{"id":208076,"date":"2023-12-27T21:00:00","date_gmt":"2023-12-27T13:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=208076"},"modified":"2023-12-27T21:00:00","modified_gmt":"2023-12-27T13:00:00","slug":"%e5%8d%9a%e5%ae%89%e7%94%9f%e7%89%a9%e5%85%a9%e6%ac%be%e9%9d%b6%e5%90%91claudin18-2%e5%9c%a8%e7%a0%94%e5%89%b5%e6%96%b0%e8%97%a5%e7%8d%b2%e7%be%8e%e5%9c%8bfda%e5%ad%a4%e5%85%92%e8%97%a5%e8%b3%87","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=208076","title":{"rendered":"\u535a\u5b89\u751f\u7269\u5169\u6b3e\u9776\u5411Claudin18.2\u5728\u7814\u5275\u65b0\u85e5\u7372\u7f8e\u570bFDA\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a"},"content":{"rendered":"
\n

\u7159\u53f02023\u5e7412\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — \u535a\u5b89\u751f\u7269\u5ba3\u4f48\uff0c\u5176\u81ea\u4e3b\u958b\u767c\u7684\u5169\u6b3e\u9776\u5411Claudin18.2\u7684\u5728\u7814\u7522\u54c1\u2014\u2014\u5275\u65b0\u6297\u9ad4BA1105\u3001\u5275\u65b0\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08Antibody\u2013Drug Conjugate\uff0cADC\uff09BA1301\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u6cbb\u7642\u80f0\u817a\u764c\u9069\u61c9\u75c7\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff08Orphan-drug Designation\uff0cODD\uff09\u3002<\/p>\n

\u5b64\u5152\u85e5\u53c8\u7a31\u70ba\u7f55\u898b\u75c5\u85e5\uff0c\u6307\u7528\u65bc\u9810\u9632\u3001\u6cbb\u7642\u3001\u8a3a\u65b7\u7f55\u898b\u75c5\u7684\u85e5\u54c1\u3002BA1105\u548cBA1301\u6b64\u6b21\u7372\u5f97\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u5c07\u5229\u65bc\u5176\u5f8c\u7e8c\u5728\u7f8e\u570b\u7684\u7814\u767c\u3001\u8a3b\u518a\u53ca\u5546\u696d\u5316\u7b49\u65b9\u9762\u7372\u5f97\u76f8\u95dc\u653f\u7b56\u652f\u6301\uff0c\u4e26\u5c07\u6709\u52a9\u65bc\u964d\u4f4e\u7814\u767c\u6295\u5165\u3001\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\u53ca\u4e0a\u5e02\u9032\u5ea6\u3002<\/p>\n

\u80f0\u817a\u764c\u88ab\u8996\u70ba\u6700\u81f4\u547d\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u662f\u81e8\u5e8a\u8a3a\u6cbb\u7684\u4e00\u5927\u96e3\u984c\u3002\u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb\uff08IARC\uff09\u6578\u64da\u986f\u793a\uff1a2020\u5e74\u5168\u7403\u80f0\u817a\u764c\u7684\u65b0\u767c\u75c5\u4f8b49.6\u842c\u3001\u6b7b\u4ea1\u75c5\u4f8b46.6\u842c[1]<\/sup>\uff0c\u5176\u4e2d\u7f8e\u570b\u65b0\u767c\u75c5\u4f8b5.7\u842c\u4f8b\u3001\u6b7b\u4ea1\u75c5\u4f8b4.8\u842c\u4f8b[2]<\/sup>\u3002\u7531\u65bc\u8a72\u75be\u75c5\u65e9\u671f\u75c7\u72c0\u96b1\u533f\uff0c\u5927\u90e8\u5206\u60a3\u8005\u4e00\u7d93\u767c\u73fe\u5df2\u8655\u65bc\u4e2d\u665a\u671f\u3002\u665a\u671f\u80f0\u817a\u764c\u9810\u5f8c\u6975\u5dee\uff0c\u6cbb\u7642\u4ee5\u59d1\u606f\u5316\u7642\u70ba\u4e3b\uff0c\u7e3d\u9ad4\u7642\u6548\u548c\u9810\u5f8c\u6975\u4e0d\u7406\u60f3\uff1b\u56e0\u6b64\uff0c\u81e8\u5e8a\u4e9f\u9700\u65b0\u7684\u9776\u9ede\u6cbb\u7642\u85e5\u7269\uff0c\u4ee5\u63d0\u5347\u6cbb\u7642\u6548\u679c\u3002<\/p>\n

