{"id":204672,"date":"2023-12-13T13:32:00","date_gmt":"2023-12-13T05:32:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=204672"},"modified":"2023-12-13T13:32:00","modified_gmt":"2023-12-13T05:32:00","slug":"%e6%96%b0%e7%89%88%e5%9c%8b%e5%ae%b6%e9%86%ab%e4%bf%9d%e7%9b%ae%e9%8c%84%e5%85%ac%e4%bd%88%ef%bc%9a%e8%a1%9b%e5%81%89%e8%bf%a6%e5%92%8c%e7%b4%90%e5%86%8d%e6%a8%82%ef%bc%88%e5%8f%a3%e6%9c%8d%e5%8a%91","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=204672","title":{"rendered":"\u65b0\u7248\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u516c\u4f48\uff1a\u885b\u5049\u8fe6\u548c\u7d10\u518d\u6a02\uff08\u53e3\u670d\u5291\u578b\uff09\u9996\u6b21\u7d0d\u5165\uff0c\u5247\u6a02\u6210\u529f\u7e8c\u7d04"},"content":{"rendered":"
\n

\u4e2d\u570b\u4e0a\u6d77\uff0c\u7f8e\u570b\u99ac\u85a9\u8af8\u585e\u5dde\u528d\u6a4b2023\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u518d\u9f0e\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aZLAB\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u4efd\u4ee3\u865f\uff1a9688\uff09\u4eca\u5929\u5ba3\u4f48\uff0c\u4ee5\u4e0b\u85e5\u7269\u53ca\u9069\u61c9\u8b49\u88ab\u7d0d\u5165\u4e86\u570b\u5bb6\u91ab\u7642\u4fdd\u969c\u5c40 (\u570b\u5bb6\u91ab\u4fdd\u5c40) \u516c\u4f48\u7684 2023 \u5e74\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304 (\u91ab\u4fdd\u76ee\u9304)\uff1a<\/p>\n

\u885b\u5049\u8fe6\u00ae\uff08\u827e\u52a0\u83ab\u5fb7\u03b1\u6ce8\u5c04\u6db2\uff09\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642\u4e59\u9170\u81bd\u9e7c\u53d7\u9ad4\uff08AChR\uff09\u6297\u9ad4\u967d\u6027\u7684\u6210\u4eba\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\uff08gMG\uff09\u60a3\u8005\uff1b<\/p>\n

\u7d10\u518d\u6a02\u00ae\uff08\u5967\u99ac\u74b0\u7d20\uff09\u7684\u53e3\u670d\u5291\u578b\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3\uff08ABSSSI\uff09\u6210\u4eba\u60a3\u8005\uff1b<\/p>\n

\u5247\u6a02\u00ae\uff08\u5c3c\u62c9\u5e15\u5229\uff09\u7528\u65bc\u6210\u4eba\u9251\u654f\u611f\u5fa9\u767c\u5375\u5de2\u764c\u548c\u4e00\u7dda\u5375\u5de2\u764c\u7dad\u6301\u6cbb\u7642\u6210\u529f\u7e8c\u7d04\uff1b<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u9996\u5e2d\u5546\u52d9\u5b98\u517c\u5927\u4e2d\u83ef\u5340\u7e3d\u88c1\u6881\u6021\u8868\u793a\uff1a\u300c<\/span> \u885b\u5049\u8fe6\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u5c0d\u65bc\u6240\u6709 gMG \u60a3\u8005\u4f86\u8aaa\u90fd\u662f\u4e00\u500b\u975e\u5e38\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u9ad4\u73fe\u4e86\u518d\u9f0e\u91ab\u85e5\u6301\u7e8c\u70ba\u91ab\u60a3\u96d9\u65b9\u5e36\u4f86\u81e8\u5e8a\u50f9\u503c\u7684\u627f\u8afe\u3002\u6b64\u6b21\u885b\u5049\u8fe6\u548c\u7d10\u518d\u6a02\uff08\u53e3\u670d\u5291\u578b\uff09\u7684\u7d0d\u5165\uff0c\u4ee5\u53ca\u5247\u6a02\u7684\u7e8c\u7d04\uff0c\u964d\u4f4e\u4e86\u60a3\u8005\u53ca\u5176\u5bb6\u5c6c\u7684\u6cbb\u7642\u652f\u51fa\uff0c\u8b93\u60a3\u8005\u53ef\u4ee5\u4ee5\u66f4\u4f4e\u7684\u50f9\u683c\u53d7\u76ca\u65bc\u5275\u65b0\u85e5\u7269\u3002\u300d<\/span>\u00a0<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u9996\u5e2d\u904b\u71df\u5b98Josh Smiley\u8868\u793a\uff1a\u300c<\/span> \u518d\u9f0e\u91ab\u85e5\u7684\u91cd\u8981\u4f7f\u547d\u662f\u70ba\u570b\u5167\u5916\u5b58\u5728\u672a\u6eff\u8db3\u91ab\u7642\u9700\u6c42\u7684\u60a3\u8005\u63d0\u4f9b\u5177\u6709\u8b8a\u9769\u6027\u7684\u5275\u65b0\u85e5\u7269\u3002\u6211\u5011\u5f88\u9ad8\u8208\u5df2\u6709\u56db\u6b3e\u7522\u54c1\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u4e26\u5c07\u7e7c\u7e8c\u52aa\u529b\u901a\u904e\u9032\u5165\u91ab\u4fdd\uff0c\u64f4\u5927\u60a3\u8005\u7372\u5f97\u5275\u65b0\u7642\u6cd5\u7684\u6a5f\u6703\u3002\u5341\u5206\u611f\u8b1d\u570b\u5bb6\u91ab\u4fdd\u5c40\uff0c\u6211\u5011\u671f\u5f85\u7e7c\u7e8c\u7a4d\u6975\u914d\u5408\u570b\u5bb6\u91ab\u4fdd\u5c40\u5de5\u4f5c\uff0c\u4e0d\u65b7\u6539\u5584\u60a3\u8005\u7372\u5f97\u9ad8\u54c1\u8cea\u6cbb\u7642\u624b\u6bb5\u7684\u53ef\u53ca\u6027\u53ca\u652f\u4ed8\u58d3\u529b\u3002\u300d<\/span>\u00a0<\/p>\n

