{"id":183026,"date":"2023-10-11T08:10:00","date_gmt":"2023-10-11T00:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=183026"},"modified":"2023-10-11T08:10:00","modified_gmt":"2023-10-11T00:10:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%9c%a8%e6%ad%90%e6%b4%b2%e7%9a%ae%e8%86%9a%e7%97%85%e8%88%87%e6%80%a7%e7%97%85%e5%ad%b8%e6%9c%832023%e5%b9%b4%e5%a4%a7%e6%9c%83%e4%bb%a5%e5%a3%81%e5%a0%b1","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=183026","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u5728\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u67032023\u5e74\u5927\u6703\u4ee5\u58c1\u5831\u5c55\u793aFASN\u6291\u5236\u5291ASC40\u6cbb\u7642\u75e4\u7621II\u671f\u7814\u7a76\u9802\u7dda\u7d50\u679c"},"content":{"rendered":"
\n

\u676d\u5dde\u548c\u7d39\u8208<\/span>2023\u5e7410\u670811\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u5728\u5fb7\u570b\u67cf\u6797\u53ec\u958b\u7684\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff092023\u5e74\u5927\u6703\u4e0a\u4ee5\u58c1\u5831\u5f62\u5f0f\u5c55\u793a\u540c\u985e\u9996\u5275\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\u6cbb\u7642\u75e4\u7621\u7684II\u671f\u7814\u7a76\u9802\u7dda\u7d50\u679c<\/span>\u3002\u8a72\u58c1\u5831\u7684\u6982\u8981\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n

\u6a19\u984c\uff1a<\/b>\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\u6cbb\u7642\u5c0b\u5e38\u75e4\u7621\u60a3\u8005\u7684II\u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u9802\u7dda\u7d50\u679c<\/p>\n

\u5c55\u793a\u4eba\uff1a<\/b>\u5433\u52c1\u6893\u535a\u58eb<\/p>\n

\u4e3b\u8981\u7814\u7a76\u8005\uff1a<\/b>\u9805\u857e\u7d05\u6559\u6388\uff0c\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662<\/p>\n

\u58c1\u5831\u7de8\u865f\uff1a<\/b>P0053<\/p>\n

\u985e\u5225\uff1a<\/b>\u75e4\u7621\u53ca\u76f8\u95dc\u75be\u75c5\uff0c\u81bf\u76b0\u6027\u6c57\u817a\u708e<\/p>\n

\u7814\u7a76\u8a2d\u8a08\uff1a<\/b><\/p>\n

\u9019\u9805II\u671f\u8a66\u9a57\uff08ClinicalTrials.gov: NCT05104125<\/a>\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u7814\u7a76\u3002180\u4f8b\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u5c0b\u5e38\u75e4\u7621\u60a3\u8005\u88ab\u6309\u71671\ufe301\ufe301\ufe301\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e09\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u4e26\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670dASC40\uff0825\u6beb\u514b\u300150\u6beb\u514b\u621675\u6beb\u514b\u7247\u5291\uff09\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u7247\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u4e26\u96a8\u8a2a2\u5468\u3002\u5df2\u8a55\u4f30ASC40\u6216\u5b89\u6170\u5291\u6cbb\u764212\u5468\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u7d50\u679c\uff1a<\/b><\/p>\n

\u88681\u7e3d\u7d50\u4e86\u8207\u57fa\u7dda\u76f8\u6bd4\u7b2c12\u5468\u6642\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7642\u6548\u7d42\u9ede\u7684\u9802\u7dda\u6578\u64da\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u4e09\u7a2e\u5291\u91cf\u7684ASC40\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u7642\u6548\u3002ASC40\u7684\u7642\u6548\u572850\u6beb\u514b\u5291\u91cf\u4e2d\u9054\u5230\u4e86\u6700\u5927\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u88681. \u53e3\u670d25\u6beb\u514b\u300150\u6beb\u514b\u548c75\u6beb\u514bASC40\u7247\u5291\uff0c\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09\u7684\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff08n=179\uff09
<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7642\u6548\u7d42\u9ede<\/span><\/p>\n<\/td>\n

\n

\u53e3\u670d<\/span>25<\/span>\u6beb\u514b<\/span>SC40<\/span>\uff0c<\/span><\/p>\n

