{"id":199733,"date":"2023-11-24T06:22:00","date_gmt":"2023-11-23T22:22:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=199733"},"modified":"2023-11-24T06:22:00","modified_gmt":"2023-11-23T22:22:00","slug":"menarini-group-%e5%9c%a8-2023-%e5%b9%b4%e8%81%96%e5%ae%89%e6%9d%b1%e5%b0%bc%e5%a5%a7%e4%b9%b3%e7%99%8c%e7%a0%94%e8%a8%8e%e6%9c%83%e4%b8%8a%e5%85%ac%e4%bd%88-orserdu-elacestrant-%e7%9a%84","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=199733","title":{"rendered":"Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&#8211; \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u7684\u5341\u4e00\u9805\u5c08\u984c\u5831\u544a\uff0c\u8b93\u516c\u773e\u9032\u4e00\u6b65\u4e86\u89e3\u4e86\u9019\u4e9b\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u7684\u6f5b\u5728\u76ca\u8655<\/p>\n<p>&#8211; ORSERDU \u6578\u64da\u5f37\u5316\u4e86\u5176\u5728\u6cbb\u7642\u651c\u5e36\u00a0ESR1 \u7a81\u8b8a\u7684\u00a0ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u00a0(mBC) \u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da<\/p>\n<p>&#8211; ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da<\/p>\n<p><span class=\"legendSpanClass\">\u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a0<\/span><span class=\"legendSpanClass\">2023\u5e7411\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU<sup>\u00ae<\/sup> (elacestrant) \u548c\u00a0ELZONRIS<sup>\u00ae<\/sup> (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n<p>ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a0<a href=\"https:\/\/www.menarini.com\/en-us\/news\/news-detail\/stemline-therapeutics-a-subsidiary-of-menarini-group-receives-us-fda-approval-for-orserdutm-elacestrant-as-the-first-and-only-treatment-specifically-indicated-for-patients-with-esr1-mutations\" target=\"_blank\" rel=\"nofollow noopener\">2023 \u5e74 1 \u6708<\/a>\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u3002<a href=\"https:\/\/www.menarini.com\/en-us\/news\/news-detail\/european-commission-approves-menarini-groups-orserdu174-elacestrant-for-the-treatment-of-patients-with-er-her2-locally-advanced-or-metastatic-breast-cancer-with-an-activating-esr1-mutation\" target=\"_blank\" rel=\"nofollow noopener\">2023 \u5e74 9 \u6708<\/a>\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0<\/p>\n<p>2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002<\/p>\n<p>ELZONRIS \u65bc\u00a0<a href=\"http:\/\/www.elzonris.com\/\" target=\"_blank\" rel=\"nofollow noopener\">2018 \u5e74 12 \u6708<\/a>\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u3002<a href=\"https:\/\/www.menarini.com\/en-us\/news\/news-archive\/article-details\/menarini-receives-european-commission-approval-of-elzonris-tagraxofusp-for-the-treatment-of-blastic-plasmacytoid-dendritic-cell-neoplasm-bpdcn\" target=\"_blank\" rel=\"nofollow noopener\">2021 \u5e74 1 \u6708<\/a>\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002<\/p>\n<p>Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d<\/p>\n<p>\u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a<\/p>\n<p><b>2023 <\/b><b>\u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703<\/b><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e3b\u8981\u4f5c\u8005<\/b> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6458\u8981\u6a19\u984c\u53ca<\/b><b>\u00a0ID<\/b> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5831\u544a\u8a73\u60c5<\/b> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Bardia, A <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">ESR1 <\/span><span class=\"prnews_span\">\u7a81\u8b8a\u7684<\/span><span class=\"prnews_span\"> ER+\/HER2- <\/span><span class=\"prnews_span\">\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c<\/span><span class=\"prnews_span\"> (mBC) <\/span><span class=\"prnews_span\">\u4e2d<\/span><span class=\"prnews_span\"> elacetrant <\/span><span class=\"prnews_span\">\u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea<\/span><span class=\"prnews_span\"> EMERALD 3 <\/span><span class=\"prnews_span\">\u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1576519\/PS17-02 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 8 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u9ede\u81f3<\/span><span class=\"prnews_span\"> 8 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d77\u5831\u805a\u7126\u8a0e\u8ad6<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">Hemisfair 1-2 <\/span><span class=\"prnews_span\">\u865f\u5bb4\u6703\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Rugo, H <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">ELEVATE<\/span><span class=\"prnews_span\">\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f<\/span><span class=\"prnews_span\"> 1b\/2 <\/span><span class=\"prnews_span\">\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30<\/span><span class=\"prnews_span\"> elacestrant <\/span><span class=\"prnews_span\">\u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027<\/span><span class=\"prnews_span\"> (ER+)<\/span><span class=\"prnews_span\">\u3001<\/span><span class=\"prnews_span\">HER2 <\/span><span class=\"prnews_span\">\u9670\u6027<\/span><span class=\"prnews_span\">(HER2-) <\/span><span class=\"prnews_span\">\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c<\/span><span class=\"prnews_span\"> (mBC) <\/span><span class=\"prnews_span\">\u60a3\u8005<\/span><span class=\"prnews_span\"> (pts) <\/span><span class=\"prnews_span\">\u7684\u7642\u6548<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1576517\/PO2-05-04 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 6 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348<\/span><span class=\"prnews_span\"> 5 <\/span><span class=\"prnews_span\">\u9ede\u81f3<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d77\u5831<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2-3 <\/span><span class=\"prnews_span\">\u865f\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Ibrahim, N <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">ELECTRA: <\/span><span class=\"prnews_span\">\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3<\/span><span class=\"prnews_span\"> 1b\/2 <\/span><span class=\"prnews_span\">\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30<\/span><span class=\"prnews_span\"> elacestrant <\/span><span class=\"prnews_span\">\u548c<\/span><span class=\"prnews_span\"> abemaciclib <\/span><span class=\"prnews_span\">\u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027<\/span><span class=\"prnews_span\"> (ER+)<\/span><span class=\"prnews_span\">\u3001<\/span><span class=\"prnews_span\">HER2 <\/span><span class=\"prnews_span\">\u9670\u6027<\/span><span class=\"prnews_span\"> (HER2-) <\/span><span class=\"prnews_span\">\u4e73\u764c<\/span><span class=\"prnews_span\"> (BC) <\/span><span class=\"prnews_span\">\u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1576518\/PO2-05-05 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 6 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348<\/span><span class=\"prnews_span\"> 5 <\/span><span class=\"prnews_span\">\u9ede\u81f3<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d77\u5831<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2-3 <\/span><span class=\"prnews_span\">\u865f\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Patnaik, A <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">SUMIT-ELA: <\/span><span class=\"prnews_span\">\u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u6291\u5236\u5291<\/span><span class=\"prnews_span\"> (CDK7i) samuraciclib <\/span><span class=\"prnews_span\">\u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291<\/span><span class=\"prnews_span\"> (SERD) elacestrant <\/span><span class=\"prnews_span\">\u806f\u5408\u6cbb\u7642<\/span><span class=\"prnews_span\"> CDK4\/6i* <\/span><span class=\"prnews_span\">\u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027<\/span><span class=\"prnews_span\"> (HR+) <\/span><span class=\"prnews_span\">\u4e73\u817a\u764c\u7684<\/span><span class=\"prnews_span\"> 1b\/2 <\/span><span class=\"prnews_span\">\u671f\u7814\u7a76<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">NA\/PO3-04-13 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u9ede\u5230\u4e0b\u5348<\/span><span class=\"prnews_span\"> 2 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d77\u5831<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2-3 <\/span><span class=\"prnews_span\">\u865f\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Bellet, M <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5728\u505c\u7d93\u524d<\/span><span class=\"prnews_span\"> HR+\/HER2- <\/span><span class=\"prnews_span\">\u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528<\/span><span class=\"prnews_span\"> elacestrant <\/span><span class=\"prnews_span\">\u806f\u5408<\/span><span class=\"prnews_span\">\/<\/span><span class=\"prnews_span\">\u4e0d\u806f\u5408<\/span><span class=\"prnews_span\"> triptorelin <\/span><span class=\"prnews_span\">\u7684\u6548\u679c\u7684<\/span><span class=\"prnews_span\"> II <\/span><span class=\"prnews_span\">\u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57<\/span><span class=\"prnews_span\"> &#8212; SOLTI-2104- I <\/span><span class=\"prnews_span\">\u671f\u8a66\u9a57<\/span><span class=\"prnews_span\">* <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1580190\/PO3-19-08 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 7 <\/span><span class=\"prnews_span\">\u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u9ede\u81f3\u4e0b\u5348<\/span><span class=\"prnews_span\"> 2 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d77\u5831<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2-3 <\/span><span class=\"prnews_span\">\u865f\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>* \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0<\/p>\n<p><b>2023 <\/b><b>\u5e74\u7b2c<\/b><b>\u00a065 <\/b><b>\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703<\/b><b>\u00a0(ASH) <\/b><b>\u5e74\u6703<\/b>\u00a0<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e3b\u8981\u4f5c\u8005<\/b> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f<\/b> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6703\u8b70\u540d\u7a31<\/b> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5831\u544a\u8a73\u60c5<\/b> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Angelucci <\/span><span class=\"prnews_span\">\u7b49\u4eba<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a href=\"https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper178734.