{"id":199113,"date":"2023-11-22T12:35:00","date_gmt":"2023-11-22T04:35:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=199113"},"modified":"2023-11-22T12:35:00","modified_gmt":"2023-11-22T04:35:00","slug":"diabetes-care%e7%99%bc%e8%a1%a8%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e7%91%aa%e4%bb%95%e5%ba%a6%e8%82%bd-ibi362-%e5%9c%a8%e4%b8%ad%e5%9c%8b2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8f%97%e8%a9%a6","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=199113","title":{"rendered":"Diabetes Care\u767c\u8868\u4fe1\u9054\u751f\u7269\u746a\u4ed5\u5ea6\u80bd (IBI362) \u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5168\u6587"},"content":{"rendered":"<div>\n<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2023\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08glucagon receptor, GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI362\uff09\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5168\u6587\u8fd1\u65e5\u5728\u570b\u969b\u6b0a\u5a01\u7cd6\u5c3f\u75c5\u671f\u520a<a href=\"https:\/\/diabetesjournals.org\/care\/article\/doi\/10.2337\/dc23-1287\/153858\/Efficacy-and-Safety-of-Mazdutide-in-Chinese\" target=\"_blank\" rel=\"nofollow noopener\"><i>Diabetes Care<\/i><\/a>\u5728\u7dda\u767c\u8868\u3002<\/p>\n<p><b>\u672c\u6587\u901a\u8a0a\u4f5c\u8005\u53ca\u672c\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u65e5\u53cb\u597d\u91ab\u9662\u5167\u5206\u6ccc\u79d1\u694a\u6587\u82f1\u6559\u6388<\/b>\u8868\u793a\uff1a\u300c\u76ee\u524d\uff0c\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ecd\u5b58\u5728\u8840\u7cd6\u7e3d\u9ad4\u9054\u6a19\u7387\u504f\u4f4e\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5408\u4f75\u591a\u7a2e\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u56e0\u7d20\uff0c\u5982\u80a5\u80d6\uff0c\u9ad8\u8102\u8840\u75c7\uff0c\u51a0\u5fc3\u75c5\uff0c\u8102\u80aa\u809d\uff0c\u75db\u98a8\u7b49\u60c5\u6cc1\uff0c\u9019\u65e2\u589e\u52a0\u4e86\u60a3\u8005\u7684\u75be\u75c5\u8ca0\u64d4\uff0c\u4e5f\u7d66\u81e8\u5e8a\u6cbb\u7642\u589e\u52a0\u4e86\u96e3\u5ea6\u548c\u8907\u96dc\u6027\u3002\u81e8\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u80fd\u6709\u7642\u6548\u78ba\u5207\uff0c\u5b89\u5168\u6027\u597d\uff0c\u7d66\u85e5\u4fbf\u6377\uff0c\u4f4e\u8840\u7cd6\u98a8\u96aa\u4f4e\uff0c\u4e14\u80fd\u517c\u5177\u6e1b\u91cd\u4f5c\u7528\u3001\u5be6\u73fe\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u591a\u91cd\u7372\u76ca\u7684\u5275\u65b0\u85e5\u7269\u3002\u5728\u6b64\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\u4e0d\u50c5\u5c55\u73fe\u51fa\u660e\u78ba\u7684\u964d\u7cd6\u7642\u6548\uff0c\u4e14\u5728\u540c\u6642\u964d\u4f4eHbA1c\u8207\u9ad4\u91cd\u96d9\u9805\u6307\u6a19\u4e0a\u5c55\u793a\u51fa\u512a\u65bcGLP-1\u55ae\u9776\u85e5\u7269\u5ea6\u62c9\u7cd6\u80bd\u7684\u6f5b\u8cea\uff0c\u6709\u671b\u70ba2\u578b\u7cd6\u5c3f\u75c5\u5408\u4f75\u80a5\u80d6\u60a3\u8005\u5e36\u4f86\u984d\u5916\u7372\u76ca\u3002\u8a72\u7814\u7a76\u7d50\u679c\u9084\u8868\u660e\uff0c\u4e2d\u570b2\u578b\u7cd6\u5c3f\u53d7\u8a66\u8005\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd\u6cbb\u764220\u5468\u5f8c\u591a\u7a2e\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u7372\u76ca\u660e\u986f\uff0c\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002\u5f88\u9ad8\u8208\u770b\u5230\u7814\u7a76\u7d50\u679c\u9806\u5229\u767c\u8868\u65bc<i>Diabetes Care<\/i>\uff0c\u6211\u671f\u5f85\u5728\u6b63\u5728\u9032\u884c\u7684\u5169\u9805III\u671f\u7814\u7a76\u4e2d\u746a\u4ed5\u5ea6\u80bd\u53ef\u4ee5\u5c55\u73fe\u51fa\u66f4\u52a0\u9a5a\u8277\u7684\u7d50\u679c\uff0c\u4e26\u65e9\u65e5\u70ba\u6211\u570b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e36\u4f86\u66f4\u512a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n<p><b>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u746a\u4ed5\u5ea6\u80bd\u662f\u5168\u7403\u958b\u767c\u9032\u5ea6\u6700\u5feb\u7684GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\uff0c\u517c\u5177\u986f\u8457\u964d\u7cd6\u6e1b\u91cd\u7642\u6548\u548c\u826f\u597d\u5b89\u5168\u6027\u3002\u5728\u672c\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u746a\u4ed5\u5ea6\u80bd\u7684\u964d\u7cd6\u3001\u6e1b\u91cd\u548c\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u7d9c\u5408\u7372\u76ca\u65b9\u9762\u7684\u512a\u52e2\u5f97\u5230\u5168\u9762\u9a57\u8b49\uff0c\u4e26\u518d\u6b21\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u540c\u6642\u76f8\u8f03\u5ea6\u62c9\u7cd6\u80bd\u7d44\uff0c\u746a\u4ed5\u5ea6\u80bd4.5 