Claudin 18.2\u86cb\u767d\u662f\u4e00\u7a2e\u53c3\u8207\u8abf\u63a7\u7d30\u80de\u9593\u7dca\u5bc6\u9023\u63a5\u7684\u8de8\u819c\u86cb\u767d\uff0c\u80fd\u6301\u7e8c\u3001\u7a69\u5b9a\u5730\u5728\u6d88\u5316\u9053\u816b\u7624\u4e2d\u9ad8\u8868\u9054\u3002\u7814\u7a76\u767c\u73fe\uff1aClaudin18.2\u572870%\u80c3\u764c\u60a3\u8005\u300150%\u80f0\u817a\u764c\u60a3\u8005\u548c30%\u98df\u7ba1\u764c\u60a3\u8005\u4e0a\u8868\u9054\uff0c\u9019\u4f7f\u5176\u6210\u70ba\u5177\u6709\u8f03\u5927\u6f5b\u529b\u7684\u6297\u816b\u7624\u85e5\u7269\u5206\u5b50\u9776\u9ede\u3002<\/p>\n

BA1105<\/b>\u63a1\u7528<\/b>ADCC<\/b>\u589e\u5f37\u6280\u8853\uff0c\u5177\u6709\u66f4\u5f37\u85e5\u6548\u6f5b\u529b<\/b><\/p>\n

BA1105\u662f\u91cd\u7d44\u6297Claudin18.2\u5168\u4eba\u6e90IgG1\u578b\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7528\u65bc\u6cbb\u7642Claudin18.2\u967d\u6027\u8868\u9054\u7684\u665a\u671f\u5be6\u9ad4\u7624\uff0c\u63a1\u7528ADCC\uff08\u6297\u9ad4\u4f9d\u8cf4\u7684\u7d30\u80de\u4ecb\u5c0e\u7684\u7d30\u80de\u6bd2\u6027\u4f5c\u7528\uff09\u589e\u5f37\u6280\u8853\u5177\u6709\u66f4\u5f37\u85e5\u6548\u6f5b\u529b\uff0c\u76ee\u524d\u5728\u4e2d\u570b\u8655\u65bcI\u671f\u81e8\u5e8a\u968e\u6bb5\u3002<\/p>\n

\u5df2\u5b8c\u6210\u7684\u975e\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a\u5728Claudin 18.2\u967d\u6027\u8868\u9054\u7684\u4eba\u80f0\u817a\u764c\u548c\u80c3\u764c\u5c0f\u9f20\u79fb\u690d\u7624\u6a21\u578b\u4e2d\uff0cBA1105\u55ae\u7528\u6216\u806f\u5408\u5316\u7642\u85e5\u7269\u5747\u986f\u793a\u4e86\u8f03\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\uff1b\u76f8\u6bd4\u5c0d\u7167\u6297\u9ad4\uff0cBA1105\u5c0dClaudin18.2\u4e0d\u540c\u8868\u9054\u6c34\u5e73\u7684\u816b\u7624\u7d30\u80de\u5747\u5177\u670910\u500d\u4ee5\u4e0a\u66f4\u5f37\u7684\u816b\u7624\u6bba\u50b7\u6d3b\u6027\uff0c\u4e26\u4e14\u5c0d\u4f4e\u8868\u9054\u816b\u7624\u6709\u6548\u3002<\/p>\n

BA1301<\/b>\u901a\u904e\u5b9a\u9ede\u5076\u806f\u6280\u8853\u5c55\u73fe\u9ad8\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2<\/b><\/p>\n

BA1301\u662f\u535a\u5b89\u751f\u7269\u9996\u500b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684ADC\u7522\u54c1\uff0c\u76ee\u524d\u5728\u4e2d\u570b\u8655\u65bcI\u671f\u81e8\u5e8a\u968e\u6bb5\u3002BA1301\u63a1\u7528\u5b9a\u9ede\u5076\u806f\u6280\u8853\uff0c\u5c07\u5c0f\u5206\u5b50\u7d30\u80de\u6bd2\u7d20\u8207\u9776\u5411Claudin 18.2\u7684\u55ae\u6297\u5076\u806f\uff0c\u901a\u904e\u6297\u9ad4\u7684\u9776\u5411\u6027\u5f15\u5c0e\u5c0f\u5206\u5b50\u6bd2\u7d20\u5230\u9054\u816b\u7624\u90e8\u4f4d\uff0c\u767c\u63ee\u6bba\u50b7\u816b\u7624\u6548\u679c\u7684\u540c\u6642\uff0c\u964d\u4f4e\u5c0f\u5206\u5b50\u6bd2\u7d20\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u63d0\u9ad8\u6cbb\u7642\u7a97\u53e3\u3002<\/p>\n