\u95dc\u65bc\u91cd\u75c7\u808c\u7121\u529b\u5728\u4e2d\u570b<\/b><\/p>\n

\u91cd\u75c7\u808c\u7121\u529b (MG) \u662f\u4e00\u7a2e\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5e38\u5e38\u6703\u5c0e\u81f4\u4eba\u9ad4\u8870\u5f31\u548c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u7684\u808c\u7121\u529b\u3002\u4e2d\u570b\u5927\u7d04\u670917\u842c\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\u60a3\u8005[1]<\/sup>\u3002\u5176\u4e2d\u7d0485%\u60a3\u8005\u6709\u78ba\u8a8d\u7684AChR\u6297\u9ad4\u967d\u6027\uff1b\u5728gMG\u4e2d\uff0c\u5168\u8eab\u9aa8\u9abc\u808c\u5747\u53ef\u53d7\u7d2f\uff0c\u9032\u800c\u5c0e\u81f4\u865b\u5f31\u548c\u65e9\u671f\u75b2\u52de\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/i><\/p>\n

[1]<\/sup>. HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan<\/span> [J]. Frontiers in Neurology, 2023.<\/i><\/p>\n

\u95dc\u65bc\u885b\u5049\u8fe6\u00ae\uff08\u827e\u52a0\u83ab\u5fb7\u03b1\u6ce8\u5c04\u6db2\uff09<\/b><\/p>\n

\u827e\u52a0\u83ab\u5fb7\u662f\u4e00\u6b3e\u4ebaIgG1\u6297\u9ad4\u7684Fc\u7247\u6bb5\uff0c\u53ef\u8207\u65b0\u751f\u5152Fc\u53d7\u9ad4\uff08FcRn\uff09\u7d50\u5408\uff0c\u65e8\u5728\u6e1b\u5c11\u81f4\u75c5\u6027\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u6297\u9ad4\u4e26\u963b\u65b7IgG\u5faa\u74b0\u3002Fc \u53d7\u9ad4\u5728\u5168\u8eab\u5ee3\u6cdb\u8868\u9054\uff0c\u5728\u4fdd\u8b77IgG\u6297\u9ad4\u4f7f\u5176\u514d\u65bc\u964d\u89e3\u65b9\u9762\u767c\u63ee\u8457\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n

2023\u5e746\u6708\uff0c\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u885b\u5049\u8fe6\u8207\u5e38\u898f\u6cbb\u7642\u85e5\u7269\u806f\u5408\uff0c\u7528\u65bc\u6cbb\u7642\u4e59\u9170\u81bd\u9e7c\uff08AChR\uff09\u6297\u9ad4\u967d\u6027\u7684\u6210\u4ebagMG\u60a3\u8005\u3002\u885b\u5049\u8fe6\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7684FcRn\u62ee\u6297\u5291\u3002\u518d\u9f0e\u91ab\u85e5\u65bc 2023 \u5e74 9 \u6708\u5c07\u885b\u5049\u8fe6\u5728\u4e2d\u570b\u5546\u696d\u5316\u4e0a\u5e02\u3002<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u8207argenx\u9054\u6210\u7368\u5bb6\u6388\u6b0a\u5408\u4f5c\uff0c\u5728\u5927\u4e2d\u83ef\u5340\uff08\u4e2d\u570b\u5167\u5730\uff0c\u9999\u6e2f\u3001\u6fb3\u9580\u548c\u53f0\u7063\u5730\u5340\uff09\u958b\u767c\u548c\u5546\u696d\u5316\u827e\u52a0\u83ab\u5fb7\u3002<\/p>\n

