{"id":158964,"date":"2023-06-26T08:10:00","date_gmt":"2023-06-26T00:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=158964"},"modified":"2023-06-26T08:10:00","modified_gmt":"2023-06-26T00:10:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%9c%a8%e6%ad%90%e6%b4%b2%e8%82%9d%e8%87%9f%e7%a0%94%e7%a9%b6%e5%8d%94%e6%9c%832023%e5%b9%b4%e5%a4%a7%e6%9c%83%e4%bb%a5%e5%a3%81%e5%a0%b1%e5%bd%a2%e5%bc%8f","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=158964","title":{"rendered":"\u6b4c\u79ae\u5ba3\u5e03\u5728\u6b50\u6d32\u809d\u81df\u7814\u7a76\u5354\u67032023\u5e74\u5927\u6703\u4ee5\u58c1\u5831\u5f62\u5f0f\u5831\u544aFXR\u6fc0\u52d5\u5291ASC42\u7528\u65bc\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\u7684II\u671f\u7814\u7a76"},"content":{"rendered":"
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180<\/span>\u5fae\u514b<\/span><\/p>\n<\/td>\n

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(N=15)<\/span><\/p>\n<\/td>\n

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(N=653)<\/span><\/p>\n<\/td>\n

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(N=271)<\/span><\/p>\n<\/td>\n

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26 (10)<\/span><\/p>\n

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8 (20)<\/span><\/p>\n

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[1]. Data on file
[2]. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial [J]. The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7
[3]. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B [J]. N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470
[4]. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH [J]. Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622
[5]. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study [J]. Hepatology, 2023.DOI: 10.1097\/hep.0000000000000439<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . 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\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u5728\u6b50\u6d32\u809d\u81df\u7814\u7a76\u5354\u6703\uff08EASL\uff092023\u5e74\u5927\u6703\u4e0a\u4ee5\u58c1\u5831\u5f62\u5f0f\u5831\u544a\u4e86\u65b0\u578b\u6cd5\u5c3c\u9187X\u53d7\u9ad4\uff08FXR\uff09\u6fc0\u52d5\u5291ASC42\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\uff08PEG-IFN\uff09\u548c\u6069\u66ff\u5361\u97cb\uff08ETV\uff09\u7528\u85e512\u5468\u6cbb\u7642\u6162\u6027\u4e59\u578b\u809d\u708e\uff08\u6162\u4e59\u809d\uff09\u60a3\u8005\u7684\u6700\u65b0\u7d50\u679c\u3002\u8a72\u6458\u8981\u7684\u6982\u8981\u4fe1\u606f\u5982\u4e0b\uff1a 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IU\/mL\uff09\u3001\u6b63\u5728\u670d\u7528\u6069\u66ff\u5361\u97cb\u7684\u6162\u4e59\u809d\u60a3\u8005\u96a8\u6a5f\u5165\u7d443\u500b\u968a\u5217\uff0c\u5206\u5225\u63a5\u53d7\u4e00\u65e5\u4e00\u6b21\u53e3\u670d10\u6beb\u514bASC42\u7247\u300115\u6beb\u514bASC42\u7247\u4ee5\u53ca\u5c0d\u61c9\u7684\u5b89\u6170\u5291\uff0c\u4e26\u806f\u5408\u6069\u66ff\u5361\u97cb\uff080.5\u6beb\u514b\uff0c\u53e3\u670d\u4e00\u65e5\u4e00\u6b21\uff09\u548c\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\uff08180\u5fae\u514b\uff0c\u76ae\u4e0b\u8a3b\u5c04\u4e00\u5468\u4e00\u6b21\uff09\u806f\u5408\u6cbb\u764212\u5468\uff0c\u4e26\u96a8\u8a2a24\u5468\uff08\u7e7c\u7e8c\u670d\u7528\u6069\u66ff\u5361\u97cb\uff09\u3002\u572812\u5468\u6cbb\u7642\u671f\u548c24\u5468\u96a8\u8a2a\u671f\u5167\uff0c\u6aa2\u6e2c\u8840\u6e05\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u548c\u4e59\u809d\u75c5\u6bd2\u524d\u57fa\u56e0\u7d44RNA\uff08pgRNA\uff09\u76f8\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u3002 \u7d50\u679c\uff1a 10\u6beb\u514bASC42\u300115\u6beb\u514bASC42\u548c\u5b89\u6170\u5291\u968a\u5217\u4e2d\uff0c\u5206\u5225\u5171\u5831\u544a\u4e86122\u3001119\u548c107\u4f8b\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\uff0c\u4e14\u5927\u591a\u6578\u4e0d\u826f\u4e8b\u4ef6\uff0894.3%\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\u300215\u6beb\u514bASC42\u968a\u5217\u4e2d\u7684\u4e00\u540d\u53d7\u8a66\u8005\u51fa\u73fe\u809d\u529f\u80fd\u640d\u50b7\u76843\u7d1a\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0c\u6700\u7d42\u6062\u5fa9\u6b63\u5e38\u3002\u7619\u7662\u662f\u6700\u5e38\u898b\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u572810\u6beb\u514bASC42\u300115\u6beb\u514bASC42\u548c\u5b89\u6170\u5291\u968a\u5217\u4e2d\uff0c\u5206\u5225\u67091\u4f4d\uff086.7%\uff09\u30017\u4f4d\uff0850%\uff09\u548c0\u4f4d\uff080%\uff09\u53d7\u8a66\u8005\u88ab\u5831\u544a\u8207\u7814\u7a76\u85e5\u7269\u76f8\u95dc\u7684\u7619\u7662\u300210\u6beb\u514bASC42\u7684\u7619\u7662\u767c\u751f\u7387\uff086.7%\uff09\u4f4e\u65bc\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u4e2d\u7684\u7619\u7662\u767c\u751f\u7387\u3002 ASC42\u8207\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u548c\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\u7684\u7619\u7662\u767c\u751f\u7387\u6bd4\u8f03 \u00a0 ASC42 \u5967\u8c9d\u81bd\u9178 \u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a \u6614\u6d1b\u6cd5\u514b\u7d22 \u66f2\u5339\u6cd5\u7d22 10\u6beb\u514b 10\u6beb\u514b 180\u5fae\u514b 30\u6beb\u514b 140\u5fae\u514b (N=15) (N=653) (N=271) (N=40) (N=50) \u60a3\u8005\u985e\u578b \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 NASH \u00a0 \u6cbb\u7642\u5468\u671f \u00a0 12\u5468 \u00a0 18\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 \u51fa\u73fe\u7619\u7662\u7684\u75c5\u4f8b\u6578(%) \u00a0 1 (6.7) \u00a0 183 (28) \u00a0 26 (10) \u00a0 8 (20) \u00a0 20 (40) \u00a0 \u53c3\u8003\u6587\u737b\u7de8\u865f \u7d50\u8ad6\uff1a \u5728\u6162\u4e59\u809d\u60a3\u8005\u4e2d\uff0c10\u6beb\u514bASC42\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\u548c\u6069\u66ff\u5361\u97cb\u768412\u5468\u6cbb\u7642\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u51fa\u73fe\u6700\u5c0f\u7a0b\u5ea6\u548c\u8f15\u5fae\u7684\u7619\u7662\uff086.7%\uff09\u3002\u5148\u524d\u7814\u7a76\u8868\u660e\uff0c\u5728\u5065\u5eb7\u53d7\u8a66\u8005\u4e2d\uff0cASC42\u55ae\u85e5\u7d66\u85e514\u5929\uff0c\u57285\u6beb\u514b~15\u6beb\u514b\u7684\u5291\u91cf\u7bc4\u570d\u5167\uff0c\u6210\u7e96\u7dad\u7d30\u80de\u751f\u9577\u56e0\u5b5019\uff08FGF19\uff09\u589e\u52a0471%~1,780%\uff0c7\u03b1-\u7fa5\u57fa-4-\u81bd\u753e\u70ef-3-\u916e\uff08C4\uff09\u6e1b\u5c1153%~91%\u3002\u6578\u64da\u8868\u660e\uff0c\u572810\u6beb\u514b\u5291\u91cf\u4e0b\uff0c\u65b0\u578bFXR\u6fc0\u52d5\u5291ASC42\u5728\u7619\u7662\u65b9\u9762\u4e0d\u540c\u65bc\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u3002 . Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . Hepatology, 2023.DOI: 10.1097\/hep.0000000000000439 \u95dc\u65bcEASL EASL\uff0c\u5373\u6b50\u6d32\u809d\u81df\u7814\u7a76\u5354\u6703\uff0c\u6210\u7acb\u65bc1966\u5e74\uff0c\u662f\u81f4\u529b\u65bc\u8ffd\u6c42\u5353\u8d8a\u7684\u809d\u81df\u7814\u7a76\u548c\u809d\u81df\u75be\u75c5\u7684\u81e8\u5e8a\u5be6\u8e10\u4e26\u70ba\u6240\u6709\u5c0d\u809d\u75c5\u5b78\u611f\u8208\u8da3\u7684\u4eba\u58eb\u63d0\u4f9b\u6559\u80b2\u7684\u91ab\u5b78\u5354\u6703\u3002\u622a\u81f32022\u5e74\uff0cEASL\u64c1\u6709\u4f86\u81ea112\u500b\u570b\u5bb6\u76844,900\u540d\u6703\u54e1\u3002 \u95dc\u65bc\u6b4c\u79ae 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ASC42\u8207\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u548c\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\u7684\u7619\u7662\u767c\u751f\u7387\u6bd4\u8f03 \u00a0 ASC42 \u5967\u8c9d\u81bd\u9178 \u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a \u6614\u6d1b\u6cd5\u514b\u7d22 \u66f2\u5339\u6cd5\u7d22 10\u6beb\u514b 10\u6beb\u514b 180\u5fae\u514b 30\u6beb\u514b 140\u5fae\u514b (N=15) (N=653) (N=271) (N=40) (N=50) \u60a3\u8005\u985e\u578b \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 NASH \u00a0 \u6cbb\u7642\u5468\u671f \u00a0 12\u5468 \u00a0 18\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 \u51fa\u73fe\u7619\u7662\u7684\u75c5\u4f8b\u6578(%) \u00a0 1 (6.7) \u00a0 183 (28) \u00a0 26 (10) \u00a0 8 (20) \u00a0 20 (40) \u00a0 \u53c3\u8003\u6587\u737b\u7de8\u865f \u7d50\u8ad6\uff1a 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Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\\\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\\\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\\\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . 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Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . 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\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u5728\u6b50\u6d32\u809d\u81df\u7814\u7a76\u5354\u6703\uff08EASL\uff092023\u5e74\u5927\u6703\u4e0a\u4ee5\u58c1\u5831\u5f62\u5f0f\u5831\u544a\u4e86\u65b0\u578b\u6cd5\u5c3c\u9187X\u53d7\u9ad4\uff08FXR\uff09\u6fc0\u52d5\u5291ASC42\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\uff08PEG-IFN\uff09\u548c\u6069\u66ff\u5361\u97cb\uff08ETV\uff09\u7528\u85e512\u5468\u6cbb\u7642\u6162\u6027\u4e59\u578b\u809d\u708e\uff08\u6162\u4e59\u809d\uff09\u60a3\u8005\u7684\u6700\u65b0\u7d50\u679c\u3002\u8a72\u6458\u8981\u7684\u6982\u8981\u4fe1\u606f\u5982\u4e0b\uff1a 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IU\/mL\uff09\u3001\u6b63\u5728\u670d\u7528\u6069\u66ff\u5361\u97cb\u7684\u6162\u4e59\u809d\u60a3\u8005\u96a8\u6a5f\u5165\u7d443\u500b\u968a\u5217\uff0c\u5206\u5225\u63a5\u53d7\u4e00\u65e5\u4e00\u6b21\u53e3\u670d10\u6beb\u514bASC42\u7247\u300115\u6beb\u514bASC42\u7247\u4ee5\u53ca\u5c0d\u61c9\u7684\u5b89\u6170\u5291\uff0c\u4e26\u806f\u5408\u6069\u66ff\u5361\u97cb\uff080.5\u6beb\u514b\uff0c\u53e3\u670d\u4e00\u65e5\u4e00\u6b21\uff09\u548c\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\uff08180\u5fae\u514b\uff0c\u76ae\u4e0b\u8a3b\u5c04\u4e00\u5468\u4e00\u6b21\uff09\u806f\u5408\u6cbb\u764212\u5468\uff0c\u4e26\u96a8\u8a2a24\u5468\uff08\u7e7c\u7e8c\u670d\u7528\u6069\u66ff\u5361\u97cb\uff09\u3002\u572812\u5468\u6cbb\u7642\u671f\u548c24\u5468\u96a8\u8a2a\u671f\u5167\uff0c\u6aa2\u6e2c\u8840\u6e05\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u548c\u4e59\u809d\u75c5\u6bd2\u524d\u57fa\u56e0\u7d44RNA\uff08pgRNA\uff09\u76f8\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u3002 \u7d50\u679c\uff1a 10\u6beb\u514bASC42\u300115\u6beb\u514bASC42\u548c\u5b89\u6170\u5291\u968a\u5217\u4e2d\uff0c\u5206\u5225\u5171\u5831\u544a\u4e86122\u3001119\u548c107\u4f8b\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\uff0c\u4e14\u5927\u591a\u6578\u4e0d\u826f\u4e8b\u4ef6\uff0894.3%\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\u300215\u6beb\u514bASC42\u968a\u5217\u4e2d\u7684\u4e00\u540d\u53d7\u8a66\u8005\u51fa\u73fe\u809d\u529f\u80fd\u640d\u50b7\u76843\u7d1a\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0c\u6700\u7d42\u6062\u5fa9\u6b63\u5e38\u3002\u7619\u7662\u662f\u6700\u5e38\u898b\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u572810\u6beb\u514bASC42\u300115\u6beb\u514bASC42\u548c\u5b89\u6170\u5291\u968a\u5217\u4e2d\uff0c\u5206\u5225\u67091\u4f4d\uff086.7%\uff09\u30017\u4f4d\uff0850%\uff09\u548c0\u4f4d\uff080%\uff09\u53d7\u8a66\u8005\u88ab\u5831\u544a\u8207\u7814\u7a76\u85e5\u7269\u76f8\u95dc\u7684\u7619\u7662\u300210\u6beb\u514bASC42\u7684\u7619\u7662\u767c\u751f\u7387\uff086.7%\uff09\u4f4e\u65bc\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u4e2d\u7684\u7619\u7662\u767c\u751f\u7387\u3002 ASC42\u8207\u5176\u4ed6FXR\u6fc0\u52d5\u5291\u548c\u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a\u7684\u7619\u7662\u767c\u751f\u7387\u6bd4\u8f03 \u00a0 ASC42 \u5967\u8c9d\u81bd\u9178 \u805a\u4e59\u4e8c\u9187\u5e79\u64fe\u7d20\u03b1-2a \u6614\u6d1b\u6cd5\u514b\u7d22 \u66f2\u5339\u6cd5\u7d22 10\u6beb\u514b 10\u6beb\u514b 180\u5fae\u514b 30\u6beb\u514b 140\u5fae\u514b (N=15) (N=653) (N=271) (N=40) (N=50) \u60a3\u8005\u985e\u578b \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 \u6162\u4e59\u809d \u00a0 NASH \u00a0 NASH \u00a0 \u6cbb\u7642\u5468\u671f \u00a0 12\u5468 \u00a0 18\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 48\u5468 \u00a0 \u51fa\u73fe\u7619\u7662\u7684\u75c5\u4f8b\u6578(%) \u00a0 1 (6.7) \u00a0 183 (28) \u00a0 26 (10) \u00a0 8 (20) \u00a0 20 (40) \u00a0 \u53c3\u8003\u6587\u737b\u7de8\u865f \u7d50\u8ad6\uff1a 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Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . 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Data on file. Younossi Z.M., Ratziu V., Loomba R., et al. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial . The Lancet, 2019, 394(10215): 2184-96.DOI: 10.1016\/s0140-6736(19)33041-7. Lau G.K., Piratvisuth T., Luo K.X., et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B . N Engl J Med, 2005, 352(26): 2682-95.DOI: 10.1056\/NEJMoa043470. Loomba R., Noureddin M., Kowdley K.V., et al. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH . Hepatology, 2021, 73(2): 625-43.DOI: 10.1002\/hep.31622. Anstee Q.M., Lucas K.J., Francque S., et al. Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study . 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