\u5df2\u5b8c\u6210\u7684\u975e\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1aBA1301\u5177\u6709\u512a\u7570\u7684\u5167\u5316\u6d3b\u6027\u548c\u65c1\u6bba\u6548\u679c\uff1b\u5728Claudin 18.2\u8868\u9054\u7684\u816b\u7624\u7d30\u80de\u6a21\u578b\u4e0a\u5c55\u793a\u4e86\u512a\u7570\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u986f\u8457\u6291\u5236Claudin 18.2\u967d\u6027\u8868\u9054\u4eba\u80f0\u817a\u764c\u5c0f\u9f20\u79fb\u690d\u7624\u7684\u751f\u9577\uff0c\u4e2d\u9ad8\u5291\u91cf\u4e0b\u53ef\u898b\u5c0f\u9f20\u816b\u7624\u5168\u90e8\u6e05\u9664\uff1bBA1301\u7684\u5c0f\u5206\u5b50\u6bd2\u7d20\u9023\u63a5\u7a69\u5b9a\uff0c\u5728\u4eba\u548c\u98df\u87f9\u7334\u8840\u6f3f\u4e2d\u5c0f\u5206\u5b50\u7684\u812b\u843d\u7387\u22640.05%\uff0c\u57fa\u672c\u672a\u898b\u812b\u843d\uff1b\u5728\u52d5\u7269\u9ad4\u5167\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002BA1301\u5c07\u70ba\u80f0\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

\u535a\u5b89\u751f\u7269\u7814\u767c\u7e3d\u88c1\u517c\u9996\u5e2d\u904b\u71df\u5b98\u7ac7\u660c\u6797\u535a\u58eb\u8868\u793a\uff1a\u300c\u7531\u65bcClaudin18.2\u5728\u7279\u5b9a\u816b\u7624\u7d44\u7e54\u4e2d\u5177\u6709\u9ad8\u5ea6\u7684\u9078\u64c7\u6027\u53ca\u7a69\u5b9a\u7684\u8868\u9054\uff0c\u8fd1\u5e74\u4f86\u5df2\u6210\u70ba\u816b\u7624\u7814\u767c\u9818\u57df\u7684\u71b1\u9580\u5206\u5b50\u9776\u9ede\uff0c\u535a\u5b89\u751f\u7269\u540c\u6642\u4f48\u5c40\u4e86\u55ae\u6297\u548cADC\u5169\u500b\u6280\u8853\u8def\u7dda\u7684\u7522\u54c1\uff0c\u4e8c\u8005\u53ef\u4ee5\u5728\u665a\u671f\u4e00\u7dda\u548c\u4e8c\u7dda\u80f0\u817a\u764c\u4e2d\u76f8\u4e92\u88dc\u4f4d\uff0c\u540c\u6642\u9084\u90fd\u5177\u6709\u8207\u535a\u5b89\u751f\u7269\u7684BA1104\uff08\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2, \u6b50\u72c4\u6c83\u00ae\u751f\u7269\u985e\u4f3c\u85e5\uff09\u806f\u5408\u589e\u6548\u7684\u6f5b\u529b\uff0c\u53ef\u4ee5\u9032\u4e00\u6b65\u63d0\u9ad8\u81e8\u5e8a\u958b\u767c\u78ba\u5b9a\u6027\uff0c\u540c\u6642\u5728\u672a\u4f86\u5f62\u6210\u5e02\u5834\u5354\u540c\u4f5c\u7528\u3002\u7f8e\u570bFDA\u5c0dBA1105\u548cBA1301\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u9ad4\u73fe\u4e86\u5c0d\u4e0a\u8ff0\u5169\u6b3e\u5275\u65b0\u85e5\u65bc\u7528\u65bc\u6cbb\u7642\u80f0\u817a\u764c\u6f5b\u529b\u7684\u521d\u6b65\u8a8d\u53ef\u3002\u6211\u5011\u5c07\u52a0\u5feb\u8a72\u5169\u6b3e\u5728\u7814\u7522\u54c1\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u4e26\u671f\u5f85\u9019\u4e9b\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u76e1\u5feb\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d<\/p>\n