\u95dc\u65bc\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e(CABP)\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3(ABSSSI)\u5728\u4e2d\u570b<\/b><\/p>\n

CABP\u662f\u91ab\u9662\u5916\u7372\u5f97\u7684\u3001\u6700\u5e38\u898b\u7684\u4e00\u7a2e\u80ba\u708e\uff0c\u5b83\u662f\u6700\u5e38\u898b\u7684\u611f\u67d3\u6027\u75be\u75c5\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u5168\u7403\u6b7b\u4ea1\u548c\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002ABSSSI\u662f\u76ae\u819a\u548c\u76f8\u95dc\u8edf\u7d44\u7e54\uff08\u5982\u758f\u9b06\u7d50\u7de0\u7d44\u7e54\u548c\u9ecf\u819c\uff09\u7684\u7d30\u83cc\u6027\u611f\u67d3\u3002ABSSSI\u5e38\u898b\u4e14\u6709\u591a\u7a2e\u75be\u75c5\u8868\u73fe\u5f62\u5f0f\uff0c\u5177\u6709\u4e0d\u540c\u7684\u56b4\u91cd\u7a0b\u5ea6\u30022020\u5e74\uff0c\u4e2d\u570b\u5927\u9678CABP\u7684\u9810\u4f30\u767c\u75c5\u6578\u7d04\u70ba1000\u842c[2]<\/sup>\uff1b2015\u5e74\uff0c ABSSSI\u7684\u9810\u4f30\u767c\u75c5\u6578\u70ba280\u842c\u4f8b[3]<\/sup>\uff1b\u5c0d\u65bc\u5b89\u5168\u6027\u826f\u597d\u3001\u6cbb\u7642\u591a\u91cd\u8010\u85e5\u7d30\u83cc\u611f\u67d3\u7684\u5ee3\u8b5c\u6297\u83cc\u85e5\uff0c\u4ecd\u5b58\u5728\u5927\u91cf\u7684\u672a\u6eff\u8db3\u9700\u6c42\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/i><\/p>\n

[2]<\/sup>. Incidence of community-acquired pneumonia in urban China<\/span>: A national population-based study, 2020.<\/i><\/p>\n

[3]<\/sup>. 2015 estimates, Zai Lab<\/span> analysis.<\/i><\/p>\n

\u95dc\u65bc\u7d10\u518d\u6a02\u00ae<\/b><\/p>\n

\u7d10\u518d\u6a02\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u7684\u3001\u64c1\u6709\u53e3\u670d\u548c\u975c\u8108\u8f38\u6ce8\u5169\u7a2e\u5291\u578b\u7684\u65b0\u578b\u56db\u74b0\u7d20\u985e\u6297\u83cc\u85e5\uff0c\u5c08\u9580\u8a2d\u8a08\u7528\u65bc\u514b\u670d\u56db\u74b0\u7d20\u985e\u8010\u85e5\u6027\u4e26\u63d0\u9ad8\u5ee3\u8b5c\u6297\u83cc\u6d3b\u6027\uff0c\u5982\u9769\u862d\u967d\u6027\u3001\u9769\u862d\u9670\u6027\u3001\u975e\u5178\u578b\u548c\u8a31\u591a\u5176\u4ed6\u75c5\u539f\u9ad4\u5f15\u8d77\u7684\u7d30\u83cc\u611f\u67d3\u3002<\/p>\n

NMPA\u65bc2021\u5e7412\u6708\u6279\u51c6\u570b\u5bb6\u4e00\u985e\u65b0\u85e5\u7d10\u518d\u6a02\uff08\u53e3\u670d\u548c\u975c\u8108\u5291\u578b\uff09\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u6210\u4eba\u60a3\u8005\u30022023\u5e741\u6708\u7d10\u518d\u6a02\u7684\u975c\u8108\u6ce8\u5c04\u5291\u578b\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\uff1b\u7d10\u518d\u6a02\u7684\u53e3\u670d\u5291\u578b\u5c07\u65bc2024\u5e741\u6708\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u3002<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5f9eParatek Pharmaceuticals\u7372\u5f97\u7368\u5bb6\u6388\u6b0a\uff0c\u5728\u5927\u4e2d\u83ef\u5340\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7d10\u518d\u6a02\u3002<\/p>\n

