{"id":212382,"date":"2024-01-18T22:08:00","date_gmt":"2024-01-18T14:08:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=212382"},"modified":"2024-01-18T22:08:00","modified_gmt":"2024-01-18T14:08:00","slug":"pepromene-bio-inc-%e5%ae%a3%e4%bd%88%e5%9c%a8-city-of-hope-%e9%80%b2%e8%a1%8c%e7%9a%84-pmb-ct01%ef%bc%88baffr-car-t-%e7%b4%b0%e8%83%9e%ef%bc%89%e7%ac%ac-1-%e6%9c%9f%e8%87%a8%e5%ba%8a%e8%a9%a6","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=212382","title":{"rendered":"PeproMene Bio, Inc. \u5ba3\u4f48\u5728 City of Hope \u9032\u884c\u7684 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u9996\u4f4d\u63a5\u53d7\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (B-ALL) \u6cbb\u7642\u7684\u60a3\u8005\u9054\u6210\u5b8c\u5168\u7de9\u89e3"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u52a0\u5dde\u723e\u7063<\/span><span class=\"legendSpanClass\">2024\u5e741\u670818\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; PeproMene Bio, Inc. \u662f\u4e00\u5bb6\u958b\u767c\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u7684\u65b0\u578b\u7642\u6cd5\u4e4b\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u8a72\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5728 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7684\u7b2c 1 \u671f\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (r\/r B-ALL) \u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u7684\u9996\u4f4d\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u5f8c\u4e00\u500b\u6708\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u3002<\/p>\n<p>\u9019\u9805\u7d50\u679c\u70ba\u00a0PeproMene Bio \u5728\u4e0a\u500b\u6708\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u5ea6\u6703\u8b70\u4e2d\uff0c\u6240\u767c\u8868\u6709\u95dc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u00a0PMB-CT01 \u81e8\u5e8a\u8a66\u9a57\u5831\u544a\u63d0\u4f9b\u88dc\u5145\u3002\u8a66\u9a57\u7d50\u679c\u7531\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u6dcb\u5df4\u7624\u5206\u90e8\u526f\u6559\u6388\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=1799349245&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D1034072064%26u%3Dhttps%253A%252F%252Fwww.cityofhope.org%252Felizabeth-budde%26a%3DElizabeth%2BBudde&amp;a=Elizabeth+Budde\" target=\"_blank\" rel=\"nofollow noopener\"><span class=\"xn-person\">Elizabeth Budde<\/span><\/a>\u00a0\u535a\u58eb\u9032\u884c\u5831\u544a\uff0c\u7d50\u679c\u5f15\u8d77\u76f8\u7576\u5927\u7684\u8208\u596e\uff0c\u56e0\u70ba\u4e09\u4f4d\u60a3\u8005\u5168\u90e8\u90fd\u9054\u6210\u6301\u4e45\u7684\u5b8c\u5168\u7de9\u89e3\uff0c\u800c\u4e14\u6bd2\u6027\u53cd\u61c9\u8f15\u5fae\u00a0(<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=600803028&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D4172726076%26u%3Dhttps%253A%252F%252Fash.confex.com%252Fash%252F2023%252Fwebprogram%252FPaper183032.html%26a%3Dhttps%253A%252F%252Fash.confex.com%252Fash%252F2023%252Fwebprogram%252FPaper183032.html&amp;a=https%3A%2F%2Fash.confex.com%2Fash%2F2023%2Fwebprogram%2FPaper183032.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper183032.html<\/a>)\u3002<\/p>\n<p>\u8a66\u9a57\u5728\u7f8e\u570b\u5176\u4e2d\u4e00\u5bb6\u6700\u5927\u578b\u7684\u764c\u75c7\u7814\u7a76\u53ca\u6cbb\u7642\u6a5f\u69cb\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=1615778848&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D333320117%26u%3Dhttps%253A%252F%252Fwww.cityofhope.org%252F%26a%3DCity%2Bof%2BHope&amp;a=City+of+Hope\" target=\"_blank\" rel=\"nofollow noopener\">City of Hope<\/a>\u00a0\u9032\u884c\uff0c\u5b83\u4ea6\u662f\u958b\u767c\u51fa\u9019\u9805\u7642\u6cd5\u7684\u6a5f\u69cb\u3002<\/p>\n<p>\u5728\u6cbb\u7642\u7684\u7b2c\u4e00\u500b\u6708\uff0c\u60a3\u8005\u5728\u6cbb\u7642\u671f\u9593\u9047\u5230\u7684\u6bd2\u6027\u53ea\u5c6c\u8f15\u5ea6\uff0c\u5305\u62ec\u5728\u7121\u9700\u8655\u7406\u5c31\u80fd\u89e3\u6c7a\u7684\u00a01 \u7d1a\u7d30\u80de\u56e0\u5b50\u91cb\u653e\u7d9c\u5408\u5fb5\uff08\u300cCRS\u300d\uff09\uff0c\u800c\u4e14\u6c92\u6709\u51fa\u73fe\u514d\u75ab\u6548\u61c9\u7d30\u80de\u76f8\u95dc\u795e\u7d93\u6bd2\u6027\u7d9c\u5408\u75c7\uff08\u300cICANS\u300d\uff09\u3002\u00a0 \u00a0<\/p>\n<p>\u300c\u6211\u5011\u5c0d\u6cbb\u7642\u7d50\u679c\u611f\u5230\u8208\u596e\uff0c\u56e0\u70ba\u9019\u540d\u60a3\u8005\u4e4b\u524d\u5728\u63a5\u53d7\u5316\u7642\u548c\u00a0blinatumomab \u6cbb\u7642\u5f8c\u51fa\u73fe\u00a0B-cell ALL \u5fa9\u767c\u3002\u4ed6\u75be\u75c5\u5fa9\u767c\u6642\u00a0CD19- \u548c\u00a0CD22- \u7686\u70ba\u9670\u6027\uff0c\u4ee3\u8868\u4ed6\u53ef\u7528\u7684\u6cbb\u7642\u9078\u9805\u975e\u5e38\u6709\u9650\u3002\u300d\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u526f\u6559\u6388\uff0c\u517c\u9019\u6b21\u55ae\u4e2d\u5fc3\u5291\u91cf\u905e\u589e\u53ca\u5ef6\u4f38\u8a66\u9a57\u00a0(NCT04690595) \u7684\u4e3b\u8981\u7814\u7a76\u8005\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=971682275&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D4234699732%26u%3Dhttps%253A%252F%252Fwww.cityofhope.org%252Fibrahim-aldoss%26a%3DIbrahim%2BT.%2BAldoss&amp;a=Ibrahim+T.+Aldoss\" target=\"_blank\" rel=\"nofollow noopener\">Ibrahim T. Aldoss<\/a>\u00a0\u535a\u58eb\u8868\u793a\u3002<\/p>\n<p>\u300c\u4ed6\u5c0d\u00a0BAFFR-CAR T \u7d30\u80de\u6cbb\u7642\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u6709\u8f15\u5fae\u7684\u9810\u671f\u6bd2\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u4ed6\u5df2\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u548c\u5fae\u91cf\u6b98\u5b58\u75be\u75c5\u00a0(MRD) \u6e05\u9664\uff0c\u4ee3\u8868\u5c0d\u9019\u7a2e\u6709\u6548\u7642\u6cd5\u7684\u826f\u597d\u53cd\u61c9\u3002\u300d<\/p>\n<p>\u300cPeproMene \u5728\u00a0PMB-CT01 \u7684\u958b\u767c\u548c\u8a55\u4f30\u65c5\u7a0b\u4e2d\u5df2\u53d6\u5f97\u5353\u8d8a\u7684\u91cc\u7a0b\u7891\uff0c\u56e0\u70ba\u5728\u9019\u4f4d\u4ee5\u00a0PMB-CT01 \u6cbb\u7642\u7684\u00a0B-ALL \u60a3\u8005\u8eab\u4e0a\u89c0\u5bdf\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u4e9b\u7531\u00a0City of Hope \u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u652f\u6301\u7684\u521d\u6b65\u81e8\u5e8a\u7d50\u679c\u5df2\u5728\u00a02019 \u5e74\u65bc\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\u4e2d\u767c\u4f48\uff0c\u7d50\u679c\u986f\u793a\u00a0BAFFR-CAR T \u7d30\u80de\u80fd\u6709\u6548\u6d88\u9664\u591a\u7a2e\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\uff0c\u5305\u62ec\u00a0B-ALL \u4ee5\u53ca\u4e0d\u540c\u7684\u00a0B \u6dcb\u5df4\u7624\u5206\u985e\u3002\u300dPeproMene \u71df\u904b\u7e3d\u76e3\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=1700638411&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D3938479930%26u%3Dhttps%253A%252F%252Fpepromenebio.com%252Fteam%252F%26a%3DHazel%2BCheng&amp;a=Hazel+Cheng\" target=\"_blank\" rel=\"nofollow noopener\"><span class=\"xn-person\">Hazel Cheng<\/span><\/a>\u00a0\u535a\u58eb\u8868\u793a\u3002<\/p>\n<p>PMB-CT01 \u7531\u00a0City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3\u526f\u7e3d\u88c1\u517c\u526f\u4e3b\u4efb\u3001\u00a0PeproMene \u79d1\u5b78\u5275\u8fa6\u4eba\u517c\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u5e36\u85aa\u4e3b\u5e2d\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=2924526941&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D1068703650%26u%3Dhttps%253A%252F%252Fwww.cityofhope.org%252Flarry-kwak%26a%3DLarry%2BW.%2BKwak&amp;a=Larry+W.