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">\u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c<\/a><\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u51fa\u7248\u865f\uff1a<\/span><span class=\"prnews_span\">547 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">906. <\/span><span class=\"prnews_span\">\u6210\u679c\u7814\u7a76<\/span><span class=\"prnews_span\"> &#8212; <\/span><span class=\"prnews_span\">\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u53e3\u982d\u5831\u544a<\/b> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 10 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e2d\u5348<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u9ede<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97<\/span><span class=\"prnews_span\"> (Marriott Marquis San Diego Marina) <\/span><span class=\"prnews_span\">\uff0c\u842c\u8c6a<\/span><span class=\"prnews_span\"> 11-13 <\/span><span class=\"prnews_span\">\u5927\u5bb4\u6703\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Minetto <\/span><span class=\"prnews_span\">\u7b49\u4eba<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><u><a href=\"https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper189417.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">\u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57<\/a><\/u><u>\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c<\/u><u>* <\/u><\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u51fa\u7248\u865f\uff1a<\/span><span class=\"prnews_span\">2918 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">616. <\/span><span class=\"prnews_span\">\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831<\/span><span class=\"prnews_span\"> II<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d77\u5831\u5c55\u793a<\/b> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 10 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e0b\u5348<\/span><span class=\"prnews_span\"> 6:00 &#8211; <\/span><span class=\"prnews_span\">\u665a\u4e0a<\/span><span class=\"prnews_span\"> 8:00 <br \/><\/span><span class=\"prnews_span\">\u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0c<\/span><span class=\"prnews_span\">G-H <\/span><span class=\"prnews_span\">\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Lane <\/span><span class=\"prnews_span\">\u7b49\u4eba<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a href=\"https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper180010.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217<\/a><\/span><span class=\"prnews_span\">* <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u51fa\u7248\u865f\uff1a<\/span><span class=\"prnews_span\">4277 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">616. <\/span><span class=\"prnews_span\">\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831<\/span><span class=\"prnews_span\"> III <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d77\u5831\u5c55\u793a<\/b> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 11 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e0b\u5348<\/span><span class=\"prnews_span\"> 6:00 &#8211; <\/span><span class=\"prnews_span\">\u665a\u4e0a<\/span><span class=\"prnews_span\"> 8:00 <br \/><\/span><span class=\"prnews_span\">\u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0c<\/span><span class=\"prnews_span\">G-H <\/span><span class=\"prnews_span\">\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Boichut <\/span><span class=\"prnews_span\">\u7b49\u4eba<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a href=\"https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper186126.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">\u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027<\/a><\/span><span class=\"prnews_span\">*\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u51fa\u7248\u865f\uff1a<\/span><span class=\"prnews_span\">2783 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">604. <\/span><span class=\"prnews_span\">\u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831<\/span><span class=\"prnews_span\"> II<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d77\u5831\u5c55\u793a<\/b> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 10 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"><br \/><\/span><span class=\"prnews_span\">\u4e0b\u5348<\/span><span class=\"prnews_span\"> 6:00 &#8211; <\/span><span class=\"prnews_span\">\u665a\u4e0a<\/span><span class=\"prnews_span\"> 8:00 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3<\/span><span class=\"prnews_span\"> G-H <\/span><span class=\"prnews_span\">\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">Navarro Vicente <\/span><span class=\"prnews_span\">\u7b49\u4eba<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a href=\"https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper190296.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">\u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790<\/a><\/span><span class=\"prnews_span\">* <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u51fa\u7248\u865f\uff1a<\/span><span class=\"prnews_span\">4234 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 <\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">613. <\/span><span class=\"prnews_span\">\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831<\/span><span class=\"prnews_span\"> III<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d77\u5831\u5c55\u793a<\/b> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a02023 <\/span><span class=\"prnews_span\">\u5e74<\/span><span class=\"prnews_span\"> 12 <\/span><span class=\"prnews_span\">\u6708<\/span><span class=\"prnews_span\"> 11 <\/span><span class=\"prnews_span\">\u65e5<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u4e0b\u5348<\/span><span class=\"prnews_span\"> 6:00 &#8211; <\/span><span class=\"prnews_span\">\u665a\u4e0a<\/span><span class=\"prnews_span\"> 8:00 <br \/><\/span><span class=\"prnews_span\">\u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0c<\/span><span class=\"prnews_span\">G-H <\/span><span class=\"prnews_span\">\u5ef3<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>* \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0<\/p>\n<p><b>EMERALD <\/b><b>\u7b2c<\/b><b>\u00a03 <\/b><b>\u671f\u7814\u7a76<\/b><b>\u00a0(NCT03778931) <\/b><b>\u7c21\u4ecb<\/b><br \/>\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>\u00a0ORSERDU<sup>\u00ae<\/sup> (elacestrant) <\/b>\u00a0<\/p>\n<p><b>\u7f8e\u570b\u9069\u61c9\u75c7\uff1a<\/b>\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002<\/p>\n<p>\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0<a href=\"http:\/\/www.orserdu.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.orserdu.com<\/a>\u3002<\/p>\n<p><b>\u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0c<\/b><b>ORSERDU<sup>\u00ae<\/sup><\/b>\u00a0<\/p>\n<p>\u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0<\/p>\n<p>\u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002<\/p>\n<p>\u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002<\/p>\n<p>\u4e0d\u826f\u53cd\u61c9\u00a0<\/p>\n<p>\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002<\/p>\n<p>ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002<\/p>\n<p>\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0<\/p>\n<p>\u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002<\/p>\n<p>\u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0<\/p>\n<p>\u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002<\/p>\n<p>\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002<\/p>\n<p>ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002<\/p>\n<p>\u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0<a href=\"http:\/\/www.fda.gov\/medwatch\" target=\"_blank\" rel=\"nofollow noopener\">www.fda.gov\/medwatch<\/a>\u3002<\/p>\n<p>Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05563220\" target=\"_blank\" rel=\"nofollow noopener\">NCT05563220<\/a>) \uff1bELECTRA (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05386108\" target=\"_blank\" rel=\"nofollow noopener\">NCT05386108<\/a>) \uff1b\u4ee5\u53ca\u00a0ELCIN (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05596409\" target=\"_blank\" rel=\"nofollow noopener\">NCT05596409<\/a>) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>\u00a0ELZONRIS<sup>\u00ae<\/sup> (tagraxofusp-erzs) <\/b>\u00a0<\/p>\n<p><b>\u7f8e\u570b\u9069\u61c9\u75c7\uff1a<\/b>\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002<\/p>\n<p>\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0<a href=\"http:\/\/www.elzonris.