\u95dc\u65bc\u5375\u5de2\u764c\u5728\u4e2d\u570b<\/b><\/p>\n

\u5375\u5de2\u764c\u662f\u4e2d\u570b\u767c\u75c5\u7387\u6700\u9ad8\u7684\u5a66\u79d1\u816b\u7624\u4e4b\u4e00\uff0c\u5728\u4e2d\u570b\u6bcf\u5e74\u6709\u8d85\u904e55,000\u4f8b\u65b0\u767c\u60a3\u8005\u548c37,000\u4f8b\u6b7b\u4ea1\u60a3\u8005[4]<\/sup>\u3002\u5118\u7ba1\u5375\u5de2\u764c\u7d93\u904e\u521d\u59cb\u542b\u9251\u5316\u7642\u5f8c\u53ef\u4ee5\u5f97\u5230\u7de9\u89e3\uff0c\u4f46\u5927\u591a\u6578\u60a3\u8005\u90fd\u6703\u7121\u53ef\u907f\u514d\u9762\u81e8\u5fa9\u767c\u3002\u5c0d\u9251\u654f\u611f\u7684\u5fa9\u767c\u6027\u5375\u5de2\u764c\u60a3\u8005\u7684\u6709\u6548\u6cbb\u7642\u9078\u64c7\u4ecd\u7136\u6709\u9650\u3002\u5275\u65b0\u85e5\u7269\u53ef\u5ef6\u9577\u4e00\u7dda\u542b\u9251\u5316\u7642\u5f8c\u7684\u7de9\u89e3\u6642\u9593\uff0c\u5ef6\u7de9\u5fa9\u767c\uff0c\u9020\u798f\u4e2d\u570b\u5375\u5de2\u764c\u60a3\u8005\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/i><\/p>\n

[4]<\/sup>. Globocan 2020.<\/i><\/p>\n

\u95dc\u65bc\u5247\u6a02\u00ae\uff08\u5c3c\u62c9\u5e15\u5229\uff09<\/b><\/p>\n

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\u95dc\u65bc\u518d\u9f0e\u91ab\u85e5<\/b><\/p>\n

