{"id":191984,"date":"2023-11-08T18:00:00","date_gmt":"2023-11-08T10:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=191984"},"modified":"2023-11-08T18:00:00","modified_gmt":"2023-11-08T10:00:00","slug":"%e5%a4%a9%e6%bc%94%e8%97%a5%e6%a5%ad%ef%bc%88adag-us%ef%bc%89%e5%9c%a8%e7%ac%ac38%e5%b1%86sitc%e5%b9%b4%e6%9c%83%e4%b8%8a%e5%85%ac%e4%bd%88%e5%85%b6%e7%b2%be%e6%ba%96%e6%8e%a9%e8%94%bd%e5%9e%8b","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=191984","title":{"rendered":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da"},"content":{"rendered":"
\n

\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c<\/i>10 mg\/kg<\/i>\u6bcf<\/i>3<\/i>\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08<\/i>MSS CRC<\/i>\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3<\/i><\/p>\n

\u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86<\/i>ADG126<\/i>\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624<\/i>CTLA-4<\/i>\u806f\u5408\u6297<\/i>PD-1<\/i>\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578<\/i><\/p>\n

\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e5<\/span>2023\u5e7411\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b> ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347<\/a>\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002<\/p>\n

\u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b> ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002<\/p>\n

\u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002<\/p>\n

\u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae<\/span><\/b>\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002<\/p>\n

\u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b> ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76<\/a>\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002<\/p>\n

\u95dc\u65bc<\/u><\/b>ADG126<\/u><\/b>\u53ca\u5b89\u5168\u6297\u9ad4<\/u><\/b>SAFEbody\u00ae<\/span><\/b><\/u><\/b>\u6280\u8853<\/u><\/b><\/p>\n

\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b>\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b>\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002<\/p>\n

\u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002<\/p>\n

\u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002<\/p>\n

*<\/i>\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08<\/i>MSS CRC<\/i>\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u7684<\/i>95%<\/i>\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002<\/i><\/p>\n

\u95dc\u65bc\u5929\u6f14\u85e5\u696d<\/b><\/p>\n

\u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae<\/span><\/b>\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002<\/p>\n

\u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com<\/a>\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1<\/a>\u3001\u9818\u82f1<\/a>\u53ca\u63a8\u7279<\/a>\u5b98\u65b9\u8cec\u865f\u3002<\/p>\n

SAFEbody\u00ae<\/span><\/b> \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002<\/p>\n

