{"id":160292,"date":"2023-06-30T17:04:00","date_gmt":"2023-06-30T09:04:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=160292"},"modified":"2023-06-30T17:04:00","modified_gmt":"2023-06-30T09:04:00","slug":"%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e6%96%bcesmo-gi%e5%85%ac%e5%b8%83tst001%e8%81%af%e5%90%88capox%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e4%b8%8d%e5%90%8ccldn18-2%e8%a1%a8%e9%81%94%e6%b0%b4%e5%b9%b3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=160292","title":{"rendered":"\u5275\u52dd\u96c6\u5718\u65bcESMO GI\u516c\u5e03TST001\u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u4e0d\u540cCLDN18.2\u8868\u9054\u6c34\u5e73\u7684\u665a\u671f\u80c3\u764cI\/II\u671f\u7684PFS\u6578\u64da"},"content":{"rendered":"<div>\n<ul type=\"disc\">\n<li>TranStar102(TST001-1002)\u7814\u7a76\u768464\u4f8bCLDN18.2\u967d\u6027\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c\u60a3\u8005\u5df2\u5165\u7d44\u3002CLDN18.2\u967d\u6027\u5b9a\u7fa9\uff1a\u226510%\u7684\u816b\u7624\u7d30\u80de\u6709\u22651+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\u3002\u8a72\u7b49\u60a3\u8005\u7d04\u5360\u6240\u6709\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u817a\u764c\u60a3\u8005\u768455%\u3002\u6574\u9ad4\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u70ba9.5\u500b\u6708\uff0c\u672a\u89c0\u5bdf\u5230CLDN18.2\u8868\u9054\u5c0e\u81f4\u7684\u660e\u986f\u5dee\u7570\u3002<\/li>\n<li>Osemitamab (TST001)\u8207\u5316\u7642\u806f\u7528\uff0c\u53ef\u70baCLDN18.2\u967d\u6027\u816b\u7624\u60a3\u8005\uff0c\u5305\u62ec\u4f4e\u8868\u9054\u60a3\u8005\uff08\u226510%\u816b\u7624\u7d30\u80de\u6709\u22651+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\uff0c\u4f46\uff1c40%\u7684\u816b\u7624\u7d30\u80de\u6709&lt;2+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\uff09\u63d0\u4f9b\u7372\u76ca\u3002<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e746\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u5ba3\u5e03\u5df2\u65bc2023\u5e74ESMO\u4e16\u754c\u80c3\u8178\u9053\u816b\u7624\u5927\u6703\u4e0a\u516c\u5e03Osemitamab (TST001) \u806f\u5408\u5361\u57f9\u4ed6\u6ff1\u548c\u5967\u6c99\u5229\u9251(CAPOX)\u4e00\u7dda\u6cbb\u7642CLDN18.2\u8868\u9054\u6c34\u5e73\u7684\u665a\u671f\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8(G\/GEJ)\u764c\u7684I\/II\u671f\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u6578\u64da\u3002\u8a72\u7b49\u6578\u64da\u5c07\u652f\u6301\u65bc2023\u5e74\u4e0b\u534a\u5e74\u555f\u52d5\u7684\u5168\u7403\u95dc\u9375\u6027III\u671f\u8a66\u9a57\u3002<\/p>\n<p><b>\u6a19\u984c<\/b><\/p>\n<p>Osemitamab (TST001)\u806f\u5408\u5361\u57f9\u4ed6\u6ff1\u548c\u5967\u6c99\u5229\u9251(CAPOX) \u4e00\u7dda\u6cbb\u7642\u665a\u671f\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c\uff1a\u4f86\u81eaTranStar102\/TST001-1002\u7814\u7a76C\u968a\u5217\u7684Claudin18.2\u8868\u9054\u6c34\u5e73\u7684\u6700\u65b0\u7642\u6548\u6578\u64da\u3002<\/p>\n<p><b>\u8a66\u9a57\u8a2d\u8a08<\/b><\/p>\n<p>\u672c\u7814\u7a76\u70ba\u5728\u4e2d\u570b\u9032\u884c\u7684I\/II\u671f\u5291\u91cf\u905e\u589e\u548c\u64f4\u5c55\u7814\u7a76\uff08TranStar102\u7684C\u968a\u5217\uff0cNCT04495296)\uff0c \u65e8\u5728\u8a55\u4f30Osemitamab (TST001)\u8207CAPOX\u806f\u7528\uff0c\u4f5c\u70ba\u665a\u671fG\/GEJ\u764c\u60a3\u8005\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u53c3\u8207\u5291\u91cf\u64f4\u5c55\u671f\u7684\u60a3\u8005\uff08\u9664\u4e86\u5b89\u5168\u6027\u5c0e\u5165\u671f\u76848 \u540d\u60a3\u8005\uff09\u8981\u6c42CLDN18.2\u967d\u6027\u8868\u9054\uff0c\u5177\u9ad4\u5b9a\u7fa9\u70ba\u7528LDT\u65b9\u6cd5\u226510%\u816b\u7624\u7d30\u80de\u7684Claudin18.2 IHC\u819c\u67d3\u8272\u5f37\u5ea6\u22651+\uff0c\u7be9\u9078\u51fa\u7d0455%\u7684\u60a3\u8005\u3002<\/p>\n<p><b>\u81e8\u5e8a\u7d50\u679c<\/b><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32023 \u5e744 \u670821 \u65e5\uff0c \u5171\u670964 \u4f8b\u60a3\u8005\u63a5\u53d7\u4e86Osemitamab (TST001 ) \u806f\u5408CAPOX\u6cbb\u7642\uff0c\u5176\u4e2d15 \u4f8b\u60a3\u8005\u5728\u5291\u91cf\u905e\u589e\u968e\u6bb5\u63a5\u53d7\u6bcf3 \u54681~8 mg\/kg\u5291\u91cf\u7684Osemitamab (TST001)\u6cbb\u7642\uff0c\u53e6\u591649\u4f8b\u60a3\u8005\u5728\u5291\u91cf\u64f4\u5c55\u968e\u6bb5\u63a5\u53d7\u6bcf3\u54686mg\/kg \u5291\u91cf\u7684Osemitamab (TST001)\u6cbb\u7642\u3002\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba195\u5929\u3002<\/li>\n<li>\u5728\u5291\u91cf\u64f4\u5c55\u968e\u6bb5\u63a5\u53d7 6 mg\/kg \u5291\u91cf\u6cbb\u7642\u768449 \u4f8b\u60a3\u8005\u4e2d\uff0c\u5176\u4e2d 41 \u4f8b\u60a3\u8005CLDN18.2\u967d\u6027\uff08\u9ad8\u8868\u90549\u4f8b\uff0c\u4e2d\u8868\u905413\u4f8b\uff0c\u4f4e\u8868\u905419\u4f8b\uff09\uff0c8\u4f8b\u60a3\u8005\u672a\u9032\u884c\u816b\u7624\u6aa2\u6e2c(CLDN18.2\u8868\u9054\u672a\u77e5\uff09\u3002\u9019\u4e00\u5291\u91cf\u64f4\u5c55\u7684\u57fa\u7dda\u4eba\u53e3\u7d71\u8a08\u5b78\u82072023 ASCO \u4e0a\u767c\u8868\u7684\u7e3d\u9ad4\u4eba\u7fa4\u76f8\u4f3c\uff08\u6458\u8981\u7de8\u865f\uff1a4046*\uff09\u3002\u4e0d\u540cCLDN18.2\u8868\u9054\u6c34\u5e73\u4e4b\u9593\u7684\u57fa\u7dda\u7279\u5f81\u7121\u986f\u8457\u81e8\u5e8a\u5dee\u7570\u3002<\/li>\n<li>Osemitamab (TST001)\u7684\u5b89\u5168\u6027\u4e3b\u8981\u8868\u73fe\u70ba\u53ef\u63a7\u7684\u975e\u7279\u7570\u6027\u9776\u5411\u526f\u4f5c\u7528\uff0c\u5b89\u5168\u6027\u6578\u64da\u5df2\u57282023 ASCO\u5927\u6703\u4e0a\u767c\u5e03\uff08\u6458\u8981\u7de8\u865f\uff1a4046*\uff09\u3002\u4e0d\u826f\u53cd\u61c9\u591a\u70ba1~2\u7d1a\uff0c\u767c\u751f\u5728\u524d2\u500b\u7642\u7a0b\u3002<\/li>\n<li>\u5728\u5291\u91cf\u64f4\u5c55\u968e\u6bb5\u63a5\u53d76mg\/kg\u5291\u91cf\u6cbb\u7642\u768449\u4f8b\u60a3\u8005\u4e2d\uff0c\u5176\u4e2d42\u4f8b\u60a3\u8005\u5177\u6709\u53ef\u6e2c\u91cf\u75c5\u7076\u4e26\u63a5\u53d7\u81f3\u5c11\u4e00\u6b21\u6cbb\u7642\u5f8c\u816b\u7624\u8a55\u4f30\uff0c28\u4f8b\u60a3\u8005(66.7%)\u9054\u5230\u90e8\u5206\u7de9\u89e3\u3002\u65bc\u622a\u6b62\u65e5\u671f2023\u5e744\u670821\u65e5\uff0c64\u4f8b\u60a3\u8005\u4e2d\u670926\u4f8b\u60a3\u8005\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\uff0c\u9810\u8a08\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u70ba9.5\u500b\u6708\u3002\u7121\u9032\u5c55\u751f\u5b58\u671f\u8207CLDN18.2\u8868\u9054\u6c34\u5e73\u7121\u660e\u986f\u76f8\u95dc\u6027\u3002<\/li>\n<\/ul>\n<p>\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff1a\u300c\u70ba\u4e86\u512a\u5316Osemitamab (TST001)\u7684\u7372\u76ca\u8207\u98a8\u96aa\u6bd4\uff0c\u6070\u7576\u5730\u9078\u64c7\u60a3\u8005\u81f3\u95dc\u91cd\u8981\u3002\u6211\u5011\u4f7f\u7528CLDN18.2\u7279\u7570\u6027\u7684\u514d\u75ab\u7d44\u5316\u6aa2\u6e2c\u65b9\u6cd5\uff0c\u7be9\u9078\u51fa55%\u7684G\/GEJ\u764c\u60a3\u8005\uff0c\u4e26\u4e14\u767c\u73fe\u4f4e\u8868\u9054\u60a3\u8005\u8207\u9ad8\u8868\u9054\u60a3\u8005\u5177\u6709\u76f8\u540c\u7684\u6301\u4e45\u7372\u76ca\u3002\u9019\u5c6c\u65bc\u986f\u8457\u5dee\u7570\uff0c\u540c\u6642\u4e5f\u662f\u652f\u6301\u6211\u5011\u9032\u884c\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u8a2d\u8a08\u7684\u91cd\u8981\u6578\u64da\u3002\u300d<\/p>\n<p><b>\u95dc\u65bcOsemitamab (TST001)<\/b><\/p>\n<p>Osemitamab (TST001) \u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411Claudin18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u8303\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684Claudin18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054Claudin18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(NCT05190575\u3001NCT04396821\u3001NCT04495296\u3001NCT05608785 \/ CTR20201281)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) 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href=\"https:\/\/www.transcenta.com\/\" target=\"_blank\" rel=\"nofollow 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\u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411Claudin18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u8303\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684Claudin18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054Claudin18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(NCT05190575\u3001NCT04396821\u3001NCT04495296\u3001NCT05608785 \/ CTR20201281)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) \u7528\u65bc\u6cbb\u7642\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c(GC\/GEJ)\u548c\u80f0\u817a\u764c\u60a3\u8005\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002 \u95dc\u65bc\u5275\u52dd\u96c6\u5718 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name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=160292\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5275\u52dd\u96c6\u5718\u65bcESMO GI\u516c\u5e03TST001\u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u4e0d\u540cCLDN18.2\u8868\u9054\u6c34\u5e73\u7684\u665a\u671f\u80c3\u764cI\/II\u671f\u7684PFS\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"TranStar102(TST001-1002)\u7814\u7a76\u768464\u4f8bCLDN18.2\u967d\u6027\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c\u60a3\u8005\u5df2\u5165\u7d44\u3002CLDN18.2\u967d\u6027\u5b9a\u7fa9\uff1a\u226510%\u7684\u816b\u7624\u7d30\u80de\u6709\u22651+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\u3002\u8a72\u7b49\u60a3\u8005\u7d04\u5360\u6240\u6709\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u817a\u764c\u60a3\u8005\u768455%\u3002\u6574\u9ad4\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u70ba9.5\u500b\u6708\uff0c\u672a\u89c0\u5bdf\u5230CLDN18.2\u8868\u9054\u5c0e\u81f4\u7684\u660e\u986f\u5dee\u7570\u3002  Osemitamab (TST001)\u8207\u5316\u7642\u806f\u7528\uff0c\u53ef\u70baCLDN18.2\u967d\u6027\u816b\u7624\u60a3\u8005\uff0c\u5305\u62ec\u4f4e\u8868\u9054\u60a3\u8005\uff08\u226510%\u816b\u7624\u7d30\u80de\u6709\u22651+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\uff0c\u4f46\uff1c40%\u7684\u816b\u7624\u7d30\u80de\u6709&lt;2+\u7684\u819c\u67d3\u8272\u5f37\u5ea6\uff09\u63d0\u4f9b\u7372\u76ca\u3002 \u8607\u5dde2023\u5e746\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u5ba3\u5e03\u5df2\u65bc2023\u5e74ESMO\u4e16\u754c\u80c3\u8178\u9053\u816b\u7624\u5927\u6703\u4e0a\u516c\u5e03Osemitamab (TST001) \u806f\u5408\u5361\u57f9\u4ed6\u6ff1\u548c\u5967\u6c99\u5229\u9251(CAPOX)\u4e00\u7dda\u6cbb\u7642CLDN18.2\u8868\u9054\u6c34\u5e73\u7684\u665a\u671f\u80c3\/\u80c3\u98df\u7ba1\u9023\u63a5\u90e8(G\/GEJ)\u764c\u7684I\/II\u671f\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u6578\u64da\u3002\u8a72\u7b49\u6578\u64da\u5c07\u652f\u6301\u65bc2023\u5e74\u4e0b\u534a\u5e74\u555f\u52d5\u7684\u5168\u7403\u95dc\u9375\u6027III\u671f\u8a66\u9a57\u3002 \u6a19\u984c Osemitamab 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