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\u4e2d\u570b\u676d\u5dde\u548c\u7d39\u8208<\/span>2023\u5e7411\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08AASLD\uff09\u5e74\u6703\uff08The Liver Meeting\u00ae<\/sup> 2023\uff09\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\u6458\u8981\u58c1\u5831\u5f62\u5f0f\u5c55\u793aASC22\uff08\u6069\u6c83\u5229\u55ae\u6297\uff09\u7528\u65bc\u6162\u6027\u4e59\u578b\u809d\u708e\uff08\u6162\u6027\u4e59\u809d\uff09\u529f\u80fd\u6027\u6cbb\u6108\u7684IIb\u671f\u64f4\u5c55\u968a\u5217\u671f\u4e2d\u7d50\u679c\uff0c\u4e26\u4ee5\u6458\u8981\u58c1\u5831\u5f62\u5f0f\u5c55\u793aASC41\u6cbb\u7642\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684I\u671f\u7814\u7a76\u7d50\u679c\u3002<\/p>\n

\u6700\u65b0\u7a81\u7834\u6458\u8981\u58c1\u5831\u5c55\u793a\uff1a<\/b><\/p>\n

\u58c1\u5831\u7de8\u865f\uff1a5052-C<\/b><\/p>\n

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\u80cc\u666f\uff1a<\/b><\/p>\n

49\u4f8b\u57fa\u7dda\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u2264100 IU\/mL\u7684\u60a3\u8005\u64f4\u5c55\u968a\u5217\u5df2\u555f\u52d5\uff0c\u65e8\u5728\u63a2\u7d22\u5728\u6b64\u7279\u5b9a\u4eba\u7fa4\u4e2d\u5be6\u73feHBsAg\u6301\u7e8c\u6e05\u9664\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/b><\/p>\n

ASC22\u64f4\u5c55\u968a\u5217\u5165\u7d44\u4e8649\u4f8b\u57fa\u7ddaHBsAg\u2264100 IU\/mL\u7684\u60a3\u8005\u3002\u60a3\u8005\u63a5\u53d7\u6bcf\u5169\u5468\u4e00\u6b21\uff08Q2W\uff09\u76ae\u4e0b\u8a3b\u5c041.0\u6beb\u514b\/\u516c\u65a4ASC22\uff08ASC22\u968a\u5217\uff0cn=40\uff09\u6216\u5b89\u6170\u5291\uff08n=9\uff09\uff0c\u6bd4\u4f8b\u7d04\u70ba4:1\uff0c\u6cbb\u764224\u5468\uff0c\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u6838\u82f7\uff08\u9178\uff09\u985e\u4f3c\u7269\uff08NAs\uff09\u4f5c\u70ba\u80cc\u666f\u6cbb\u7642\u3002\u6cbb\u7642\u7d50\u675f\u5f8c\uff0c\u518d\u9032\u884c24\u5468\u96a8\u8a2a\u3002\u63a5\u53d7ASC22\u6cbb\u764224\u5468\u5f8c\u5be6\u73feHBsAg\u6e05\u9664\u7684\u60a3\u8005\u9810\u8a08\u5728\u96a8\u8a2a\u968e\u6bb5\u505c\u6b62NAs\u80cc\u666f\u6cbb\u7642\u3002\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70baHBsAg\u4e0b\u964d\u3002\u671f\u4e2d\u5206\u6790\u5728\u7d0450%\u5165\u7d44\u60a3\u8005\u5b8c\u621024\u5468ASC22\u6216\u5b89\u6170\u5291\u6cbb\u7642\u6642\u9032\u884c\u3002<\/p>\n

\u7d50\u8ad6\uff1a<\/b><\/p>\n

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\u58c1\u5831\u5c55\u793a\uff1a<\/b><\/p>\n

\u58c1\u5831\u7de8\u865f: 2401-C<\/b><\/p>\n

\u6a19\u984c\uff1a<\/b><\/p>\n

\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\u6fc0\u52d5\u5291ASC41\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u60a3\u8005\u4e2d\u986f\u793a\u5e7e\u4e4e\u6c92\u6709\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u3001\u964d\u8102\u6548\u679c\u986f\u8457\u4e14\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5f81\u76f8\u4f3c\uff1a\u5169\u9805I\u671f\u7814\u7a76\u7684\u7d50\u679c<\/p>\n