\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e5<\/span>12<\/span>\u5468<\/span><\/p>\n

\uff08<\/span>n=45<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

\u53e3\u670d<\/span>50<\/span>\u6beb\u514b<\/span>SC40<\/span>\uff0c<\/span><\/p>\n

\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e5<\/span>12<\/span>\u5468<\/span><\/p>\n

\uff08<\/span>n=44<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

\u53e3\u670d<\/span>75<\/span>\u6beb\u514b<\/span>SC40<\/span>\uff0c<\/span><\/p>\n

\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e5<\/span>12<\/span>\u5468<\/span><\/p>\n

\uff08<\/span>n=45<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

\u53e3\u670d\u5b89\u6170\u5291\uff0c<\/span><\/p>\n

\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e5<\/span>12\u5468<\/span><\/p>\n

\uff08<\/span>n=45<\/span>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7b2c<\/span>12<\/span>\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684<\/span>\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u4e3b\u8981\u7d42\u9ede\uff09<\/span>\u00a7<\/span><\/sup><\/p>\n<\/td>\n

\n

-53.2<\/span><\/p>\n<\/td>\n

\n

-61.3<\/span><\/p>\n<\/td>\n

\n

-53.1<\/span><\/p>\n<\/td>\n

\n

-34.2<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

P<\/span><\/i>\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09<\/span><\/p>\n<\/td>\n

\n

0.005<\/span><\/p>\n<\/td>\n

\n

0.008<\/span><\/p>\n<\/td>\n

\n

0.008<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7b2c<\/span>12<\/span>\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684<\/span>\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09<\/span>\u00a7<\/span><\/sup><\/p>\n<\/td>\n

\n

-56.0<\/span><\/p>\n<\/td>\n

\n

-60.5<\/span><\/p>\n<\/td>\n

\n

-46.0<\/span><\/p>\n<\/td>\n

\n

-37.0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

P<\/span><\/i>\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09<\/span><\/p>\n<\/td>\n

\n

0.024<\/span><\/p>\n<\/td>\n

\n

0.030<\/span><\/p>\n<\/td>\n

\n

0.083<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7b2c<\/span>12<\/span>\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684<\/span>\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09<\/span>\u00a7<\/span><\/sup><\/p>\n<\/td>\n

\n

-54.4<\/span><\/p>\n<\/td>\n

\n

-65.0<\/span><\/p>\n<\/td>\n

\n

-60.0<\/span><\/p>\n<\/td>\n

\n

-31.4<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

P<\/span><\/i>\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09<\/span><\/p>\n<\/td>\n

\n

0.006<\/span><\/p>\n<\/td>\n

\n

0.003<\/span><\/p>\n<\/td>\n

\n

0.029<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7b2c<\/span>12<\/span>\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684<\/span>\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09<\/span>\u00a7<\/span><\/sup><\/p>\n<\/td>\n

\n

-25.0<\/span><\/p>\n<\/td>\n

\n

-26.0<\/span><\/p>\n<\/td>\n

\n

-22.0<\/span><\/p>\n<\/td>\n

\n

-13.0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

P<\/span><\/i>\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09<\/span><\/p>\n<\/td>\n

\n

0.007<\/span><\/p>\n<\/td>\n

\n

0.003<\/span><\/p>\n<\/td>\n

\n

0.032<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8a3b\u91cb\uff1a\u00a7 \u6578\u64da\u70ba\u4e2d\u4f4d\u6578\u3002<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u7d50\u8ad6\uff1a<\/b><\/p>\n

\u9019\u9805\u7814\u7a76\u9802\u7dda\u7d50\u679c\u986f\u793a\uff0c\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC40\u3001\u6cbb\u764212\u5468\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002ASC40\u986f\u8457\u6539\u5584\u4e86\u7e3d\u76ae\u640d\u3001\u708e\u6027\u76ae\u640d\u548cIGA\uff08\u7814\u7a76\u8005\u6574\u9ad4\u8a55\u4f30\uff09\u6cbb\u7642\u6210\u529f\u7387\u3002\u9019\u9805II\u671f\u7814\u7a76\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u8a55\u4f30\u70baIII\u671f\u81e8\u5e8a\u8a66\u9a57\u63d0\u4f9b\u4e86\u652f\u6301\uff0cIII\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5f88\u5feb\u555f\u52d5\u3002<\/span><\/p>\n