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.elzonris.com<\/a>\u3002<\/p>\n<p><b>\u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0c<\/b><b>ELZONRIS<sup>\u00ae <\/sup><\/b>\u00a0<\/p>\n<p><b>\u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4<\/b>\u00a0<\/p>\n<ul type=\"disc\">\n<li><b>\u63a5\u53d7<\/b><b>\u00a0ELZONRIS <\/b><b>\u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4<\/b><b>\u00a0(CLS)<\/b><b>\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c<\/b><b>\u00a0CLS <\/b><b>\u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002<\/b><\/li>\n<\/ul>\n<p><b>\u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805<\/b>\u00a0<\/p>\n<p><b>\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4<\/b>\u00a0<\/p>\n<p>\u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002<\/p>\n<p>\u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002<\/p>\n<p><b>\u904e\u654f\u53cd\u61c9<\/b>\u00a0<\/p>\n<p>ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c43% (53\/122) \u7684\u60a3\u8005\u5831\u544a\u51fa\u73fe\u904e\u654f\u53cd\u61c9\uff0c7% (9\/122) \u7684\u60a3\u8005\u51fa\u73fe\u22653 \u7d1a\u904e\u654f\u53cd\u61c9\u3002\u2265 5% \u7684\u60a3\u8005\u51fa\u73fe\u7684\u904e\u654f\u53cd\u61c9\u8868\u73fe\u5305\u62ec\u76ae\u75b9\u3001\u75d5\u7662\u548c\u53e3\u8154\u708e\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u61c9\u76e3\u6e2c\u60a3\u8005\u662f\u5426\u6709\u904e\u654f\u53cd\u61c9\u3002\u5982\u679c\u767c\u751f\u904e\u654f\u53cd\u61c9\uff0c\u61c9\u4e2d\u65b7\u00a0ELZONRIS \u7684\u8f38\u6ce8\uff0c\u4e26\u6839\u64da\u9700\u8981\u63d0\u4f9b\u652f\u6301\u6027\u8b77\u7406\u3002<\/p>\n<p><b>\u809d\u6bd2\u6027<\/b>\u00a0<\/p>\n<p>\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u8207\u809d\u81df\u9175\u7d20\u5347\u9ad8\u6709\u95dc\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c79% (96\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0ALT \u5347\u9ad8\uff0c76% (93\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0AST \u5347\u9ad8\u300226% (32\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0ALT \u5347\u9ad8\u300230% (36\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0AST \u5347\u9ad8\uff0c3% (4\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a04 \u7d1a\u00a0AST \u5347\u9ad8\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u7b2c\u4e00\u9031\u671f\u51fa\u73fe\u809d\u9175\u7d20\u5347\u9ad8\uff0c\u4e2d\u65b7\u5291\u91cf\u5f8c\u53ef\u6062\u5fa9\u3002<\/p>\n<p>\u6bcf\u6b21\u8f38\u6ce8\u00a0ELZONRIS \u524d\uff0c\u76e3\u6e2c\u4e19\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(ALT) \u548c\u5929\u9580\u51ac\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(AST)\u3002\u82e5\u8f49\u6c28\u9176\u5347\u81f3\u6b63\u5e38\u503c\u4e0a\u9650\u7684\u00a05 \u500d\u4ee5\u4e0a\uff0c\u61c9\u66ab\u6642\u505c\u7528\u00a0ELZONRIS\uff0c\u5f85\u8f49\u6c28\u9176\u6062\u5fa9\u6b63\u5e38\u6216\u7de9\u89e3\u5f8c\u518d\u7e7c\u7e8c\u6cbb\u7642\u3002<\/p>\n<p><b>\u4e0d\u826f\u53cd\u61c9<\/b>\u00a0<\/p>\n<p>\u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9\u70ba\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u3001\u5641\u5fc3\u3001\u75b2\u5026\u3001\u767c\u71d2\u3001\u9031\u908a\u6c34\u816b\u548c\u9ad4\u91cd\u589e\u52a0\uff0c\u767c\u751f\u7387\u2265 30%\u3002\u6700\u5e38\u898b\u7684\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7570\u5e38\u662f\u767d\u86cb\u767d\u3001\u8840\u5c0f\u677f\u3001\u8840\u7d05\u7d20\u3001\u9223\u548c\u9209\u4e0b\u964d\uff0c\u8461\u8404\u7cd6\u3001ALT \u548c\u00a0AST \u5347\u9ad8\uff0c\u767c\u751f\u7387\u8d85\u904e50%\u3002<\/p>\n<p><b>\u8acb\u53c3\u95b1\u5b8c\u6574\u7684\u300a<\/b><a href=\"http:\/\/pi.elzonris.com\/\" target=\"_blank\" rel=\"nofollow noopener\"><b>\u8655\u65b9\u8cc7\u8a0a<\/b><\/a><b>\u300b\uff0c\u5305\u62ec\u300c\u7981\u5fcc\u8b66\u544a\u300d\u3002<\/b>\u00a0<\/p>\n<p>\u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0<a href=\"https:\/\/www.fda.gov\/medwatch\" target=\"_blank\" rel=\"nofollow noopener\">www.fda.gov\/medwatch<\/a>\u3002<\/p>\n<p><b>Menarini Group <\/b><b>\u7c21\u4ecb<\/b>\u00a0<\/p>\n<p>Menarini Group \u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e\u00a044 \u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e\u00a017,000 \u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u6cbb\u7642\u9700\u6c42\u9ad8\u5ea6\u672a\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709\u00a018 \u500b\u751f\u7522\u57fa\u5730\u548c\u00a09 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403\u00a0140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u00a0\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd\u00a0<a href=\"https:\/\/www.menarini.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.menarini.com<\/a>\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>\u00a0Stemline Therapeutics Inc. <\/b>\u00a0<\/p>\n<p>Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f\u00a0Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002Stemline \u5c07\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316\u00a0ORSERDU<sup>\u00ae<\/sup> (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa\u4e86\u00a0ELZONRIS<sup>\u00ae<\/sup> (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d\u00a0CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624\u00a0(BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684\u00a0BPDCN \u6cbb\u7642\u65b9\u6848\u3002Stemline \u4ea6\u5c07\u5728\u6b50\u6d32\u5546\u696d\u5316\u00a0NEXPOVIO<sup>\u00ae<\/sup> (selinexor) \uff0c\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u00a0XPO1 \u6291\u5236\u5291\u3002\u00a0\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002\u00a0<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199734,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-199733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"- \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u7684\u5341\u4e00\u9805\u5c08\u984c\u5831\u544a\uff0c\u8b93\u516c\u773e\u9032\u4e00\u6b65\u4e86\u89e3\u4e86\u9019\u4e9b\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u7684\u6f5b\u5728\u76ca\u8655 - ORSERDU \u6578\u64da\u5f37\u5316\u4e86\u5176\u5728\u6cbb\u7642\u651c\u5e36\u00a0ESR1 \u7a81\u8b8a\u7684\u00a0ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u00a0(mBC) \u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da - ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \/\u7f8e\u901a\u793e\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703   \u4e3b\u8981\u4f5c\u8005    \u6458\u8981\u6a19\u984c\u53ca\u00a0ID    \u5831\u544a\u8a73\u60c5    Bardia, A    ESR1 \u7a81\u8b8a\u7684 ER+\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\/PS17-02    2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0    Rugo, H    ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\/PO2-05-04    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3    Ibrahim, N    ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\/PO2-05-05    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Patnaik, A    SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\/2 \u671f\u7814\u7a76 NA\/PO3-04-13    2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Bellet, M    \u5728\u505c\u7d93\u524d HR+\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\/PO3-19-08    2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0   \u4e3b\u8981\u4f5c\u8005    \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f    \u6703\u8b70\u540d\u7a31    \u5831\u544a\u8a73\u60c5    Angelucci \u7b49\u4eba    \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0    906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c    \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0    Minetto \u7b49\u4eba    \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Lane \u7b49\u4eba    Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Boichut \u7b49\u4eba    \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783    604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3    Navarro Vicente \u7b49\u4eba    \u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790* \u00a0 \u51fa\u7248\u865f\uff1a4234 \u00a0    613. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831 III    \u6d77\u5831\u5c55\u793a \u00a02023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0 EMERALD \u7b2c\u00a03 \u671f\u7814\u7a76\u00a0(NCT03778931) \u7c21\u4ecb\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002 ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.elzonris.