{"id":201252,"date":"2023-11-30T09:53:00","date_gmt":"2023-11-30T01:53:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=201252"},"modified":"2023-11-30T09:53:00","modified_gmt":"2023-11-30T01:53:00","slug":"%e4%b8%89%e9%99%b0%e6%80%a7%e3%80%8c%e8%b6%85%e6%83%a1%e3%80%8d%e4%b9%b3%e7%99%8c-%e5%b0%88%e5%ae%b6%e5%b0%8f%e7%b5%84%e9%81%94%e6%9c%ac%e5%9c%b0%e6%b2%bb%e7%99%82%e5%85%b1%e8%ad%98","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=201252","title":{"rendered":"\u4e09\u9670\u6027\u300c\u8d85\u60e1\u300d\u4e73\u764c \u5c08\u5bb6\u5c0f\u7d44\u9054\u672c\u5730\u6cbb\u7642\u5171\u8b58"},"content":{"rendered":"<div>\n<p><b>\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703<\/b>\u63a8\u51fa<b>\u300c\u514d\u75ab\u6cbb\u7642\u85e5\u7269\u8cc7\u52a9\u8a08\u5283\u300d<\/b>\u60e0\u53ca\u6709\u9700\u8981\u75c5\u4eba<\/p>\n<p><span class=\"legendSpanClass\">\u9999\u6e2f<\/span><span class=\"legendSpanClass\">2023\u5e7411\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u3002<sup>3<\/sup><\/p>\n<p>\u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 IHC\uff09\u6aa2\u6e2c\uff0c\u78ba\u5b9a\u75c5\u4eba\u7684ER\u3001PR\u548cHER2\u72c0\u6cc1\uff0c\u70ba\u60a3\u8005\u7684\u4e73\u764c\u5206\u985e\uff0c\u4ee5\u5236\u5b9a\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u5c0d\u7b2cII\u671f\u548c\u7b2cIII\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u53ea\u8981\u81e8\u5e8a\u72c0\u6cc1\u5408\u9069\uff0c\u8853\u524d\u6cbb\u7642\u61c9\u8a72\u88ab\u8996\u70ba\u6a19\u6e96\u548c\u512a\u5148\u8003\u616e\u7684\u6cbb\u7642\u65b9\u6848\u3002\u91ab\u751f\u4ea6\u61c9\u8a72\u8003\u616e\u4ee5\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u3002<\/p>\n<p><b>\u90b1\u632f\u4e2d\u91ab\u751f<\/b>\u6307\u51fa\uff0c\u5c0d\u65bc\u7b2cII\u671f\u548c\u7b2cIII\u671f\u7684\u65e9\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u53ef\u4ee5\u63d0\u5347\u6cbb\u7642\u6548\u679c\u3002\u6839\u64da\u570b\u969b\u91ab\u5b78\u6578\u64da\uff0c\u66f4\u53ef\u4ee5\u63d0\u5347\u300c\u75c5\u7406\u5b8c\u5168\u7de9\u89e3\u300d\uff08pathological complete response\uff09\u7684\u6a5f\u6703\u7387\u81f365%\uff0c\u800c\u7121\u4e8b\u4ef6\u5b58\u6d3b\u671f\uff08event-free