\u300c\u975e\u5e38\u69ae\u5e78\u5728EADV\u5927\u6703\u5c55\u793aASC40\u6cbb\u7642\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u3002\u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba[1]<\/sup>\u3002\u8102\u80aa\u9178\u5408\u6210\u9176\u6291\u5236\u662f\u6cbb\u7642\u75e4\u7621\u7684\u65b0\u6a5f\u5236\uff0cASC40\u662f\u8a72\u6a5f\u5236\u7684\u540c\u985e\u9996\u5275\u5019\u9078\u85e5\u7269\uff0c\u5728II\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5f88\u5feb\u555f\u52d5\uff0c\u6211\u5011\u671f\u5f85\u672a\u4f86\u70ba\u75e4\u7621\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n

\n\n\n\n
\n

[1] <\/sup>Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u95dc\u65bcEADV<\/b><\/p>\n

\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u64c1\u6709\u4f86\u81ea\u5168\u7403\u8d85\u904e8,500\u540d\u6703\u54e1\uff0c14,000\u540d\u5c08\u696d\u4eba\u58eb\u6d3b\u8e8d\u5176\u4e2d\u3002\u4e00\u5e74\u4e00\u5ea6\u570b\u969b\u6027\u7684EADV<\/span>\u5927\u6703\u805a\u7126\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6700\u65b0\u7684\u79d1\u5b78\u9032\u5c55\u548c\u7814\u7a76\uff0c\u5f59\u96c6\u4e86\u5168\u7403\u91ab\u7642\u5c08\u696d\u4eba\u58eb\u3001\u7d44\u7e54\u548c\u884c\u696d\uff0c\u4ee5\u6c42\u5c07\u5f71\u97ff\u767c\u63ee\u5230\u6700\u5927\u3002\u4eca\u5e74\u7684\u5927\u6703\u5c07\u65bc10\u670811\u65e5\u81f314\u65e5\u5728\u5fb7\u570b\u67cf\u6797\u8209\u884c\u3002<\/p>\n

\u95dc\u65bc\u6b4c\u79ae<\/b><\/p>\n

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\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u7684\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u6388\u6b0a\u3002<\/span><\/p>\n

