6709\u53ef\u6e2c\u91cfCNS\u8f49\u79fb\u7076\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u9871\u5167ORR\u905490.9%\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5118\u7ba1\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u60a3\u8005\u6bd4\u5c0d\u7167\u7d44\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u7684\u6642\u9593\u66f4\u9577\uff0823.9\u500b\u6708 vs. 12.9\u500b\u6708\uff09\uff0c\u5169\u7d44\u91cd\u5ea6\u4e0d\u826f\u53cd\u61c9\uff083\u7d1a\u62164\u7d1a\uff09\u7684\u767c\u751f\u7387\u76f8\u7576\uff0851.7% vs.49.7%\uff09\u3002 \u57fa\u65bcINSPIRE\u7814\u7a76\u7684\u7d50\u679c\uff0c\u4f0a\u9b6f\u963f\u514b\u65bc\u4eca\u5e741\u6708\u88ab\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u55ae\u85e5\u7528\u65bcALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u76ee\u524d\u8a72\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u65b0\u7684\u8cc7\u6599\u5c07\u9678\u7e8c\u5728\u5404\u5927\u5b78\u8853\u6703\u8b70\u4e0a\u516c\u4f48\u3002 \u539f\u6587\u9023\u7d50\uff1ahttps:\/\/www.jto.org\/article\/S1556-0864(24)00033-9\/fulltext\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=214960\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-30T02:53:00+00:00\" \/>\n<meta property=\"og:image\" 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INSPIRE\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4f0a\u9b6f\u963f\u514b\u8207\u514b\u5511\u66ff\u5c3c\u5c0d\u6bd4\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u904eALK\u6291\u5236\u5291\u6cbb\u7642\u7684ALK\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u6b64\u524d\uff0c\u90e8\u5206\u8cc7\u6599\u57282023\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u8868\u3002 2019\u5e749\u67084\u65e5\u81f32020\u5e7412\u67082\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d44292\u4f8bALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec81\u4f8b\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u8f49\u79fb\u7684\u60a3\u8005\u3002 \u57fa\u65bc\u6b64\u6b21\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u7684\u7d50\u679c\uff0c\u622a\u81f32022\u5e7411\u670813\u65e5\uff0cIRC\u8a55\u4f30\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u7684\u4e2d\u4f4dPFS\u5206\u5225\u70ba27.7\u500b\u6708\u548c14.6\u500b\u6708\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u70ba0.34\uff0898.02% \u7f6e\u4fe1\u5340\u9593CI, 0.23-0.52\uff09\u3002\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u8005\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8666\uff05\u3002\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u7d50\u679c\u8207IRC\u8a55\u4f30\u7d50\u679c\u4e00\u81f4\u3002\u81f3\u8cc7\u6599\u622a\u6b62\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44OS\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f26.7\u500b\u6708\uff0c\u5c0d\u7167\u7d44\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f25.9\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\u3002 \u4e9e\u7d44\u5206\u6790\u53ca\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\u4e5f\u652f\u6301\u4f0a\u9b6f\u963f\u514b\u7684\u512a\u7570\u7642\u6548\u3002\u4f0a\u9b6f\u963f\u514b\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u6240\u7522\u751f\u7684\u816b\u7624\u7de9\u89e3\u66f4\u6301\u4e45\uff08\u4e2d\u4f4dDoR, 26.8\u500b\u6708 vs. 12.9\u500b\u6708\uff1bHR\uff0c0.31\uff09\u3002\u5728\u57fa\u7dda\u6709CNS\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684CNS\u5ba2\u89c0\u7de9\u89e3\u7387\u66f4\u9ad8\uff08\u9871\u5167ORR\uff0c57.9% vs. 25.6%\uff1b\u9871\u5167CR\uff0c31.6% vs. 2.6%\uff09\uff1b\u5728\u57fa\u7dda\u6709\u53ef\u6e2c\u91cfCNS\u8f49\u79fb\u7076\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u9871\u5167ORR\u905490.9%\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5118\u7ba1\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u60a3\u8005\u6bd4\u5c0d\u7167\u7d44\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u7684\u6642\u9593\u66f4\u9577\uff0823.9\u500b\u6708 vs. 12.9\u500b\u6708\uff09\uff0c\u5169\u7d44\u91cd\u5ea6\u4e0d\u826f\u53cd\u61c9\uff083\u7d1a\u62164\u7d1a\uff09\u7684\u767c\u751f\u7387\u76f8\u7576\uff0851.7% vs.49.7%\uff09\u3002 \u57fa\u65bcINSPIRE\u7814\u7a76\u7684\u7d50\u679c\uff0c\u4f0a\u9b6f\u963f\u514b\u65bc\u4eca\u5e741\u6708\u88ab\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u55ae\u85e5\u7528\u65bcALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u76ee\u524d\u8a72\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u65b0\u7684\u8cc7\u6599\u5c07\u9678\u7e8c\u5728\u5404\u5927\u5b78\u8853\u6703\u8b70\u4e0a\u516c\u4f48\u3002 \u539f\u6587\u9023\u7d50\uff1ahttps:\/\/www.jto.org\/article\/S1556-0864(24)00033-9\/fulltext","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=214960","og_locale":"zh_TW","og_type":"article","og_title":"\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514bIII\u671fINSPIRE\u7814\u7a76\u6210\u679c\u767b\u4e0a\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u6fdf\u53572024\u5e741\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u8fd1\u65e5\uff0c\u9f4a\u9b6f\u88fd\u85e5\u4f0a\u9b6f\u963f\u514b\u7247\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684III\u671fINSPIRE\u7814\u7a76\u4e2d\u671f\u5206\u6790\u7d50\u679c\u5728\u570b\u969b\u80ba\u764c\u7814\u7a76\u5354\u6703\u5b98\u65b9\u671f\u520a\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08Journal of Thoracic Oncology\uff0cIF=20.4\uff09\u767c\u8868\u3002\u4f0a\u9b6f\u963f\u514bINSPIRE\u7814\u7a76\u7d50\u679c\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520a\u7684\u767c\u8868\uff0c\u9ad4\u73fe\u4e86\u570b\u969b\u5b78\u8853\u754c\u5c0d\u65bc\u672c\u9805\u7814\u7a76\u6210\u679c\u81e8\u5e8a\u610f\u7fa9\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9032\u4e00\u6b65\u52a0\u6df1\u5b78\u754c\u5c0dINSPIRE\u7814\u7a76\u548c\u4f0a\u9b6f\u963f\u514b\u7684\u8a8d\u8b58\u3002 \u4f0a\u9b6f\u963f\u514b\u662f\u65b0\u4e00\u4ee3ALK\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\uff0c\u5c0d\u91ce\u751f\u578b\u548c\u7a81\u8b8a\u578bALK\u878d\u5408\u57fa\u56e0\u5747\u6709\u6291\u5236\u4f5c\u7528\u3002\u9019\u9805\u7814\u7a76\u5728\u5168\u570b40\u5bb6\u4e2d\u5fc3\u958b\u5c55\uff0c\u727d\u982d\u7814\u7a76\u8005\u70ba\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u77f3\u9060\u51f1\u6559\u6388\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u986f\u8457\u5ef6\u9577\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u540c\u6642\u986f\u793a\u51fa\u66f4\u512a\u7684\u9871\u5167\u6297\u816b\u7624\u6d3b\u6027\u3002 INSPIRE\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4f0a\u9b6f\u963f\u514b\u8207\u514b\u5511\u66ff\u5c3c\u5c0d\u6bd4\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u904eALK\u6291\u5236\u5291\u6cbb\u7642\u7684ALK\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u6b64\u524d\uff0c\u90e8\u5206\u8cc7\u6599\u57282023\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u8868\u3002 2019\u5e749\u67084\u65e5\u81f32020\u5e7412\u67082\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d44292\u4f8bALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec81\u4f8b\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u8f49\u79fb\u7684\u60a3\u8005\u3002 \u57fa\u65bc\u6b64\u6b21\u300a\u80f8\u90e8\u816b\u7624\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u7684\u7d50\u679c\uff0c\u622a\u81f32022\u5e7411\u670813\u65e5\uff0cIRC\u8a55\u4f30\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u7684\u4e2d\u4f4dPFS\u5206\u5225\u70ba27.7\u500b\u6708\u548c14.6\u500b\u6708\uff0c\u98a8\u96aa\u6bd4\uff08HR\uff09\u70ba0.34\uff0898.02% \u7f6e\u4fe1\u5340\u9593CI, 0.23-0.52\uff09\u3002\u8207\u514b\u5511\u66ff\u5c3c\u7d44\u76f8\u6bd4\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u8005\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e\u4e8666\uff05\u3002\u7814\u7a76\u8005\u8a55\u4f30\u7684PFS\u7d50\u679c\u8207IRC\u8a55\u4f30\u7d50\u679c\u4e00\u81f4\u3002\u81f3\u8cc7\u6599\u622a\u6b62\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44OS\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f26.7\u500b\u6708\uff0c\u5c0d\u7167\u7d44\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u662f25.9\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\u3002 \u4e9e\u7d44\u5206\u6790\u53ca\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\u4e5f\u652f\u6301\u4f0a\u9b6f\u963f\u514b\u7684\u512a\u7570\u7642\u6548\u3002\u4f0a\u9b6f\u963f\u514b\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u6240\u7522\u751f\u7684\u816b\u7624\u7de9\u89e3\u66f4\u6301\u4e45\uff08\u4e2d\u4f4dDoR, 26.8\u500b\u6708 vs. 12.9\u500b\u6708\uff1bHR\uff0c0.31\uff09\u3002\u5728\u57fa\u7dda\u6709CNS\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684CNS\u5ba2\u89c0\u7de9\u89e3\u7387\u66f4\u9ad8\uff08\u9871\u5167ORR\uff0c57.9% vs. 25.6%\uff1b\u9871\u5167CR\uff0c31.6% vs. 2.6%\uff09\uff1b\u5728\u57fa\u7dda\u6709\u53ef\u6e2c\u91cfCNS\u8f49\u79fb\u7076\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u9871\u5167ORR\u905490.9%\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5118\u7ba1\u4f0a\u9b6f\u963f\u514b\u7d44\u7684\u60a3\u8005\u6bd4\u5c0d\u7167\u7d44\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u7684\u6642\u9593\u66f4\u9577\uff0823.9\u500b\u6708 vs. 12.9\u500b\u6708\uff09\uff0c\u5169\u7d44\u91cd\u5ea6\u4e0d\u826f\u53cd\u61c9\uff083\u7d1a\u62164\u7d1a\uff09\u7684\u767c\u751f\u7387\u76f8\u7576\uff0851.7% vs.49.7%\uff09\u3002 \u57fa\u65bcINSPIRE\u7814\u7a76\u7684\u7d50\u679c\uff0c\u4f0a\u9b6f\u963f\u514b\u65bc\u4eca\u5e741\u6708\u88ab\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u55ae\u85e5\u7528\u65bcALK\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u76ee\u524d\u8a72\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u65b0\u7684\u8cc7\u6599\u5c07\u9678\u7e8c\u5728\u5404\u5927\u5b78\u8853\u6703\u8b70\u4e0a\u516c\u4f48\u3002 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