survival\uff09\u4ea6\u6bd4\u55ae\u7528\u5316\u7642\u7684\u60a3\u8005\u986f\u8457\u5ef6\u9577\u3002<sup>4<\/sup>\u300c\u75c5\u4eba\u539f\u672c\u53ef\u80fd\u9700\u8981\u63a5\u53d7\u5168\u4e73\u5207\u9664\u624b\u8853\uff0c\u4f46\u82e5\u5148\u63a5\u53d7\u514d\u75ab\u6cbb\u7642\u518d\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\uff0c\u6709\u6a5f\u6703\u7e2e\u5c0f\u816b\u7624\uff0c\u4ee4\u75c5\u4eba\u6bcb\u9808\u5207\u9664\u6574\u500b\u4e73\u623f\uff0c\u5c0d\u75c5\u4eba\u7684\u5fc3\u7406\u548c\u751f\u6d3b\u8cea\u7d20\u90fd\u6709\u5f88\u5927\u7684\u6539\u5584\u3002\u300d<\/p>\n<p><b>\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u4e3b\u5e2d\u970d\u4f55\u7dba\u83ef\u535a\u58eb<\/b>\u8868\u793a\ufe55\u300c\u96a8\u8457\u91ab\u5b78\u6280\u8853\u7684\u9032\u6b65\uff0c\u7d9c\u5408\u5c08\u5bb6\u7d44\u7684\u8a3a\u65b7\u548c\u5206\u6790\uff0c\u70ba\u60a3\u4e0a\u65e9\u671f\u9ad8\u98a8\u96aa\u4e09\u9670\u6027\u4e73\u764c\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u66d9\u5149\u3002\u514d\u75ab\u6cbb\u7642\u85e5\u7269\u6df7\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\uff0c\u4e26\u8f14\u52a9\u60a3\u8005\u65bc\u624b\u8853\u5f8c\u4f5c\u70ba\u8853\u5f8c\u6cbb\u7642\uff0c\u80fd\u6e1b\u8f15\u8eab\u9ad4\u4e0d\u9069\u4e26\u540c\u6642\u5f97\u5230\u9069\u5207\u7684\u6cbb\u7642\u3002\u300d<\/p>\n<p>\u70ba\u652f\u63f4\u9019\u6279\u65e9\u671f\u9ad8\u98a8\u96aa\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c<b>\u57fa\u91d1\u6703<\/b>\u63a8\u51fa<b>\u300c\u514d\u75ab\u6cbb\u7642\u85e5\u7269\u8cc7\u52a9\u8a08\u5283\u300d\uff0c<\/b>\u8cc7\u52a9\u5408\u8cc7\u683c\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\uff0c\u6210\u529f\u7372\u6279\u7684\u60a3\u8005\u6bcf\u6b21\u7642\u7a0b\u53ef\u7372\u73fe\u91d1\u8cc7\u52a9\u6e2f\u5e6313,600\u5143\u3002\u53c3\u8207\u8a08\u5283\u7684\u60a3\u8005\u9700\u8981\u7b26\u5408\u4ee5\u4e0b\u689d\u4ef6\uff1a<\/p>\n<p>1.\u00a0\u00a0\u00a0\u00a0\u00a0 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Hong Kong Med J. 2023;29(3):198-207. (\u53ea\u9650\u82f1\u6587\u7248\u672c)<br \/>3 Kong X et al. Eur J Cancer. 2011;47(14):2084-2090. (\u53ea\u9650\u82f1\u6587\u7248\u672c)<br \/>4\u00a0Schmid P et al. N Eng J Med 2020;382:810-21. 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 IHC\uff09\u6aa2\u6e2c\uff0c\u78ba\u5b9a\u75c5\u4eba\u7684ER\u3001PR\u548cHER2\u72c0\u6cc1\uff0c\u70ba\u60a3\u8005\u7684\u4e73\u764c\u5206\u985e\uff0c\u4ee5\u5236\u5b9a\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u5c0d\u7b2cII\u671f\u548c\u7b2cIII\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u53ea\u8981\u81e8\u5e8a\u72c0\u6cc1\u5408\u9069\uff0c\u8853\u524d\u6cbb\u7642\u61c9\u8a72\u88ab\u8996\u70ba\u6a19\u6e96\u548c\u512a\u5148\u8003\u616e\u7684\u6cbb\u7642\u65b9\u6848\u3002\u91ab\u751f\u4ea6\u61c9\u8a72\u8003\u616e\u4ee5\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u3002 