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HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . Frontiers in Neurology, 2023. \u95dc\u65bc\u885b\u5049\u8fe6\u00ae\uff08\u827e\u52a0\u83ab\u5fb7\u03b1\u6ce8\u5c04\u6db2\uff09 \u827e\u52a0\u83ab\u5fb7\u662f\u4e00\u6b3e\u4ebaIgG1\u6297\u9ad4\u7684Fc\u7247\u6bb5\uff0c\u53ef\u8207\u65b0\u751f\u5152Fc\u53d7\u9ad4\uff08FcRn\uff09\u7d50\u5408\uff0c\u65e8\u5728\u6e1b\u5c11\u81f4\u75c5\u6027\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u6297\u9ad4\u4e26\u963b\u65b7IgG\u5faa\u74b0\u3002Fc \u53d7\u9ad4\u5728\u5168\u8eab\u5ee3\u6cdb\u8868\u9054\uff0c\u5728\u4fdd\u8b77IgG\u6297\u9ad4\u4f7f\u5176\u514d\u65bc\u964d\u89e3\u65b9\u9762\u767c\u63ee\u8457\u6838\u5fc3\u4f5c\u7528\u3002 2023\u5e746\u6708\uff0c\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u885b\u5049\u8fe6\u8207\u5e38\u898f\u6cbb\u7642\u85e5\u7269\u806f\u5408\uff0c\u7528\u65bc\u6cbb\u7642\u4e59\u9170\u81bd\u9e7c\uff08AChR\uff09\u6297\u9ad4\u967d\u6027\u7684\u6210\u4ebagMG\u60a3\u8005\u3002\u885b\u5049\u8fe6\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7684FcRn\u62ee\u6297\u5291\u3002\u518d\u9f0e\u91ab\u85e5\u65bc 2023 \u5e74 9 \u6708\u5c07\u885b\u5049\u8fe6\u5728\u4e2d\u570b\u5546\u696d\u5316\u4e0a\u5e02\u3002 \u518d\u9f0e\u91ab\u85e5\u8207argenx\u9054\u6210\u7368\u5bb6\u6388\u6b0a\u5408\u4f5c\uff0c\u5728\u5927\u4e2d\u83ef\u5340\uff08\u4e2d\u570b\u5167\u5730\uff0c\u9999\u6e2f\u3001\u6fb3\u9580\u548c\u53f0\u7063\u5730\u5340\uff09\u958b\u767c\u548c\u5546\u696d\u5316\u827e\u52a0\u83ab\u5fb7\u3002 \u95dc\u65bc\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e(CABP)\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3(ABSSSI)\u5728\u4e2d\u570b CABP\u662f\u91ab\u9662\u5916\u7372\u5f97\u7684\u3001\u6700\u5e38\u898b\u7684\u4e00\u7a2e\u80ba\u708e\uff0c\u5b83\u662f\u6700\u5e38\u898b\u7684\u611f\u67d3\u6027\u75be\u75c5\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u5168\u7403\u6b7b\u4ea1\u548c\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002ABSSSI\u662f\u76ae\u819a\u548c\u76f8\u95dc\u8edf\u7d44\u7e54\uff08\u5982\u758f\u9b06\u7d50\u7de0\u7d44\u7e54\u548c\u9ecf\u819c\uff09\u7684\u7d30\u83cc\u6027\u611f\u67d3\u3002ABSSSI\u5e38\u898b\u4e14\u6709\u591a\u7a2e\u75be\u75c5\u8868\u73fe\u5f62\u5f0f\uff0c\u5177\u6709\u4e0d\u540c\u7684\u56b4\u91cd\u7a0b\u5ea6\u30022020\u5e74\uff0c\u4e2d\u570b\u5927\u9678CABP\u7684\u9810\u4f30\u767c\u75c5\u6578\u7d04\u70ba1000\u842c\uff1b2015\u5e74\uff0c ABSSSI\u7684\u9810\u4f30\u767c\u75c5\u6578\u70ba280\u842c\u4f8b\uff1b\u5c0d\u65bc\u5b89\u5168\u6027\u826f\u597d\u3001\u6cbb\u7642\u591a\u91cd\u8010\u85e5\u7d30\u83cc\u611f\u67d3\u7684\u5ee3\u8b5c\u6297\u83cc\u85e5\uff0c\u4ecd\u5b58\u5728\u5927\u91cf\u7684\u672a\u6eff\u8db3\u9700\u6c42\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . Incidence of community-acquired pneumonia in urban China: A national population-based study, 2020. . 2015 estimates, Zai Lab analysis. \u95dc\u65bc\u7d10\u518d\u6a02\u00ae \u7d10\u518d\u6a02\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u7684\u3001\u64c1\u6709\u53e3\u670d\u548c\u975c\u8108\u8f38\u6ce8\u5169\u7a2e\u5291\u578b\u7684\u65b0\u578b\u56db\u74b0\u7d20\u985e\u6297\u83cc\u85e5\uff0c\u5c08\u9580\u8a2d\u8a08\u7528\u65bc\u514b\u670d\u56db\u74b0\u7d20\u985e\u8010\u85e5\u6027\u4e26\u63d0\u9ad8\u5ee3\u8b5c\u6297\u83cc\u6d3b\u6027\uff0c\u5982\u9769\u862d\u967d\u6027\u3001\u9769\u862d\u9670\u6027\u3001\u975e\u5178\u578b\u548c\u8a31\u591a\u5176\u4ed6\u75c5\u539f\u9ad4\u5f15\u8d77\u7684\u7d30\u83cc\u611f\u67d3\u3002 