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Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. \u95dc\u65bcEADV \u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u64c1\u6709\u4f86\u81ea\u5168\u7403\u8d85\u904e8,500\u540d\u6703\u54e1\uff0c14,000\u540d\u5c08\u696d\u4eba\u58eb\u6d3b\u8e8d\u5176\u4e2d\u3002\u4e00\u5e74\u4e00\u5ea6\u570b\u969b\u6027\u7684EADV\u5927\u6703\u805a\u7126\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6700\u65b0\u7684\u79d1\u5b78\u9032\u5c55\u548c\u7814\u7a76\uff0c\u5f59\u96c6\u4e86\u5168\u7403\u91ab\u7642\u5c08\u696d\u4eba\u58eb\u3001\u7d44\u7e54\u548c\u884c\u696d\uff0c\u4ee5\u6c42\u5c07\u5f71\u97ff\u767c\u63ee\u5230\u6700\u5927\u3002\u4eca\u5e74\u7684\u5927\u6703\u5c07\u65bc10\u670811\u65e5\u81f314\u65e5\u5728\u5fb7\u570b\u67cf\u6797\u8209\u884c\u3002 \u95dc\u65bc\u6b4c\u79ae 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\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u7684\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u6388\u6b0a\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=183026\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u4f48\u5728\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u67032023\u5e74\u5927\u6703\u4ee5\u58c1\u5831\u5c55\u793aFASN\u6291\u5236\u5291ASC40\u6cbb\u7642\u75e4\u7621II\u671f\u7814\u7a76\u9802\u7dda\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u676d\u5dde\u548c\u7d39\u82082023\u5e7410\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u5728\u5fb7\u570b\u67cf\u6797\u53ec\u958b\u7684\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff092023\u5e74\u5927\u6703\u4e0a\u4ee5\u58c1\u5831\u5f62\u5f0f\u5c55\u793a\u540c\u985e\u9996\u5275\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\u6cbb\u7642\u75e4\u7621\u7684II\u671f\u7814\u7a76\u9802\u7dda\u7d50\u679c\u3002\u8a72\u58c1\u5831\u7684\u6982\u8981\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c\uff1a\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\u6cbb\u7642\u5c0b\u5e38\u75e4\u7621\u60a3\u8005\u7684II\u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u8a66\u9a57\u7684\u9802\u7dda\u7d50\u679c \u5c55\u793a\u4eba\uff1a\u5433\u52c1\u6893\u535a\u58eb \u4e3b\u8981\u7814\u7a76\u8005\uff1a\u9805\u857e\u7d05\u6559\u6388\uff0c\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662 \u58c1\u5831\u7de8\u865f\uff1aP0053 \u985e\u5225\uff1a\u75e4\u7621\u53ca\u76f8\u95dc\u75be\u75c5\uff0c\u81bf\u76b0\u6027\u6c57\u817a\u708e \u7814\u7a76\u8a2d\u8a08\uff1a \u9019\u9805II\u671f\u8a66\u9a57\uff08ClinicalTrials.gov: NCT05104125\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u7814\u7a76\u3002180\u4f8b\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u5c0b\u5e38\u75e4\u7621\u60a3\u8005\u88ab\u6309\u71671\ufe301\ufe301\ufe301\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e09\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u4e26\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670dASC40\uff0825\u6beb\u514b\u300150\u6beb\u514b\u621675\u6beb\u514b\u7247\u5291\uff09\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u7247\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u4e26\u96a8\u8a2a2\u5468\u3002\u5df2\u8a55\u4f30ASC40\u6216\u5b89\u6170\u5291\u6cbb\u764212\u5468\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002 \u7d50\u679c\uff1a \u88681\u7e3d\u7d50\u4e86\u8207\u57fa\u7dda\u76f8\u6bd4\u7b2c12\u5468\u6642\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7642\u6548\u7d42\u9ede\u7684\u9802\u7dda\u6578\u64da\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u4e09\u7a2e\u5291\u91cf\u7684ASC40\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u5747\u986f\u793a\u51fa\u826f\u597d\u7684\u7642\u6548\u3002ASC40\u7684\u7642\u6548\u572850\u6beb\u514b\u5291\u91cf\u4e2d\u9054\u5230\u4e86\u6700\u5927\u3002 \u88681. \u53e3\u670d25\u6beb\u514b\u300150\u6beb\u514b\u548c75\u6beb\u514bASC40\u7247\u5291\uff0c\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09\u7684\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff08n=179\uff09 \u7642\u6548\u7d42\u9ede \u53e3\u670d25\u6beb\u514bSC40\uff0c \u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=45\uff09 \u53e3\u670d50\u6beb\u514bSC40\uff0c \u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=44\uff09 \u53e3\u670d75\u6beb\u514bSC40\uff0c \u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=45\uff09 \u53e3\u670d\u5b89\u6170\u5291\uff0c \u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=45\uff09 \u7b2c12\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u4e3b\u8981\u7d42\u9ede\uff09\u00a7 -53.2 -61.3 -53.1 -34.2 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.005 0.008 0.008 NA \u7b2c12\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -56.0 -60.5 -46.0 -37.0 