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survival\uff09\u4ea6\u6bd4\u55ae\u7528\u5316\u7642\u7684\u60a3\u8005\u986f\u8457\u5ef6\u9577\u30024\u300c\u75c5\u4eba\u539f\u672c\u53ef\u80fd\u9700\u8981\u63a5\u53d7\u5168\u4e73\u5207\u9664\u624b\u8853\uff0c\u4f46\u82e5\u5148\u63a5\u53d7\u514d\u75ab\u6cbb\u7642\u518d\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\uff0c\u6709\u6a5f\u6703\u7e2e\u5c0f\u816b\u7624\uff0c\u4ee4\u75c5\u4eba\u6bcb\u9808\u5207\u9664\u6574\u500b\u4e73\u623f\uff0c\u5c0d\u75c5\u4eba\u7684\u5fc3\u7406\u548c\u751f\u6d3b\u8cea\u7d20\u90fd\u6709\u5f88\u5927\u7684\u6539\u5584\u3002\u300d 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\u6bcf\u6b21\u7642\u7a0b\u4f7f\u7528\u5339\u535a\u5229\u7d44\u55ae\u6297\uff08Pembrolizumab\uff09200 \u6beb\u514b\u6216\u00a0400 \u6beb\u514b\u5291\u91cf\u7684\u75c5\u4eba\u3002 *\u79c1\u5bb6\u91ab\u9662\u6216\u8a3a\u6240\u8f49\u4ecb\u7684\u60a3\u8005\u9700\u901a\u904e\u5165\u606f\u5be9\u67e5\uff0c\u6700\u8fd112\u500b\u6708\u5e73\u5747\u500b\u4eba\u5165\u606f\u6bcf\u6708\u5c11\u65bc\u6e2f\u5e636\u842c\u5143 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\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u6709\u95dc\ufe55\u300c\u514d\u75ab\u6cbb\u7642\u85e5\u7269\u8cc7\u52a9\u8a08\u5283\u300d\u7533\u8acb\u8a73\u60c5\uff0c\u8acb\u700f\u89bd\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u7db2\u7ad9\u3002 \u4e0b\u8f09\u65b0\u805e\u767c\u4f48\u6703\u76f8\u7247\uff1ahttps:\/\/drive.google.com\/drive\/folders\/15hg_7wg7sBZH5nbAa4QeiimRQiGi8kwY?usp=sharing\u00a0 \u95dc\u65bc\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u00a0 \u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u65bc\u00a02005 \u5e74\u00a03 \u6708\u00a08 \u65e5\u6210\u7acb\uff0c\u662f\u672c\u6e2f\u9996\u9593\u5c08\u6ce8\u4e73\u5065\u6559\u80b2\u3001\u60a3\u8005\u652f\u63f4\u3001\u7814\u7a76\u53ca\u5021\u8b70\u00a0\u7684\u975e\u725f\u5229\u6148\u5584\u7d44\u7e54\uff0c\u81f4\u529b\u6e1b\u4f4e\u4e73\u764c\u5728\u672c\u5730\u7684\u5a01\u8105\u3002\u5176\u4f7f\u547d\u662f\u63d0\u9ad8\u516c\u773e\u5c0d\u4e73\u764c\u7684\u8a8d\u8b58\u53ca\u63a8\u5ee3\u4e73\u623f\u5065\u00a0\u5eb7\u7684\u91cd\u8981\u6027\uff1b\u652f\u63f4\u4e73\u764c\u60a3\u8005\u8e0f\u4e0a\u5eb7\u5fa9\u4e4b\u8def\u53ca\u5021\u8b70\u6539\u5584\u672c\u6e2f\u4e73\u764c\u9632\u63a7\u548c\u91ab\u8b77\u65b9\u6848\u3002\u00a0 1 \u91ab\u9662\u7ba1\u7406\u5c40\u9999\u6e2f\u764c\u75c7\u8cc7\u6599\u7d71\u8a08\u4e2d\u5fc320212 Chan YHY et al. Hong Kong Med J. 2023;29(3):198-207. (\u53ea\u9650\u82f1\u6587\u7248\u672c)3 Kong X et al. Eur J Cancer. 