{"id":165257,"date":"2023-07-21T20:04:00","date_gmt":"2023-07-21T12:04:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=165257"},"modified":"2023-07-21T20:04:00","modified_gmt":"2023-07-21T12:04:00","slug":"%e7%99%be%e6%bf%9f%e7%a5%9e%e5%b7%9e%ef%bc%88beigene%ef%bc%89%e5%ae%a3%e4%bd%88%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%96%ae%e6%8a%97%e7%8d%b2%e6%ad%90%e6%b4%b2%e8%97%a5%e5%93%81%e7%ae%a1%e7%90%86","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=165257","title":{"rendered":"\u767e\u6fdf\u795e\u5dde\uff08BeiGene\uff09\u5ba3\u4f48\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7372\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\u7a4d\u6975\u610f\u898b\uff0c\u652f\u6301\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u60a3\u8005"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u4e2d\u570b\u5317\u4eac\uff0c\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e<\/span><span class=\"legendSpanClass\">2023\u5e747\u670821\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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302\uff08NCT03430843\uff09\u7d50\u679c\uff0c\u8a72\u8a66\u9a57\u65e8\u5728\u6bd4\u8f03\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u548c\u7814\u7a76\u8005\u9078\u64c7\u7684\u5316\u7642\u5728\u4e0d\u53ef\u5207\u9664\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7dda\u6cbb\u7642\u6642\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u5165\u7d44\u4e86\u4f86\u81ea\u4e9e\u6d32\u3001\u6b50\u6d32\u548c\u5317\u7f8e\u6d3211\u500b\u570b\u5bb6\u548c\u5730\u5340\u5171132\u500b\u7814\u7a76\u4e2d\u5fc3\u7684513\u4f8b\u60a3\u8005\uff0c\u4e26\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\uff1a\u8207\u5316\u7642\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5177\u6709\u986f\u8457\u7684\u751f\u5b58\u7372\u76ca\uff08\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f8.6 vs 6.3\u500b\u6708\uff1bHR 0.70 [95%CI: 0.57 ~ 0.85]\uff1b\u55ae\u5074P=0.0001\uff09\u3002\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7684\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u8a66\u9a57\u4e00\u81f4<sup>[i]<\/sup>\u3002MAA\u7533\u5831\u8cc7\u6599\u4e2d\u5305\u542b\u4e867\u9805\u81e8\u5e8a\u8a66\u9a57\u4e2d\u76841972\u4f8b\u63a5\u53d7\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u60a3\u8005\u7684\u5b89\u5168\u6027\u8cc7\u6599\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u76ee\u524d\u5c1a\u672a\u5728\u6b50\u6d32\u7372\u6279\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>ESCC<\/b><sup><b><b>[ii]<\/b><\/b><\/sup><\/p>\n<p>\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u98df\u7ba1\u764c\uff08EC\uff09\u662f\u764c\u75c7\u76f8\u95dc\u6b7b\u4ea1\u7684\u7b2c\u516d\u5927\u5e38\u898b\u539f\u56e0\uff0cESCC\u662f\u6700\u5e38\u898b\u7684\u7d44\u7e54\u5b78\u4e9e\u578b\uff0c\u5360EC\u768485%\u4ee5\u4e0a\u3002\u9810\u8a082040\u5e74\u5c07\u6709957,000\u4f8b\u65b0\u767cEC\u75c5\u4f8b\uff0c\u6bd42020\u5e74\u589e\u52a0\u8fd160%\uff0c\u9019\u8868\u660e\u9700\u8981\u984d\u5916\u7684\u6709\u6548\u6cbb\u7642\u3002\u00a0<\/p>\n<p><b>\u95dc\u65bc\u767e\u6fa4\u5b89<\/b><sup><b>\u00ae<\/b><\/sup><b>\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09<\/b><\/p>\n<p>\u767e\u6fa4\u5b89<sup>\u00ae<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297PD-1\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u8a2d\u8a08\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u8207\u5de8\u566c\u7d30\u80de\u4e2d\u7684Fc\u03b3\u53d7\u9ad4\u7d50\u5408\uff0c\u5e6b\u52a9\u4eba\u9ad4\u514d\u75ab\u7d30\u80de\u8b58\u5225\u4e26\u6bba\u50b7\u816b\u7624\u7d30\u80de\u3002\u81e8\u5e8a\u524d\u8cc7\u6599\u8868\u660e\uff0c\u5de8\u566c\u7d30\u80de\u4e2d\u7684Fc\u03b3\u53d7\u9ad4\u7d50\u5408\u4e4b\u5f8c\u6703\u555f\u52d5\u6297\u9ad4\u4f9d\u8cf4\u7d30\u80de\u4ecb\u5c0e\u6bba\u50b7T\u7d30\u80de\uff0c\u5f9e\u800c\u964d\u4f4e\u4e86PD-1\u6297\u9ad4\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n<p>2021\u5e74\uff0c\u767e\u6fdf\u795e\u5dde\u8207\u8afe\u83ef\u5ba3\u4f48\u9054\u6210\u5408\u4f5c\u5354\u5b9a\uff0c\u6388\u6b0a\u8afe\u83ef\u5728\u7f8e\u570b\u3001\u52a0\u62ff\u5927\u3001\u58a8\u897f\u54e5\u3001\u6b50\u76df\u6210\u54e1\u570b\u3001\u82f1\u570b\u3001\u632a\u5a01\u3001\u745e\u58eb\u3001\u51b0\u5cf6\u3001\u5217\u652f\u6566\u58eb\u767b\u3001\u4fc4\u7f85\u65af\u548c\u65e5\u672c\u5171\u540c\u958b\u767c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u3002\u6839\u64da\u5354\u5b9a\uff0c\u8afe\u83ef\u8ca0\u8cac\u5728\u9019\u4e9b\u6388\u6b0a\u570b\u5bb6\u7684\u8a3b\u518a\u7533\u8acb\uff0c\u4e26\u5728\u7372\u6279\u5f8c\u958b\u5c55\u5546\u696d\u5316\u6d3b\u52d5\u3002<\/p>\n<p>EMA\u6b63\u5728\u5be9\u8a55\u7684\u76f8\u95dc\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u5305\u62ec\uff1a\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5