\u80cc\u666f\uff1a<\/b><\/p>\n

ASC41\u5728\u7f8e\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u4e2d\u7684\u85e5\u7269-\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u4ee5\u53ca\u5728\u4e2d\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u6216\u7f8e\u570b\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u53d7\u8a66\u8005\u4e2d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u3001\u5b89\u5168\u6027\u548c\u85e5\u6548\u5b78\uff08PD\uff09\u7d50\u679c\u5df2\u767c\u5e03\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/b><\/p>\n

NCT04527250<\/span><\/a><\/span> \u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u55ae\u6b21\u548c\u591a\u6b21\u5291\u91cf\u905e\u589e\u53e3\u670dASC41\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002NCT04845646<\/span><\/a><\/span> \u662f\u4e00\u9805\u958b\u653e\u6a19\u7c3d\u3001DDI\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u670d\u75285\u6beb\u514b\u55ae\u5291\u91cf\u7684ASC41\u7247\u5291\u5f8c\uff0c\u4f0a\u66f2\u5eb7\u5511\uff08CYP3A\u5f37\u6291\u88fd\u5291\uff09\u548c\u82ef\u59a5\u82f1\uff08CYP3A\u5f37\u8a98\u5c0e\u5291\uff09\u5c0dASC41\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u5f71\u97ff\u4ee5\u53caASC41\u5728NAFLD\u60a3\u8005\u4e2d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u3002<\/p>\n

\u7d50\u8ad6\uff1a<\/b><\/p>\n

ASC41\u7684\u6d3b\u6027\u4ee3\u8b1d\u7269ASC41-A\u5728\u7f8e\u570b\u548c\u4e2d\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u4ee5\u53caNAFLD\u60a3\u8005\u4e2d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u76f8\u4f3c\u3002ASC41\u8868\u73fe\u51fa\u986f\u8457\u964d\u4f4e\u4e86\u8102\u80aa\u3002ASC41\u8868\u73fe\u51fa\u4e86\u4ee4\u4eba\u6eff\u610f\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002ASC41\/ASC41-A\u8207\u5f37\u6548CYP3A4\u6291\u88fd\u5291\u6216\u8a98\u5c0e\u5291\u7684\u85e5\u7269-\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u5f31\uff0c\u986f\u793a\u51fa\u5176\u76f8\u8f03\u5176\u4ed6\u8655\u65bc\u5f8c\u671f\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u6fc0\u52d5\u5291\u7684\u7af6\u722d\u512a\u52e2\u3002ASC41\/ASC41-A\u8207\u6700\u5e38\u7528\u7684\u6297\u6291\u90c1\u85e5\u7269\u548c\u4ed6\u6c40\u985e\u85e5\u7269\u4e4b\u9593\u7522\u751f\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u85e5\u7269-\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u5c0f\uff0c\u8868\u660e\u5176\u53ef\u5728NASH\u60a3\u8005\u4e2d\u5ee3\u6cdb\u4f7f\u7528\u3002ASC41\u76ee\u524d\u6b63\u5728\u958b\u5c55\u4e00\u9805\u70ba\u671f52\u5468\u7684II\u671f\u8a66\u9a57\uff0c\u7528\u65bc\u6cbb\u7642\u6d3b\u6aa2\u8b49\u5be6\u7684NASH\u60a3\u8005\u3002<\/p>\n