2011;47(14):2084-2090. (\u53ea\u9650\u82f1\u6587\u7248\u672c)4\u00a0Schmid P et al. N Eng J Med 2020;382:810-21. (\u53ea\u9650\u82f1\u6587\u7248\u672c) \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=201252\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e09\u9670\u6027\u300c\u8d85\u60e1\u300d\u4e73\u764c \u5c08\u5bb6\u5c0f\u7d44\u9054\u672c\u5730\u6cbb\u7642\u5171\u8b58 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u63a8\u51fa\u300c\u514d\u75ab\u6cbb\u7642\u85e5\u7269\u8cc7\u52a9\u8a08\u5283\u300d\u60e0\u53ca\u6709\u9700\u8981\u75c5\u4eba \u9999\u6e2f2023\u5e7411\u670829\u65e5 \/\u7f8e\u901a\u793e\/ -- 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\u5c08\u5bb6\u7d44\u6210\u54e1\u4e4b\u4e00\u3001\u9999\u6e2f\u4e73\u764c\u57fa\u91d1\u6703\u7ba1\u6cbb\u59d4\u54e1\u6703\u526f\u4e3b\u5e2d\u90b1\u632f\u4e2d\u91ab\u751f\u8868\u793a\uff0c\u4e09\u9670\u6027\u4e73\u764c\u5373\u8377\u723e\u8499\u53d7\u9ad4\u4e2d\u7684\u96cc\u6fc0\u7d20\u53d7\u9ad4\uff08ER\uff09\u3001\u5b55\u916e\u53d7\u9ad4\uff08PR\uff09\u3001\u7b2c\u4e8c\u578b\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\uff08HER2\uff09\u4e09\u8005\u6e2c\u8a66\u7686\u5c6c\u9670\u6027\uff0c\u56e0\u6b64\u8377\u723e\u8499\u6cbb\u7642\u548c\u6a19\u9776\u85e5\u7269\u5c0d\u4e09\u9670\u6027\u4e73\u764c\u7684\u6cbb\u7642\u6548\u679c\u4e0d\u5927\u3002\u6839\u6cbb\u6027\u624b\u8853\u4e00\u76f4\u662f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\u7684\u4e3b\u8981\u6cbb\u7642\u65b9\u5f0f\u3002\u8fd1\u5e74\u4f86\u91ab\u5b78\u754c\u958b\u59cb\u65bc\u624b\u8853\u524d\u61c9\u7528\u524d\u7f6e\u5316\u7642\uff0c\u5e0c\u671b\u900f\u904e\u85e5\u7269\u65bc\u9032\u884c\u624b\u8853\u524d\u7e2e\u5c0f\u816b\u7624\uff0c\u589e\u52a0\u5916\u79d1\u91ab\u751f\u9032\u884c\u4fdd\u7559\u4e73\u623f\u624b\u8853\u7684\u6a5f\u6703\uff0c\u5f9e\u800c\u907f\u514d\u60a3\u8005\u9700\u8981\u63a5\u53d7\u5168\u4e73\u5207\u9664\u624b\u8853\u5c07\u6574\u500b\u4e73\u623f\u5207\u9664\u30022\u60a3\u8005\u82e5\u679c\u53ef\u4ee5\u900f\u904e\u8853\u524d\u6cbb\u7642\u4f7f\u816b\u7624\u9054\u81f3\u300c\u75c5\u7406\u5b8c\u5168\u7de9\u89e3\u300d\uff08pathological complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 IHC\uff09\u6aa2\u6e2c\uff0c\u78ba\u5b9a\u75c5\u4eba\u7684ER\u3001PR\u548cHER2\u72c0\u6cc1\uff0c\u70ba\u60a3\u8005\u7684\u4e73\u764c\u5206\u985e\uff0c\u4ee5\u5236\u5b9a\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u5c0d\u7b2cII\u671f\u548c\u7b2cIII\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u53ea\u8981\u81e8\u5e8a\u72c0\u6cc1\u5408\u9069\uff0c\u8853\u524d\u6cbb\u7642\u61c9\u8a72\u88ab\u8996\u70ba\u6a19\u6e96\u548c\u512a\u5148\u8003\u616e\u7684\u6cbb\u7642\u65b9\u6848\u3002\u91ab\u751f\u4ea6\u61c9\u8a72\u8003\u616e\u4ee5\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u3002 