NMPA\u65bc2021\u5e7412\u6708\u6279\u51c6\u570b\u5bb6\u4e00\u985e\u65b0\u85e5\u7d10\u518d\u6a02\uff08\u53e3\u670d\u548c\u975c\u8108\u5291\u578b\uff09\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u6210\u4eba\u60a3\u8005\u30022023\u5e741\u6708\u7d10\u518d\u6a02\u7684\u975c\u8108\u6ce8\u5c04\u5291\u578b\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\uff1b\u7d10\u518d\u6a02\u7684\u53e3\u670d\u5291\u578b\u5c07\u65bc2024\u5e741\u6708\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u3002 \u518d\u9f0e\u91ab\u85e5\u5f9eParatek Pharmaceuticals\u7372\u5f97\u7368\u5bb6\u6388\u6b0a\uff0c\u5728\u5927\u4e2d\u83ef\u5340\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7d10\u518d\u6a02\u3002 \u95dc\u65bc\u5375\u5de2\u764c\u5728\u4e2d\u570b \u5375\u5de2\u764c\u662f\u4e2d\u570b\u767c\u75c5\u7387\u6700\u9ad8\u7684\u5a66\u79d1\u816b\u7624\u4e4b\u4e00\uff0c\u5728\u4e2d\u570b\u6bcf\u5e74\u6709\u8d85\u904e55,000\u4f8b\u65b0\u767c\u60a3\u8005\u548c37,000\u4f8b\u6b7b\u4ea1\u60a3\u8005\u3002\u5118\u7ba1\u5375\u5de2\u764c\u7d93\u904e\u521d\u59cb\u542b\u9251\u5316\u7642\u5f8c\u53ef\u4ee5\u5f97\u5230\u7de9\u89e3\uff0c\u4f46\u5927\u591a\u6578\u60a3\u8005\u90fd\u6703\u7121\u53ef\u907f\u514d\u9762\u81e8\u5fa9\u767c\u3002\u5c0d\u9251\u654f\u611f\u7684\u5fa9\u767c\u6027\u5375\u5de2\u764c\u60a3\u8005\u7684\u6709\u6548\u6cbb\u7642\u9078\u64c7\u4ecd\u7136\u6709\u9650\u3002\u5275\u65b0\u85e5\u7269\u53ef\u5ef6\u9577\u4e00\u7dda\u542b\u9251\u5316\u7642\u5f8c\u7684\u7de9\u89e3\u6642\u9593\uff0c\u5ef6\u7de9\u5fa9\u767c\uff0c\u9020\u798f\u4e2d\u570b\u5375\u5de2\u764c\u60a3\u8005\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . 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HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . Frontiers in Neurology, 2023. \u95dc\u65bc\u885b\u5049\u8fe6\u00ae\uff08\u827e\u52a0\u83ab\u5fb7\u03b1\u6ce8\u5c04\u6db2\uff09 \u827e\u52a0\u83ab\u5fb7\u662f\u4e00\u6b3e\u4ebaIgG1\u6297\u9ad4\u7684Fc\u7247\u6bb5\uff0c\u53ef\u8207\u65b0\u751f\u5152Fc\u53d7\u9ad4\uff08FcRn\uff09\u7d50\u5408\uff0c\u65e8\u5728\u6e1b\u5c11\u81f4\u75c5\u6027\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u6297\u9ad4\u4e26\u963b\u65b7IgG\u5faa\u74b0\u3002Fc \u53d7\u9ad4\u5728\u5168\u8eab\u5ee3\u6cdb\u8868\u9054\uff0c\u5728\u4fdd\u8b77IgG\u6297\u9ad4\u4f7f\u5176\u514d\u65bc\u964d\u89e3\u65b9\u9762\u767c\u63ee\u8457\u6838\u5fc3\u4f5c\u7528\u3002 2023\u5e746\u6708\uff0c\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u885b\u5049\u8fe6\u8207\u5e38\u898f\u6cbb\u7642\u85e5\u7269\u806f\u5408\uff0c\u7528\u65bc\u6cbb\u7642\u4e59\u9170\u81bd\u9e7c\uff08AChR\uff09\u6297\u9ad4\u967d\u6027\u7684\u6210\u4ebagMG\u60a3\u8005\u3002\u885b\u5049\u8fe6\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7684FcRn\u62ee\u6297\u5291\u3002\u518d\u9f0e\u91ab\u85e5\u65bc 2023 \u5e74 9 \u6708\u5c07\u885b\u5049\u8fe6\u5728\u4e2d\u570b\u5546\u696d\u5316\u4e0a\u5e02\u3002 \u518d\u9f0e\u91ab\u85e5\u8207argenx\u9054\u6210\u7368\u5bb6\u6388\u6b0a\u5408\u4f5c\uff0c\u5728\u5927\u4e2d\u83ef\u5340\uff08\u4e2d\u570b\u5167\u5730\uff0c\u9999\u6e2f\u3001\u6fb3\u9580\u548c\u53f0\u7063\u5730\u5340\uff09\u958b\u767c\u548c\u5546\u696d\u5316\u827e\u52a0\u83ab\u5fb7\u3002 \u95dc\u65bc\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e(CABP)\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3(ABSSSI)\u5728\u4e2d\u570b CABP\u662f\u91ab\u9662\u5916\u7372\u5f97\u7684\u3001\u6700\u5e38\u898b\u7684\u4e00\u7a2e\u80ba\u708e\uff0c\u5b83\u662f\u6700\u5e38\u898b\u7684\u611f\u67d3\u6027\u75be\u75c5\u4e4b\u4e00\uff0c\u4e5f\u662f\u5c0e\u81f4\u5168\u7403\u6b7b\u4ea1\u548c\u767c\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002ABSSSI\u662f\u76ae\u819a\u548c\u76f8\u95dc\u8edf\u7d44\u7e54\uff08\u5982\u758f\u9b06\u7d50\u7de0\u7d44\u7e54\u548c\u9ecf\u819c\uff09\u7684\u7d30\u83cc\u6027\u611f\u67d3\u3002ABSSSI\u5e38\u898b\u4e14\u6709\u591a\u7a2e\u75be\u75c5\u8868\u73fe\u5f62\u5f0f\uff0c\u5177\u6709\u4e0d\u540c\u7684\u56b4\u91cd\u7a0b\u5ea6\u30022020\u5e74\uff0c\u4e2d\u570b\u5927\u9678CABP\u7684\u9810\u4f30\u767c\u75c5\u6578\u7d04\u70ba1000\u842c\uff1b2015\u5e74\uff0c