\u300c\u975e\u5e38\u69ae\u5e78\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\u4ee5\u6700\u65b0\u7a81\u7834\u6458\u8981\u58c1\u5831\u548c\u6458\u8981\u58c1\u5831\u5206\u5225\u5c55\u793a\u4e86ASC22\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108IIb\u64f4\u5c55\u968a\u5217\u7684\u671f\u4e2d\u7d50\u679c\u548cASC41\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684I\u671f\u7814\u7a76\u7d50\u679c\uff0c\u9019\u6a19\u8a8c\u8457\u6b4c\u79ae\u5728\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u9818\u57df\u53d6\u5f97\u4e86\u65b0\u7684\u7a4d\u6975\u9032\u5c55\u3002\u6162\u6027\u4e59\u809d\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u5728\u4e16\u754c\u7bc4\u570d\u5167\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\uff1a\u4e2d\u570b\u7d04\u67098,600\u842c\u4eba\u611f\u67d3\u4e59\u809d\u75c5\u6bd2[1]<\/sup>\uff0c\u5176\u4e2d\u7d04\u670915%~22%\u7684\u60a3\u8005\u4e59\u809d\u8868\u9762\u6297\u539f\u5c0f\u65bc\u7b49\u65bc100 IU\/mL[2][3]<\/sup>\uff1b\u52302030\u5e74\u4e2d\u570b\u9810\u8a08\u7d04\u67094,800\u842c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u60a3\u8005[4]<\/sup>\uff0c\u76ee\u524d\u5c1a\u7121\u4efb\u4f55\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u85e5\u7269\u7372\u6279\u4e0a\u5e02\u3002\u6211\u5011\u5c07\u52a0\u5feb\u81e8\u5e8a\u7814\u7a76\uff0c\u7e7c\u7e8c\u63d0\u9ad8\u6211\u5011\u5728\u809d\u75c5\u6cbb\u7642\u9818\u57df\u7684\u7af6\u722d\u529b\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n

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[1]Lim J K, Nguyen M H, Kim W R, et al. Prevalence of Chronic Hepatitis B Virus Infection in the United States [J]. The American journal of gastroenterology 2020, 115(9): 1429-38.<\/p>\n

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[2]Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0<\/p>\n

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[3]Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022<\/p>\n

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[4]Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0<\/p>\n

<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u95dc\u65bcAASLD<\/b><\/p>\n

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IU\/mL\uff1b\u52302030\u5e74\u4e2d\u570b\u9810\u8a08\u7d04\u67094,800\u842c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u7121\u4efb\u4f55\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u85e5\u7269\u7372\u6279\u4e0a\u5e02\u3002\u6211\u5011\u5c07\u52a0\u5feb\u81e8\u5e8a\u7814\u7a76\uff0c\u7e7c\u7e8c\u63d0\u9ad8\u6211\u5011\u5728\u809d\u75c5\u6cbb\u7642\u9818\u57df\u7684\u7af6\u722d\u529b\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 Lim J K, Nguyen M H, Kim W R, et al. Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0 Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022 Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0 \u95dc\u65bcAASLD 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content=\"\u6b4c\u79ae\u5ba3\u5e03\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\u7684\u58c1\u5831\u5c55\u793a\u5305\u62ecASC22\u7528\u65bc\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108IIb\u671f\u64f4\u5c55\u968a\u5217\u671f\u4e2d\u7d50\u679c\u7684\u6700\u65b0\u7a81\u7834\u6458\u8981 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u570b\u676d\u5dde\u548c\u7d39\u82082023\u5e7411\u670813\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08AASLD\uff09\u5e74\u6703\uff08The Liver Meeting\u00ae 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Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0 Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022 Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0 \u95dc\u65bcAASLD 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Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\\\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0 Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022 Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0 \u95dc\u65bcAASLD 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IU\/mL\uff1b\u52302030\u5e74\u4e2d\u570b\u9810\u8a08\u7d04\u67094,800\u842c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u7121\u4efb\u4f55\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u85e5\u7269\u7372\u6279\u4e0a\u5e02\u3002\u6211\u5011\u5c07\u52a0\u5feb\u81e8\u5e8a\u7814\u7a76\uff0c\u7e7c\u7e8c\u63d0\u9ad8\u6211\u5011\u5728\u809d\u75c5\u6cbb\u7642\u9818\u57df\u7684\u7af6\u722d\u529b\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 Lim J K, Nguyen M H, Kim W R, et al. Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0 Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022 Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0 \u95dc\u65bcAASLD 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Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. 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Prevalence of Chronic Hepatitis B Virus Infection in the United States . The American journal of gastroenterology 2020, 115(9): 1429-38. Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0 Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022 Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0 \u95dc\u65bcAASLD 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