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\u65e5\u6210\u7acb\uff0c\u662f\u672c\u6e2f\u9996\u9593\u5c08\u6ce8\u4e73\u5065\u6559\u80b2\u3001\u60a3\u8005\u652f\u63f4\u3001\u7814\u7a76\u53ca\u5021\u8b70\u00a0\u7684\u975e\u725f\u5229\u6148\u5584\u7d44\u7e54\uff0c\u81f4\u529b\u6e1b\u4f4e\u4e73\u764c\u5728\u672c\u5730\u7684\u5a01\u8105\u3002\u5176\u4f7f\u547d\u662f\u63d0\u9ad8\u516c\u773e\u5c0d\u4e73\u764c\u7684\u8a8d\u8b58\u53ca\u63a8\u5ee3\u4e73\u623f\u5065\u00a0\u5eb7\u7684\u91cd\u8981\u6027\uff1b\u652f\u63f4\u4e73\u764c\u60a3\u8005\u8e0f\u4e0a\u5eb7\u5fa9\u4e4b\u8def\u53ca\u5021\u8b70\u6539\u5584\u672c\u6e2f\u4e73\u764c\u9632\u63a7\u548c\u91ab\u8b77\u65b9\u6848\u3002\u00a0 1 \u91ab\u9662\u7ba1\u7406\u5c40\u9999\u6e2f\u764c\u75c7\u8cc7\u6599\u7d71\u8a08\u4e2d\u5fc320212 Chan YHY et al. Hong Kong Med J. 2023;29(3):198-207. (\u53ea\u9650\u82f1\u6587\u7248\u672c)3 Kong X et al. Eur J Cancer. 2011;47(14):2084-2090. (\u53ea\u9650\u82f1\u6587\u7248\u672c)4\u00a0Schmid P et al. N Eng J Med 2020;382:810-21. 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 IHC\uff09\u6aa2\u6e2c\uff0c\u78ba\u5b9a\u75c5\u4eba\u7684ER\u3001PR\u548cHER2\u72c0\u6cc1\uff0c\u70ba\u60a3\u8005\u7684\u4e73\u764c\u5206\u985e\uff0c\u4ee5\u5236\u5b9a\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u5c0d\u7b2cII\u671f\u548c\u7b2cIII\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u53ea\u8981\u81e8\u5e8a\u72c0\u6cc1\u5408\u9069\uff0c\u8853\u524d\u6cbb\u7642\u61c9\u8a72\u88ab\u8996\u70ba\u6a19\u6e96\u548c\u512a\u5148\u8003\u616e\u7684\u6cbb\u7642\u65b9\u6848\u3002\u91ab\u751f\u4ea6\u61c9\u8a72\u8003\u616e\u4ee5\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u3002 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\u6bcf\u6b21\u7642\u7a0b\u4f7f\u7528\u5339\u535a\u5229\u7d44\u55ae\u6297\uff08Pembrolizumab\uff09200 \u6beb\u514b\u6216\u00a0400 \u6beb\u514b\u5291\u91cf\u7684\u75c5\u4eba\u3002 *\u79c1\u5bb6\u91ab\u9662\u6216\u8a3a\u6240\u8f49\u4ecb\u7684\u60a3\u8005\u9700\u901a\u904e\u5165\u606f\u5be9\u67e5\uff0c\u6700\u8fd112\u500b\u6708\u5e73\u5747\u500b\u4eba\u5165\u606f\u6bcf\u6708\u5c11\u65bc\u6e2f\u5e636\u842c\u5143 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Hong Kong Med J. 2023;29(3):198-207. (\u53ea\u9650\u82f1\u6587\u7248\u672c)3 Kong X et al. Eur J Cancer. 