{"id":162044,"date":"2023-07-07T16:42:00","date_gmt":"2023-07-07T08:42:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=162044"},"modified":"2023-07-07T16:42:00","modified_gmt":"2023-07-07T08:42:00","slug":"osemitamab-tst001-transtar-301%e5%85%a8%e7%90%83iii%e6%9c%9f%e9%97%9c%e9%8d%b5%e6%80%a7%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e7%8d%b2%e5%be%97%e4%b8%ad%e5%9c%8b%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=162044","title":{"rendered":"Osemitamab (TST001) TranStar 301\u5168\u7403III\u671f\u95dc\u9375\u6027\u81e8\u5e8a\u8a66\u9a57\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u53ca\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8\u6279\u51c6"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e747\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\u5df2\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3(CDE)\u548c\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8(MFDS)\u6279\u51c6\uff0c\u5728HER2\u9670\u6027\u3001CLDN18.2\u8868\u9054\u7684\u4e00\u7dda\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1(G\/GEJ)\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u958b\u5c55Osemitamab(TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u7684TranStar 301\u5168\u7403III\u671f\u95dc\u9375\u6027\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u5916\uff0c\u6211\u5011\u6b63\u5728\u8207\u6b50\u76df\u548cFDA\u9032\u884c\u76e3\u7ba1\u4e92\u52d5\u3002<\/p>\n<p>\u80c3\u764c(GC)\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u7b2c\u56db\u5927\u539f\u56e0\uff0c\u7d04\u5360\u6240\u6709\u764c\u75c7\u76f8\u95dc\u6b7b\u4ea1\u7387\u76847.7%\u3002\u80c3\u764c\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4ecd\u572830%\u5de6\u53f3\u3002\u6297PD-1\u6297\u9ad4\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u5df2\u65bc\u5168\u7403\u7372\u6279\u7528\u65bc\u665a\u671f\u6216\u8f49\u79fb\u6027HER2\u9670\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u3002<\/p>\n<p>Osemitamab (TST001) \u662f\u4e00\u7a2e\u7b2c\u4e8c\u4ee3\u9776\u5411CLDN18.2 \u7684\u4eba\u6e90\u5316\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684ADCC\u4f5c\u7528\u3002\u5176\u5728\u5177\u6709\u5ee3\u6cdbCLDN18.2\u8868\u9054\u7684\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u6297\u816b\u7624\u6d3b\u6027\u3002\u8fd1\u65e5\uff0c\u5275\u52dd\u96c6\u5718\u65bc2023\u5e74ASCO\u5e74\u6703\u548c2023\u5e74ESMO GI\u5e74\u6703\u516c\u4f48Osemitamab ( TST001) \u806f\u5408CAPOX\u4f5c\u70ba\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\u6578\u64da\u300264 \u4f8bCLDN18.2 \u967d\u6027\u60a3\u8005\uff08\u5b9a\u7fa9\u70ba\uff1a\u7528LDT\u65b9\u6cd5\u226510%\u816b\u7624\u7d30\u80de\u7684CLDN18.2 IHC\u819c\u67d3\u8272\u5f37\u5ea6\u22651+\uff0c\u7be9\u9078\u51fa\u7d0455%\u7684\u60a3\u8005\uff09\u63a5\u53d7\u4e86\u6cbb\u7642\uff0c\u5176\u4e2d49\u4f8b\u63a5\u53d7\u4e866mg\/kg\u7684\u5291\u91cf\u6cbb\u7642\u3002\u6578\u64da\u986f\u793a\uff0c\u6240\u6709\u5291\u91cf\u7d44\u4e2d\uff0c\u9810\u8a08\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba9.5\u500b\u6708\uff0c\u8207\u6240\u6709CLDN18.2\u8868\u9054\u6c34\u5e73\u4e00\u81f4\uff0c\u9810\u8a08\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u70ba9.9\u500b\u6708\u3002<\/p>\n<p>\u81e8\u5e8a\u524d\u7814\u7a76\u5df2\u8b49\u660eOsemitamab (TST001)\u548c\u6297PD-1\u6297\u9ad4\u5728CLDN18.2\u8868\u9054\u7684\u816b\u7624\u6a21\u578b\u4e2d\u5177\u6709\u5354\u540c\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u8fd1\u671f\uff0c\u5275\u52dd\u96c6\u5718\u5831\u544a\u7a31\uff0c\u5df2\u670982 \u540d\u60a3\u8005\u5165\u7d44TranStar 102\uff0c\u4ee5\u8a55\u4f30Osemitamab (TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207CAPOX\u6cbb\u7642\u7684\u5b89\u5168\u6027\u53ca\u7642\u6548\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u8a72\u806f\u5408\u7642\u6cd5\u7684\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n<p>TranStar 301\u662f\u4e00\u9805\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30Osemitamab (TST001) \u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u5728HER2 \u9670\u6027\u3001CLDN18.2 \u8868\u9054\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u4e2d\u7684\u4e00\u7dda\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff1a\u300c \u6211\u5011\u6b63\u5728\u7a4d\u6975\u63a8\u9032Osemitamab (TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u6cbb\u7642\u4e00\u7ddaCLDN18.2\u8868\u9054\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u5927\u578b\u8de8\u570bIII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7372\u5f97CDE\u548cMFDS\u6279\u51c6\u662f\u4e00\u500b\u4ee4\u4eba\u8208\u596e\u7684\u91cc\u7a0b\u7891\uff0c\u76f8\u4fe1\u5176\u4ed6\u91cc\u7a0b\u7891\u4e5f\u5373\u5c07\u5230\u4f86\u3002\u6211\u5011\u671f\u5f85\u5728\u672a\u4f86\u80fd\u5920\u8207\u5927\u5bb6\u5206\u4eab\u66f4\u591a\u81e8\u5e8a\u9032\u5c55\u3002\u300d<\/p>\n<p>\u53c3\u8003\u8cc7\u6599\uff1a<br \/>[1] ESMO 2023\u58c1\u5831\uff1a<a href=\"https:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-173.