mg\u7d44\u548c6 mg\u7d44\u5728\u7b2c20\u5468\u6642\u7684HbA1c\u6c34\u5e73\u4ecd\u4fdd\u6301\u4e0b\u964d\u8da8\u52e2\u3002\u6b64\u9805\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u7cd6\u5c3f\u75c5\u9818\u57df\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u4e0a\uff0c\u4e00\u65b9\u9762\u8b49\u660e\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u81e8\u5e8a\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u9ad4\u73fe\u4e86\u4e2d\u570b\u7814\u7a76\u8005\u5353\u8d8a\u7684\u81e8\u5e8a\u7814\u7a76\u6c34\u5e73\u548c\u4fe1\u9054\u751f\u7269\u7d2e\u5be6\u7684\u7814\u767c\u80fd\u529b<b>\u3002<\/b>\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684\u5169\u9805III\u671f\u8a3b\u518a\u7814\u7a76\uff08DREAMS-1\u548cDREAMS-2\uff09\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u5c07\u63d0\u4f9b\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u4eba\u7fa4\u4e2d\u7684\u5927\u898f\u6a21\u6a23\u672c\u91cf\u7684\u91ab\u5b78\u8b49\u64da\uff0c\u6211\u5011\u5e0c\u671b\u9019\u6b3e\u9ad8\u8cea\u91cf\u85e5\u7269\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u5ee3\u5927\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002\u300d<\/p>\n<p>\u672c\u6b21\u6587\u7ae0\u767c\u4f48\u7684\u7814\u7a76\u7d50\u679c\u4f86\u81ea\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u3002\u7814\u7a76\u5171\u5165\u7d44252\u4f8b\u5728\u7d93\u81f3\u5c113\u500b\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u4f34\u6216\u4e0d\u4f34\u7a69\u5b9a\u5291\u91cf\u4e8c\u7532\u96d9\u80cd\u6cbb\u7642\u5f8c\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73 [\u7be9\u9078\u6642\u7cd6\u5316\u8840\u7d05\u86cb\u767d\uff08HbA1c 7.0-10.5%\uff09] \u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\uff0c\u63091:1:1:1:1\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd 3 mg\u30014.5 mg\u62166 mg\u3001\u5b89\u6170\u5291\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u9031\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e520\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c20\u5468\u6642HbA1c\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u3002\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u6b21\u7814\u7a76\u85e5\u7269\u6cbb\u7642\u7684\u53d7\u8a66\u8005\uff08n=250\uff09\u57fa\u7dda\u5e73\u5747BMI\u70ba27.4 kg\/m<sup>2<\/sup>\uff0c\u57fa\u7dda\u5e73\u5747HbA1c \u70ba8.06%\u3002<\/p>\n<p><b>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u5747\u53ef\u986f\u8457\u964d\u4f4e<\/b><b>HbA1c\u6c34\u5e73\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li>\u7b2c20\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44HbA1c\u6c34\u5e73\u8f03\u57fa\u7dda\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba-1.41%\u3001-1.67%\u548c-1.55%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba-1.35%\uff1b\u5b89\u6170\u5291\u7d44\u70ba0.03%\u3002\u746a\u4ed5\u5ea6\u80bd\u5404\u5291\u91cf\u7d44\u7b2c20\u5468\u7684HbA1c\u6c34\u5e73\u5e73\u5747\u964d\u5e45\u5747\u986f\u8457\u5927\u65bc\u5b89\u6170\u5291\u7d44\uff08P&lt;0.0001\uff09\u3002<\/li>\n<li>\u540c\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44HbA1c\uff1c7.0%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905454.0%\u300166.7%\u548c73.5%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba60.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba17.6%\uff09\uff1bHbA1c\u22646.5%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905428.0%\u300156.3%\u548c51.0%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba46.