\u535a\u5b89\u751f\u7269\u6191\u501f\u81ea\u6709\u65b0\u85e5\u767c\u73fe\u5e73\u53f0\u7684\u5275\u65b0\u80fd\u529b\uff0c\u73fe\u5df2\u958b\u767c\u51fa7\u6b3e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684\u5728\u7814\u5275\u65b0\u85e5\uff0c\u6db5\u84cb\u4e86CD25\u3001CEA\/CD3\u3001IL-4R\u0251\u3001Claudin 18.2\u3001CD228\u7b49\u9776\u9ede\uff0c\u6280\u8853\u8def\u7dda\u5305\u62ec\u55ae\u6297\u3001\u96d9\u6297\u53caADC\u3002\u53e6\u5916\u503c\u5f97\u8aaa\u660e\u7684\u662f\uff0c\u535a\u5b89\u751f\u7269\u76842\u6b3e\u5df2\u4e0a\u5e02\u751f\u7269\u985e\u4f3c\u85e5\u548c4\u6b3e\u5728\u7814\u751f\u7269\u985e\u4f3c\u85e5\u5728\u570b\u5167\u7684\u958b\u767c\u9032\u5ea6\u5747\u4f4d\u8655\u524d\u5217\u6216\u8005\u9996\u4f4d\uff0c\u5177\u5099\u7387\u5148\u4e0a\u5e02\u7684\u5148\u767c\u512a\u52e2\uff1b\u540c\u6642\u90e8\u5206\u54c1\u7a2e\u6b63\u5728\u6b50\u7f8e\u65e5\u7b49\u6d77\u5916\u5e02\u5834\u9032\u884c\u570b\u969b\u81e8\u5e8a\u548c\u8a3b\u518a\u3002\u4e0a\u8ff0\u5275\u65b0\u85e5\u548c\u751f\u7269\u985e\u4f3c\u85e5\u7dca\u8ddf\u570b\u5167\u5916\u81e8\u5e8a\u9700\u6c42\uff0c\u69cb\u5efa\u4e86\u535a\u5b89\u751f\u7269\u8c50\u5bcc\u7684\u7522\u54c1\u7d44\u5408\u3002<\/p>\n

\u95dc\u65bc\u535a\u5b89\u751f\u7269<\/u><\/b><\/p>\n

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1. \u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb\uff08IARC\uff09\u5b98\u7db2. \u5168\u7403\u80f0\u817a\u764c\u8ca0\u64d4\u6982\u6cc1https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/13-Pancreas-fact-sheet.pdf<\/a>
2. \u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb\uff08IARC\uff09\u5b98\u7db2. \u7f8e\u570b\u764c\u75c7\u8ca0\u64d4\u6982\u6cc1https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/840-united-states-of-america-fact-sheets.pdf<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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\u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb\uff08IARC\uff09\u5b98\u7db2. \u5168\u7403\u80f0\u817a\u764c\u8ca0\u64d4\u6982\u6cc1https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/13-Pancreas-fact-sheet.pdf2. \u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb\uff08IARC\uff09\u5b98\u7db2. \u7f8e\u570b\u764c\u75c7\u8ca0\u64d4\u6982\u6cc1https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/840-united-states-of-america-fact-sheets.pdf\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=208076\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u535a\u5b89\u751f\u7269\u5169\u6b3e\u9776\u5411Claudin18.2\u5728\u7814\u5275\u65b0\u85e5\u7372\u7f8e\u570bFDA\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7159\u53f02023\u5e7412\u670827\u65e5 \/\u7f8e\u901a\u793e\/ -- \u535a\u5b89\u751f\u7269\u5ba3\u4f48\uff0c\u5176\u81ea\u4e3b\u958b\u767c\u7684\u5169\u6b3e\u9776\u5411Claudin18.2\u7684\u5728\u7814\u7522\u54c1\u2014\u2014\u5275\u65b0\u6297\u9ad4BA1105\u3001\u5275\u65b0\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08Antibody\u2013Drug Conjugate\uff0cADC\uff09BA1301\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u6cbb\u7642\u80f0\u817a\u764c\u9069\u61c9\u75c7\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff08Orphan-drug Designation\uff0cODD\uff09\u3002 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