{"id":186293,"date":"2023-10-24T11:25:00","date_gmt":"2023-10-24T03:25:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=186293"},"modified":"2023-10-24T11:25:00","modified_gmt":"2023-10-24T03:25:00","slug":"2023-esmo%ef%bd%9cskb264%ef%bc%88trop2-adc%ef%bc%89%e7%94%a8%e6%96%bc%e7%b6%93%e6%b2%bbhr-her2-%e8%bd%89%e7%a7%bb%e6%80%a7%e4%b9%b3%e8%85%ba%e7%99%8c%e6%82%a3%e8%80%85%e5%89%8d%e6%99%af%e5%8f%af","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=186293","title":{"rendered":"2023 ESMO\uff5cSKB264\uff08TROP2-ADC\uff09\u7528\u65bc\u7d93\u6cbbHR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u524d\u666f\u53ef\u671f\uff0c\u591a\u764c\u7a2e\u958b\u767c\u9f4a\u982d\u4e26\u9032"},"content":{"rendered":"
\n

\u6210\u90fd<\/span>2023\u5e7410\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4eba\u6ecb\u990a\u5c64\u7d30\u80de\u8868\u9762\u6297\u539f 2\uff08TROP2\uff09\u5728\u591a\u7a2e\u5be6\u9ad4\u7624\u9ad8\u8868\u9054\uff0c\u662f\u8fd1\u5e74\u4f86\u816b\u7624\u9818\u57df\u7684\u71b1\u9580\u9776\u9ede\uff0c\u570d\u7e5e\u9019\u4e00\u9776\u9ede\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC\uff09\u7684\u7814\u767c\u9032\u5c55\u5099\u53d7\u95dc\u6ce8\u3002\u572810\u670820-24\u65e5\u65bc\u897f\u73ed\u7259\u99ac\u5fb7\u91cc\u8209\u884c\u76842023\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u5927\u6703\u4e0a\uff0c\u7531\u79d1\u502b\u535a\u6cf0\u548c\u9ed8\u6c99\u6771\u806f\u5408\u958b\u767c\u7684\u5275\u65b0TROP2-ADC\uff08SKB264\uff0cMK-2870\uff09\u7528\u65bc\u7d93\u6cbb\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027\uff08HR+\uff09\/\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad42\u9670\u6027\uff08HER2-\uff09\u8f49\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\uff1a\u4e00\u9805\u2160\/\u2161\u671f\u55ae\u81c2\u3001\u7c43\u5b50\u8a66\u9a57\u7684\u7d50\u679c\uff08\u6458\u8981\u865f\uff1a380MO\uff09\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\uff0c\u7814\u7a76\u7d50\u679c\u8b49\u5be6\u4e86SKB264\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u5177\u6709\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u6bb7\u8a60\u6885\u6559\u6388\u4ee3\u8868\u7814\u7a76\u5718\u968a\u5728\u6703\u4e0a\u5c0d\u7814\u7a76\u53ca\u5176\u4e3b\u8981\u7d50\u679c\u9032\u884c\u4e86\u5927\u6703\u5831\u544a\u3002<\/p>\n