316\u7642\u5f8c\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u4ee5\u53ca\u806f\u5408\u5316\u7642\u7528\u65bc\u65e2\u5f80\u672a\u7d93\u6cbb\u7642\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u3002\u7f8e\u570b\u3001\u82f1\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u4e2d\u570b\u3001\u7d10\u897f\u862d\u3001\u5df4\u897f\u3001\u97d3\u570b\u548c\u745e\u58eb\u7684\u76e3\u7ba1\u7576\u5c40\u4e5f\u6b63\u5728\u5be9\u8a55\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7684\u7533\u5831\u8cc7\u6599\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u5728\u8d85\u904e30\u500b\u570b\u5bb6\u548c\u5730\u5340\u958b\u5c5521\u9805\u8a3b\u518a\u81e8\u5e8a\u8a66\u9a57\uff0c\u5165\u7d44\u8d85\u904e12,000\u4f8b\u60a3\u8005\u3002\u622a\u81f3\u76ee\u524d\uff0c\u767e\u6fdf\u795e\u5dde\u5df2\u5ba3\u4f4810\u98053\u671f\u95dc\u9375\u6027\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u9019\u4e9b\u7814\u7a76\u6d89\u53ca\u591a\u7a2e\u816b\u7624\u985e\u578b\u548c\u75be\u75c5\u80cc\u666f\uff0c\u5982\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u80c3\u764c\u3001\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u3001\u809d\u7d30\u80de\u764c\u548c\u9f3b\u54bd\u764c\u3002\u66f4\u591a\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u81e8\u5e8a\u8a66\u9a57\u9805\u76ee\u7684\u76f8\u95dc\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a<a href=\"https:\/\/www.beigene.com.cn\/our-science-and-medicines\/pipeline\/\" target=\"_blank\" rel=\"nofollow 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href=\"http:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.beigene.com.cn\/<\/a>\uff1b<a href=\"http:\/\/www.beigene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.beigene.com<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 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class=\"prnml4\"><span class=\"prnews_span\">[i]\u00a0Shen, L., Kato, K., Kim, S. B., Ajani, J. A., Zhao, K., He, Z., &#8230; &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[ii]\u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., &#8230; &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. Gastroenterology, 163(3),\u00a0649-658.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u570b\u5317\u4eac\uff0c\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-165257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002   \u53c3\u8003\u6587\u737b   \u00a0Shen, L., Kato, K., Kim, S. B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926   \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. 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302\uff08NCT03430843\uff09\u7d50\u679c\uff0c\u8a72\u8a66\u9a57\u65e8\u5728\u6bd4\u8f03\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u548c\u7814\u7a76\u8005\u9078\u64c7\u7684\u5316\u7642\u5728\u4e0d\u53ef\u5207\u9664\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7dda\u6cbb\u7642\u6642\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u5165\u7d44\u4e86\u4f86\u81ea\u4e9e\u6d32\u3001\u6b50\u6d32\u548c\u5317\u7f8e\u6d3211\u500b\u570b\u5bb6\u548c\u5730\u5340\u5171132\u500b\u7814\u7a76\u4e2d\u5fc3\u7684513\u4f8b\u60a3\u8005\uff0c\u4e26\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\uff1a\u8207\u5316\u7642\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u55ae\u6297\u5177\u6709\u986f\u8457\u7684\u751f\u5b58\u7372\u76ca\uff08\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f8.6 vs 6.3\u500b\u6708\uff1bHR 0.70 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B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926   \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. 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B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\\\/JCO.21.01926 \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. Gastroenterology, 163(3),\u00a0649-658. 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B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926   \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. 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B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926   \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. 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B., Ajani, J. A., Zhao, K., He, Z., ... &amp; Van Cutsem, E. (2022). Tislelizumab versus chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-302): A randomized phase III study. Journal of Clinical Oncology, 40(26), 3065-3076. DOI: 10.1200\/JCO.21.01926 \u00a0Morgan, E., Soerjomataram, I., Rumgay, H., Coleman, H. G., Thrift, A. P., Vignat, J., ... &amp; Arnold, M. (2022). The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality\u00a0in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. 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