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cELZONRIS\u00ae \u00a0 \u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS)\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c\u00a0CLS \u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002 \u904e\u654f\u53cd\u61c9\u00a0 ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c43% (53\/122) \u7684\u60a3\u8005\u5831\u544a\u51fa\u73fe\u904e\u654f\u53cd\u61c9\uff0c7% (9\/122) \u7684\u60a3\u8005\u51fa\u73fe\u22653 \u7d1a\u904e\u654f\u53cd\u61c9\u3002\u2265 5% \u7684\u60a3\u8005\u51fa\u73fe\u7684\u904e\u654f\u53cd\u61c9\u8868\u73fe\u5305\u62ec\u76ae\u75b9\u3001\u75d5\u7662\u548c\u53e3\u8154\u708e\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u61c9\u76e3\u6e2c\u60a3\u8005\u662f\u5426\u6709\u904e\u654f\u53cd\u61c9\u3002\u5982\u679c\u767c\u751f\u904e\u654f\u53cd\u61c9\uff0c\u61c9\u4e2d\u65b7\u00a0ELZONRIS \u7684\u8f38\u6ce8\uff0c\u4e26\u6839\u64da\u9700\u8981\u63d0\u4f9b\u652f\u6301\u6027\u8b77\u7406\u3002 \u809d\u6bd2\u6027\u00a0 \u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u8207\u809d\u81df\u9175\u7d20\u5347\u9ad8\u6709\u95dc\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c79% (96\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0ALT \u5347\u9ad8\uff0c76% (93\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0AST \u5347\u9ad8\u300226% (32\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0ALT \u5347\u9ad8\u300230% (36\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0AST \u5347\u9ad8\uff0c3% (4\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a04 \u7d1a\u00a0AST \u5347\u9ad8\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u7b2c\u4e00\u9031\u671f\u51fa\u73fe\u809d\u9175\u7d20\u5347\u9ad8\uff0c\u4e2d\u65b7\u5291\u91cf\u5f8c\u53ef\u6062\u5fa9\u3002 \u6bcf\u6b21\u8f38\u6ce8\u00a0ELZONRIS \u524d\uff0c\u76e3\u6e2c\u4e19\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(ALT) \u548c\u5929\u9580\u51ac\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(AST)\u3002\u82e5\u8f49\u6c28\u9176\u5347\u81f3\u6b63\u5e38\u503c\u4e0a\u9650\u7684\u00a05 \u500d\u4ee5\u4e0a\uff0c\u61c9\u66ab\u6642\u505c\u7528\u00a0ELZONRIS\uff0c\u5f85\u8f49\u6c28\u9176\u6062\u5fa9\u6b63\u5e38\u6216\u7de9\u89e3\u5f8c\u518d\u7e7c\u7e8c\u6cbb\u7642\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9\u70ba\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u3001\u5641\u5fc3\u3001\u75b2\u5026\u3001\u767c\u71d2\u3001\u9031\u908a\u6c34\u816b\u548c\u9ad4\u91cd\u589e\u52a0\uff0c\u767c\u751f\u7387\u2265 30%\u3002\u6700\u5e38\u898b\u7684\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7570\u5e38\u662f\u767d\u86cb\u767d\u3001\u8840\u5c0f\u677f\u3001\u8840\u7d05\u7d20\u3001\u9223\u548c\u9209\u4e0b\u964d\uff0c\u8461\u8404\u7cd6\u3001ALT \u548c\u00a0AST \u5347\u9ad8\uff0c\u767c\u751f\u7387\u8d85\u904e50%\u3002 \u8acb\u53c3\u95b1\u5b8c\u6574\u7684\u300a\u8655\u65b9\u8cc7\u8a0a\u300b\uff0c\u5305\u62ec\u300c\u7981\u5fcc\u8b66\u544a\u300d\u3002\u00a0 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Menarini Group \u7c21\u4ecb\u00a0 Menarini Group \u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e\u00a044 \u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e\u00a017,000 \u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u6cbb\u7642\u9700\u6c42\u9ad8\u5ea6\u672a\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709\u00a018 \u500b\u751f\u7522\u57fa\u5730\u548c\u00a09 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403\u00a0140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u00a0\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd\u00a0www.menarini.com\u3002 \u95dc\u65bc\u00a0Stemline Therapeutics Inc. \u00a0 Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f\u00a0Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002Stemline \u5c07\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316\u00a0ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa\u4e86\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d\u00a0CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624\u00a0(BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684\u00a0BPDCN \u6cbb\u7642\u65b9\u6848\u3002Stemline \u4ea6\u5c07\u5728\u6b50\u6d32\u5546\u696d\u5316\u00a0NEXPOVIO\u00ae (selinexor) \uff0c\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u00a0XPO1 \u6291\u5236\u5291\u3002\u00a0\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002\u00a0 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=199733\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"- \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u7684\u5341\u4e00\u9805\u5c08\u984c\u5831\u544a\uff0c\u8b93\u516c\u773e\u9032\u4e00\u6b65\u4e86\u89e3\u4e86\u9019\u4e9b\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u7684\u6f5b\u5728\u76ca\u8655 - ORSERDU \u6578\u64da\u5f37\u5316\u4e86\u5176\u5728\u6cbb\u7642\u651c\u5e36\u00a0ESR1 \u7a81\u8b8a\u7684\u00a0ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u00a0(mBC) \u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da - ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \/\u7f8e\u901a\u793e\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703   \u4e3b\u8981\u4f5c\u8005    \u6458\u8981\u6a19\u984c\u53ca\u00a0ID    \u5831\u544a\u8a73\u60c5    Bardia, A    ESR1 \u7a81\u8b8a\u7684 ER+\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\/PS17-02    2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0    Rugo, H    ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\/PO2-05-04    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3    Ibrahim, N    ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\/PO2-05-05    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Patnaik, A    SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\/2 \u671f\u7814\u7a76 NA\/PO3-04-13    2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Bellet, M    \u5728\u505c\u7d93\u524d HR+\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\/PO3-19-08    2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0   \u4e3b\u8981\u4f5c\u8005    \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f    \u6703\u8b70\u540d\u7a31    \u5831\u544a\u8a73\u60c5    Angelucci \u7b49\u4eba    \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0    906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c    \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0    Minetto \u7b49\u4eba    \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Lane \u7b49\u4eba    Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Boichut \u7b49\u4eba    \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783    604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3    Navarro Vicente \u7b49\u4eba    \u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790* \u00a0 \u51fa\u7248\u865f\uff1a4234 \u00a0    613. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831 III    \u6d77\u5831\u5c55\u793a \u00a02023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0 EMERALD \u7b2c\u00a03 \u671f\u7814\u7a76\u00a0(NCT03778931) \u7c21\u4ecb\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002 ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.elzonris.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cELZONRIS\u00ae \u00a0 \u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS)\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c\u00a0CLS \u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002 \u904e\u654f\u53cd\u61c9\u00a0 ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c43% (53\/122) \u7684\u60a3\u8005\u5831\u544a\u51fa\u73fe\u904e\u654f\u53cd\u61c9\uff0c7% (9\/122) \u7684\u60a3\u8005\u51fa\u73fe\u22653 \u7d1a\u904e\u654f\u53cd\u61c9\u3002\u2265 5% \u7684\u60a3\u8005\u51fa\u73fe\u7684\u904e\u654f\u53cd\u61c9\u8868\u73fe\u5305\u62ec\u76ae\u75b9\u3001\u75d5\u7662\u548c\u53e3\u8154\u708e\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u61c9\u76e3\u6e2c\u60a3\u8005\u662f\u5426\u6709\u904e\u654f\u53cd\u61c9\u3002\u5982\u679c\u767c\u751f\u904e\u654f\u53cd\u61c9\uff0c\u61c9\u4e2d\u65b7\u00a0ELZONRIS \u7684\u8f38\u6ce8\uff0c\u4e26\u6839\u64da\u9700\u8981\u63d0\u4f9b\u652f\u6301\u6027\u8b77\u7406\u3002 \u809d\u6bd2\u6027\u00a0 \u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u8207\u809d\u81df\u9175\u7d20\u5347\u9ad8\u6709\u95dc\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c79% (96\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0ALT \u5347\u9ad8\uff0c76% (93\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0AST \u5347\u9ad8\u300226% (32\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0ALT \u5347\u9ad8\u300230% (36\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0AST \u5347\u9ad8\uff0c3% (4\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a04 \u7d1a\u00a0AST \u5347\u9ad8\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u7b2c\u4e00\u9031\u671f\u51fa\u73fe\u809d\u9175\u7d20\u5347\u9ad8\uff0c\u4e2d\u65b7\u5291\u91cf\u5f8c\u53ef\u6062\u5fa9\u3002 \u6bcf\u6b21\u8f38\u6ce8\u00a0ELZONRIS \u524d\uff0c\u76e3\u6e2c\u4e19\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(ALT) \u548c\u5929\u9580\u51ac\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(AST)\u3002\u82e5\u8f49\u6c28\u9176\u5347\u81f3\u6b63\u5e38\u503c\u4e0a\u9650\u7684\u00a05 \u500d\u4ee5\u4e0a\uff0c\u61c9\u66ab\u6642\u505c\u7528\u00a0ELZONRIS\uff0c\u5f85\u8f49\u6c28\u9176\u6062\u5fa9\u6b63\u5e38\u6216\u7de9\u89e3\u5f8c\u518d\u7e7c\u7e8c\u6cbb\u7642\u3002 