ABSSSI\u7684\u9810\u4f30\u767c\u75c5\u6578\u70ba280\u842c\u4f8b\uff1b\u5c0d\u65bc\u5b89\u5168\u6027\u826f\u597d\u3001\u6cbb\u7642\u591a\u91cd\u8010\u85e5\u7d30\u83cc\u611f\u67d3\u7684\u5ee3\u8b5c\u6297\u83cc\u85e5\uff0c\u4ecd\u5b58\u5728\u5927\u91cf\u7684\u672a\u6eff\u8db3\u9700\u6c42\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . Incidence of community-acquired pneumonia in urban China: A national population-based study, 2020. . 2015 estimates, Zai Lab analysis. \u95dc\u65bc\u7d10\u518d\u6a02\u00ae \u7d10\u518d\u6a02\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u7684\u3001\u64c1\u6709\u53e3\u670d\u548c\u975c\u8108\u8f38\u6ce8\u5169\u7a2e\u5291\u578b\u7684\u65b0\u578b\u56db\u74b0\u7d20\u985e\u6297\u83cc\u85e5\uff0c\u5c08\u9580\u8a2d\u8a08\u7528\u65bc\u514b\u670d\u56db\u74b0\u7d20\u985e\u8010\u85e5\u6027\u4e26\u63d0\u9ad8\u5ee3\u8b5c\u6297\u83cc\u6d3b\u6027\uff0c\u5982\u9769\u862d\u967d\u6027\u3001\u9769\u862d\u9670\u6027\u3001\u975e\u5178\u578b\u548c\u8a31\u591a\u5176\u4ed6\u75c5\u539f\u9ad4\u5f15\u8d77\u7684\u7d30\u83cc\u611f\u67d3\u3002 NMPA\u65bc2021\u5e7412\u6708\u6279\u51c6\u570b\u5bb6\u4e00\u985e\u65b0\u85e5\u7d10\u518d\u6a02\uff08\u53e3\u670d\u548c\u975c\u8108\u5291\u578b\uff09\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u6210\u4eba\u60a3\u8005\u30022023\u5e741\u6708\u7d10\u518d\u6a02\u7684\u975c\u8108\u6ce8\u5c04\u5291\u578b\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\uff1b\u7d10\u518d\u6a02\u7684\u53e3\u670d\u5291\u578b\u5c07\u65bc2024\u5e741\u6708\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642CABP\u548cABSSSI\u3002 \u518d\u9f0e\u91ab\u85e5\u5f9eParatek Pharmaceuticals\u7372\u5f97\u7368\u5bb6\u6388\u6b0a\uff0c\u5728\u5927\u4e2d\u83ef\u5340\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7d10\u518d\u6a02\u3002 \u95dc\u65bc\u5375\u5de2\u764c\u5728\u4e2d\u570b \u5375\u5de2\u764c\u662f\u4e2d\u570b\u767c\u75c5\u7387\u6700\u9ad8\u7684\u5a66\u79d1\u816b\u7624\u4e4b\u4e00\uff0c\u5728\u4e2d\u570b\u6bcf\u5e74\u6709\u8d85\u904e55,000\u4f8b\u65b0\u767c\u60a3\u8005\u548c37,000\u4f8b\u6b7b\u4ea1\u60a3\u8005\u3002\u5118\u7ba1\u5375\u5de2\u764c\u7d93\u904e\u521d\u59cb\u542b\u9251\u5316\u7642\u5f8c\u53ef\u4ee5\u5f97\u5230\u7de9\u89e3\uff0c\u4f46\u5927\u591a\u6578\u60a3\u8005\u90fd\u6703\u7121\u53ef\u907f\u514d\u9762\u81e8\u5fa9\u767c\u3002\u5c0d\u9251\u654f\u611f\u7684\u5fa9\u767c\u6027\u5375\u5de2\u764c\u60a3\u8005\u7684\u6709\u6548\u6cbb\u7642\u9078\u64c7\u4ecd\u7136\u6709\u9650\u3002\u5275\u65b0\u85e5\u7269\u53ef\u5ef6\u9577\u4e00\u7dda\u542b\u9251\u5316\u7642\u5f8c\u7684\u7de9\u89e3\u6642\u9593\uff0c\u5ef6\u7de9\u5fa9\u767c\uff0c\u9020\u798f\u4e2d\u570b\u5375\u5de2\u764c\u60a3\u8005\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . Globocan 2020. \u95dc\u65bc\u5247\u6a02\u00ae\uff08\u5c3c\u62c9\u5e15\u5229\uff09 \u5247\u6a02\uff08\u5c3c\u62c9\u5e15\u5229\uff09\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176\uff08PARP\uff09\u6291\u5236\u5291\uff0cPARP \u6291\u5236\u5291\u53ef\u4ee5\u963b\u6b62\u816b\u7624\u7d30\u80de\u5728\u53d7\u5230\u653e\u7642\u548c\u67d0\u4e9b\u5316\u7642\u640d\u50b7\u5f8c\u9032\u884c\u81ea\u6211\u4fee\u5fa9\u7684\u80fd\u529b\u3002 \u9019\u7a2e\u5c0d DNA \u640d\u50b7\u4fee\u5fa9\u7684\u6291\u5236\u53ef\u80fd\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u7121\u6cd5\u81ea\u6211\u8907\u88fd\u4e26\u5c0e\u81f4\u7d30\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u3002 \u7f3a\u4e4f\u95dc\u9375 DNA \u640d\u50b7\u4fee\u5fa9\u9014\u5f91\u7684\u816b\u7624\uff0c\u4f8b\u5982 BRCA1 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\u516c\u4f48\u7684 2023 \u5e74\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304 (\u91ab\u4fdd\u76ee\u9304)\uff1a \u885b\u5049\u8fe6\u00ae\uff08\u827e\u52a0\u83ab\u5fb7\u03b1\u6ce8\u5c04\u6db2\uff09\u9996\u6b21\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642\u4e59\u9170\u81bd\u9e7c\u53d7\u9ad4\uff08AChR\uff09\u6297\u9ad4\u967d\u6027\u7684\u6210\u4eba\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\uff08gMG\uff09\u60a3\u8005\uff1b \u7d10\u518d\u6a02\u00ae\uff08\u5967\u99ac\u74b0\u7d20\uff09\u7684\u53e3\u670d\u5291\u578b\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u7528\u65bc\u6cbb\u7642\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3\uff08ABSSSI\uff09\u6210\u4eba\u60a3\u8005\uff1b 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\u518d\u9f0e\u91ab\u85e5\u7684\u91cd\u8981\u4f7f\u547d\u662f\u70ba\u570b\u5167\u5916\u5b58\u5728\u672a\u6eff\u8db3\u91ab\u7642\u9700\u6c42\u7684\u60a3\u8005\u63d0\u4f9b\u5177\u6709\u8b8a\u9769\u6027\u7684\u5275\u65b0\u85e5\u7269\u3002\u6211\u5011\u5f88\u9ad8\u8208\u5df2\u6709\u56db\u6b3e\u7522\u54c1\u88ab\u7d0d\u5165\u91ab\u4fdd\u76ee\u9304\uff0c\u4e26\u5c07\u7e7c\u7e8c\u52aa\u529b\u901a\u904e\u9032\u5165\u91ab\u4fdd\uff0c\u64f4\u5927\u60a3\u8005\u7372\u5f97\u5275\u65b0\u7642\u6cd5\u7684\u6a5f\u6703\u3002\u5341\u5206\u611f\u8b1d\u570b\u5bb6\u91ab\u4fdd\u5c40\uff0c\u6211\u5011\u671f\u5f85\u7e7c\u7e8c\u7a4d\u6975\u914d\u5408\u570b\u5bb6\u91ab\u4fdd\u5c40\u5de5\u4f5c\uff0c\u4e0d\u65b7\u6539\u5584\u60a3\u8005\u7372\u5f97\u9ad8\u54c1\u8cea\u6cbb\u7642\u624b\u6bb5\u7684\u53ef\u53ca\u6027\u53ca\u652f\u4ed8\u58d3\u529b\u3002\u300d\u00a0 \u95dc\u65bc\u91cd\u75c7\u808c\u7121\u529b\u5728\u4e2d\u570b \u91cd\u75c7\u808c\u7121\u529b (MG) \u662f\u4e00\u7a2e\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5e38\u5e38\u6703\u5c0e\u81f4\u4eba\u9ad4\u8870\u5f31\u548c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u7684\u808c\u7121\u529b\u3002\u4e2d\u570b\u5927\u7d04\u670917\u842c\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\u60a3\u8005\u3002\u5176\u4e2d\u7d0485%\u60a3\u8005\u6709\u78ba\u8a8d\u7684AChR\u6297\u9ad4\u967d\u6027\uff1b\u5728gMG\u4e2d\uff0c\u5168\u8eab\u9aa8\u9abc\u808c\u5747\u53ef\u53d7\u7d2f\uff0c\u9032\u800c\u5c0e\u81f4\u865b\u5f31\u548c\u65e9\u671f\u75b2\u52de\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . 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\u662f\u4e00\u7a2e\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5e38\u5e38\u6703\u5c0e\u81f4\u4eba\u9ad4\u8870\u5f31\u548c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u7684\u808c\u7121\u529b\u3002\u4e2d\u570b\u5927\u7d04\u670917\u842c\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\u60a3\u8005\u3002\u5176\u4e2d\u7d0485%\u60a3\u8005\u6709\u78ba\u8a8d\u7684AChR\u6297\u9ad4\u967d\u6027\uff1b\u5728gMG\u4e2d\uff0c\u5168\u8eab\u9aa8\u9abc\u808c\u5747\u53ef\u53d7\u7d2f\uff0c\u9032\u800c\u5c0e\u81f4\u865b\u5f31\u548c\u65e9\u671f\u75b2\u52de\u3002 \u53c3\u8003\u8cc7\u6599\uff1a . HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . 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HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . 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HERR K, SP SHEN, LIU Y, et al. The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan . 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