2011;47(14):2084-2090. (\u53ea\u9650\u82f1\u6587\u7248\u672c)4\u00a0Schmid P et al. N Eng J Med 2020;382:810-21. 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 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Hong Kong Med J. 2023;29(3):198-207. (\u53ea\u9650\u82f1\u6587\u7248\u672c)3 Kong X et al. Eur J Cancer. 2011;47(14):2084-2090. (\u53ea\u9650\u82f1\u6587\u7248\u672c)4\u00a0Schmid P et al. N Eng J Med 2020;382:810-21. 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complete response\uff09\u2014 \u5373\u60a3\u8005\u5b8c\u6210\u8853\u524d\u6cbb\u7642\u5f8c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u4e14\u5728\u624b\u8853\u5f8c\u7684\u75c5\u7406\u6aa2\u67e5\u7576\u4e2d\u4ea6\u627e\u4e0d\u5230\u764c\u7d30\u80de\u3002\u6b64\u985e\u60a3\u8005\u7684\u9810\u5f8c\u4ea6\u6703\u76f8\u5c0d\u8f03\u597d\u30023 \u5c08\u5bb6\u5c0f\u7d44\u7d93\u8a0e\u8ad6\u53ca\u6295\u7968\u5f8c\u9054\u6210\u6cbb\u7642\u5171\u8b58\u3002\u5728\u8a3a\u65b7\u65b9\u9762\uff0c\u5c08\u5bb6\u5c0f\u7d44\u540c\u610f\u70ba\u4e73\u764c\u500b\u6848\u61c9\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u00a0\uff08Immunohistochemistry \u2013 IHC\uff09\u6aa2\u6e2c\uff0c\u78ba\u5b9a\u75c5\u4eba\u7684ER\u3001PR\u548cHER2\u72c0\u6cc1\uff0c\u70ba\u60a3\u8005\u7684\u4e73\u764c\u5206\u985e\uff0c\u4ee5\u5236\u5b9a\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u6cbb\u7642\u65b9\u9762\uff0c\u5c0d\u7b2cII\u671f\u548c\u7b2cIII\u671f\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\uff0c\u53ea\u8981\u81e8\u5e8a\u72c0\u6cc1\u5408\u9069\uff0c\u8853\u524d\u6cbb\u7642\u61c9\u8a72\u88ab\u8996\u70ba\u6a19\u6e96\u548c\u512a\u5148\u8003\u616e\u7684\u6cbb\u7642\u65b9\u6848\u3002\u91ab\u751f\u4ea6\u61c9\u8a72\u8003\u616e\u4ee5\u514d\u75ab\u6cbb\u7642\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\u548c\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u3002 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survival\uff09\u4ea6\u6bd4\u55ae\u7528\u5316\u7642\u7684\u60a3\u8005\u986f\u8457\u5ef6\u9577\u30024\u300c\u75c5\u4eba\u539f\u672c\u53ef\u80fd\u9700\u8981\u63a5\u53d7\u5168\u4e73\u5207\u9664\u624b\u8853\uff0c\u4f46\u82e5\u5148\u63a5\u53d7\u514d\u75ab\u6cbb\u7642\u518d\u914d\u5408\u5316\u7642\u4f5c\u70ba\u8853\u524d\u6cbb\u7642\uff0c\u6709\u6a5f\u6703\u7e2e\u5c0f\u816b\u7624\uff0c\u4ee4\u75c5\u4eba\u6bcb\u9808\u5207\u9664\u6574\u500b\u4e73\u623f\uff0c\u5c0d\u75c5\u4eba\u7684\u5fc3\u7406\u548c\u751f\u6d3b\u8cea\u7d20\u90fd\u6709\u5f88\u5927\u7684\u6539\u5584\u3002\u300d 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