{"id":186842,"date":"2023-10-26T12:56:00","date_gmt":"2023-10-26T04:56:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=186842"},"modified":"2023-10-26T12:56:00","modified_gmt":"2023-10-26T04:56:00","slug":"2023-esmo%ef%bd%9c%e6%ae%b7%e8%a9%a0%e6%a2%85%e6%95%99%e6%8e%88%ef%bc%9atrop2-adc-skb264%e7%a0%b4%e5%b1%80hr-her2-%e4%b9%b3%e8%85%ba%e7%99%8c%e6%b2%bb%e7%99%82%e5%9b%b0%e5%a2%83","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=186842","title":{"rendered":"2023 ESMO\uff5c\u6bb7\u8a60\u6885\u6559\u6388\uff1aTROP2-ADC SKB264\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\u6cbb\u7642\u56f0\u5883"},"content":{"rendered":"
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\u4e2d\u570b\u539f\u5275<\/b>TROP2-ADC<\/b>\u52c7\u6500\u9ad8\u5cf0\uff0c\u6311\u6230\u7d93\u6cbb<\/b>HR+\/HER2-<\/b>\u8f49\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7642\u56f0\u5c40<\/b><\/p>\n

\u64da\u570b\u969b\u764c\u75c7\u7814\u7a76\u6a5f\u69cb(IARC)2020\u8cc7\u6599\u986f\u793a\uff0c\u4e73\u817a\u764c\u65b0\u767c\u75c5\u4f8b\u6578\u5df2\u8d85\u904e\u80ba\u764c\uff0c\u6210\u70ba\u5168\u7403\u7b2c\u4e00\u5927\u764c\u7a2e\u3002\u5176\u4e2dHR+\/HER2-\u4e73\u817a\u764c\u5360\u6bd4\u7d04\u70ba70%\uff0c\u662f\u6700\u5e38\u898b\u7684\u4e73\u817a\u764c\u4e9e\u578b\u3002\u5167\u5206\u6ccc\u6cbb\u7642\u662fHR+\/HER2-\u4e73\u817a\u764c\u6cbb\u7642\u7684\u57fa\u77f3\uff0c\u800cCDK4\/6\u6291\u5236\u5291\u6975\u5927\u5ef6\u9577\u4e86HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u751f\u5b58\u6642\u9593\u3002\u4f46\u5c0d\u65bc\u5167\u5206\u6ccc\u548cCDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u7576\u524d\u53ef\u9078\u7684\u6cbb\u7642\u65b9\u6848\u7642\u6548\u6709\u9650\uff0c\u4e9f\u9700\u66f4\u6709\u6548\u7684\u6cbb\u7642\u85e5\u7269\uff0c\u6539\u5584\u81e8\u5e8a\u9810\u5f8c\u3002<\/p>\n

\u8fd1\u5e74\u4f86\uff0c\u4ee5TROP2-ADC\u70ba\u4ee3\u8868\u7684\u65b0\u578bADC\u85e5\u7269\uff0c\u70baHR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u5e36\u4f86\u4e86\u65b0\u7684\u9078\u64c7\u3002\u6208\u6c99\u59a5\u73e0\u55ae\u6297\uff08SG\uff09\u5df2\u7372FDA\u6279\u51c6\u7528\u65bc\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u548c\u22652\u7dda\u7cfb\u7d71\u6cbb\u7642\uff08\u91dd\u5c0d\u8f49\u79fb\u6027\u75be\u75c5\uff09\u7684HR+\/HER2-\u4e73\u817a\u764c\u9069\u61c9\u75c7\uff1b\u6b64\u5916\uff0c\u540c\u6a23\u9776\u5411TROP2\u7684Dato-DXd\u7684\u2162\u671f\u7814\u7a76\u4e5f\u5728\u4eca\u5e74ESMO\u5927\u6703\u4e0a\u516c\u4f48\u3002\u4f46\u76ee\u524d\u5c1a\u7121TROP2-ADC\u5728\u570b\u5167\u7372\u6279\u7528\u65bcHR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u3002<\/p>\n