+Kwak\" target=\"_blank\" rel=\"nofollow noopener\"><span class=\"xn-person\">Larry W. Kwak<\/span><\/a>\u00a0\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u767c\u660e\u3002Kwak \u5728\u00a0PeproMene \u64c1\u6709\u80a1\u6b0a\u3002<\/p>\n<p>City of Hope \u6301\u6709\u6b63\u5728\u9032\u884c\u7814\u7a76\u7684\u8a66\u9a57\u6027\u5316\u5408\u7269\u300cBAFFR(EQ)BB\u03b6\/EGFRt+ CAR T \u7d30\u80de\u300d\u7684\u6b0a\u76ca\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>\u00a0PMB-CT01<\/b><\/p>\n<p>PMB-CT01 \u662f\u4e00\u7a2e\u9996\u5275\u7684\u00a0BAFFR \u9776\u5411\u81ea\u9ad4\u00a0CAR T \u7d30\u80de\u7642\u6cd5\u3002BAFF-R\uff08B \u7d30\u80de\u6d3b\u5316\u56e0\u5b50\u53d7\u9ad4\uff09\u662f\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u00a0(TNF) \u53d7\u9ad4\u8d85\u5bb6\u65cf\u6210\u54e1\uff0c\u662f\u00a0BAFF \u7684\u4e3b\u8981\u53d7\u9ad4\uff0c\u5e7e\u4e4e\u53ea\u5728\u00a0B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u7531\u65bc\u00a0BAFF-R \u4fe1\u865f\u80fd\u4fc3\u9032\u6b63\u5e38\u00a0B \u7d30\u80de\u7684\u589e\u6b96\uff0c\u800c\u4e14\u4f3c\u4e4e\u662f\u00a0B \u7d30\u80de\u5b58\u6d3b\u6240\u5fc5\u9700\u7684\uff0c\u56e0\u6b64\u816b\u7624\u7d30\u80de\u4e0d\u592a\u53ef\u80fd\u901a\u904e\u5931\u53bb\u00a0BAFF-R \u6297\u539f\u4f86\u9003\u907f\u514d\u75ab\u53cd\u61c9\u3002\u9019\u7a2e\u7368\u7279\u7684\u7279\u6027\u4f7f\u00a0BAFFR-CAR T \u7642\u6cd5\u6210\u70ba\u6cbb\u7642\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u4e00\u5927\u6f5b\u5728\u7642\u6cd5\u3002BAFFR-CAR T \u662f\u5229\u7528\u6297\u00a0BAFF-R scFv\uff08\u55ae\u93c8\u7247\u6bb5\u53ef\u8b8a\uff09\u6297\u9ad4\u8207\u5305\u542b\u00a0CD3\u03b6 \u548c\u00a04-1BB \u7684\u7b2c\u00a02 \u4ee3\u4fe1\u865f\u7d50\u69cb\u57df\u69cb\u5efa\u800c\u6210\u3002\u6211\u5011\u7684\u7814\u7a76\u767c\u73fe\uff0cBAFFR-CAR T \u7d30\u80de\u80fd\u5728\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u4e2d\u6bba\u6b7b\u4eba\u985e\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u3002PeproMene \u5df2\u5f9e\u00a0City of Hope \u7372\u5f97\u00a0PMB-CT01 \u7684\u76f8\u95dc\u77e5\u8b58\u7522\u6b0a\u8a31\u53ef\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>\u00a0PeproMene<\/b><\/p>\n<p>PeproMene \u662f\u4e00\u5bb6\u4f4d\u65bc\u52a0\u5dde\u723e\u7063\u5e02\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u958b\u767c\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u7684\u65b0\u578b\u7642\u6cd5\u3002PeproMene \u7684\u4e3b\u8981\u5019\u9078\u7642\u6cd5\u00a0PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u76ee\u524d\u6b63\u5728\u9032\u884c\u7b2c\u00a01 \u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u6cbb\u7642\u5fa9\u767c\u548c\u96e3\u6cbb\u6027\u00a0B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u00a0(B-ALL\uff1bNCT04690595) \u548c B \u7d30\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u00a0(B-NHL\uff1bNCT05370430)\u3002PeproMene \u9084\u5728\u958b\u767c\u00a0BAFFR \u96d9\u7279\u7570\u6027\u00a0T \u7d30\u80de\u00a0Engager \u548c\u00a0BAFFR-CAR NK \u7d30\u80de\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u767c\u9001\u96fb\u90f5\u81f3\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=4143548766&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D2500864342%26u%3Dhttp%253A%252F%252Fmailto%253Ahazel.cheng%2540pepromenebio.com%252F%26a%3Dhazel.cheng%2540pepromenebio.com&amp;a=hazel.cheng%40pepromenebio.com\" target=\"_blank\" rel=\"nofollow noopener\">hazel.cheng@pepromenebio.com<\/a>\u00a0\u8207\u00a0PeproMene Bio Inc. \u7684\u00a0Hazel Cheng \u535a\u58eb\u806f\u7d61\uff0c\u6216\u700f\u89bd\u00a0<a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=zh-hant&amp;o=4067499-1&amp;h=311938114&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4067499-1%26h%3D869262409%26u%3Dhttps%253A%252F%252Fwww.pepromenebio.com%252F%26a%3Dwww.pepromenebio.com&amp;a=www.pepromenebio.com\" target=\"_blank\" rel=\"nofollow noopener\">www.pepromenebio.com<\/a>\u3002<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u52a0\u5dde\u723e\u70632024\u5e741\u670818\u65e5 &#8230;<\/p>\n","protected":false},"author":16,"featured_media":212383,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-212382","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PeproMene Bio, Inc. \u5ba3\u4f48\u5728 City of Hope \u9032\u884c\u7684 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u9996\u4f4d\u63a5\u53d7\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (B-ALL) \u6cbb\u7642\u7684\u60a3\u8005\u9054\u6210\u5b8c\u5168\u7de9\u89e3 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u52a0\u5dde\u723e\u70632024\u5e741\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- PeproMene Bio, Inc. \u662f\u4e00\u5bb6\u958b\u767c\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u7684\u65b0\u578b\u7642\u6cd5\u4e4b\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u8a72\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5728 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7684\u7b2c 1 \u671f\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (r\/r B-ALL) \u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u7684\u9996\u4f4d\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u5f8c\u4e00\u500b\u6708\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u3002 \u9019\u9805\u7d50\u679c\u70ba\u00a0PeproMene Bio \u5728\u4e0a\u500b\u6708\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u5ea6\u6703\u8b70\u4e2d\uff0c\u6240\u767c\u8868\u6709\u95dc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u00a0PMB-CT01 \u81e8\u5e8a\u8a66\u9a57\u5831\u544a\u63d0\u4f9b\u88dc\u5145\u3002\u8a66\u9a57\u7d50\u679c\u7531\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u6dcb\u5df4\u7624\u5206\u90e8\u526f\u6559\u6388\u00a0Elizabeth Budde\u00a0\u535a\u58eb\u9032\u884c\u5831\u544a\uff0c\u7d50\u679c\u5f15\u8d77\u76f8\u7576\u5927\u7684\u8208\u596e\uff0c\u56e0\u70ba\u4e09\u4f4d\u60a3\u8005\u5168\u90e8\u90fd\u9054\u6210\u6301\u4e45\u7684\u5b8c\u5168\u7de9\u89e3\uff0c\u800c\u4e14\u6bd2\u6027\u53cd\u61c9\u8f15\u5fae\u00a0(https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper183032.html)\u3002 \u8a66\u9a57\u5728\u7f8e\u570b\u5176\u4e2d\u4e00\u5bb6\u6700\u5927\u578b\u7684\u764c\u75c7\u7814\u7a76\u53ca\u6cbb\u7642\u6a5f\u69cb\u00a0City of Hope\u00a0\u9032\u884c\uff0c\u5b83\u4ea6\u662f\u958b\u767c\u51fa\u9019\u9805\u7642\u6cd5\u7684\u6a5f\u69cb\u3002 \u5728\u6cbb\u7642\u7684\u7b2c\u4e00\u500b\u6708\uff0c\u60a3\u8005\u5728\u6cbb\u7642\u671f\u9593\u9047\u5230\u7684\u6bd2\u6027\u53ea\u5c6c\u8f15\u5ea6\uff0c\u5305\u62ec\u5728\u7121\u9700\u8655\u7406\u5c31\u80fd\u89e3\u6c7a\u7684\u00a01 \u7d1a\u7d30\u80de\u56e0\u5b50\u91cb\u653e\u7d9c\u5408\u5fb5\uff08\u300cCRS\u300d\uff09\uff0c\u800c\u4e14\u6c92\u6709\u51fa\u73fe\u514d\u75ab\u6548\u61c9\u7d30\u80de\u76f8\u95dc\u795e\u7d93\u6bd2\u6027\u7d9c\u5408\u75c7\uff08\u300cICANS\u300d\uff09\u3002\u00a0 \u00a0 \u300c\u6211\u5011\u5c0d\u6cbb\u7642\u7d50\u679c\u611f\u5230\u8208\u596e\uff0c\u56e0\u70ba\u9019\u540d\u60a3\u8005\u4e4b\u524d\u5728\u63a5\u53d7\u5316\u7642\u548c\u00a0blinatumomab \u6cbb\u7642\u5f8c\u51fa\u73fe\u00a0B-cell ALL \u5fa9\u767c\u3002\u4ed6\u75be\u75c5\u5fa9\u767c\u6642\u00a0CD19- \u548c\u00a0CD22- \u7686\u70ba\u9670\u6027\uff0c\u4ee3\u8868\u4ed6\u53ef\u7528\u7684\u6cbb\u7642\u9078\u9805\u975e\u5e38\u6709\u9650\u3002\u300d\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u526f\u6559\u6388\uff0c\u517c\u9019\u6b21\u55ae\u4e2d\u5fc3\u5291\u91cf\u905e\u589e\u53ca\u5ef6\u4f38\u8a66\u9a57\u00a0(NCT04690595) \u7684\u4e3b\u8981\u7814\u7a76\u8005\u00a0Ibrahim T. Aldoss\u00a0\u535a\u58eb\u8868\u793a\u3002 \u300c\u4ed6\u5c0d\u00a0BAFFR-CAR T \u7d30\u80de\u6cbb\u7642\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u6709\u8f15\u5fae\u7684\u9810\u671f\u6bd2\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u4ed6\u5df2\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u548c\u5fae\u91cf\u6b98\u5b58\u75be\u75c5\u00a0(MRD) \u6e05\u9664\uff0c\u4ee3\u8868\u5c0d\u9019\u7a2e\u6709\u6548\u7642\u6cd5\u7684\u826f\u597d\u53cd\u61c9\u3002\u300d \u300cPeproMene \u5728\u00a0PMB-CT01 \u7684\u958b\u767c\u548c\u8a55\u4f30\u65c5\u7a0b\u4e2d\u5df2\u53d6\u5f97\u5353\u8d8a\u7684\u91cc\u7a0b\u7891\uff0c\u56e0\u70ba\u5728\u9019\u4f4d\u4ee5\u00a0PMB-CT01 \u6cbb\u7642\u7684\u00a0B-ALL \u60a3\u8005\u8eab\u4e0a\u89c0\u5bdf\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u4e9b\u7531\u00a0City of Hope \u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u652f\u6301\u7684\u521d\u6b65\u81e8\u5e8a\u7d50\u679c\u5df2\u5728\u00a02019 \u5e74\u65bc\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\u4e2d\u767c\u4f48\uff0c\u7d50\u679c\u986f\u793a\u00a0BAFFR-CAR T \u7d30\u80de\u80fd\u6709\u6548\u6d88\u9664\u591a\u7a2e\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\uff0c\u5305\u62ec\u00a0B-ALL \u4ee5\u53ca\u4e0d\u540c\u7684\u00a0B \u6dcb\u5df4\u7624\u5206\u985e\u3002\u300dPeproMene \u71df\u904b\u7e3d\u76e3\u00a0Hazel Cheng\u00a0\u535a\u58eb\u8868\u793a\u3002 PMB-CT01 \u7531\u00a0City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3\u526f\u7e3d\u88c1\u517c\u526f\u4e3b\u4efb\u3001\u00a0PeproMene \u79d1\u5b78\u5275\u8fa6\u4eba\u517c\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u5e36\u85aa\u4e3b\u5e2d\u00a0Larry W. Kwak\u00a0\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u767c\u660e\u3002Kwak \u5728\u00a0PeproMene \u64c1\u6709\u80a1\u6b0a\u3002 City of Hope \u6301\u6709\u6b63\u5728\u9032\u884c\u7814\u7a76\u7684\u8a66\u9a57\u6027\u5316\u5408\u7269\u300cBAFFR(EQ)BB\u03b6\/EGFRt+ CAR T \u7d30\u80de\u300d\u7684\u6b0a\u76ca\u3002 \u95dc\u65bc\u00a0PMB-CT01 PMB-CT01 \u662f\u4e00\u7a2e\u9996\u5275\u7684\u00a0BAFFR \u9776\u5411\u81ea\u9ad4\u00a0CAR T \u7d30\u80de\u7642\u6cd5\u3002BAFF-R\uff08B \u7d30\u80de\u6d3b\u5316\u56e0\u5b50\u53d7\u9ad4\uff09\u662f\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u00a0(TNF) \u53d7\u9ad4\u8d85\u5bb6\u65cf\u6210\u54e1\uff0c\u662f\u00a0BAFF \u7684\u4e3b\u8981\u53d7\u9ad4\uff0c\u5e7e\u4e4e\u53ea\u5728\u00a0B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u7531\u65bc\u00a0BAFF-R \u4fe1\u865f\u80fd\u4fc3\u9032\u6b63\u5e38\u00a0B \u7d30\u80de\u7684\u589e\u6b96\uff0c\u800c\u4e14\u4f3c\u4e4e\u662f\u00a0B \u7d30\u80de\u5b58\u6d3b\u6240\u5fc5\u9700\u7684\uff0c\u56e0\u6b64\u816b\u7624\u7d30\u80de\u4e0d\u592a\u53ef\u80fd\u901a\u904e\u5931\u53bb\u00a0BAFF-R \u6297\u539f\u4f86\u9003\u907f\u514d\u75ab\u53cd\u61c9\u3002\u9019\u7a2e\u7368\u7279\u7684\u7279\u6027\u4f7f\u00a0BAFFR-CAR T \u7642\u6cd5\u6210\u70ba\u6cbb\u7642\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u4e00\u5927\u6f5b\u5728\u7642\u6cd5\u3002BAFFR-CAR T \u662f\u5229\u7528\u6297\u00a0BAFF-R scFv\uff08\u55ae\u93c8\u7247\u6bb5\u53ef\u8b8a\uff09\u6297\u9ad4\u8207\u5305\u542b\u00a0CD3\u03b6 \u548c\u00a04-1BB \u7684\u7b2c\u00a02 \u4ee3\u4fe1\u865f\u7d50\u69cb\u57df\u69cb\u5efa\u800c\u6210\u3002\u6211\u5011\u7684\u7814\u7a76\u767c\u73fe\uff0cBAFFR-CAR T \u7d30\u80de\u80fd\u5728\u9ad4\u5916\u548c\u52d5\u7269\u6a21\u578b\u4e2d\u6bba\u6b7b\u4eba\u985e\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u3002PeproMene \u5df2\u5f9e\u00a0City of Hope \u7372\u5f97\u00a0PMB-CT01 \u7684\u76f8\u95dc\u77e5\u8b58\u7522\u6b0a\u8a31\u53ef\u3002 \u95dc\u65bc\u00a0PeproMene PeproMene \u662f\u4e00\u5bb6\u4f4d\u65bc\u52a0\u5dde\u723e\u7063\u5e02\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u958b\u767c\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u7684\u65b0\u578b\u7642\u6cd5\u3002PeproMene \u7684\u4e3b\u8981\u5019\u9078\u7642\u6cd5\u00a0PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u76ee\u524d\u6b63\u5728\u9032\u884c\u7b2c\u00a01 \u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u6cbb\u7642\u5fa9\u767c\u548c\u96e3\u6cbb\u6027\u00a0B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u00a0(B-ALL\uff1bNCT04690595) \u548c B \u7d30\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u00a0(B-NHL\uff1bNCT05370430)\u3002PeproMene \u9084\u5728\u958b\u767c\u00a0BAFFR \u96d9\u7279\u7570\u6027\u00a0T \u7d30\u80de\u00a0Engager \u548c\u00a0BAFFR-CAR NK \u7d30\u80de\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u767c\u9001\u96fb\u90f5\u81f3\u00a0hazel.cheng@pepromenebio.com\u00a0\u8207\u00a0PeproMene Bio Inc. \u7684\u00a0Hazel Cheng \u535a\u58eb\u806f\u7d61\uff0c\u6216\u700f\u89bd\u00a0www.pepromenebio.com\u3002 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=212382\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PeproMene Bio, Inc. \u5ba3\u4f48\u5728 City of Hope \u9032\u884c\u7684 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u9996\u4f4d\u63a5\u53d7\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (B-ALL) \u6cbb\u7642\u7684\u60a3\u8005\u9054\u6210\u5b8c\u5168\u7de9\u89e3 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u52a0\u5dde\u723e\u70632024\u5e741\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- PeproMene Bio, Inc. \u662f\u4e00\u5bb6\u958b\u767c\u6cbb\u7642\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u7684\u65b0\u578b\u7642\u6cd5\u4e4b\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u8a72\u516c\u53f8\u4eca\u65e5\u5ba3\u4f48\u5728 PMB-CT01\uff08BAFFR-CAR T \u7d30\u80de\uff09\u7684\u7b2c 1 \u671f\u5fa9\u767c\u548c\u96e3\u6cbb\u6027 B \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (r\/r B-ALL) \u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u7b2c 1 \u7d44\u7684\u9996\u4f4d\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u5f8c\u4e00\u500b\u6708\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u3002 \u9019\u9805\u7d50\u679c\u70ba\u00a0PeproMene Bio \u5728\u4e0a\u500b\u6708\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u5ea6\u6703\u8b70\u4e2d\uff0c\u6240\u767c\u8868\u6709\u95dc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u00a0PMB-CT01 \u81e8\u5e8a\u8a66\u9a57\u5831\u544a\u63d0\u4f9b\u88dc\u5145\u3002\u8a66\u9a57\u7d50\u679c\u7531\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u6dcb\u5df4\u7624\u5206\u90e8\u526f\u6559\u6388\u00a0Elizabeth Budde\u00a0\u535a\u58eb\u9032\u884c\u5831\u544a\uff0c\u7d50\u679c\u5f15\u8d77\u76f8\u7576\u5927\u7684\u8208\u596e\uff0c\u56e0\u70ba\u4e09\u4f4d\u60a3\u8005\u5168\u90e8\u90fd\u9054\u6210\u6301\u4e45\u7684\u5b8c\u5168\u7de9\u89e3\uff0c\u800c\u4e14\u6bd2\u6027\u53cd\u61c9\u8f15\u5fae\u00a0(https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper183032.html)\u3002 \u8a66\u9a57\u5728\u7f8e\u570b\u5176\u4e2d\u4e00\u5bb6\u6700\u5927\u578b\u7684\u764c\u75c7\u7814\u7a76\u53ca\u6cbb\u7642\u6a5f\u69cb\u00a0City of Hope\u00a0\u9032\u884c\uff0c\u5b83\u4ea6\u662f\u958b\u767c\u51fa\u9019\u9805\u7642\u6cd5\u7684\u6a5f\u69cb\u3002 \u5728\u6cbb\u7642\u7684\u7b2c\u4e00\u500b\u6708\uff0c\u60a3\u8005\u5728\u6cbb\u7642\u671f\u9593\u9047\u5230\u7684\u6bd2\u6027\u53ea\u5c6c\u8f15\u5ea6\uff0c\u5305\u62ec\u5728\u7121\u9700\u8655\u7406\u5c31\u80fd\u89e3\u6c7a\u7684\u00a01 \u7d1a\u7d30\u80de\u56e0\u5b50\u91cb\u653e\u7d9c\u5408\u5fb5\uff08\u300cCRS\u300d\uff09\uff0c\u800c\u4e14\u6c92\u6709\u51fa\u73fe\u514d\u75ab\u6548\u61c9\u7d30\u80de\u76f8\u95dc\u795e\u7d93\u6bd2\u6027\u7d9c\u5408\u75c7\uff08\u300cICANS\u300d\uff09\u3002\u00a0 \u00a0 \u300c\u6211\u5011\u5c0d\u6cbb\u7642\u7d50\u679c\u611f\u5230\u8208\u596e\uff0c\u56e0\u70ba\u9019\u540d\u60a3\u8005\u4e4b\u524d\u5728\u63a5\u53d7\u5316\u7642\u548c\u00a0blinatumomab \u6cbb\u7642\u5f8c\u51fa\u73fe\u00a0B-cell ALL \u5fa9\u767c\u3002\u4ed6\u75be\u75c5\u5fa9\u767c\u6642\u00a0CD19- \u548c\u00a0CD22- \u7686\u70ba\u9670\u6027\uff0c\u4ee3\u8868\u4ed6\u53ef\u7528\u7684\u6cbb\u7642\u9078\u9805\u975e\u5e38\u6709\u9650\u3002\u300d\u00a0City of Hope \u8840\u6db2\u5b78\u8207\u9020\u8840\u7d30\u80de\u79fb\u690d\u7cfb\u526f\u6559\u6388\uff0c\u517c\u9019\u6b21\u55ae\u4e2d\u5fc3\u5291\u91cf\u905e\u589e\u53ca\u5ef6\u4f38\u8a66\u9a57\u00a0(NCT04690595) \u7684\u4e3b\u8981\u7814\u7a76\u8005\u00a0Ibrahim T. Aldoss\u00a0\u535a\u58eb\u8868\u793a\u3002 \u300c\u4ed6\u5c0d\u00a0BAFFR-CAR T \u7d30\u80de\u6cbb\u7642\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u6709\u8f15\u5fae\u7684\u9810\u671f\u6bd2\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u4ed6\u5df2\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u548c\u5fae\u91cf\u6b98\u5b58\u75be\u75c5\u00a0(MRD) \u6e05\u9664\uff0c\u4ee3\u8868\u5c0d\u9019\u7a2e\u6709\u6548\u7642\u6cd5\u7684\u826f\u597d\u53cd\u61c9\u3002\u300d \u300cPeproMene \u5728\u00a0PMB-CT01 \u7684\u958b\u767c\u548c\u8a55\u4f30\u65c5\u7a0b\u4e2d\u5df2\u53d6\u5f97\u5353\u8d8a\u7684\u91cc\u7a0b\u7891\uff0c\u56e0\u70ba\u5728\u9019\u4f4d\u4ee5\u00a0PMB-CT01 \u6cbb\u7642\u7684\u00a0B-ALL \u60a3\u8005\u8eab\u4e0a\u89c0\u5bdf\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u4e9b\u7531\u00a0City of Hope \u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u652f\u6301\u7684\u521d\u6b65\u81e8\u5e8a\u7d50\u679c\u5df2\u5728\u00a02019 \u5e74\u65bc\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\u4e2d\u767c\u4f48\uff0c\u7d50\u679c\u986f\u793a\u00a0BAFFR-CAR T \u7d30\u80de\u80fd\u6709\u6548\u6d88\u9664\u591a\u7a2e\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\uff0c\u5305\u62ec\u00a0B-ALL \u4ee5\u53ca\u4e0d\u540c\u7684\u00a0B \u6dcb\u5df4\u7624\u5206\u985e\u3002\u300dPeproMene \u71df\u904b\u7e3d\u76e3\u00a0Hazel Cheng\u00a0\u535a\u58eb\u8868\u793a\u3002 PMB-CT01 \u7531\u00a0City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3\u526f\u7e3d\u88c1\u517c\u526f\u4e3b\u4efb\u3001\u00a0PeproMene \u79d1\u5b78\u5275\u8fa6\u4eba\u517c\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u5e36\u85aa\u4e3b\u5e2d\u00a0Larry W. Kwak\u00a0\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u767c\u660e\u3002Kwak \u5728\u00a0PeproMene \u64c1\u6709\u80a1\u6b0a\u3002 City of Hope \u6301\u6709\u6b63\u5728\u9032\u884c\u7814\u7a76\u7684\u8a66\u9a57\u6027\u5316\u5408\u7269\u300cBAFFR(EQ)BB\u03b6\/EGFRt+ CAR T \u7d30\u80de\u300d\u7684\u6b0a\u76ca\u3002 \u95dc\u65bc\u00a0PMB-CT01 PMB-CT01 \u662f\u4e00\u7a2e\u9996\u5275\u7684\u00a0BAFFR \u9776\u5411\u81ea\u9ad4\u00a0CAR T \u7d30\u80de\u7642\u6cd5\u3002BAFF-R\uff08B \u7d30\u80de\u6d3b\u5316\u56e0\u5b50\u53d7\u9ad4\uff09\u662f\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u00a0(TNF) \u53d7\u9ad4\u8d85\u5bb6\u65cf\u6210\u54e1\uff0c\u662f\u00a0BAFF \u7684\u4e3b\u8981\u53d7\u9ad4\uff0c\u5e7e\u4e4e\u53ea\u5728\u00a0B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u7531\u65bc\u00a0BAFF-R \u4fe1\u865f\u80fd\u4fc3\u9032\u6b63\u5e38\u00a0B \u7d30\u80de\u7684\u589e\u6b96\uff0c\u800c\u4e14\u4f3c\u4e4e\u662f\u00a0B 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Aldoss\u00a0\u535a\u58eb\u8868\u793a\u3002 \u300c\u4ed6\u5c0d\u00a0BAFFR-CAR T \u7d30\u80de\u6cbb\u7642\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u6709\u8f15\u5fae\u7684\u9810\u671f\u6bd2\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u4ed6\u5df2\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u548c\u5fae\u91cf\u6b98\u5b58\u75be\u75c5\u00a0(MRD) \u6e05\u9664\uff0c\u4ee3\u8868\u5c0d\u9019\u7a2e\u6709\u6548\u7642\u6cd5\u7684\u826f\u597d\u53cd\u61c9\u3002\u300d \u300cPeproMene \u5728\u00a0PMB-CT01 \u7684\u958b\u767c\u548c\u8a55\u4f30\u65c5\u7a0b\u4e2d\u5df2\u53d6\u5f97\u5353\u8d8a\u7684\u91cc\u7a0b\u7891\uff0c\u56e0\u70ba\u5728\u9019\u4f4d\u4ee5\u00a0PMB-CT01 \u6cbb\u7642\u7684\u00a0B-ALL \u60a3\u8005\u8eab\u4e0a\u89c0\u5bdf\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u4e9b\u7531\u00a0City of Hope \u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u652f\u6301\u7684\u521d\u6b65\u81e8\u5e8a\u7d50\u679c\u5df2\u5728\u00a02019 \u5e74\u65bc\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\u4e2d\u767c\u4f48\uff0c\u7d50\u679c\u986f\u793a\u00a0BAFFR-CAR T \u7d30\u80de\u80fd\u6709\u6548\u6d88\u9664\u591a\u7a2e\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\uff0c\u5305\u62ec\u00a0B-ALL \u4ee5\u53ca\u4e0d\u540c\u7684\u00a0B \u6dcb\u5df4\u7624\u5206\u985e\u3002\u300dPeproMene \u71df\u904b\u7e3d\u76e3\u00a0Hazel Cheng\u00a0\u535a\u58eb\u8868\u793a\u3002 PMB-CT01 \u7531\u00a0City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3\u526f\u7e3d\u88c1\u517c\u526f\u4e3b\u4efb\u3001\u00a0PeproMene \u79d1\u5b78\u5275\u8fa6\u4eba\u517c\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u5e36\u85aa\u4e3b\u5e2d\u00a0Larry W. 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Aldoss\u00a0\u535a\u58eb\u8868\u793a\u3002 \u300c\u4ed6\u5c0d\u00a0BAFFR-CAR T \u7d30\u80de\u6cbb\u7642\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u6709\u8f15\u5fae\u7684\u9810\u671f\u6bd2\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c\u4ed6\u5df2\u9054\u6210\u5b8c\u5168\u7de9\u89e3\u548c\u5fae\u91cf\u6b98\u5b58\u75be\u75c5\u00a0(MRD) \u6e05\u9664\uff0c\u4ee3\u8868\u5c0d\u9019\u7a2e\u6709\u6548\u7642\u6cd5\u7684\u826f\u597d\u53cd\u61c9\u3002\u300d \u300cPeproMene \u5728\u00a0PMB-CT01 \u7684\u958b\u767c\u548c\u8a55\u4f30\u65c5\u7a0b\u4e2d\u5df2\u53d6\u5f97\u5353\u8d8a\u7684\u91cc\u7a0b\u7891\uff0c\u56e0\u70ba\u5728\u9019\u4f4d\u4ee5\u00a0PMB-CT01 \u6cbb\u7642\u7684\u00a0B-ALL \u60a3\u8005\u8eab\u4e0a\u89c0\u5bdf\u5230\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u548c\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u4e9b\u7531\u00a0City of Hope \u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u652f\u6301\u7684\u521d\u6b65\u81e8\u5e8a\u7d50\u679c\u5df2\u5728\u00a02019 \u5e74\u65bc\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\u4e2d\u767c\u4f48\uff0c\u7d50\u679c\u986f\u793a\u00a0BAFFR-CAR T \u7d30\u80de\u80fd\u6709\u6548\u6d88\u9664\u591a\u7a2e\u00a0B \u7d30\u80de\u60e1\u6027\u816b\u7624\uff0c\u5305\u62ec\u00a0B-ALL \u4ee5\u53ca\u4e0d\u540c\u7684\u00a0B \u6dcb\u5df4\u7624\u5206\u985e\u3002\u300dPeproMene \u71df\u904b\u7e3d\u76e3\u00a0Hazel Cheng\u00a0\u535a\u58eb\u8868\u793a\u3002 PMB-CT01 \u7531\u00a0City of Hope \u7d9c\u5408\u764c\u75c7\u4e2d\u5fc3\u526f\u7e3d\u88c1\u517c\u526f\u4e3b\u4efb\u3001\u00a0PeproMene \u79d1\u5b78\u5275\u8fa6\u4eba\u517c\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u5e36\u85aa\u4e3b\u5e2d\u00a0Larry W. Kwak\u00a0\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u767c\u660e\u3002Kwak \u5728\u00a0PeproMene \u64c1\u6709\u80a1\u6b0a\u3002 City of Hope \u6301\u6709\u6b63\u5728\u9032\u884c\u7814\u7a76\u7684\u8a66\u9a57\u6027\u5316\u5408\u7269\u300cBAFFR(EQ)BB\u03b6\/EGFRt+ CAR T \u7d30\u80de\u300d\u7684\u6b0a\u76ca\u3002 \u95dc\u65bc\u00a0PMB-CT01 PMB-CT01 \u662f\u4e00\u7a2e\u9996\u5275\u7684\u00a0BAFFR \u9776\u5411\u81ea\u9ad4\u00a0CAR T \u7d30\u80de\u7642\u6cd5\u3002BAFF-R\uff08B \u7d30\u80de\u6d3b\u5316\u56e0\u5b50\u53d7\u9ad4\uff09\u662f\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u00a0(TNF) \u53d7\u9ad4\u8d85\u5bb6\u65cf\u6210\u54e1\uff0c\u662f\u00a0BAFF \u7684\u4e3b\u8981\u53d7\u9ad4\uff0c\u5e7e\u4e4e\u53ea\u5728\u00a0B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u7531\u65bc\u00a0BAFF-R \u4fe1\u865f\u80fd\u4fc3\u9032\u6b63\u5e38\u00a0B \u7d30\u80de\u7684\u589e\u6b96\uff0c\u800c\u4e14\u4f3c\u4e4e\u662f\u00a0B 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