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ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \\\/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 \u4e3b\u8981\u4f5c\u8005 \u6458\u8981\u6a19\u984c\u53ca\u00a0ID \u5831\u544a\u8a73\u60c5 Bardia, A ESR1 \u7a81\u8b8a\u7684 ER+\\\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\\\/PS17-02 2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0 Rugo, H ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\\\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\\\/PO2-05-04 2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 Ibrahim, N ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\\\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\\\/PO2-05-05 2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 Patnaik, A SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\\\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\\\/2 \u671f\u7814\u7a76 NA\\\/PO3-04-13 2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 Bellet, M \u5728\u505c\u7d93\u524d HR+\\\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\\\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\\\/PO3-19-08 2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0 \u4e3b\u8981\u4f5c\u8005 \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f \u6703\u8b70\u540d\u7a31 \u5831\u544a\u8a73\u60c5 Angelucci \u7b49\u4eba \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0 906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0 Minetto \u7b49\u4eba \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\\\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0 616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 Lane \u7b49\u4eba Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277 616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0 \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 Boichut \u7b49\u4eba \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783 604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3 Navarro Vicente \u7b49\u4eba \u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790* \u00a0 \u51fa\u7248\u865f\uff1a4234 \u00a0 613. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831 III \u6d77\u5831\u5c55\u793a \u00a02023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0 EMERALD \u7b2c\u00a03 \u671f\u7814\u7a76\u00a0(NCT03778931) \u7c21\u4ecb\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\\\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\\\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002 ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\\\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\\\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 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\u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da - ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \/\u7f8e\u901a\u793e\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703   \u4e3b\u8981\u4f5c\u8005    \u6458\u8981\u6a19\u984c\u53ca\u00a0ID    \u5831\u544a\u8a73\u60c5    Bardia, A    ESR1 \u7a81\u8b8a\u7684 ER+\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\/PS17-02    2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0    Rugo, H    ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\/PO2-05-04    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3    Ibrahim, N    ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\/PO2-05-05    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Patnaik, A    SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\/2 \u671f\u7814\u7a76 NA\/PO3-04-13    2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Bellet, M    \u5728\u505c\u7d93\u524d HR+\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\/PO3-19-08    2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0   \u4e3b\u8981\u4f5c\u8005    \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f    \u6703\u8b70\u540d\u7a31    \u5831\u544a\u8a73\u60c5    Angelucci \u7b49\u4eba    \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0    906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c    \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0    Minetto \u7b49\u4eba    \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Lane \u7b49\u4eba    Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Boichut \u7b49\u4eba    \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783    604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3    Navarro Vicente \u7b49\u4eba    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\u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 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\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.elzonris.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cELZONRIS\u00ae \u00a0 \u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS)\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c\u00a0CLS \u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002 \u904e\u654f\u53cd\u61c9\u00a0 ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c43% (53\/122) \u7684\u60a3\u8005\u5831\u544a\u51fa\u73fe\u904e\u654f\u53cd\u61c9\uff0c7% (9\/122) \u7684\u60a3\u8005\u51fa\u73fe\u22653 \u7d1a\u904e\u654f\u53cd\u61c9\u3002\u2265 5% \u7684\u60a3\u8005\u51fa\u73fe\u7684\u904e\u654f\u53cd\u61c9\u8868\u73fe\u5305\u62ec\u76ae\u75b9\u3001\u75d5\u7662\u548c\u53e3\u8154\u708e\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u61c9\u76e3\u6e2c\u60a3\u8005\u662f\u5426\u6709\u904e\u654f\u53cd\u61c9\u3002\u5982\u679c\u767c\u751f\u904e\u654f\u53cd\u61c9\uff0c\u61c9\u4e2d\u65b7\u00a0ELZONRIS \u7684\u8f38\u6ce8\uff0c\u4e26\u6839\u64da\u9700\u8981\u63d0\u4f9b\u652f\u6301\u6027\u8b77\u7406\u3002 \u809d\u6bd2\u6027\u00a0 \u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u8207\u809d\u81df\u9175\u7d20\u5347\u9ad8\u6709\u95dc\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c79% (96\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0ALT \u5347\u9ad8\uff0c76% (93\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0AST \u5347\u9ad8\u300226% (32\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0ALT \u5347\u9ad8\u300230% (36\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0AST \u5347\u9ad8\uff0c3% (4\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a04 \u7d1a\u00a0AST \u5347\u9ad8\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u7b2c\u4e00\u9031\u671f\u51fa\u73fe\u809d\u9175\u7d20\u5347\u9ad8\uff0c\u4e2d\u65b7\u5291\u91cf\u5f8c\u53ef\u6062\u5fa9\u3002 \u6bcf\u6b21\u8f38\u6ce8\u00a0ELZONRIS \u524d\uff0c\u76e3\u6e2c\u4e19\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(ALT) \u548c\u5929\u9580\u51ac\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(AST)\u3002\u82e5\u8f49\u6c28\u9176\u5347\u81f3\u6b63\u5e38\u503c\u4e0a\u9650\u7684\u00a05 \u500d\u4ee5\u4e0a\uff0c\u61c9\u66ab\u6642\u505c\u7528\u00a0ELZONRIS\uff0c\u5f85\u8f49\u6c28\u9176\u6062\u5fa9\u6b63\u5e38\u6216\u7de9\u89e3\u5f8c\u518d\u7e7c\u7e8c\u6cbb\u7642\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9\u70ba\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u3001\u5641\u5fc3\u3001\u75b2\u5026\u3001\u767c\u71d2\u3001\u9031\u908a\u6c34\u816b\u548c\u9ad4\u91cd\u589e\u52a0\uff0c\u767c\u751f\u7387\u2265 30%\u3002\u6700\u5e38\u898b\u7684\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7570\u5e38\u662f\u767d\u86cb\u767d\u3001\u8840\u5c0f\u677f\u3001\u8840\u7d05\u7d20\u3001\u9223\u548c\u9209\u4e0b\u964d\uff0c\u8461\u8404\u7cd6\u3001ALT \u548c\u00a0AST \u5347\u9ad8\uff0c\u767c\u751f\u7387\u8d85\u904e50%\u3002 \u8acb\u53c3\u95b1\u5b8c\u6574\u7684\u300a\u8655\u65b9\u8cc7\u8a0a\u300b\uff0c\u5305\u62ec\u300c\u7981\u5fcc\u8b66\u544a\u300d\u3002\u00a0 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Menarini Group \u7c21\u4ecb\u00a0 Menarini Group \u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e\u00a044 \u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e\u00a017,000 \u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u6cbb\u7642\u9700\u6c42\u9ad8\u5ea6\u672a\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709\u00a018 \u500b\u751f\u7522\u57fa\u5730\u548c\u00a09 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403\u00a0140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u00a0\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd\u00a0www.menarini.com\u3002 \u95dc\u65bc\u00a0Stemline Therapeutics Inc. \u00a0 Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f\u00a0Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002Stemline \u5c07\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316\u00a0ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa\u4e86\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d\u00a0CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624\u00a0(BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684\u00a0BPDCN \u6cbb\u7642\u65b9\u6848\u3002Stemline \u4ea6\u5c07\u5728\u6b50\u6d32\u5546\u696d\u5316\u00a0NEXPOVIO\u00ae (selinexor) \uff0c\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u00a0XPO1 \u6291\u5236\u5291\u3002\u00a0\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002\u00a0 \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=199733","og_locale":"zh_TW","og_type":"article","og_title":"Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"- \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u7684\u5341\u4e00\u9805\u5c08\u984c\u5831\u544a\uff0c\u8b93\u516c\u773e\u9032\u4e00\u6b65\u4e86\u89e3\u4e86\u9019\u4e9b\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u7684\u6f5b\u5728\u76ca\u8655 - ORSERDU \u6578\u64da\u5f37\u5316\u4e86\u5176\u5728\u6cbb\u7642\u651c\u5e36\u00a0ESR1 \u7a81\u8b8a\u7684\u00a0ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u00a0(mBC) \u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da - ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \/\u7f8e\u901a\u793e\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703   \u4e3b\u8981\u4f5c\u8005    \u6458\u8981\u6a19\u984c\u53ca\u00a0ID    \u5831\u544a\u8a73\u60c5    Bardia, A    ESR1 \u7a81\u8b8a\u7684 ER+\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\/PS17-02    2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0    Rugo, H    ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\/PO2-05-04    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3    Ibrahim, N    ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\/PO2-05-05    2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Patnaik, A    SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\/2 \u671f\u7814\u7a76 NA\/PO3-04-13    2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0    Bellet, M    \u5728\u505c\u7d93\u524d HR+\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\/PO3-19-08    2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0   \u4e3b\u8981\u4f5c\u8005    \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f    \u6703\u8b70\u540d\u7a31    \u5831\u544a\u8a73\u60c5    Angelucci \u7b49\u4eba    \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0    906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c    \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0    Minetto \u7b49\u4eba    \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Lane \u7b49\u4eba    Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277    616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3    Boichut \u7b49\u4eba    \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783    604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II    \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3    Navarro Vicente \u7b49\u4eba    \u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790* \u00a0 \u51fa\u7248\u865f\uff1a4234 \u00a0    613. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831 III    \u6d77\u5831\u5c55\u793a \u00a02023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3     * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0 EMERALD \u7b2c\u00a03 \u671f\u7814\u7a76\u00a0(NCT03778931) \u7c21\u4ecb\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002 ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.elzonris.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cELZONRIS\u00ae \u00a0 \u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS)\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c\u00a0CLS \u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002 \u904e\u654f\u53cd\u61c9\u00a0 ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c43% (53\/122) \u7684\u60a3\u8005\u5831\u544a\u51fa\u73fe\u904e\u654f\u53cd\u61c9\uff0c7% (9\/122) \u7684\u60a3\u8005\u51fa\u73fe\u22653 \u7d1a\u904e\u654f\u53cd\u61c9\u3002\u2265 5% \u7684\u60a3\u8005\u51fa\u73fe\u7684\u904e\u654f\u53cd\u61c9\u8868\u73fe\u5305\u62ec\u76ae\u75b9\u3001\u75d5\u7662\u548c\u53e3\u8154\u708e\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u61c9\u76e3\u6e2c\u60a3\u8005\u662f\u5426\u6709\u904e\u654f\u53cd\u61c9\u3002\u5982\u679c\u767c\u751f\u904e\u654f\u53cd\u61c9\uff0c\u61c9\u4e2d\u65b7\u00a0ELZONRIS \u7684\u8f38\u6ce8\uff0c\u4e26\u6839\u64da\u9700\u8981\u63d0\u4f9b\u652f\u6301\u6027\u8b77\u7406\u3002 \u809d\u6bd2\u6027\u00a0 \u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u8207\u809d\u81df\u9175\u7d20\u5347\u9ad8\u6709\u95dc\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c79% (96\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0ALT \u5347\u9ad8\uff0c76% (93\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a0AST \u5347\u9ad8\u300226% (32\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0ALT \u5347\u9ad8\u300230% (36\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a03 \u7d1a\u00a0AST \u5347\u9ad8\uff0c3% (4\/122) \u7684\u60a3\u8005\u51fa\u73fe\u00a04 \u7d1a\u00a0AST \u5347\u9ad8\u3002\u5927\u591a\u6578\u60a3\u8005\u5728\u7b2c\u4e00\u9031\u671f\u51fa\u73fe\u809d\u9175\u7d20\u5347\u9ad8\uff0c\u4e2d\u65b7\u5291\u91cf\u5f8c\u53ef\u6062\u5fa9\u3002 \u6bcf\u6b21\u8f38\u6ce8\u00a0ELZONRIS \u524d\uff0c\u76e3\u6e2c\u4e19\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(ALT) \u548c\u5929\u9580\u51ac\u80fa\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u00a0(AST)\u3002\u82e5\u8f49\u6c28\u9176\u5347\u81f3\u6b63\u5e38\u503c\u4e0a\u9650\u7684\u00a05 \u500d\u4ee5\u4e0a\uff0c\u61c9\u66ab\u6642\u505c\u7528\u00a0ELZONRIS\uff0c\u5f85\u8f49\u6c28\u9176\u6062\u5fa9\u6b63\u5e38\u6216\u7de9\u89e3\u5f8c\u518d\u7e7c\u7e8c\u6cbb\u7642\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9\u70ba\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u3001\u5641\u5fc3\u3001\u75b2\u5026\u3001\u767c\u71d2\u3001\u9031\u908a\u6c34\u816b\u548c\u9ad4\u91cd\u589e\u52a0\uff0c\u767c\u751f\u7387\u2265 30%\u3002\u6700\u5e38\u898b\u7684\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7570\u5e38\u662f\u767d\u86cb\u767d\u3001\u8840\u5c0f\u677f\u3001\u8840\u7d05\u7d20\u3001\u9223\u548c\u9209\u4e0b\u964d\uff0c\u8461\u8404\u7cd6\u3001ALT \u548c\u00a0AST \u5347\u9ad8\uff0c\u767c\u751f\u7387\u8d85\u904e50%\u3002 \u8acb\u53c3\u95b1\u5b8c\u6574\u7684\u300a\u8655\u65b9\u8cc7\u8a0a\u300b\uff0c\u5305\u62ec\u300c\u7981\u5fcc\u8b66\u544a\u300d\u3002\u00a0 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Menarini Group \u7c21\u4ecb\u00a0 Menarini Group \u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e\u00a044 \u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e\u00a017,000 \u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u6cbb\u7642\u9700\u6c42\u9ad8\u5ea6\u672a\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709\u00a018 \u500b\u751f\u7522\u57fa\u5730\u548c\u00a09 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403\u00a0140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u00a0\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd\u00a0www.menarini.com\u3002 \u95dc\u65bc\u00a0Stemline Therapeutics Inc. \u00a0 Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f\u00a0Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002Stemline \u5c07\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316\u00a0ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa\u4e86\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d\u00a0CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624\u00a0(BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684\u00a0BPDCN \u6cbb\u7642\u65b9\u6848\u3002Stemline \u4ea6\u5c07\u5728\u6b50\u6d32\u5546\u696d\u5316\u00a0NEXPOVIO\u00ae (selinexor) \uff0c\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u00a0XPO1 \u6291\u5236\u5291\u3002\u00a0\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002\u00a0 \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=199733","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2023-11-23T22:22:00+00:00","og_image":[{"width":400,"height":121,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/11\/MENARINI_GROUP_Logo.jpg","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"2 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=199733#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=199733"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da","datePublished":"2023-11-23T22:22:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=199733"},"wordCount":350,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=199733#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/11\/MENARINI_GROUP_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=199733","url":"https:\/\/pingtungtimes.com.tw\/?p=199733","name":"Menarini Group \u5728 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u4e0a\u516c\u4f48 ORSERDU\u00ae (elacestrant) \u7684\u6700\u65b0\u6578\u64da\uff0c\u4e26\u5728\u7b2c 65 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\u516c\u4f48 ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=199733#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=199733#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/11\/MENARINI_GROUP_Logo.jpg","datePublished":"2023-11-23T22:22:00+00:00","description":"- \u9019\u4e9b\u6578\u64da\u6d89\u53ca\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u7684\u5341\u4e00\u9805\u5c08\u984c\u5831\u544a\uff0c\u8b93\u516c\u773e\u9032\u4e00\u6b65\u4e86\u89e3\u4e86\u9019\u4e9b\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u7684\u6f5b\u5728\u76ca\u8655 - ORSERDU \u6578\u64da\u5f37\u5316\u4e86\u5176\u5728\u6cbb\u7642\u651c\u5e36\u00a0ESR1 \u7a81\u8b8a\u7684\u00a0ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u00a0(mBC) \u816b\u7624\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u540c\u6642\u5c55\u793a\u4e86\u806f\u5408\u8a66\u9a57\u7684\u521d\u6b65\u6578\u64da - ELZONRIS \u4ecb\u7d39\u6f14\u793a\u5305\u62ec\u4f86\u81ea\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u6578\u64da \u610f\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u7f8e\u570b\u7d10\u7d04\u00a02023\u5e7411\u670824\u65e5 \/\u7f8e\u901a\u793e\/ -- \u610f\u5927\u5229\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group (\u300cMenarini\u300d) \u548c Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u4eca\u5929\u5ba3\u4f48\uff0c\u96d9\u65b9\u5c07\u5728\u5373\u5c07\u8209\u884c\u7684\u5169\u5834\u5927\u6703\u4e0a\u5c55\u793a ORSERDU\u00ae (elacestrant) \u548c\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u7684\u6700\u65b0\u6578\u64da\u3002 ORSERDU \u662f\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u55ae\u85e5\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u505c\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u00a0ER+\u3001HER2-\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u51fa\u73fe\u9032\u5c55\uff0cORSERDU \u65bc\u00a02023 \u5e74 1 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08U.S. FDA\uff09\u7684\u512a\u5148\u5be9\u67e5\u548c\u5feb\u901f\u901a\u9053\u6279\u51c6\u30022023 \u5e74 9 \u6708\uff0cORSERDU \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u00a0 2023 \u5e7412 \u6708\u00a05 \u65e5\u81f3\u00a012 \u6708\u00a09 \u65e5\u8209\u884c\u7684\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703\u00a0(San Antonio Breast Cancer Symposium\uff0c\u7c21\u7a31\u00a0SABCS) \u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u91cd\u9ede\u8a0e\u8ad6\u00a0EMERALD \u4e09\u671f\u8a66\u9a57\u7684\u5176\u4ed6\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790\uff0c\u4ee5\u53ca\u8a55\u4f30\u00a0elacestrant \u5728\u591a\u7a2e\u806f\u5408\u7528\u85e5\u60c5\u6cc1\u4e0b\u7684\u65b0\u5b89\u5168\u6027\u66f4\u65b0\u3002 ELZONRIS \u65bc\u00a02018 \u5e74 12 \u6708\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u6210\u4eba\u548c\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u7624\u00a0(BPDCN)\uff0c\u9069\u7528\u65bc\u672a\u7d93\u6cbb\u7642\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u4eba\u7fa4\u30022021 \u5e74 1 \u6708\uff0cELZONRIS \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\u3002\u5728\u00a02023 \u5e74\u00a012 \u6708\u00a09 \u65e5\u81f3\u00a012 \u65e5\u65bc\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u66a8\u535a\u89bd\u6703\u4e0a\uff0c\u516c\u53f8\u5c07\u516c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5305\u62ec\u5c0d\u00a0BPDCN \u6cbb\u7642\u7121\u6548\u60a3\u8005\u7684\u6700\u65b0\u5be6\u969b\u7d50\u679c\u7684\u53e3\u982d\u5831\u544a\uff0c\u9019\u4e9b\u7d50\u679c\u986f\u793a\u4e86\u6301\u4e45\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u5f9e\u800c\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002 Menarini Group \u884c\u653f\u7e3d\u88c1\u00a0Elcin Barker Ergun \u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u65b0\u578b\u816b\u7624\u7642\u6cd5\u6db5\u84cb\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u5176\u6578\u64da\u7684\u5ee3\u6cdb\u6027\u7a81\u986f\u4e86\u6211\u5011\u81f4\u529b\u65bc\u89e3\u6c7a\u96e3\u4ee5\u6cbb\u7642\u7684\u764c\u75c7\u4e2d\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\uff0c\u5728\u00a0Menarini Stemline\uff0c\u6211\u5011\u81f4\u529b\u65bc\u63a8\u52d5\u816b\u7624\u5b78\u9818\u57df\u7684\u5275\u65b0\uff0c\u63d0\u4f9b\u6a19\u9776\u7642\u6cd5\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u548c\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u5e36\u4f86\u50f9\u503c\u3002\u300d \u6709\u95dc\u00a0Menarini Group \/Stemline Therapeutics \u5373\u5c07\u8209\u884c\u7684\u4ecb\u7d39\u6f14\u793a\u7684\u8a73\u7d30\u8cc7\u8a0a\uff0c\u8acb\u53c3\u95b1\u4e0b\u6587\uff1a 2023 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 \u4e3b\u8981\u4f5c\u8005 \u6458\u8981\u6a19\u984c\u53ca\u00a0ID \u5831\u544a\u8a73\u60c5 Bardia, A ESR1 \u7a81\u8b8a\u7684 ER+\/HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u4e2d elacetrant \u8207\u6a19\u6e96\u6cbb\u7642\u7684\u6bd4\u8f03\uff1a\u4f86\u81ea EMERALD 3 \u671f\u8a66\u9a57\u7684\u95dc\u9375\u751f\u7269\u6a19\u8a18\u548c\u81e8\u5e8a\u4e9e\u7d44\u5206\u6790 1576519\/PS17-02 2023 \u5e74 12 \u6708 8 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0a\u5348 7 \u9ede\u81f3 8 \u9ede \u6d77\u5831\u805a\u7126\u8a0e\u8ad6 Hemisfair 1-2 \u865f\u5bb4\u6703\u5ef3 \u00a0 Rugo, H ELEVATE\uff1a\u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c64\u7684\u5098\u5f0f 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u5728\u4e0d\u540c\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\u5c0d\u96cc\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027(HER2-) \u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60a3\u8005 (pts) \u7684\u7642\u6548 1576517\/PO2-05-04 2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 Ibrahim, N ELECTRA: \u8a72\u7814\u7a76\u70ba\u958b\u653e\u6a19\u7c3d\u7684\u591a\u4e2d\u5fc3 1b\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 elacestrant \u548c abemaciclib \u806f\u5408\u6cbb\u7642\u5728\u523a\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (ER+)\u3001HER2 \u9670\u6027 (HER2-) \u4e73\u764c (BC) \u8166\u8f49\u79fb\u60a3\u8005\u4e2d\u7684\u7642\u6548 1576518\/PO2-05-05 2023 \u5e74 12 \u6708 6 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e0b\u5348 5 \u9ede\u81f3 7 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 Patnaik, A SUMIT-ELA: \u7d30\u80de\u9031\u671f\u86cb\u767d\u4f9d\u8cf4\u6027\u6fc0\u9176 7 \u6291\u5236\u5291 (CDK7i) samuraciclib \u548c\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 (SERD) elacestrant \u806f\u5408\u6cbb\u7642 CDK4\/6i* \u5f8c\u7684\u665a\u671f\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027 (HR+) \u4e73\u817a\u764c\u7684 1b\/2 \u671f\u7814\u7a76 NA\/PO3-04-13 2023 \u5e74 12 \u6708 7 \u65e5 \u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u5230\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 Bellet, M \u5728\u505c\u7d93\u524d HR+\/HER2- \u4e73\u764c\u60a3\u8005\u4e2d\u61c9\u7528 elacestrant \u806f\u5408\/\u4e0d\u806f\u5408 triptorelin \u7684\u6548\u679c\u7684 II \u671f\u96a8\u6a5f\u8853\u524d\u6a5f\u6703\u4e4b\u7a97\u8a66\u9a57 -- SOLTI-2104- I \u671f\u8a66\u9a57* 1580190\/PO3-19-08 2023 \u5e74 12 \u6708 7 \u65e5\uff0c\u4e2d\u90e8\u590f\u4ee4\u6642\u9593\u4e2d\u5348 12 \u9ede\u81f3\u4e0b\u5348 2 \u9ede \u6d77\u5831 2-3 \u865f\u5ef3 \u00a0 * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u3002\u00a0 2023 \u5e74\u7b2c\u00a065 \u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u00a0(ASH) \u5e74\u6703\u00a0 \u4e3b\u8981\u4f5c\u8005 \u6a19\u984c\u548c\u51fa\u7248\u7269\u7de8\u865f \u6703\u8b70\u540d\u7a31 \u5831\u544a\u8a73\u60c5 Angelucci \u7b49\u4eba \u91dd\u5c0d\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u7684\u672a\u7d93\u6cbb\u7642\u60a3\u8005\uff0c\u4f7f\u7528 Tagraxofusp \u6cbb\u7642\u53ef\u5be6\u73fe\u7642\u6548\u6301\u4e45\u548c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5f9e\u800c\u5ef6\u9577\u60a3\u8005\u7684\u5b58\u6d3b\u671f\u3002\u6b50\u6d32\u6307\u5b9a\u60a3\u8005\u9805\u76ee\u7684\u6700\u65b0\u7d50\u679c \u00a0 \u51fa\u7248\u865f\uff1a547 \u00a0 906. \u6210\u679c\u7814\u7a76 -- \u9ad3\u7cfb\u60e1\u6027\u816b\u7624\uff1a\u771f\u5be6\u4e16\u754c\u7684\u6cbb\u7642\u6a21\u5f0f\u8207\u7d50\u679c \u53e3\u982d\u5831\u544a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e2d\u5348 12 \u9ede \u8056\u5730\u7259\u54e5\u78bc\u982d\u842c\u8c6a\u4faf\u7235\u9152\u5e97 (Marriott Marquis San Diego Marina) \uff0c\u842c\u8c6a 11-13 \u5927\u5bb4\u6703\u5ef3 \u00a0 Minetto \u7b49\u4eba \u55ae\u85e5 Tagraxofusp \u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027 CD123 \u967d\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u610f\u5927\u5229 GIMEMA AML2020 \u8a66\u9a57\u7684\u4e2d\u671f\u5206\u6790\u7d50\u679c* \u00a0 \u51fa\u7248\u865f\uff1a2918 \u00a0 616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 II \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 Lane \u7b49\u4eba Tagraxofusp \u8207 Azacitidine \u548c Venetoclax \u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u7684 CD123+ \u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c1b \u671f\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u64f4\u5927\u968a\u5217* \u00a0 \u51fa\u7248\u865f\uff1a4277 616. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u7814\u7a76\u7642\u6cd5\uff0c\u4e0d\u5305\u62ec\u79fb\u690d\u548c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\uff1a\u6d77\u5831 III \u00a0 \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 Boichut \u7b49\u4eba \u5206\u6790 tagraxofusp \u4f5c\u70ba\u55ae\u85e5\u53ca\u8207 BCL2 \u6291\u5236\u5291\u806f\u7528\u5c0d AML-PDC \u7684\u6d3b\u6027*\u00a0 \u00a0 \u51fa\u7248\u865f\uff1a2783 604. \u5206\u5b50\u85e5\u7406\u5b78\u8207\u6297\u85e5\u6027\uff1a\u9ad3\u7cfb\u816b\u7624\uff1a\u6d77\u5831 II \u6d77\u5831\u5c55\u793a \u00a0 2023 \u5e74 12 \u6708 10 \u65e5\u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3 G-H \u5ef3 Navarro Vicente \u7b49\u4eba \u78ba\u8a3a\u70ba\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7279\u5fb5\u8207\u6cbb\u7642\uff1aPethema \u6d41\u884c\u75c5\u5b78\u767b\u8a18 (EPI-BLAS \u7814\u7a76) \u7684\u4e2d\u671f\u5206\u6790* \u00a0 \u51fa\u7248\u865f\uff1a4234 \u00a0 613. \u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u8207\u6d41\u884c\u75c5\u5b78\uff1a\u6d77\u5831 III \u6d77\u5831\u5c55\u793a \u00a02023 \u5e74 12 \u6708 11 \u65e5 \u4e0b\u5348 6:00 - \u665a\u4e0a 8:00 \u8056\u5730\u7259\u54e5\u6703\u8b70\u4e2d\u5fc3\uff0cG-H \u5ef3 * \u8868\u793a\u7814\u7a76\u8005\u8d0a\u52a9\u7684\u7814\u7a76\u6216\u5408\u4f5c\u7814\u7a76\u00a0 EMERALD \u7b2c\u00a03 \u671f\u7814\u7a76\u00a0(NCT03778931) \u7c21\u4ecb\u00a0EMERALD \u7b2c\u00a03 \u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u5f0f\u3001\u4e3b\u52d5\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u00a0elacestrant \u4f5c\u70ba\u7b2c\u4e8c\u6216\u7b2c\u4e09\u7dda\u55ae\u85e5\u6cbb\u7642\u65b9\u6848\u5c0d\u65bc\u00a0ER+\u3001HER2- \u665a\u671f\/\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u7684\u7642\u6548\u3002\u00a0\u8a72\u7814\u7a76\u62db\u52df\u4e86\u00a0478 \u540d\u5148\u524d\u63a5\u53d7\u904e\u4e00\u7dda\u6216\u4e8c\u7dda\u5167\u5206\u6ccc\u7642\u6cd5\u00a0(\u5305\u62ec\u00a0CDK4\/6 \u6291\u5236\u5291) \u7684\u60a3\u8005\u3002\u53d7\u8a66\u60a3\u8005\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u00a0Elacestrant \u6216\u7814\u7a76\u8005\u9078\u64c7\u7684\u5df2\u6279\u51c6\u8377\u723e\u8499\u85e5\u7269\u3002\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u81e8\u5e8a\u7d42\u9ede\u662f\u8a55\u91cf\u6574\u500b\u60a3\u8005\u7fa4\u9ad4\u548c\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a01 \u57fa\u56e0\u00a0(ESR1) \u7a81\u8b8a\u60a3\u8005\u7684\u75be\u75c5\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u00a0(PFS)\u3002\u5728\u816b\u7624\u5177\u6709\u00a0ESR1 \u7a81\u8b8a\u7684\u60a3\u8005\u7d44\u4e2d\uff0c\u63a1\u7528\u00a0elacestrant \u6cbb\u7642\u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a03.8 \u500b\u6708\uff0c\u800c\u63a1\u7528\u00a0SOC \u7684\u4e2d\u4f4d\u00a0PFS \u70ba\u00a01.9 \u500b\u6708\uff0c\u4e26\u4e14\u76f8\u6bd4\u65bc\u00a0SOC\uff0c\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa\u964d\u4f4e\u4e86\u00a045% (PFS HR=0.55, 95% CI: 0.39, 0.77) \u3002 \u95dc\u65bc\u00a0ORSERDU\u00ae (elacestrant) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ORSERDU (elacestrant) \uff0c345 \u6beb\u514b\u6bcf\u9320\uff0c\u7d93\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u00a0(FDA) \u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u00a0(ER) \u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u00a02 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u81f3\u5c11\u63a5\u53d7\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u7684\u75be\u75c5\u9032\u5c55\u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cORSERDU\u00ae\u00a0 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c\u00a04 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba\u00a00.9% \u548c\u00a02.2%\u3002\u5728\u958b\u59cb\u00a0ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u4e2d\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u5411\u5b55\u5a66\u9032\u884c\u00a0ORSERDU \u7d66\u85e5\u53ef\u80fd\u6703\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u64c1\u6709\u5177\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\u7684\u7537\u6027\u60a3\u8005\uff0c\u5efa\u8b70\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u81f3\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9\u00a0 \u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c12% \u7684\u60a3\u8005\u51fa\u73fe\u4e86\u56b4\u91cd\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e\u00a01%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(1.7%)\u00a0 \u548c\u5641\u5fc3\u00a0(1.3%) \u30021.7% \u7684\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u4e86\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\u00a0(\u5404\u4e00\u4f8b) \u3002 ORSERDU \u7684\u6700\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u00a0(&gt;10%) \uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u6aa2\u6e2c\u7d50\u679c\u7570\u5e38\uff0c\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u00a0(41%)\u3001\u5641\u5fc3\u00a0(35%)\u3001\u81bd\u56fa\u9187\u589e\u9ad8\u00a0(30%)\u3001AST \u589e\u9ad8\u00a0(29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u9ad8\u00a0(27%) \u3001\u75b2\u52de\u00a0(26%)\u3001\u8840\u7d05\u86cb\u767d\u964d\u4f4e\u00a0(26%)\u3001\u5614\u5410\u00a0(19%)\u3001ALT \u6c34\u5e73\u589e\u9ad8\u00a0(17%)\u3001\u9209\u964d\u4f4e\u00a0(16%)\u3001\u808c\u9178\u9150\u589e\u9ad8\u00a0(16%)\u3001\u98df\u617e\u964d\u4f4e\u00a0(15%)\u3001\u8179\u7009\u00a0(13%)\u3001\u982d\u75db\u00a0(12%)\u3001\u4fbf\u79d8\u00a0(12%) \u3001\u8179\u75db\u00a0(11%)\u3001\u6f6e\u7d05\u00a0(11%) \u548c\u6d88\u5316\u4e0d\u826f\u00a0(10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u00a0 \u8207\u00a0CYP3A4 \u8a98\u5c0e\u5291\u53ca\/\u6216\u6291\u5236\u5291\u540c\u6642\u4f7f\u7528\uff1a\u00a0\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u6291\u5236\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u00a0\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6\u00a0CYP3A4 \u8a98\u5c0e\u5291\u548c\u00a0ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u7279\u5b9a\u4eba\u7fa4\u7684\u4f7f\u7528\u00a0 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7\u00a0ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684\u00a01 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002 \u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u5c0d\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528\u00a0ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d\u00a0(Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c0f\u00a0ORSERDU \u7684\u5291\u91cf\u3002 ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u82e5\u8981\u5831\u544a\u53ef\u7591\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u806f\u7d61\u00a0Stemline Therapeutics, Inc.\uff0c\u96fb\u8a71\u865f\u78bc\u70ba\u00a01-877-332-7961\uff0c\u6216\u8005\u81f4\u96fb\u00a01-800-FDA-1088 \u806f\u7d61\u00a0FDA\uff0c\u6216\u700f\u89bd\u00a0www.fda.gov\/medwatch\u3002 Elacestrant \u9084\u5728\u6578\u500b\u8f49\u79fb\u6027\u4e73\u764c\u75be\u75c5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u9032\u884c\u7814\u7a76\uff0c\u55ae\u7368\u6216\u662f\u7d50\u5408\u5176\u4ed6\u7642\u6cd5\uff1aELEVATE (NCT05563220) \uff1bELECTRA (NCT05386108) \uff1b\u4ee5\u53ca\u00a0ELCIN (NCT05596409) \u3002Elacestrant \u4e5f\u5c07\u5728\u65e9\u671f\u4e73\u764c\u75be\u75c5\u4e2d\u9032\u884c\u8a55\u4f30\u3002 \u95dc\u65bc\u00a0ELZONRIS\u00ae (tagraxofusp-erzs) \u00a0 \u7f8e\u570b\u9069\u61c9\u75c7\uff1a\u00a0ELZONRIS (tagraxofusp-erzs) \u662f\u4e00\u7a2e\u8655\u65b9\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u548c\u00a02 \u6b72\u53ca\u4ee5\u4e0a\u5152\u7ae5\u60a3\u8005\u7684\u6f3f\u7d30\u80de\u6027\u6a39\u7a81\u72c0\u7d30\u80de\u816b\u7624\u00a0(BPDCN) \u3002 \u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\u53ef\u4ee5\u700f\u89bd\u00a0www.elzonris.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\uff0cELZONRIS\u00ae \u00a0 \u7981\u5fcc\u8b66\u544a\uff1a\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS)\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u6216\u5c0e\u81f4\u6b7b\u4ea1\u3002\u76e3\u6e2c\u00a0CLS \u7684\u5fb5\u5146\u548c\u75c7\u72c0\uff0c\u4e26\u6309\u7167\u5efa\u8b70\u63a1\u53d6\u63aa\u65bd\u3002 \u8b66\u544a\u548c\u4f7f\u7528\u6ce8\u610f\u4e8b\u9805\u00a0 \u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0 \u6709\u5831\u544a\u7a31\uff0c\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u51fa\u73fe\u6bdb\u7d30\u8840\u7ba1\u6ef2\u6f0f\u75c7\u5019\u7fa4\u00a0(CLS) \uff0c\u5305\u62ec\u5371\u53ca\u751f\u547d\u548c\u81f4\u547d\u7684\u75c5\u4f8b\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0cCLS \u7684\u7e3d\u767c\u751f\u7387\u70ba\u00a053% (65\/122) \uff0c\u5176\u4e2d\u00a043% (52\/122) \u7684\u60a3\u8005\u70ba\u00a01 \u7d1a\u6216\u00a02 \u7d1a\uff0c7% (8\/122) \u7684\u60a3\u8005\u70ba\u00a03 \u7d1a\uff0c1% (1\/122) \u7684\u60a3\u8005\u70ba\u00a04 \u7d1a\uff0c\u56db\u4eba\u70ba\u6b7b\u4ea1\u75c5\u4f8b\u00a0(3%) \u3002\u767c\u75c5\u6642\u9593\u4e2d\u4f4d\u6578\u70ba\u00a04 \u5929\u00a0(\u767c\u75c5\u6642\u9593\u5f9e\u00a01 \u81f3\u00a046 \u5929\u4e0d\u7b49) \uff0c\u9664\u00a05 \u540d\u60a3\u8005\u5916\uff0c\u5176\u9918\u60a3\u8005\u5747\u5728\u7b2c\u4e00\u5468\u671f\u5167\u7b2c\u4e00\u6b21\u767c\u75c5\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u524d\uff0c\u78ba\u4fdd\u60a3\u8005\u5fc3\u80ba\u529f\u80fd\u8db3\u4ee5\u63a5\u53d7\u6cbb\u7642\uff0c\u4e14\u8840\u6e05\u767d\u86cb\u767d\u5927\u65bc\u6216\u7b49\u65bc\u00a03.2 g\/dL\u3002\u5728\u4f7f\u7528\u00a0ELZONRIS \u6cbb\u7642\u671f\u9593\uff0c\u5728\u958b\u59cb\u4f7f\u7528\u6bcf\u6b21\u5291\u91cf\u7684\u00a0ELZONRIS \u4e4b\u524d\u548c\u4e4b\u5f8c\u6839\u64da\u81e8\u5e8a\u6307\u793a\u76e3\u6e2c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\uff0c\u4e26\u8a55\u4f30\u60a3\u8005\u662f\u5426\u51fa\u73fe\u00a0CLS \u7684\u5176\u4ed6\u9ad4\u5fb5\u6216\u75c7\u72c0\uff0c\u5305\u62ec\u9ad4\u91cd\u589e\u52a0\u3001\u00a0\u65b0\u51fa\u73fe\u6216\u60e1\u5316\u7684\u6c34\u816b\u00a0(\u5305\u62ec\u80ba\u6c34\u816b) \u3001\u4f4e\u8840\u58d3\u6216\u8840\u6db2\u52d5\u529b\u5b78\u4e0d\u7a69\u5b9a\u3002 \u904e\u654f\u53cd\u61c9\u00a0 ELZONRIS \u53ef\u5c0e\u81f4\u56b4\u91cd\u904e\u654f\u53cd\u61c9\u3002\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u63a5\u53d7\u00a0ELZONRIS 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