\u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e<\/b><\/p>\n

\u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c…<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-191984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=191984\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=191984\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-08T10:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da\",\"datePublished\":\"2023-11-08T10:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984\"},\"wordCount\":95,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984\",\"name\":\"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"datePublished\":\"2023-11-08T10:00:00+00:00\",\"description\":\"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\\\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\\\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\\\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\\\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\\\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\\\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\\\/\\\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":\"3000\",\"height\":\"1990\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=191984#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=191984","og_locale":"zh_TW","og_type":"article","og_title":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=191984","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2023-11-08T10:00:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da","datePublished":"2023-11-08T10:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984"},"wordCount":95,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=191984","url":"https:\/\/pingtungtimes.com.tw\/?p=191984","name":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","datePublished":"2023-11-08T10:00:00+00:00","description":"\u6578\u64da\u5c55\u793a\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u7528\u9023\u7e8c\u7d66\u85e5\u7684\u5291\u91cf\u512a\u5316\uff0c10 mg\/kg\u6bcf3\u9031\u4e00\u6b21\u7684\u65b9\u6848\u76ee\u524d\u6b63\u5728\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u4e2d\u9032\u884c\u968a\u5217\u64f4\u5c55\u7814\u7a76\uff0c\u4e26\u89c0\u5bdf\u5230\u4e00\u4f8b\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3 \u7d9c\u5408\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u81e8\u5e8a\u6578\u64da\u5206\u6790\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\uff0c\u64c1\u6709\u8de8\u816b\u7624CTLA-4\u806f\u5408\u6297PD-1\u7642\u6cd5\u6700\u4f73\u6cbb\u7642\u6307\u6578 \u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u8056\u5730\u4e9e\u54e52023\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5929\u6f14\u85e5\u696d\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u516c\u53f8\u300d\u6216\u300c\u5929\u6f14\u300d\uff09\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u7642\u6cd5\u3002\u4eca\u5929\uff0c\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u53ec\u958b\u7684\u7b2c38\u5c46\u7f8e\u570b\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u5b78\u6703\uff08The Society for Immunotherapy of Cancer\uff0c\u7c21\u7a31SITC\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u53f8\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u7684\u5291\u91cf\u512a\u5316\u6700\u65b0\u8a66\u9a57\u7d50\u679c\u3002\u6d77\u5831\u6a19\u984c\u70ba\uff1a\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\uff08Quantitative Systems Pharmacology, QSP\uff09\u6a21\u578b\u6307\u5c0e\u4e0b\u7684ADG126\uff08\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae \uff09\u806f\u5408\u6297PD-1\u6297\u9ad4\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u6cbb\u7642\u6307\u6578\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\uff08Ipilimumab\uff09\u986f\u8457\u63d0\u5347\uff0c\u5177\u9ad4\u5167\u5bb9\u53ef\u767b\u9678\u516c\u53f8\u5b98\u7db2\u67e5\u95b1\u3002 \u7d9c\u5408\u81e8\u5e8a\u7d50\u679c\u8207\u751f\u7406\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u5b9a\u91cf\u7cfb\u7d71\u85e5\u7406\u5b78\u6a21\u578b\u8868\u660e\uff0c\u5929\u6f14\u85e5\u696d\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u53ef\u6709\u6548\u9776\u5411\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684CTLA-4\u3002ADG126\uff0810 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u76f8\u8f03\u4f0a\u5339\u55ae\u6297\uff081 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf6\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0c\u5176\u6cbb\u7642\u6307\u6578\u63d0\u5347\u9ad8\u905430\u500d\u3002 \u7531\u65bcADG126\u80fd\u5920\u66f4\u591a\u5730\u5728\u816b\u7624\u5fae\u74b0\u5883\u800c\u975e\u5916\u5468\u5faa\u74b0\u8840\u6db2\u74b0\u5883\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u5176\u6cbb\u7642\u6307\u6578\u5f97\u5230\u986f\u8457\u63d0\u5347\uff0c\u5f9e\u800c\u4f7fADG126\u80fd\u4ee5\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u4e26\u53ef\u591a\u6b21\u806f\u5408\u6297PD-1\u91cd\u8907\u7d66\u85e5\u3002\u6b64\u5916\uff0c\u6578\u64da\u7d50\u679c\u9084\u8868\u660e\uff0c\u4ee510 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u7684\u5291\u91cf\u512a\u5316\uff0c\u53ef\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7642\u6548\uff0c\u4e14\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e26\u672a\u986f\u8457\u589e\u52a0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6b63\u5728\u9032\u884c\u7684\u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u665a\u671f\/\u8f49\u79fb\u6027\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c*\u60a3\u8005\u7684\u968a\u5217\u64f4\u5c55\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u5c55\u793a\u4e86\u4e00\u4f8b\u81e8\u5e8a\u75c5\u4f8b\uff0c\u63a5\u53d710 mg\/kg\u7684\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u5728\u6cbb\u76424\u500b\u9031\u671f\uff08\u537312\u5468\uff09\u5f8c\u89c0\u5bdf\u5230\u78ba\u8a8d\u7684\u90e8\u5206\u7de9\u89e3\u3002\u8a72\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u904e\u5169\u7a2e\u7642\u6cd5\uff08\u5206\u5225\u70ba\u8c9d\u4f10\u73e0\u55ae\u6297\u548cFOLFOX\u65b9\u6848\u806f\u7528\uff0c\u4ee5\u53ca\u963f\u67cf\u897f\u666e\u548cFOLFIRI\u65b9\u6848\u806f\u7528\uff09\uff0c\u4e14\u89c0\u5bdf\u5230\u53ef\u63a7\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8207\u514d\u75ab\u7642\u6cd5\u4e2d\u5df2\u77e5\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u4e00\u81f4\u3002 \u8a72\u6d77\u5831\u7d50\u8ad6\u5982\u4e0b\uff1a\u4f86\u81eaSAFEbody\u00ae\u00a0ADG126\u7814\u7a76\u9805\u76ee\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u8b49\u5be6\uff0c\u5c0d\u6bd4\u4f0a\u5339\u55ae\u6297\u806f\u5408\u6297PD-1\u7642\u6cd5\uff0cADG126\u806f\u5408\u6297PD-1\u7642\u6cd5\u5728\u300c\u71b1\u300d\u816b\u7624\u548c\u300c\u51b7\u300d\u816b\u7624\uff08\u5305\u62ec\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff09\u4e2d\u90fd\u53ef\u5e36\u4f86\u66f4\u5927\u7684\u81e8\u5e8a\u7372\u76ca\uff0c\u9019\u662f\u7531\u65bcADG126\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u80fd\u5920\u66f4\u597d\u5730\u8207\u9776\u9ede\u7d50\u5408\uff0c\u5f9e\u800c\u5177\u5099\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u4f7f\u66f4\u9ad8\u5291\u91cf\u3001\u66f4\u9ad8\u983b\u7387\u7684\u591a\u6b21\u91cd\u8907\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002 \u8655\u65bc\u9818\u5148\u81e8\u5e8a\u968e\u6bb5\u7684\u6297CTLA-4 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\uff0c\u7d50\u5408\u4e86\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u548c\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u529f\u80fd\uff0c\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u958b\u5c55\u4e00\u98052\u671f\u5291\u91cf\u64f4\u5c55\u968a\u5217\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30ADG126\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u5728\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u95dc\u65bcADG126\u53ca\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853 \u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u6280\u8853\u65e8\u5728\u901a\u904e\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u8f15\u7531\u65bc\u9776\u5411\u5728\u5065\u5eb7\u7d44\u7e54\u4e2d\u8868\u9054\u7684\u9776\u9ede\u800c\u8a98\u767c\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u89e3\u6c7a\u6297\u9ad4\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u554f\u984c\u3002ADG126\u662f\u4e00\u7a2e\u63a9\u853d\u578b\u6297CTLA-4\u7642\u6cd5\uff0c\u5c07\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u4f5c\u7528\u65bc\u89aa\u672c\u6297\u9ad4ADG116\u800c\u751f\u6210\uff0c\u5be6\u73fe\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u7279\u7570\u6027\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u89e3\u6c7a\u73fe\u6709\u6297CTLA-4\u6709\u6548\u7d66\u85e5\u5291\u91cf\u548c\u512a\u5316\u7d66\u85e5\u9031\u671f\u4e2d\u5b58\u5728\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\uff0c\u5f9e\u800c\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002 \u6b64\u5916\uff0c\u63a9\u853d\u578bADG126\u7d50\u5408\u8207ADG116\u76f8\u540c\u7684\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7368\u7279\u8868\u4f4d\uff0c\u901a\u904e\u5f37\u529b\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u4e26\u767c\u63ee\u90e8\u5206\u914d\u9ad4\u963b\u65b7\u6548\u679c\uff0c\u7a69\u6b65\u7a4d\u7d2f\u4e26\u5ef6\u9577\u85e5\u7269\u5c0d\u816b\u7624\u7684\u6bba\u50b7\u4f5c\u7528\uff0c\u5f9e\u800c\u63d0\u5347\u5b89\u5168\u6027\u8207\u7642\u6548\u3002 \u81e8\u5e8a\u7d50\u679c\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7684\u5206\u6790\u6578\u64da\u8b49\u5be6\u4e86ADG126\u7684\u7368\u7279\u4f5c\u7528\u6a5f\u5236\u53ca\u5176\u4f5c\u70ba\u540c\u985e\u6700\u4f73CTLA-4\u7642\u6cd5\u7684\u6f5b\u529b\u3002 *\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\uff08MSS CRC\uff09\u75c5\u4f8b\u7d04\u5360\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u768495%\u3002\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u816b\u7624\u88ab\u7a31\u70ba\u300c\u51b7\u300d\u816b\u7624\uff0c\u56e0\u70ba\u5b83\u5011\u901a\u5e38\u4e0d\u6703\u5f15\u767c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u5f37\u70c8\u53cd\u61c9\u3002\u76ee\u524d\u9084\u6c92\u6709\u91dd\u5c0d\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u7d50\u76f4\u8178\u764c\u7684\u7372\u6279\u816b\u7624\u514d\u75ab\u7642\u6cd5\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d \u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a45\u52d5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5c08\u6709\u7684\u52d5\u614b\u7cbe\u6e96\u6297\u9ad4\u6280\u8853\uff08\u5373\u4e09\u9ad4\u6280\u8853\uff0c\u7531\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\u4e09\u7a2e\u7368\u5bb6\u5c08\u5229\u6280\u8853\u7d44\u6210\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002 \u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a https:\/\/investor.adagene.com\uff0c\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u8cec\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u85e5\u696d\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u95dc\u65bc\u5b89\u5168\u6e2f\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ecADG126\u90e8\u5206\u81e8\u5e8a\u7d50\u679c\uff0cADG126\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u610f\u7fa9\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u5c0d\u5176\u5019\u9078\u7522\u54c1\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u7684\u63a8\u9032\u548c\u9810\u671f\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u50cf\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u8cc7\u91d1\u7528\u65bc\u904b\u71df\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u85e5\u696d\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u7684\u6587\u4ef6\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u8a73\u7d30\u63a2\u8a0e\u7684\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=191984"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":"3000","height":"1990"},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=191984#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u5929\u6f14\u85e5\u696d\uff08ADAG.US\uff09\u5728\u7b2c38\u5c46SITC\u5e74\u6703\u4e0a\u516c\u4f48\u5176\u7cbe\u6e96\u63a9\u853d\u578b\u6297CTLA-4\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae ADG126\u5177\u5099\u540c\u985e\u6700\u4f73\u6cbb\u7642\u6307\u6578\u53ca\u5176\u5728\u51b7\u816b\u7624\u4e2d\u7684\u76f8\u95dc\u6578\u64da"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/191984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=191984"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/191984\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/199219"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=191984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=191984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=191984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}