\u7814\u7a76\u80cc\u666f<\/b><\/p>\n

TROP2\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u4e2d\u904e\u8868\u9054\uff0c\u4e14\u88ab\u8b49\u5be6\u8207\u60a3\u8005\u7684\u4e0d\u826f\u9810\u5f8c\u6709\u95dc\u3002SKB264<\/b>\u662f\u4e00\u6b3e\u7cbe\u5999\u8a2d\u8a08\u7684\u9776\u5411<\/b>TROP2<\/b>\u7684<\/b>ADC<\/b>\uff0c\u7531\u4eba\u6e90\u5316\u6297<\/b>TROP2<\/b>\u55ae\u6297\uff0c\u901a\u904e\u7a69\u5b9a\u6027\u7d93\u904e\u512a\u5316\u7684<\/b>CL2A<\/b>\u9023\u63a5\u5b50<\/b>\uff08<\/b>\u9023\u63a5\u5b50\u7684\u6297\u9ad4\u7aef\u63a1\u7528\u7532\u78fa\u91af\u57fa\u5627\u5576\u5be6\u73fe\u8207\u6297\u9ad4\u4e0d\u53ef\u9006\u5076\u806f<\/b>\uff09<\/b>\uff0c\u8207\u6bd2\u7d20\u5c0f\u5206\u5b50<\/b>T030<\/b>\uff08<\/b>\u62d3\u64b2\u7570\u69cb\u9176<\/b>\u2160<\/b>\u6291\u5236\u5291<\/b>\uff09<\/b>\u7d50\u5408\u800c\u6210\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4<\/b>\uff08<\/b>DAR<\/b>\uff09<\/b>\u5e73\u5747\u9ad8\u9054<\/b>7.4<\/b>\u3002<\/b>\u672c\u7814\u7a76\u662f\u9019\u4e00\u5275\u65b0\u85e5\u7269\u7528\u65bcHR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005II\u671f\u4f47\u5217\u7814\u7a76\u7684\u9996\u6b21\u516c\u958b\u5831\u544a\u3002<\/p>\n

\u7814\u7a76\u65b9\u6cd5<\/b><\/p>\n

HR+\/HER2-\uff08\u5305\u62ecHER2\u4f4e\u8868\u9054\u548cHER2\u96f6\u8868\u9054\uff09\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u63a5\u53d7SKB264 5mg\/kg Q2W\u6cbb\u7642\uff0c\u76f4\u81f3\u75be\u75c5\u9032\u5c55\u6216\u51fa\u73fe\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u7814\u7a76\u7d0d\u5165\u7684\u60a3\u8005\u65e2\u5f80\u7d93\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u4e14\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u6b21\u5316\u7642\u3002\u816b\u7624\u8a55\u4f30\u7531\u7814\u7a76\u8005\u6839\u64daRECIST v1.1\u6bcf8\u5468\u8a55\u4f30\u4e00\u6b21\u3002<\/p>\n

\u7814\u7a76\u7d50\u679c<\/b><\/p>\n

\u622a\u6b622023\u5e744\u670812\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4441\u4f8b\u60a3\u8005\uff0c\u4e2d\u4f4d\u5e74\u9f6150\u6b72\uff0c\u5176\u4e2d61%\u7684\u60a3\u8005ECOG PS\u8a55\u5206\u70ba1\u5206\u3002\u7814\u7a76\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.2\u500b\u6708\u3002<\/p>\n

\u4e3b\u8981\u4e0d\u826f\u53cd\u61c9\u4ee5\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAE)\u70ba\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\uff0836.6%\uff09\u3001\u767d\u7d30\u80de\u8a08\u6578\u964d\u4f4e\uff0822%\uff09\u3001\u8ca7\u8840\uff0814.6%\uff09\u548c\u8840\u5c0f\u677f\u8a08\u6578\u964d\u4f4e\uff089.8%\uff09\u3002\u5927\u591a\u6578\u8840\u6db2\u5b78\u6bd2\u6027\u5728\u6cbb\u7642\u7684\u524d\u5169\u500b\u6708\u5167\u767c\u751f\uff0c\u4e26\u5728\u63a5\u53d7G-CSF\u6216\u4fc3\u7d05\u7d30\u80de\u751f\u6210\u7d20\u6cbb\u7642\u5f8c\u5f97\u5230\u6062\u5fa9\uff0c\u7121\u9700\u8f38\u8840\u300217.1%\uff087\/41\uff09\u7684\u60a3\u8005\u56e0TRAE\u5c0e\u81f4\u5291\u91cf\u964d\u4f4e\uff0c\u7121TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u6b7b\u4ea1\u3002\u80c3\u8178\u9053TRAE\u767c\u751f\u7387\u4f4e\uff0c\u672a\u89c0\u5bdf\u5230\u8207\u85e5\u7269\u76f8\u95dc\u7684\u795e\u7d93\u75c5\u8b8a\u3001\u9593\u8cea\u6027\u80ba\u75c5\/\u80ba\u708e\u767c\u751f\u3002<\/p>\n