SKB264\u662f\u7531\u79d1\u502b\u535a\u6cf0\u81ea\u4e3b\u7814\u767c\u7684\u5275\u65b0TROP2-ADC\uff0c\u6b64\u6b21\u4eae\u76f82023 ESMO\u7684\u7814\u7a76\uff0c\u521d\u6b65\u63a2\u7d22\u4e86SKB264\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u53ca\u5b89\u5168\u6027\uff0c\u5176\u5c55\u793a\u7684\u5353\u6709\u524d\u666f\u7684\u7642\u6548\u8cc7\u6599\uff0c\u5c0d\u81e8\u5e8a\u6cbb\u7642\u548c\u5f8c\u7e8c\u63a2\u7d22\u7684\u50f9\u503c\uff0c\u6210\u70ba\u672c\u6b21\u5165\u9078ESMO\u53e3\u982d\u5831\u544a\u7684\u4e3b\u8981\u56e0\u7d20\u3002SKB264<\/b>\u7528\u65bc<\/b>\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027<\/b>HR+\/HER2-<\/b>\u4e73\u817a\u764c\u60a3\u8005\u5df2\u7372\u5f97<\/b>\u4e2d\u570b\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08<\/b>CDE<\/b>\uff09\u6388\u4e88\u7684\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/b><\/p>\n

\u5728\u4e73\u817a\u764c\u9818\u57df\uff0c\u9664\u4e86HR+\/HER2-\u4e73\u817a\u764c\uff0cSKB264<\/b>\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027<\/b>TNBC<\/b>\u4e5f\u7372\u5f97<\/b>CDE<\/b>\u6388\u4e88\u7684\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/b>SKB264<\/b>\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027<\/b>TNBC<\/b>\u7684\u2162\u671f\u8a3b\u518a\u7814\u7a76\u5df2\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\uff0c\u8a08\u756b\u5e74\u5e95\u7533\u5831\u4e0a\u5e02\uff0c\u6709\u671b\u5728\u4e2d\u570b\u6210\u70ba\u9996\u500b\u5b8c\u5168\u7372\u6279\u7684<\/b>TROP2-ADC<\/b>\u3002<\/b><\/p>\n

SKB264<\/b>\u7642\u6548\u8cc7\u6599\u4eae\u773c\uff0c\u6709\u671b\u6210\u70ba\u7d93\u6cbb<\/b>HR+\/HER2-<\/b>\u8f49\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7642\u65b0\u9078\u64c7<\/b><\/p>\n

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SKB264<\/b>\u7368\u7279\u7d50\u69cb\u8a2d\u8a08\uff0c\u517c\u9867\u5f37\u5927\u6297\u816b\u7624\u6d3b\u6027\u8207\u5b89\u5168\u6027<\/b><\/p>\n

SKB264\u6240\u5c55\u793a\u51fa\u7684\u826f\u597d\u6297\u816b\u7624\u4f5c\u7528\u548c\u5b89\u5168\u6027\uff0c\u5f97\u76ca\u65bc\u5176ADC\u85e5\u7269\u7684\u8a2d\u8a08\u3002 SKB264\u7531\u5177\u6709\u826f\u597d\u89aa\u548c\u529b\u548c\u9776\u5411\u6027\u7684\u4eba\u6e90\u5316\u6297TROP2\u55ae\u6297\uff0c\u901a\u904e\u7a69\u5b9a\u6027\u7d93\u904e\u512a\u5316\u7684<\/b>CL2A<\/b>\u9023\u63a5\u5b50<\/b>\uff08<\/b>\u9023\u63a5\u5b50\u7684\u6297\u9ad4\u7aef\u63a1\u7528\u7532\u78fa\u91af\u57fa\u5627\u5576\u5be6\u73fe\u8207\u6297\u9ad4\u4e0d\u53ef\u9006\u5076\u806f<\/b>\uff09<\/b>\uff0c\u8207\u81ea\u7814\u6bd2\u7d20\u5c0f\u5206\u5b50<\/b>T030(<\/b>\u62d3\u64b2\u7570\u69cb\u9176\u2160\u6291\u5236\u5291<\/b>)<\/b>\u7d50\u5408\u800c\u6210\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4<\/b>(DAR)<\/b>\u5e73\u5747\u9ad8\u9054<\/b>7.4<\/b>\u3002<\/b>T030<\/b>\u6d3b\u6027\u8207<\/b>DXD<\/b>\u76f8\u7576\uff0c\u542b\u6709\u7532\u57fa\u78b8\u7d50\u69cb\uff0c\u53ef\u8207\u9023\u63a5\u5b50\u7684\u6bd2\u7d20\u7aef\u7a69\u5b9a\u7d50\u5408\uff0c\u6e1b\u5c11\u812b\u843d\u3002<\/b>SKB264<\/b>\u5728\u8840\u6db2\u8ff4\u5708\u4e2d\u7a69\u5b9a\u6027\u8f03\u9ad8\uff0c\u534a\u8870\u671f\u8f03\u9577\uff0c\u4f7f\u66f4\u591a\u85e5\u7269\u80fd\u5230\u9054\u8868\u9054<\/b>TROP2<\/b>\u7684\u816b\u7624\u7d30\u80de\uff0c\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u3002<\/b><\/p>\n