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-173.html<\/a><br \/>[2] ASCO 2023\u58c1\u5831\uff1a<a href=\"https:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-172.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-172.html<\/a><\/p>\n<p><b>\u95dc\u65bcOsemitamab (TST001)<\/b><\/p>\n<p>Osemitamab (TST001) \u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411CLDN18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u7bc4\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684CLDN18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054CLDN18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(NCT05190575\u3001NCT04396821\u3001NCT04495296\u3001NCT05608785 \/ CTR20201281)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) \u7528\u65bc\u6cbb\u7642\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c(GC\/GEJ)\u548c\u80f0\u817a\u764c\u60a3\u8005\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bc\u5275\u52dd\u96c6\u5718<\/b><\/p>\n<p>\u5275\u52dd\u96c6\u5718\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5728\u751f\u7269\u85e5\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u65b9\u9762\u5177\u6709\u5168\u9762\u7d9c\u5408\u80fd\u529b\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u4f4d\u65bc\u8607\u5dde\uff0c\u5df2\u6210\u529f\u642d\u5efa\u4e86\u5168\u7403\u7684\u696d\u52d9\u4f48\u5c40\uff1a\u5728\u8607\u5dde\u8a2d\u6709\u85e5\u7269\u767c\u73fe\u3001\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u4e2d\u5fc3\uff0c\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u53ca\u4ee5\u9023\u7e8c\u704c\u6d41\u751f\u7522\u5de5\u85dd\u70ba\u6838\u5fc3\u6280\u8853\u7684\u751f\u7522\u57fa\u5730\u4e5f\u6b63\u5728\u5efa\u8a2d\u4e2d\u3002\u5728\u676d\u5dde\u64c1\u6709\u5de5\u85dd\u8207\u7522\u54c1\u958b\u767c\u4e2d\u5fc3\u4ee5\u53ca\u85e5\u7269\u751f\u7522\u57fa\u5730\uff0c\u5728\u7f8e\u570b\u666e\u6797\u65af\u9813\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5ee3\u5dde\u5206\u5225\u8a2d\u6709\u81e8\u5e8a\u958b\u767c\u4e2d\u5fc3\uff0c\u4e26\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u3001\u6d1b\u6749\u78ef\u8a2d\u7acb\u4e86\u696d\u52d9\u62d3\u5c55\u4e2d\u5fc3\u3002\u5275\u52dd\u96c6\u5718\u7684\u958b\u767c\u7ba1\u7dda\u5df2\u6709\u5341\u4e09\u500b\u6cbb\u7642\u7528\u6297\u9ad4\u65b0\u85e5\u5206\u5b50\uff0c\u6db5\u84cb\u816b\u7624\u3001\u9aa8\u79d1\u548c\u814e\u75c5\u7b49\u9818\u57df\u3002<\/p>\n<p>\u5982\u9700\u77ad\u89e3\u95dc\u65bc\u5275\u52dd\u96c6\u5718\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.transcenta.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.transcenta.com<\/a>\u6216\u9818\u82f1\u8cec\u865f\uff1aTranscenta\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u00a0\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d \u3001\u300c \u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d \u3001\u300c\u6253\u7b97\u300d 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name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=162044\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Osemitamab (TST001) TranStar 301\u5168\u7403III\u671f\u95dc\u9375\u6027\u81e8\u5e8a\u8a66\u9a57\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u53ca\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u8607\u5dde2023\u5e747\u67087\u65e5 \/\u7f8e\u901a\u793e\/ -- 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(TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u6cbb\u7642\u4e00\u7ddaCLDN18.2\u8868\u9054\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u5927\u578b\u8de8\u570bIII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7372\u5f97CDE\u548cMFDS\u6279\u51c6\u662f\u4e00\u500b\u4ee4\u4eba\u8208\u596e\u7684\u91cc\u7a0b\u7891\uff0c\u76f8\u4fe1\u5176\u4ed6\u91cc\u7a0b\u7891\u4e5f\u5373\u5c07\u5230\u4f86\u3002\u6211\u5011\u671f\u5f85\u5728\u672a\u4f86\u80fd\u5920\u8207\u5927\u5bb6\u5206\u4eab\u66f4\u591a\u81e8\u5e8a\u9032\u5c55\u3002\u300d \u53c3\u8003\u8cc7\u6599\uff1a ESMO 2023\u58c1\u5831\uff1ahttps:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-173.html ASCO 2023\u58c1\u5831\uff1ahttps:\/\/www.transcenta.com\/ch\/Scientific_Publications\/id-172.html \u95dc\u65bcOsemitamab (TST001) Osemitamab (TST001) 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