\u7642\u6548\u53ef\u8a55\u4f30\u768438\u4f8b\u60a3\u8005\u4e2d\uff0c71%\u7684\u60a3\u8005\u70baHER2\u4f4e\u8868\u9054\uff0c47%\u7684\u60a3\u8005\u70ba\u539f\u767c\u5167\u5206\u6ccc\u8010\u85e5\uff0c79%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u4e86\u22652\u7dda\u91dd\u5c0d\u8f49\u79fb\u6027\u4e73\u817a\u764c\u7684\u5316\u7642\uff0c\u6240\u6709\u60a3\u8005\u90fd\u63a5\u53d7\u904e\u7d2b\u6749\u985e\u85e5\u7269\u6cbb\u7642\uff0c65.8%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u3002\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba36.8%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba89.5%\uff0c6\u500b\u6708\u6301\u7e8c\u7de9\u89e3\uff08DoR\uff09\u7387\u70ba80%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba11.1\u500b\u6708\u3002\u6240\u6709\u4e9e\u7d44\u5747\u7372\u76ca\uff0c\u5305\u62ecHER2\u4f4e\u8868\u9054\u548c\u96f6\u8868\u9054\u3001\u539f\u767c\u548c\u7e7c\u767c\u5167\u5206\u6ccc\u8010\u85e5\u3001\u65e2\u5f80\u4f7f\u7528\u548c\u672a\u4f7f\u7528\u904eCDK4\/6\u6291\u5236\u5291\u7684\u60a3\u8005\u3002<\/p>\n

\u7814\u7a76\u7d50\u8ad6<\/p>\n

SKB264\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u76ee\u524d\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u6b63\u5728\u8a08\u756b\u958b\u5c55\u5169\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u4e00\u9805\u570b\u5167\u7814\u7a76\u91dd\u5c0d\u8f49\u79fb\u6027\u968e\u6bb5\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u7dda\u5316\u7642\u7684\u60a3\u8005\u3002\u53e6\u4e00\u9805\u5168\u7403\u7814\u7a76\u91dd\u5c0d\u65e2\u5f80\u5728\u8f49\u79fb\u6027\u968e\u6bb5\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684\u60a3\u8005\u3002<\/p>\n

\u5c0f\u7d50<\/b>
\u6b64\u524d\uff0cSKB264\u5728\u7d93\u904e\u591a\u7dda\u6cbb\u7642\u7684\u8f49\u79fb\u6027\u4e09\u9670\u4e73\u817a\u764c\uff08TNBC\uff09\u4ee5\u53ca\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u826f\u597d\u7684\u7642\u6548\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u672c\u5c46ESMO\uff0c\u5176\u5728HR+\/HER2-\u8f49\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u518d\u6b21\u986f\u793a\u51fa\u4e86\u5de8\u5927\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u7121\u7591\u70ba\u5f8c\u7e8c\u9818\u57df\u5167\u66f4\u591a\u7cfb\u5217\u7814\u7a76\u7684\u958b\u5c55\u589e\u52a0\u4e86\u4fe1\u5fc3\u3002<\/p>\n