SKB264<\/b>\u5177\u6709\u4e09\u91cd\u6297\u816b\u7624\u4f5c\u7528\uff0c\u9996\u5148\uff0c<\/b>\u901a\u904e\u9776\u5411TROP2\u7684\u6297\u9ad4\u5230\u9054\u816b\u7624\u7d30\u80de\u5f8c\uff0c\u5c0dpH\u654f\u611f\u7684\u9023\u63a5\u5b50\u5728\u9178\u6027\u816b\u7624\u5fae\u74b0\u5883\u5373\u53ef\u88c2\u89e3\uff0c\u91cb\u653e\u6bd2\u7d20\u5c0f\u5206\u5b50\u6bba\u50b7\u5468\u570d\u816b\u7624\u7d30\u80de\u3002\u5176\u6b21\uff0c<\/b>SKB264\u88ab\u5167\u541e\u9032\u8868\u9054TROP2\u6297\u539f\u7684\u816b\u7624\u7d30\u80de\u5f8c\uff0c\u9023\u63a5\u5b50\u7684\u6bd2\u7d20\u7aef\u53ef\u88ab\u80de\u5167\u6eb6\u9176\u9ad4\u5207\u5272\uff0c\u91cb\u653e\u6bd2\u7d20\u5c0f\u5206\u5b50\u6bba\u50b7\u816b\u7624\u7d30\u80de\u3002\u6700\u5f8c\uff0c<\/b>\u6bd2\u7d20\u5c0f\u5206\u5b50\u9084\u80fd\u900f\u51fa\u7d30\u80de\u819c\uff0c\u767c\u63ee\u300c\u65c1\u89c0\u8005\u6548\u61c9\u300d\uff0c\u7e7c\u7e8c\u6bba\u50b7\u5468\u570d\u816b\u7624\u7d30\u80de\u3002<\/p>\n

SKB264\u7684\u85e5\u7269\u8a2d\u8a08\uff0c\u5728\u4fdd\u8b49\u9ad8\u6548\u6297\u816b\u7624\u6d3b\u6027\u7684\u540c\u6642\uff0c\u5f88\u597d\u5730\u5e73\u8861\u4e86\u5b89\u5168\u6027\u3002<\/p>\n

\u6df1\u5ea6\u4f48\u5c40<\/b>HR+\/HER2-<\/b>\u8f49\u79fb\u6027\u4e73\u817a\u764c\uff0c<\/b>SKB264<\/b>\u6709\u671b\u5275\u9020\u66f4\u591a\u4f73\u7e3e<\/b><\/p>\n

SKB264<\/b>\u7528\u65bc\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u7dda\u5316\u7642\u7684<\/b>HR+\/HER2-<\/b>\u8f49\u79fb\u6027\u4e73\u817a\u764c\u7684\u4e2d\u570b\u591a\u4e2d\u5fc3\u2162\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u5df2\u7372\u6279\u958b\u5c55\uff1b\u91dd\u5c0d\u65e2\u5f80\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684<\/b>HR+\/HER2-<\/b>\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u4e5f\u5373\u5c07\u958b\u5c55\uff1b\u540c\u6642<\/b>SKB264<\/b>\u806f\u5408\u6216\u4e0d\u806f\u5408<\/b>KL-A167(<\/b>\u6297<\/b>PD-L1<\/b>\u55ae\u6297<\/b>)<\/b>\u7528\u65bc<\/b>HER2<\/b>\u9670\u6027\uff08\u5305\u62ec<\/b>HR+\/HER2-<\/b>\u548c<\/b>TNBC) <\/b>\u4e73\u817a\u764c<\/b>\u60a3\u8005\u4e00\u7dda\u6cbb\u7642\u7684\u2161\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/b>\u671f\u5f85\u9019\u4e9b\u7814\u7a76\u80fd\u5920\u9032\u4e00\u6b65\u8b49\u5be6SKB264\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u6cbb\u7642\u50f9\u503c\uff0c\u70ba\u6b64\u985e\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

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