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.024 0.030 0.083 NA \u7b2c12\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -54.4 -65.0 -60.0 -31.4 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.006 0.003 0.029 NA \u7b2c12\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -25.0 -26.0 -22.0 -13.0 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.007 0.003 0.032 NA \u8a3b\u91cb\uff1a\u00a7 \u6578\u64da\u70ba\u4e2d\u4f4d\u6578\u3002 \u7d50\u8ad6\uff1a \u9019\u9805\u7814\u7a76\u9802\u7dda\u7d50\u679c\u986f\u793a\uff0c\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC40\u3001\u6cbb\u764212\u5468\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002ASC40\u986f\u8457\u6539\u5584\u4e86\u7e3d\u76ae\u640d\u3001\u708e\u6027\u76ae\u640d\u548cIGA\uff08\u7814\u7a76\u8005\u6574\u9ad4\u8a55\u4f30\uff09\u6cbb\u7642\u6210\u529f\u7387\u3002\u9019\u9805II\u671f\u7814\u7a76\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u8a55\u4f30\u70baIII\u671f\u81e8\u5e8a\u8a66\u9a57\u63d0\u4f9b\u4e86\u652f\u6301\uff0cIII\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5f88\u5feb\u555f\u52d5\u3002 \u300c\u975e\u5e38\u69ae\u5e78\u5728EADV\u5927\u6703\u5c55\u793aASC40\u6cbb\u7642\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u3002\u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba\u3002\u8102\u80aa\u9178\u5408\u6210\u9176\u6291\u5236\u662f\u6cbb\u7642\u75e4\u7621\u7684\u65b0\u6a5f\u5236\uff0cASC40\u662f\u8a72\u6a5f\u5236\u7684\u540c\u985e\u9996\u5275\u5019\u9078\u85e5\u7269\uff0c\u5728II\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5f88\u5feb\u555f\u52d5\uff0c\u6211\u5011\u671f\u5f85\u672a\u4f86\u70ba\u75e4\u7621\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. \u95dc\u65bcEADV \u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u64c1\u6709\u4f86\u81ea\u5168\u7403\u8d85\u904e8,500\u540d\u6703\u54e1\uff0c14,000\u540d\u5c08\u696d\u4eba\u58eb\u6d3b\u8e8d\u5176\u4e2d\u3002\u4e00\u5e74\u4e00\u5ea6\u570b\u969b\u6027\u7684EADV\u5927\u6703\u805a\u7126\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6700\u65b0\u7684\u79d1\u5b78\u9032\u5c55\u548c\u7814\u7a76\uff0c\u5f59\u96c6\u4e86\u5168\u7403\u91ab\u7642\u5c08\u696d\u4eba\u58eb\u3001\u7d44\u7e54\u548c\u884c\u696d\uff0c\u4ee5\u6c42\u5c07\u5f71\u97ff\u767c\u63ee\u5230\u6700\u5927\u3002\u4eca\u5e74\u7684\u5927\u6703\u5c07\u65bc10\u670811\u65e5\u81f314\u65e5\u5728\u5fb7\u570b\u67cf\u6797\u8209\u884c\u3002 \u95dc\u65bc\u6b4c\u79ae 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\u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=45\uff09 \u53e3\u670d\u5b89\u6170\u5291\uff0c \u6bcf\u65e5\u4e00\u6b21\u3001\u7528\u85e512\u5468 \uff08n=45\uff09 \u7b2c12\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u4e3b\u8981\u7d42\u9ede\uff09\u00a7 -53.2 -61.3 -53.1 -34.2 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.005 0.008 0.008 NA \u7b2c12\u5468\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -56.0 -60.5 -46.0 -37.0 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.024 0.030 0.083 NA \u7b2c12\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -54.4 -65.0 -60.0 -31.4 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.006 0.003 0.029 NA \u7b2c12\u5468\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u7d55\u5c0d\u8b8a\u5316\uff08\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff09\u00a7 -25.0 -26.0 -22.0 -13.0 P\u503c\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\uff09 0.007 0.003 0.032 NA \u8a3b\u91cb\uff1a\u00a7 \u6578\u64da\u70ba\u4e2d\u4f4d\u6578\u3002 \u7d50\u8ad6\uff1a \u9019\u9805\u7814\u7a76\u9802\u7dda\u7d50\u679c\u986f\u793a\uff0c\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21ASC40\u3001\u6cbb\u764212\u5468\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002ASC40\u986f\u8457\u6539\u5584\u4e86\u7e3d\u76ae\u640d\u3001\u708e\u6027\u76ae\u640d\u548cIGA\uff08\u7814\u7a76\u8005\u6574\u9ad4\u8a55\u4f30\uff09\u6cbb\u7642\u6210\u529f\u7387\u3002\u9019\u9805II\u671f\u7814\u7a76\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u8a55\u4f30\u70baIII\u671f\u81e8\u5e8a\u8a66\u9a57\u63d0\u4f9b\u4e86\u652f\u6301\uff0cIII\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5f88\u5feb\u555f\u52d5\u3002 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Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). 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Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). 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Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). 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Tan J K, Bhate K. A global perspective on the epidemiology of acne . Br J Dermatol 2015, 172 Suppl 1(3-12). 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