2022<\/b>\u00a0SABCS<\/b>\u5e74\u6703\uff0c<\/b>SKB<\/b>264<\/b>\u91cb<\/b>\u653e<\/b>\u4e86\u7528<\/b>\u65bc\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u4e73\u817a\u764c\uff08<\/b>TNBC<\/b>\uff09\u60a3\u8005\u2161\u671f\u62d3\u5c55\u7814\u7a76\u8cc7\u6599\u3002\u5728<\/b>55<\/b>\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684\u60a3\u8005\u4e2d\uff0c<\/b>ORR<\/b>\u70ba<\/b>\u00a043.6% <\/b>\uff0c<\/b>DCR<\/b>\u70ba<\/b>\u00a080% <\/b>\uff0c\u5176\u4e2d<\/b>TROP2<\/b>\u9ad8\u8868\u9054\u60a3\u8005\u7684<\/b>ORR<\/b>\u70ba<\/b>\u00a055.2%<\/b>\u3002<\/b>mDoR<\/b>\u70ba<\/b>11.5<\/b>\u500b\u6708\uff0c<\/b>mPFS<\/b>\u70ba<\/b>5.7<\/b>\u500b\u6708\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08<\/b>mOS<\/b>\uff09\u70ba<\/b>14.6<\/b>\u500b\u6708\uff0c<\/b>12<\/b>\u500b\u6708<\/b>OS<\/b>\u7387\u70ba<\/b>66.4%<\/b>\u3002<\/b><\/p>\n

2023\u00a0ASCO\u5e74\u6703\uff0cSKB264\u516c\u4f48\u4e86\u7528\u65bc\u7d93\u6cbb\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u2161\u671f\u62d3\u5c55\u7814\u7a76\u8cc7\u6599\u300239\u4f8b\u60a3\u8005\u7642\u6548\u53ef\u8a55\u4f30\uff0cORR\u70ba43.6%\uff0cDCR\u70ba94.9%\uff0cmDoR\u70ba9.3\u500b\u6708\uff0c6\u500b\u6708DoR\u7387\u70ba77%\uff0c12\u500b\u6708OS\u7387\u70ba70.6%\u3002EGFR<\/b>\u7a81\u8b8a\u4e9e\u7d44\u4eba\u7fa4\u7684<\/b>ORR<\/b>\u70ba<\/b>60%<\/b>\uff0c<\/b>DCR<\/b>\u70ba<\/b>100%<\/b>\uff0c<\/b>mDoR<\/b>\u70ba<\/b>9.3<\/b>\u500b\u6708\uff0c<\/b>mPFS<\/b>\u70ba<\/b>11.1<\/b>\u500b\u6708\uff0c<\/b>12<\/b>\u500b\u6708<\/b>OS<\/b>\u7387\u70ba<\/b>80.7%<\/b>\u3002<\/b><\/p>\n

\u5df2\u516c\u4f48\u7684\u7814\u7a76\u8cc7\u6599\u8868\u660e\uff0cSKB264\u6cbb\u7642\u665a\u671f\u4e09\u9670\u6027\u4e73\u817a\u764c\u3001\u665a\u671fHR+HER2-\u4e73\u817a\u764c\u548cTKI\u6cbb\u7642\u5931\u6557\u7684EGFR\u7a81\u8b8a\u7684NSCLC\uff0c\u5728ADC\u85e5\u7269\u4e2d\u5177\u6709\u540c\u985e\u6700\u4f73\u6f5b\u8cea\u3002<\/p>\n

\u57fa\u65bc<\/b>\u4e73\u817a\u764c<\/b>\u548c\u80ba\u764c<\/b>\u7684\u4eae\u773c\u7684\u7814\u7a76\u8cc7\u6599\uff0c<\/b>SKB264<\/b>\u5df2<\/b>\u7372\u5f97<\/b>CDE<\/b>\u6388\u4e88\u7684<\/b>\u4e09<\/b>\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff0c\u5206\u5225\u70ba\u55ae\u85e5\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\uff08<\/b>TNBC<\/b>\uff09<\/b>\u3001<\/b>EGFR-TKI <\/b>\u6cbb\u7642\u5931\u6557\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027<\/b>EGFR <\/b>\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/b>EGFRm NSCLC<\/b>\uff09\u548c\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u6fc0\u7d20\u53d7\u9ad4\uff08<\/b>HR<\/b>\uff09\u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0<\/b>\u5b50<\/b>\u53d7\u9ad4<\/b>2<\/b>\u9670\u6027\uff08<\/b>HER2-<\/b>\uff09\u4e73\u817a\u764c\u3002<\/b><\/p>\n

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