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba7.8%\uff09\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u986f\u8457\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u548c\u9910\u5f8c2\u5c0f\u6642\u8840\u7cd6\u6c34\u5e73\u3002<\/li>\n<\/ul>\n<p><b>\u9ad4\u91cd\u65b9\u9762\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\uff0c\u6e1b\u91cd\u964d\u7cd6\u96d9\u9054\u6a19\u7387\u9ad8\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li>\u7b2c20\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba-4.12%\u3001-5.31%\u548c-7.11%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba-2.69 %\uff1b\u5b89\u6170\u5291\u7d44\u70ba-1.38%\u3002<\/li>\n<li>\u540c\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655.0%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905424.0%\u300137.5%\u548c57.1%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba18.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba9.8%\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u5206\u5225\u670916.0%\u300129.2%\u548c49.0%\u7684\u53d7\u8a66\u8005\u7b2c20\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655.0%\u4e14HbA1c\uff1c7.0%\uff0c\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba12.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba0\u3002<\/li>\n<\/ul>\n<p><b>\u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li>\u7814\u7a76\u6cbb\u7642\u671f\u9593\uff0c\u746a\u4ed5\u5ea6\u80bd\u7d44\u7121\u53d7\u8a66\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u85e5\u7269\u6cbb\u7642\uff0c\u7121\u53d7\u8a66\u8005\u767c\u751f\u7814\u7a76\u8005\u5224\u5b9a\u8207\u746a\u4ed5\u5ea6\u80bd\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u7814\u7a76\u671f\u9593\u672a\u767c\u751f\u91cd\u5ea6\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u3002<\/li>\n<li>\u746a\u4ed5\u5ea6\u80bd\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5fb5\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u985e\u85e5\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u5831\u544a\u7684\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u8179\u7009\u3001\u98df\u617e\u6e1b\u9000\u3001\u5641\u5fc3\u548c\u5614\u5410\uff0c\u7d55\u5927\u591a\u6578\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\u3002<\/li>\n<li>\u7b2c20\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd\u5404\u5291\u91cf\u7d44\u5fc3\u7387\u8f03\u57fa\u7dda\u7684\u5e73\u5747\u589e\u5e45\u8207\u5ea6\u62c9\u7cd6\u80bd\u7d44\u76f8\u7576\uff0c\u672a\u89c0\u5bdf\u5230\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n<p>\u540c\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd\u9084\u964d\u4f4e\u8170\u570d\u3001\u8840\u58d3\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\u3001\u7518\u6cb9\u4e09\u916f\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002\u8a73\u7d30\u6578\u64da\u898b<i><a href=\"https:\/\/diabetesjournals.org\/care\/article\/doi\/10.2337\/dc23-1287\/153858\/Efficacy-and-Safety-of-Mazdutide-in-Chinese\" target=\"_blank\" rel=\"nofollow noopener\">Diabetes Care<\/a><\/i>\u5168\u6587\u3002<\/p>\n<p><b>\u95dc\u65bc\u7cd6\u5c3f\u75c5<\/b><\/p>\n<p>\u6211\u570b\u6210\u4eba\u4e2d\u7cd6\u5c3f\u75c5\u60a3\u75c5\u7387\u70ba11.6%\u3002\u5e73\u5747\u6bcf10\u500b\u6210\u5e74\u4eba\u4e2d\u5c31\u67091\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c\u5176\u4e2d2\u578b\u7cd6\u5c3f\u75c5\u7d04\u5360\u7cd6\u5c3f\u75c5\u75c5\u4eba\u7e3d\u6578\u768490%\uff0c\u767c\u75c5\u4eba\u6578\u9084\u5728\u4e0d\u65b7\u589e\u52a0\u3002\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u6703\u5c0e\u81f4\u4e0d\u53ef\u9006\u7684\u5fae\u8840\u7ba1\u548c\u5927\u8840\u7ba1\u4f75\u767c\u75c7\u5982\u8996\u529b\u4e0b\u964d\u3001\u5931\u660e\u3001\u814e\u529f\u80fd\u4e0d\u5168\u3001\u5916\u5468\u795e\u7d93\u75c5\u8b8a\u3001\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98a8\u548c\u622a\u80a2\u7b49\u3002\u7cd6\u5c3f\u75c5\u767c\u75c5\u7387\u9ad8\u3001\u96b1\u533f\u6027\u5f37\u3001\u4f75\u767c\u75c7\u56b4\u91cd\uff0c\u9019\u4e09\u5927\u7279\u5fb5\u56b4\u91cd\u5a01\u8105\u8457\u4eba\u985e\u7684\u5065\u5eb7\u3002\u76ee\u524d\u91dd\u5c0d\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7642\u65b9\u6848\u8f03\u591a\uff0c\u65b0\u578b\u964d\u7cd6\u985e\u85e5\u7269\u7684\u958b\u767c\u9664\u6709\u6548\u63a7\u5236\u8840\u7cd6\u5916\uff0c\u4e5f\u5728\u63a2\u7d22\u5c0d\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u6e1b\u8f15\u9ad4\u91cd\u3001\u964d\u4f4e\u5fc3\u8840\u7ba1\u98a8\u96aa\u3001\u4fdd\u8b77\u814e\u81df\u7b49\u65b9\u9762\u7684\u984d\u5916\u7372\u76ca\u3002<\/p>\n<p><b>\u95dc\u65bc\u746a\u4ed5\u5ea6\u80bd\uff08<\/b><b>IBI362\uff09<\/b><\/p>\n<p>\u746a\u4ed5\u5ea6\u80bd\uff08IBI362\uff09\u662f\u4fe1\u9054\u751f\u7269\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u3002\u4f5c\u70ba\u4e00\u7a2e\u54fa\u4e73\u52d5\u7269\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\uff08OXM\uff09\u985e\u4f3c\u7269\uff0c\u746a\u4ed5\u5ea6\u80bd\u9664\u4e86\u901a\u904e\u6fc0\u52d5GLP-1R\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u5916\uff0c\u9084\u53ef\u901a\u904e\u6fc0\u52d5GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u589e\u5f37\u6e1b\u91cd\u7642\u6548\uff0c\u540c\u6642\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002\u746a\u4ed5\u5ea6\u80bd\u5df2\u5728\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u512a\u79c0\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u7642\u6548\uff0c\u4ee5\u53ca\u964d\u4f4e\u8170\u570d\u3001\u8840\u8102\u3001\u8840\u58d3\u3001\u8840\u5c3f\u9178\u3001\u809d\u9176\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u6539\u5584\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u5e36\u4f86\u591a\u91cd\u4ee3\u8b1d\u7372\u76ca\u3002\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\uff08GLORY-1\uff09\u53d7\u8a66\u8005\u548c2\u578b\u7cd6\u5c3f\u75c5\uff08DREAMS-1\u548cDREAMS-2\uff09\u53d7\u8a66\u8005\u4e2d\u7684\u4e09\u9805III\u671f\u8a3b\u518a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\uff1b\u746a\u4ed5\u5ea6\u80bd9 mg\u5728\u4e2d\u570b\u80a5\u80d6\u53d7\u8a66\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u8a08\u5283\u65bc2023\u5e74\u5e95\u555f\u52d5\u3002<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<sup>\u00ae<\/sup>\uff09\u548c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<sup>\u00ae<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67097\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670919\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson 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href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow 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mg\u7d44\u5728\u7b2c20\u5468\u6642\u7684HbA1c\u6c34\u5e73\u4ecd\u4fdd\u6301\u4e0b\u964d\u8da8\u52e2\u3002\u6b64\u9805\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u7cd6\u5c3f\u75c5\u9818\u57df\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u4e0a\uff0c\u4e00\u65b9\u9762\u8b49\u660e\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u81e8\u5e8a\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u9ad4\u73fe\u4e86\u4e2d\u570b\u7814\u7a76\u8005\u5353\u8d8a\u7684\u81e8\u5e8a\u7814\u7a76\u6c34\u5e73\u548c\u4fe1\u9054\u751f\u7269\u7d2e\u5be6\u7684\u7814\u767c\u80fd\u529b\u3002\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684\u5169\u9805III\u671f\u8a3b\u518a\u7814\u7a76\uff08DREAMS-1\u548cDREAMS-2\uff09\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u5c07\u63d0\u4f9b\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u4eba\u7fa4\u4e2d\u7684\u5927\u898f\u6a21\u6a23\u672c\u91cf\u7684\u91ab\u5b78\u8b49\u64da\uff0c\u6211\u5011\u5e0c\u671b\u9019\u6b3e\u9ad8\u8cea\u91cf\u85e5\u7269\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u5ee3\u5927\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002\u300d \u672c\u6b21\u6587\u7ae0\u767c\u4f48\u7684\u7814\u7a76\u7d50\u679c\u4f86\u81ea\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u3002\u7814\u7a76\u5171\u5165\u7d44252\u4f8b\u5728\u7d93\u81f3\u5c113\u500b\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u4f34\u6216\u4e0d\u4f34\u7a69\u5b9a\u5291\u91cf\u4e8c\u7532\u96d9\u80cd\u6cbb\u7642\u5f8c\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73 \u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\uff0c\u63091:1:1:1:1\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd 3 mg\u30014.5 mg\u62166 mg\u3001\u5b89\u6170\u5291\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u9031\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e520\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c20\u5468\u6642HbA1c\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u3002\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u6b21\u7814\u7a76\u85e5\u7269\u6cbb\u7642\u7684\u53d7\u8a66\u8005\uff08n=250\uff09\u57fa\u7dda\u5e73\u5747BMI\u70ba27.4 kg\\\/m2\uff0c\u57fa\u7dda\u5e73\u5747HbA1c \u70ba8.06%\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u5747\u53ef\u986f\u8457\u964d\u4f4eHbA1c\u6c34\u5e73\u3002 \u7b2c20\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44HbA1c\u6c34\u5e73\u8f03\u57fa\u7dda\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba-1.41%\u3001-1.67%\u548c-1.55%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba-1.35%\uff1b\u5b89\u6170\u5291\u7d44\u70ba0.03%\u3002\u746a\u4ed5\u5ea6\u80bd\u5404\u5291\u91cf\u7d44\u7b2c20\u5468\u7684HbA1c\u6c34\u5e73\u5e73\u5747\u964d\u5e45\u5747\u986f\u8457\u5927\u65bc\u5b89\u6170\u5291\u7d44\uff08P&lt;0.0001\uff09\u3002 \u540c\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44HbA1c\uff1c7.0%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905454.0%\u300166.7%\u548c73.5%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba60.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba17.6%\uff09\uff1bHbA1c\u22646.5%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905428.0%\u300156.3%\u548c51.0%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba46.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba7.8%\uff09\u3002 \u6b64\u5916\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u986f\u8457\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u548c\u9910\u5f8c2\u5c0f\u6642\u8840\u7cd6\u6c34\u5e73\u3002 \u9ad4\u91cd\u65b9\u9762\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\uff0c\u6e1b\u91cd\u964d\u7cd6\u96d9\u9054\u6a19\u7387\u9ad8\u3002 \u7b2c20\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba-4.12%\u3001-5.31%\u548c-7.11%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba-2.69 %\uff1b\u5b89\u6170\u5291\u7d44\u70ba-1.38%\u3002 \u540c\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655.0%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905424.0%\u300137.5%\u548c57.1%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba18.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba9.8%\u3002 \u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7d44\u5206\u5225\u670916.0%\u300129.2%\u548c49.0%\u7684\u53d7\u8a66\u8005\u7b2c20\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655.0%\u4e14HbA1c\uff1c7.0%\uff0c\u5ea6\u62c9\u7cd6\u80bd\u7d44\u70ba12.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba0\u3002 \u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002 \u7814\u7a76\u6cbb\u7642\u671f\u9593\uff0c\u746a\u4ed5\u5ea6\u80bd\u7d44\u7121\u53d7\u8a66\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u85e5\u7269\u6cbb\u7642\uff0c\u7121\u53d7\u8a66\u8005\u767c\u751f\u7814\u7a76\u8005\u5224\u5b9a\u8207\u746a\u4ed5\u5ea6\u80bd\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u7814\u7a76\u671f\u9593\u672a\u767c\u751f\u91cd\u5ea6\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u3002 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Care\u767c\u8868\u4fe1\u9054\u751f\u7269\u746a\u4ed5\u5ea6\u80bd (IBI362) \u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5168\u6587 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2023\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08glucagon receptor, 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